Click here to switch to the map view.

The map label for this gene is cysJ [H]

Identifier: 138894931

GI number: 138894931

Start: 1338492

End: 1340321

Strand: Direct

Name: cysJ [H]

Synonym: GTNG_1269

Alternate gene names: 138894931

Gene position: 1338492-1340321 (Clockwise)

Preceding gene: 138894929

Following gene: 138894932

Centisome position: 37.7

GC content: 52.3

Gene sequence:

>1830_bases
TTGCAGCTGCAAGTAACTAACAGTCCGTTTAGTCAGGAGCAGATCGAGCTCCTGAACCGTTTGTTGCCGACATTGACGCC
GTCGCAAAAGTTTTGGCTGAGCGGGTATTTGGCCGCTGCCGAGACCGCGGTGGGCGTTCTCGATGCCGAGGCGCCGGCGC
TGTTTGCCGGGGGCGGCAAGCCGGTTTCGAAAGAAGTGACCGTTCTTTACGGTTCACAAACCGGCAATGCGCAAAAGTTG
GCTGAAAAAGCCGGCAAGGCGCTCAAAGAGCGCGGTTTTGAGGCGAAAGTATTGTCCATGCTTAATTTTAAGCCGAACGA
ATTAAAGAAAGTGGAGACGTTGCTCATTGTCGTGAGCACGCATGGGGAAGGCGATCCGCCGGATAATGCCGTATCATTTT
ACGAGTTTCTCCACAGTAAGCGGGCGCCAAAACTAAATCATCTTCGTTTCTCCGTCTTAGCACTCGGCGATACGTCATAT
GAGCATTTTTGCCAGACGGGGAAAGATTTTGATAAGCGACTGGAGGAGCTTGGAGGAGAGCGTTTTTATCCGCGCGTCGA
CTGTGATGTCGACTACGAAGAAGCGGCGGCGAAATGGCTCGATGGTGTTCTTGGTGAGTTAAGCAAACAAGCCAATGCCA
ACGGTGGAGCAGCTCCGCTCTTGTCGGCTGTGGCTGCGGAGCCGAAAGCGGAGCCGGCTGTCGTCTATTCGCGGAAAAAC
CCGTTCCTAGCTGAGGTGTTGGAAAACATTAACTTAAACGGTCGCGGATCGAATAAAGAAACGCGCCATCTCGAATTGTC
GCTTGAAGGATCGGGTTTGAAATATGAGCCGGGCGATGCGCTTGGCATTTTCCCGAAAAACGATCCAGAGCTTGTTGACC
TTGTCATCCAAGAAATGAAATGGAACCCGGAAGAAACAGTGACGATTGACAAGGACGGAGAAGTGCGTTCGCTGAAAGAA
GCGCTCACGTCCCATTTTGAAATTACCGTTTTGACGAAAGCGCTGCTGCAAAAGCTGGCGCCGCTATCGAAAAACAGCGC
GCTTCAAGAGCTTGTTGCCCCGGGCAATGAGACAAAATTAAAAGAATATGCCAAAGGCCGCGACTTGCTCGATGCACTGC
GCGATTTTGGTCCGTGGGACGCTGCGCCGCAACAAGTCATTTCCATCTTGCGGAAAATGCCGCCACGCCTGTATTCGATC
GCGAGCAGCTTAGCCGCATATCCGGATGAAGTGCATTTGACGATCGGTGCGGTTCGTTATGAGTCTTACGGCCGTCTGCG
CAAAGGGGTATGCTCGACGTTCTGTGCCGAACGTATTCAAATCGGCGATACGCTGCCGGTCTTTATTCAGCCGAATCCGA
ACTTCAAGCTGCCGAAAGATCCGTCGACGCCGATCATTATGATCGGACCGGGCACGGGGGTGGCTCCGTTCCGCGCCTTT
ATGCAAGAACGTGAAGCAACGGGAGCGAACGGAAAATCATGGCTTTTCTTCGGCGATCAGCATTTTGTGACTGACTTCCT
GTATCAAACCGAATGGCAAGCGTGGCTGAAAAGCGGCGTGCTCACAAGAATGGATGTCGCCTTCTCACGCGATACGGAGA
ACAAAGTATACGTCCAACATCGGATGCTTGAACGAAGCAAAGAGCTGTTCGGTTGGCTCGAGGAAGGCGCTGTCGTCTAC
ATTTGCGGTGACAAGCAGCACATGGCGCGCGACGTCCATCAGACGCTCATCGATATTATTGAAAAAGAAGGCGGTATGAG
CCGCGAGCAAGCGGAAGCTTATTTGACCGAAATGCAAAAACAAAAACGGTACCAACGTGACGTCTATTAA

