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The map label for this gene is czcD [H]

Identifier: 138894929

GI number: 138894929

Start: 1336400

End: 1337326

Strand: Direct

Name: czcD [H]

Synonym: GTNG_1267

Alternate gene names: 138894929

Gene position: 1336400-1337326 (Clockwise)

Preceding gene: 138894928

Following gene: 138894931

Centisome position: 37.64

GC content: 53.07

Gene sequence:

>927_bases
ATGCACCACCATGCGCACGGCCATTGCGACCATCATCATGGCCATCATCACCATGGCAGAGAAGGAAATCGAAAAGGGTT
AGCGATCGCCCTTGGCATAACGACGAGTATTATGGTTCTTGAATTTGTCGGCGGGCTTGTAACGAACAGCCTTGCTCTTC
TCTCGGATTCGGGGCATATGCTTAGCGATGCCGCTTCGCTTCTGTTGAGTCTAGTGGCAGTATGGTTAGCGGCGAAGCCT
GCCTCTCCAAAGAAAACGTACGGATTGTATCGGTTCGAGATTTTAGCCGCACTCGTCAATGGGGTAACATTGGTGGTGAT
TGCCGCCTGGATTATTTGGGAAGCGGTTGGGAGGTTCGTGAATCCGCCTGACGTAGCGAGCGGGCCGATGATGGCGGTGG
CTGCCGTTGGGTTGTTGGCGAATCTCGTGAGCGCTTGGGTGTTAATGCGCAAAGCCGATGTCAAGGGGAATGTCAATGTC
CGCAGCGCGTATCTGCATGTGCTCGGTGATGCGTTAGGTTCGGTCGGCGCGATCGGGGCCGGGCTTATCATGTGGCTGTT
TGAGTGGTATTTGGCCGATCCGCTTATTTCCGTGTTGGTAGCCATTTTGATTTTAAAAGGTGCGTTCGCTGTCGTTCGGC
AGACGGTGCACATTTTGATGGAAGGAACGCCTGTCGCCATTGACCAGACAGAAGTGAAAACGGCGCTTTCAGGCATTGAG
GGGGTGCTAGATGTCCACGATTTGCATATTTGGACGATCACCTCAGGTCTCGATTCGTTAAGCTGCCATCTGCTCATTGA
AGATGGCCGAGATGCCCAAGCGATTTTGCAGCAGGCGATTGATCTGGTGGAAACCCGCTTCCACATTCGCCATGCAACCA
TTCAAATCGAAATGCCACACATCCGCCATGGGGAGATGGAAGTGTGA

Upstream 100 bases:

>100_bases
AAGGGAAGACATTGGTGTATTCTTGCGATGATGACCATGTGATTTCGTTGTTAAAGCAGGCGATTGACCATGCACAACAC
CGGTGAGGGGGAGTCGATTT

Downstream 100 bases:

>100_bases
AGGGCGGGTCATCAATGACCACGCCCTTCTGTTATTTGTTGGCGCCAGTCCAGTTGGTTTGCAACGTTTCAAGGAAAATG
CGAACGTTTTGCTTGTTTTC

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MHHHAHGHCDHHHGHHHHGREGNRKGLAIALGITTSIMVLEFVGGLVTNSLALLSDSGHMLSDAASLLLSLVAVWLAAKP
ASPKKTYGLYRFEILAALVNGVTLVVIAAWIIWEAVGRFVNPPDVASGPMMAVAAVGLLANLVSAWVLMRKADVKGNVNV
RSAYLHVLGDALGSVGAIGAGLIMWLFEWYLADPLISVLVAILILKGAFAVVRQTVHILMEGTPVAIDQTEVKTALSGIE
GVLDVHDLHIWTITSGLDSLSCHLLIEDGRDAQAILQQAIDLVETRFHIRHATIQIEMPHIRHGEMEV

Sequences:

>Translated_308_residues
MHHHAHGHCDHHHGHHHHGREGNRKGLAIALGITTSIMVLEFVGGLVTNSLALLSDSGHMLSDAASLLLSLVAVWLAAKP
ASPKKTYGLYRFEILAALVNGVTLVVIAAWIIWEAVGRFVNPPDVASGPMMAVAAVGLLANLVSAWVLMRKADVKGNVNV
RSAYLHVLGDALGSVGAIGAGLIMWLFEWYLADPLISVLVAILILKGAFAVVRQTVHILMEGTPVAIDQTEVKTALSGIE
GVLDVHDLHIWTITSGLDSLSCHLLIEDGRDAQAILQQAIDLVETRFHIRHATIQIEMPHIRHGEMEV
>Mature_308_residues
MHHHAHGHCDHHHGHHHHGREGNRKGLAIALGITTSIMVLEFVGGLVTNSLALLSDSGHMLSDAASLLLSLVAVWLAAKP
ASPKKTYGLYRFEILAALVNGVTLVVIAAWIIWEAVGRFVNPPDVASGPMMAVAAVGLLANLVSAWVLMRKADVKGNVNV
RSAYLHVLGDALGSVGAIGAGLIMWLFEWYLADPLISVLVAILILKGAFAVVRQTVHILMEGTPVAIDQTEVKTALSGIE
GVLDVHDLHIWTITSGLDSLSCHLLIEDGRDAQAILQQAIDLVETRFHIRHATIQIEMPHIRHGEMEV

