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The map label for this gene is purU [H]

Identifier: 138895289

GI number: 138895289

Start: 1719629

End: 1720531

Strand: Reverse

Name: purU [H]

Synonym: GTNG_1633

Alternate gene names: 138895289

Gene position: 1720531-1719629 (Counterclockwise)

Preceding gene: 138895290

Following gene: 138895288

Centisome position: 48.46

GC content: 52.71

Gene sequence:

>903_bases
ATGACTACATTTCGCCAACATCGCTGGCAATCGTTTTTGCAAGGCTACGAGCAGCGGGCTCGGTTGCTGATTTCCTGCCC
GGACCGCCCCGGCATCGTTGCGGCGGTGACTTCGTTTCTTTATGAACAGGGGGCCAATATTGTCGAATCAAGCCAATACT
CGACCGATCCGGAAGGCGGGACGTTTTTCCTCCGCTTGGAGTTTGACTGCCCGAACATCGCGGGTCGGAAGGAAGAGATC
GAAACGGCGTTTGCCCCCATTGCCGAGGAATTTAGCATGACTTGGCAGCTTCGACTGCATAATGAAATTCGACGGATCGC
GATTTTCGTCTCAAAGGCTGAACATTGTTTGCTTGAGCTGCTCTGGCAATGGCAAGCGGGGGAACTGATCGCCGATATCG
CCCTTGTCATCAGCAATCATCCCGATTTGTGCGATGTGGTCGAGCCGCTCGGGATTCCGTATGTGCACATTCCGGTGACG
AAAGAAACGAAAGCGGACGCGGAGGCTGAACAAATCCGCCTGCTTCACGACTATCGGATCGATACGATTGTGCTCGCCCG
CTACATGCAAATTTTATCGCCTGCATTTGTCGCTGAATTTCCAGGGCGAATCATCAACATTCATCATTCGTTCTTGCCGG
CGTTTATCGGCGCACGGCCGTATGAGCGGGCTTATGAGCGCGGCGTCAAGCTGATCGGCGCCCCATCCCATTATGTCACC
GATGATTTGGACAAAGGACCGATCATTGAACAAGATGTTGCCCGTGTTGACCATCGCCATCATCCCGACAATTTAAAACG
GATCGGCCGCTTGATTGAAAAGACGGTGCTCGCTCGGGCGCTGAGATGGCATTTGGAAGACCGAGTCATCATTCATGGCA
ACAAAACCATCGTTTTTTATTGA

Upstream 100 bases:

>100_bases
CATCCGCGCTTCCCTGTTGGCAAGTCCGCCAATTTTTTGTATGATGGAAACTAAATATCACAAGAAACTAAATCATCGCA
AGAAAAGGGAGAGAGAACGG

Downstream 100 bases:

>100_bases
ACATAGGCGGGAGAGGATTTTTCCTTTCCCGCATGGTATAATGAAAAGAAAACGGAATCAAACAGCCCTTTGCTCTCGGT
TAGGTGAATGGAACATCAGG

Product: formyltetrahydrofolate deformylase

Products: NA

Alternate protein names: Formyl-FH(4) hydrolase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTTFRQHRWQSFLQGYEQRARLLISCPDRPGIVAAVTSFLYEQGANIVESSQYSTDPEGGTFFLRLEFDCPNIAGRKEEI
ETAFAPIAEEFSMTWQLRLHNEIRRIAIFVSKAEHCLLELLWQWQAGELIADIALVISNHPDLCDVVEPLGIPYVHIPVT
KETKADAEAEQIRLLHDYRIDTIVLARYMQILSPAFVAEFPGRIINIHHSFLPAFIGARPYERAYERGVKLIGAPSHYVT
DDLDKGPIIEQDVARVDHRHHPDNLKRIGRLIEKTVLARALRWHLEDRVIIHGNKTIVFY

Sequences:

>Translated_300_residues
MTTFRQHRWQSFLQGYEQRARLLISCPDRPGIVAAVTSFLYEQGANIVESSQYSTDPEGGTFFLRLEFDCPNIAGRKEEI
ETAFAPIAEEFSMTWQLRLHNEIRRIAIFVSKAEHCLLELLWQWQAGELIADIALVISNHPDLCDVVEPLGIPYVHIPVT
KETKADAEAEQIRLLHDYRIDTIVLARYMQILSPAFVAEFPGRIINIHHSFLPAFIGARPYERAYERGVKLIGAPSHYVT
DDLDKGPIIEQDVARVDHRHHPDNLKRIGRLIEKTVLARALRWHLEDRVIIHGNKTIVFY
>Mature_299_residues
TTFRQHRWQSFLQGYEQRARLLISCPDRPGIVAAVTSFLYEQGANIVESSQYSTDPEGGTFFLRLEFDCPNIAGRKEEIE
TAFAPIAEEFSMTWQLRLHNEIRRIAIFVSKAEHCLLELLWQWQAGELIADIALVISNHPDLCDVVEPLGIPYVHIPVTK
ETKADAEAEQIRLLHDYRIDTIVLARYMQILSPAFVAEFPGRIINIHHSFLPAFIGARPYERAYERGVKLIGAPSHYVTD
DLDKGPIIEQDVARVDHRHHPDNLKRIGRLIEKTVLARALRWHLEDRVIIHGNKTIVFY

Specific function: Produces Formate From Formyl-Tetrahydrofolate. Provides The Major Source Of Formate For The Purt-Dependent Synthesis Of 5'-Phosphoribosyl-N-Formylglycinamide (Fgar) During Aerobic Growth. Has A Role In Regulating The One-Carbon Pool. [C]

COG id: COG0788

COG function: function code F; Formyltetrahydrofolate hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=213, Percent_Identity=29.5774647887324, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI209869995, Length=213, Percent_Identity=29.5774647887324, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI209869993, Length=213, Percent_Identity=29.5774647887324, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI1787483, Length=283, Percent_Identity=43.4628975265018, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI1788846, Length=130, Percent_Identity=36.1538461538462, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17567511, Length=149, Percent_Identity=34.8993288590604, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24582400, Length=161, Percent_Identity=34.1614906832298, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR002376
- InterPro:   IPR004810 [H]

Pfam domain/function: PF01842 ACT; PF00551 Formyl_trans_N [H]

EC number: =3.5.1.10 [H]

Molecular weight: Translated: 34511; Mature: 34380

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFRQHRWQSFLQGYEQRARLLISCPDRPGIVAAVTSFLYEQGANIVESSQYSTDPEGG
CCCHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCC
TFFLRLEFDCPNIAGRKEEIETAFAPIAEEFSMTWQLRLHNEIRRIAIFVSKAEHCLLEL
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHH
LWQWQAGELIADIALVISNHPDLCDVVEPLGIPYVHIPVTKETKADAEAEQIRLLHDYRI
HHHCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCH
DTIVLARYMQILSPAFVAEFPGRIINIHHSFLPAFIGARPYERAYERGVKLIGAPSHYVT
HHHHHHHHHHHHCHHHHHHCCCCEEEEHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCC
DDLDKGPIIEQDVARVDHRHHPDNLKRIGRLIEKTVLARALRWHLEDRVIIHGNKTIVFY
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEC
>Mature Secondary Structure 
TTFRQHRWQSFLQGYEQRARLLISCPDRPGIVAAVTSFLYEQGANIVESSQYSTDPEGG
CCHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCC
TFFLRLEFDCPNIAGRKEEIETAFAPIAEEFSMTWQLRLHNEIRRIAIFVSKAEHCLLEL
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHH
LWQWQAGELIADIALVISNHPDLCDVVEPLGIPYVHIPVTKETKADAEAEQIRLLHDYRI
HHHCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCH
DTIVLARYMQILSPAFVAEFPGRIINIHHSFLPAFIGARPYERAYERGVKLIGAPSHYVT
HHHHHHHHHHHHCHHHHHHCCCCEEEEHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCC
DDLDKGPIIEQDVARVDHRHHPDNLKRIGRLIEKTVLARALRWHLEDRVIIHGNKTIVFY
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]