Upstream 100 bases:

>100_bases
CTACTTGTTTTATAGGAATAATGGATGTTTGGCGGCCACACCGATAAAAGTCAGGAAGGAATTCCGCCATCATTCTATTT
TATATTGAGGGGTGGACACG

Downstream 100 bases:

>100_bases
TCTCAAAGAAGGAGTGGAATCGAAATGGCGAAAGTCGTGTTAAAAGCGCCGGATGGACCGCCAAGCGATGTCGAGCGCAT
TAAACGGGAAAGCCGTTATT

Product: sulfite reductase (NADPH)-like protein

Products: NA

Alternate protein names: SiR-FP [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MQLQVTNSPFSQEQIELLNRLLPTLTPSQKFWLSGYLAAAETAVGVLDAEAPALFAGGGKPVSKEVTVLYGSQTGNAQKL
AEKAGKALKERGFEAKVLSMLNFKPNELKKVETLLIVVSTHGEGDPPDNAVSFYEFLHSKRAPKLNHLRFSVLALGDTSY
EHFCQTGKDFDKRLEELGGERFYPRVDCDVDYEEAAAKWLDGVLGELSKQANANGGAAPLLSAVAAEPKAEPAVVYSRKN
PFLAEVLENINLNGRGSNKETRHLELSLEGSGLKYEPGDALGIFPKNDPELVDLVIQEMKWNPEETVTIDKDGEVRSLKE
ALTSHFEITVLTKALLQKLAPLSKNSALQELVAPGNETKLKEYAKGRDLLDALRDFGPWDAAPQQVISILRKMPPRLYSI
ASSLAAYPDEVHLTIGAVRYESYGRLRKGVCSTFCAERIQIGDTLPVFIQPNPNFKLPKDPSTPIIMIGPGTGVAPFRAF
MQEREATGANGKSWLFFGDQHFVTDFLYQTEWQAWLKSGVLTRMDVAFSRDTENKVYVQHRMLERSKELFGWLEEGAVVY
ICGDKQHMARDVHQTLIDIIEKEGGMSREQAEAYLTEMQKQKRYQRDVY

Sequences:

>Translated_609_residues
MQLQVTNSPFSQEQIELLNRLLPTLTPSQKFWLSGYLAAAETAVGVLDAEAPALFAGGGKPVSKEVTVLYGSQTGNAQKL
AEKAGKALKERGFEAKVLSMLNFKPNELKKVETLLIVVSTHGEGDPPDNAVSFYEFLHSKRAPKLNHLRFSVLALGDTSY
EHFCQTGKDFDKRLEELGGERFYPRVDCDVDYEEAAAKWLDGVLGELSKQANANGGAAPLLSAVAAEPKAEPAVVYSRKN
PFLAEVLENINLNGRGSNKETRHLELSLEGSGLKYEPGDALGIFPKNDPELVDLVIQEMKWNPEETVTIDKDGEVRSLKE
ALTSHFEITVLTKALLQKLAPLSKNSALQELVAPGNETKLKEYAKGRDLLDALRDFGPWDAAPQQVISILRKMPPRLYSI
ASSLAAYPDEVHLTIGAVRYESYGRLRKGVCSTFCAERIQIGDTLPVFIQPNPNFKLPKDPSTPIIMIGPGTGVAPFRAF
MQEREATGANGKSWLFFGDQHFVTDFLYQTEWQAWLKSGVLTRMDVAFSRDTENKVYVQHRMLERSKELFGWLEEGAVVY
ICGDKQHMARDVHQTLIDIIEKEGGMSREQAEAYLTEMQKQKRYQRDVY
>Mature_609_residues
MQLQVTNSPFSQEQIELLNRLLPTLTPSQKFWLSGYLAAAETAVGVLDAEAPALFAGGGKPVSKEVTVLYGSQTGNAQKL
AEKAGKALKERGFEAKVLSMLNFKPNELKKVETLLIVVSTHGEGDPPDNAVSFYEFLHSKRAPKLNHLRFSVLALGDTSY
EHFCQTGKDFDKRLEELGGERFYPRVDCDVDYEEAAAKWLDGVLGELSKQANANGGAAPLLSAVAAEPKAEPAVVYSRKN
PFLAEVLENINLNGRGSNKETRHLELSLEGSGLKYEPGDALGIFPKNDPELVDLVIQEMKWNPEETVTIDKDGEVRSLKE
ALTSHFEITVLTKALLQKLAPLSKNSALQELVAPGNETKLKEYAKGRDLLDALRDFGPWDAAPQQVISILRKMPPRLYSI
ASSLAAYPDEVHLTIGAVRYESYGRLRKGVCSTFCAERIQIGDTLPVFIQPNPNFKLPKDPSTPIIMIGPGTGVAPFRAF
MQEREATGANGKSWLFFGDQHFVTDFLYQTEWQAWLKSGVLTRMDVAFSRDTENKVYVQHRMLERSKELFGWLEEGAVVY
ICGDKQHMARDVHQTLIDIIEKEGGMSREQAEAYLTEMQKQKRYQRDVY

Specific function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow f

COG id: COG0369

COG function: function code P; Sulfite reductase, alpha subunit (flavoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 flavodoxin-like domain [H]

Homologues:

Organism=Homo sapiens, GI127139033, Length=616, Percent_Identity=31.3311688311688, Blast_Score=276, Evalue=6e-74,
Organism=Homo sapiens, GI7657393, Length=605, Percent_Identity=31.404958677686, Blast_Score=255, Evalue=7e-68,
Organism=Homo sapiens, GI221316705, Length=611, Percent_Identity=31.2602291325696, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI221316709, Length=602, Percent_Identity=31.5614617940199, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI24041029, Length=595, Percent_Identity=32.2689075630252, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI10835173, Length=659, Percent_Identity=28.9833080424886, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI40254422, Length=655, Percent_Identity=30.6870229007634, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI221316707, Length=526, Percent_Identity=31.3688212927757, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI169790956, Length=436, Percent_Identity=29.5871559633028, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI169790958, Length=436, Percent_Identity=29.5871559633028, Blast_Score=168, Evalue=1e-41,
Organism=Escherichia coli, GI1789123, Length=602, Percent_Identity=43.8538205980066, Blast_Score=512, Evalue=1e-146,
Organism=Escherichia coli, GI1789154, Length=120, Percent_Identity=35.8333333333333, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790181, Length=141, Percent_Identity=31.9148936170213, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554134, Length=603, Percent_Identity=33.167495854063, Blast_Score=308, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI17566446, Length=579, Percent_Identity=29.1882556131261, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17531441, Length=376, Percent_Identity=23.4042553191489, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6321832, Length=640, Percent_Identity=28.75, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6325305, Length=636, Percent_Identity=25.9433962264151, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321143, Length=392, Percent_Identity=30.1020408163265, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322597, Length=143, Percent_Identity=32.8671328671329, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17137192, Length=612, Percent_Identity=33.6601307189542, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24582192, Length=513, Percent_Identity=32.943469785575, Blast_Score=254, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24660907, Length=598, Percent_Identity=27.0903010033445, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24660903, Length=598, Percent_Identity=27.0903010033445, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI78706872, Length=530, Percent_Identity=30.377358490566, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24583543, Length=530, Percent_Identity=30.377358490566, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI78706876, Length=530, Percent_Identity=30.377358490566, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24647438, Length=411, Percent_Identity=25.7907542579075, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010199
- InterPro:   IPR003097
- InterPro:   IPR017927
- InterPro:   IPR001094
- InterPro:   IPR008254
- InterPro:   IPR001709
- InterPro:   IPR023173
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00667 FAD_binding_1; PF00258 Flavodoxin_1; PF00175 NAD_binding_1 [H]