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=313, Percent_Identity=32.2683706070287, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI21361112, Length=298, Percent_Identity=31.8791946308725, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI289803013, Length=303, Percent_Identity=32.013201320132, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI289803009, Length=303, Percent_Identity=32.013201320132, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI289803007, Length=303, Percent_Identity=32.013201320132, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI289803003, Length=303, Percent_Identity=32.013201320132, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI64762489, Length=303, Percent_Identity=32.013201320132, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI21359890, Length=317, Percent_Identity=29.3375394321767, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI20070323, Length=318, Percent_Identity=27.0440251572327, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI14210520, Length=216, Percent_Identity=31.9444444444444, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI52351208, Length=163, Percent_Identity=31.2883435582822, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI222080086, Length=141, Percent_Identity=30.4964539007092, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI40255009, Length=141, Percent_Identity=30.4964539007092, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI52352803, Length=124, Percent_Identity=41.9354838709677, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI21687224, Length=279, Percent_Identity=22.5806451612903, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI301898545, Length=281, Percent_Identity=22.0640569395018, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786966, Length=279, Percent_Identity=43.010752688172, Blast_Score=181, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17555794, Length=306, Percent_Identity=36.2745098039216, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17555796, Length=308, Percent_Identity=35.3896103896104, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI193210990, Length=315, Percent_Identity=31.1111111111111, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI32564488, Length=292, Percent_Identity=29.1095890410959, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17550440, Length=130, Percent_Identity=32.3076923076923, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17550442, Length=130, Percent_Identity=32.3076923076923, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320411, Length=169, Percent_Identity=39.6449704142012, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=148, Percent_Identity=33.1081081081081, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=184, Percent_Identity=25.5434782608696, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583858, Length=331, Percent_Identity=32.6283987915408, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24656728, Length=346, Percent_Identity=29.4797687861272, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24656724, Length=346, Percent_Identity=29.4797687861272, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24656720, Length=346, Percent_Identity=29.4797687861272, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24656715, Length=346, Percent_Identity=29.4797687861272, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21357035, Length=346, Percent_Identity=29.4797687861272, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24584409, Length=142, Percent_Identity=38.0281690140845, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28574430, Length=142, Percent_Identity=38.0281690140845, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24645863, Length=111, Percent_Identity=41.4414414414414, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585900, Length=151, Percent_Identity=32.4503311258278, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585898, Length=151, Percent_Identity=32.4503311258278, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585896, Length=151, Percent_Identity=32.4503311258278, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19921672, Length=151, Percent_Identity=32.4503311258278, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33192; Mature: 33192

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHHAHGHCDHHHGHHHHGREGNRKGLAIALGITTSIMVLEFVGGLVTNSLALLSDSGHM
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHCCCCCCH
LSDAASLLLSLVAVWLAAKPASPKKTYGLYRFEILAALVNGVTLVVIAAWIIWEAVGRFV
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NPPDVASGPMMAVAAVGLLANLVSAWVLMRKADVKGNVNVRSAYLHVLGDALGSVGAIGA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GLIMWLFEWYLADPLISVLVAILILKGAFAVVRQTVHILMEGTPVAIDQTEVKTALSGIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHH
GVLDVHDLHIWTITSGLDSLSCHLLIEDGRDAQAILQQAIDLVETRFHIRHATIQIEMPH
HHHHHHHEEEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHEEEEEEEEECCC
IRHGEMEV
CCCCCCCC
>Mature Secondary Structure
MHHHAHGHCDHHHGHHHHGREGNRKGLAIALGITTSIMVLEFVGGLVTNSLALLSDSGHM
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHCCCCCCH
LSDAASLLLSLVAVWLAAKPASPKKTYGLYRFEILAALVNGVTLVVIAAWIIWEAVGRFV
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NPPDVASGPMMAVAAVGLLANLVSAWVLMRKADVKGNVNVRSAYLHVLGDALGSVGAIGA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GLIMWLFEWYLADPLISVLVAILILKGAFAVVRQTVHILMEGTPVAIDQTEVKTALSGIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHH
GVLDVHDLHIWTITSGLDSLSCHLLIEDGRDAQAILQQAIDLVETRFHIRHATIQIEMPH
HHHHHHHEEEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHEEEEEEEEECCC
IRHGEMEV
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]