Click here to switch to the map view.

The map label for this gene is uxaC

Identifier: 138895421

GI number: 138895421

Start: 1866526

End: 1867929

Strand: Reverse

Name: uxaC

Synonym: GTNG_1765

Alternate gene names: 138895421

Gene position: 1867929-1866526 (Counterclockwise)

Preceding gene: 138895422

Following gene: 138895420

Centisome position: 52.61

GC content: 44.23

Gene sequence:

>1404_bases
ATGCAGCCGTTCATTGATGATCGTTTTTTGCTGCAAAATAAACATGCCGAAGTGTTGTACCACGACTATGCCAAATCGTT
GCCGATTATTGATTACCATTGCCATTTAAGTGCGAAAGAGATTGCCGAGGACCGACGGTTTCATGATATGACAGAGCTTT
GGCTCGAAGGAGATCACTACAAATGGCGGGCGATGCGGGCGTTGGGGGTAGAAGAAAAATATATTACAGGAAGCGCTTCT
CCTGAGGAAAAGTTTCAAGCATGGGCGAAAACGGTGCCGTATTGCATTGGGAATCCACTTTATCACTGGACGCATTTAGA
GTTGAAGCGCTATTTCCAAGTCGGTGTCCTCTTAAATGAGCAGACGTGGAAGGAAGTATGGGATCATTGCAACGAGTTGC
TCCAACAAGAAGGATATTCAGCCCGTTCTTTCATGATTCAATCAAACGTGGAGTGGATCGGGACGACGGATGATCCGCTC
GATGACCTAATGGATCATCAAAAAATCGCCCAAGACTCGTCATTTTCGATCAAGGTTGTGCCATCGTTTCGGCCTGATGC
CGTTATCGAAATTAATCGGCCGTCTTTCTTGGATTACGTAAGTAAGCTAGGAGAAGTGGCTGACCTATCGGTCGACGATT
ATGGCCAACTATTGCAAGCGCTCGAAAATCGAGTTCGTTATTTTCATGAGGCAGGATGCCGGATGGCCGATCACGGTCTT
GAATCGATGCCGTACGCTGAATGCACCTTGGATGAGGCGAGGGTCATTTTTCAAAAAAGAAAAGAAGGATTTGCCCTTAG
CCGAGAGGAGGAAGAAAAATATCAAACTTTCACTTTATGTTTCTTAGCCCGTTTATACTATTCTCTTGGTTGGGTGATGC
AGCTGCACATTGGTTCGATTCGAAATACCAATCAAAAGATGTTCCAACAGCTTGGGCCGAATACTGGGTATGATTCGATT
AACGACTTTTTCTTTGCCCAGCCGTTAAACGCTTTTCTCAATCGATTGGAACGTGACGGTCAGTTGCCAAAAACGATTGT
GTATACATTAAACCCTGCTTATAACTATATTGTCGCATCAACGATCGGCAACTTTCCATCAGAAGGGGTAAAAGGGAAAG
TCCAATTTGGGGCAGCCTGGTGGTTTAACGACCATCAGGATGGCATAATACGCCATCTCAATGATCTGGCCAATGTGGGA
GTATTCAGCACATTTGTTGGCATGTTAACCGATTCGAGAAGCTTCTTATCTTATGTGCGCCATGAATACTTTCGCAGAAT
CGTATGCAATTTAATCGGCTCGTGGATTGAAAAAGGAGAGGCACCGCAAGATTATGCCTTTTTAGGGAAAATTGTCCAAG
ATATATGTTATTTCAATGCGAAACAGTATTTTGATTTATCGTGA

Upstream 100 bases:

>100_bases
GGCTTGTTGAGATTGAAAAAGATATGTTGAAAAGGCAATATCCGCATTACTTTGTTTAAGTGGCTAAAAATCCCATTGAC
GTGAAGGGAGAGGAGAAACG

Downstream 100 bases:

>100_bases
ACGGGGGAGGTGAGACCACAATGAAAATGACATTTCGCTGGTTTGGTAAGGATTATGATACGGTTTCATTGGATCATATC
CGTCAAATTCCAGGAGTAGA

Product: uronate isomerase

Products: NA

Alternate protein names: Glucuronate isomerase; Uronic isomerase

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MQPFIDDRFLLQNKHAEVLYHDYAKSLPIIDYHCHLSAKEIAEDRRFHDMTELWLEGDHYKWRAMRALGVEEKYITGSAS
PEEKFQAWAKTVPYCIGNPLYHWTHLELKRYFQVGVLLNEQTWKEVWDHCNELLQQEGYSARSFMIQSNVEWIGTTDDPL
DDLMDHQKIAQDSSFSIKVVPSFRPDAVIEINRPSFLDYVSKLGEVADLSVDDYGQLLQALENRVRYFHEAGCRMADHGL
ESMPYAECTLDEARVIFQKRKEGFALSREEEEKYQTFTLCFLARLYYSLGWVMQLHIGSIRNTNQKMFQQLGPNTGYDSI
NDFFFAQPLNAFLNRLERDGQLPKTIVYTLNPAYNYIVASTIGNFPSEGVKGKVQFGAAWWFNDHQDGIIRHLNDLANVG
VFSTFVGMLTDSRSFLSYVRHEYFRRIVCNLIGSWIEKGEAPQDYAFLGKIVQDICYFNAKQYFDLS

Sequences:

>Translated_467_residues
MQPFIDDRFLLQNKHAEVLYHDYAKSLPIIDYHCHLSAKEIAEDRRFHDMTELWLEGDHYKWRAMRALGVEEKYITGSAS
PEEKFQAWAKTVPYCIGNPLYHWTHLELKRYFQVGVLLNEQTWKEVWDHCNELLQQEGYSARSFMIQSNVEWIGTTDDPL
DDLMDHQKIAQDSSFSIKVVPSFRPDAVIEINRPSFLDYVSKLGEVADLSVDDYGQLLQALENRVRYFHEAGCRMADHGL
ESMPYAECTLDEARVIFQKRKEGFALSREEEEKYQTFTLCFLARLYYSLGWVMQLHIGSIRNTNQKMFQQLGPNTGYDSI
NDFFFAQPLNAFLNRLERDGQLPKTIVYTLNPAYNYIVASTIGNFPSEGVKGKVQFGAAWWFNDHQDGIIRHLNDLANVG
VFSTFVGMLTDSRSFLSYVRHEYFRRIVCNLIGSWIEKGEAPQDYAFLGKIVQDICYFNAKQYFDLS
>Mature_467_residues
MQPFIDDRFLLQNKHAEVLYHDYAKSLPIIDYHCHLSAKEIAEDRRFHDMTELWLEGDHYKWRAMRALGVEEKYITGSAS
PEEKFQAWAKTVPYCIGNPLYHWTHLELKRYFQVGVLLNEQTWKEVWDHCNELLQQEGYSARSFMIQSNVEWIGTTDDPL
DDLMDHQKIAQDSSFSIKVVPSFRPDAVIEINRPSFLDYVSKLGEVADLSVDDYGQLLQALENRVRYFHEAGCRMADHGL
ESMPYAECTLDEARVIFQKRKEGFALSREEEEKYQTFTLCFLARLYYSLGWVMQLHIGSIRNTNQKMFQQLGPNTGYDSI
NDFFFAQPLNAFLNRLERDGQLPKTIVYTLNPAYNYIVASTIGNFPSEGVKGKVQFGAAWWFNDHQDGIIRHLNDLANVG
VFSTFVGMLTDSRSFLSYVRHEYFRRIVCNLIGSWIEKGEAPQDYAFLGKIVQDICYFNAKQYFDLS

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1904

COG function: function code G; Glucuronate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uronate isomerase family