EC number: =1.8.1.2 [H]

Molecular weight: Translated: 67862; Mature: 67862

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50902 FLAVODOXIN_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLQVTNSPFSQEQIELLNRLLPTLTPSQKFWLSGYLAAAETAVGVLDAEAPALFAGGGK
CEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEECCCC
PVSKEVTVLYGSQTGNAQKLAEKAGKALKERGFEAKVLSMLNFKPNELKKVETLLIVVST
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHEEEEEEEEEE
HGEGDPPDNAVSFYEFLHSKRAPKLNHLRFSVLALGDTSYEHFCQTGKDFDKRLEELGGE
CCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHCCCHHHHHHHHCCCC
RFYPRVDCDVDYEEAAAKWLDGVLGELSKQANANGGAAPLLSAVAAEPKAEPAVVYSRKN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEECCC
PFLAEVLENINLNGRGSNKETRHLELSLEGSGLKYEPGDALGIFPKNDPELVDLVIQEMK
CHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEECCCCEEECCCCCCHHHHHHHHHHHC
WNPEETVTIDKDGEVRSLKEALTSHFEITVLTKALLQKLAPLSKNSALQELVAPGNETKL
CCCCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHH
KEYAKGRDLLDALRDFGPWDAAPQQVISILRKMPPRLYSIASSLAAYPDEVHLTIGAVRY
HHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEEH
ESYGRLRKGVCSTFCAERIQIGDTLPVFIQPNPNFKLPKDPSTPIIMIGPGTGVAPFRAF
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHH
MQEREATGANGKSWLFFGDQHFVTDFLYQTEWQAWLKSGVLTRMDVAFSRDTENKVYVQH
HHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHH
RMLERSKELFGWLEEGAVVYICGDKQHMARDVHQTLIDIIEKEGGMSREQAEAYLTEMQK
HHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
QKRYQRDVY
HHHHHCCCC
>Mature Secondary Structure
MQLQVTNSPFSQEQIELLNRLLPTLTPSQKFWLSGYLAAAETAVGVLDAEAPALFAGGGK
CEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEECCCC
PVSKEVTVLYGSQTGNAQKLAEKAGKALKERGFEAKVLSMLNFKPNELKKVETLLIVVST
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHEEEEEEEEEE
HGEGDPPDNAVSFYEFLHSKRAPKLNHLRFSVLALGDTSYEHFCQTGKDFDKRLEELGGE
CCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHCCCHHHHHHHHCCCC
RFYPRVDCDVDYEEAAAKWLDGVLGELSKQANANGGAAPLLSAVAAEPKAEPAVVYSRKN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEECCC
PFLAEVLENINLNGRGSNKETRHLELSLEGSGLKYEPGDALGIFPKNDPELVDLVIQEMK
CHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEECCCCEEECCCCCCHHHHHHHHHHHC
WNPEETVTIDKDGEVRSLKEALTSHFEITVLTKALLQKLAPLSKNSALQELVAPGNETKL
CCCCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHH
KEYAKGRDLLDALRDFGPWDAAPQQVISILRKMPPRLYSIASSLAAYPDEVHLTIGAVRY
HHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEEH
ESYGRLRKGVCSTFCAERIQIGDTLPVFIQPNPNFKLPKDPSTPIIMIGPGTGVAPFRAF
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHH
MQEREATGANGKSWLFFGDQHFVTDFLYQTEWQAWLKSGVLTRMDVAFSRDTENKVYVQH
HHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHH
RMLERSKELFGWLEEGAVVYICGDKQHMARDVHQTLIDIIEKEGGMSREQAEAYLTEMQK
HHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
QKRYQRDVY
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]