Homologues:

Organism=Escherichia coli, GI2367192, Length=465, Percent_Identity=52.258064516129, Blast_Score=523, Evalue=1e-149,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXAC_GEOTN (A4IP75)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001125874.1
- ProteinModelPortal:   A4IP75
- SMR:   A4IP75
- STRING:   A4IP75
- GeneID:   4966701
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_1765
- NMPDR:   fig|420246.5.peg.1700
- eggNOG:   COG1904
- HOGENOM:   HBG297087
- OMA:   AWAKTVP
- PhylomeDB:   A4IP75
- ProtClustDB:   CLSK2787261
- BioCyc:   GTHE420246:GTNG_1765-MONOMER
- HAMAP:   MF_00675
- InterPro:   IPR003766
- InterPro:   IPR023177
- Gene3D:   G3DSA:1.10.2020.10

Pfam domain/function: PF02614 UxaC

EC number: =5.3.1.12

Molecular weight: Translated: 54408; Mature: 54408

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPFIDDRFLLQNKHAEVLYHDYAKSLPIIDYHCHLSAKEIAEDRRFHDMTELWLEGDHY
CCCCCCCHHHHCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCH
KWRAMRALGVEEKYITGSASPEEKFQAWAKTVPYCIGNPLYHWTHLELKRYFQVGVLLNE
HHHHHHHHCCCHHEECCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHEECH
QTWKEVWDHCNELLQQEGYSARSFMIQSNVEWIGTTDDPLDDLMDHQKIAQDSSFSIKVV
HHHHHHHHHHHHHHHHCCCCHHHEEEECCCCEECCCCCCHHHHHHHHHHHCCCCCEEEEE
PSFRPDAVIEINRPSFLDYVSKLGEVADLSVDDYGQLLQALENRVRYFHEAGCRMADHGL
CCCCCCEEEEECCCHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
ESMPYAECTLDEARVIFQKRKEGFALSREEEEKYQTFTLCFLARLYYSLGWVMQLHIGSI
CCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RNTNQKMFQQLGPNTGYDSINDFFFAQPLNAFLNRLERDGQLPKTIVYTLNPAYNYIVAS
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
TIGNFPSEGVKGKVQFGAAWWFNDHQDGIIRHLNDLANVGVFSTFVGMLTDSRSFLSYVR
HHCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
HEYFRRIVCNLIGSWIEKGEAPQDYAFLGKIVQDICYFNAKQYFDLS
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure
MQPFIDDRFLLQNKHAEVLYHDYAKSLPIIDYHCHLSAKEIAEDRRFHDMTELWLEGDHY
CCCCCCCHHHHCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCH
KWRAMRALGVEEKYITGSASPEEKFQAWAKTVPYCIGNPLYHWTHLELKRYFQVGVLLNE
HHHHHHHHCCCHHEECCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHEECH
QTWKEVWDHCNELLQQEGYSARSFMIQSNVEWIGTTDDPLDDLMDHQKIAQDSSFSIKVV
HHHHHHHHHHHHHHHHCCCCHHHEEEECCCCEECCCCCCHHHHHHHHHHHCCCCCEEEEE
PSFRPDAVIEINRPSFLDYVSKLGEVADLSVDDYGQLLQALENRVRYFHEAGCRMADHGL
CCCCCCEEEEECCCHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
ESMPYAECTLDEARVIFQKRKEGFALSREEEEKYQTFTLCFLARLYYSLGWVMQLHIGSI
CCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RNTNQKMFQQLGPNTGYDSINDFFFAQPLNAFLNRLERDGQLPKTIVYTLNPAYNYIVAS
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
TIGNFPSEGVKGKVQFGAAWWFNDHQDGIIRHLNDLANVGVFSTFVGMLTDSRSFLSYVR
HHCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
HEYFRRIVCNLIGSWIEKGEAPQDYAFLGKIVQDICYFNAKQYFDLS
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA