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The map label for this gene is bfmBAB [H]

Identifier: 138894292

GI number: 138894292

Start: 687507

End: 688526

Strand: Direct

Name: bfmBAB [H]

Synonym: GTNG_0618

Alternate gene names: 138894292

Gene position: 687507-688526 (Clockwise)

Preceding gene: 138894291

Following gene: 138894293

Centisome position: 19.36

GC content: 47.65

Gene sequence:

>1020_bases
ATGCAACAAACAAAACAGCGGTTGTTAACAGGAAATAAAGCGTTGGCTGAAGCGATTCGGCTTGAAATGGAAAGAGACCC
TAACGTTTTTGTGATGGGAGAAGATGTCGGAGTATACGGTGGGATTTTTGGAGCGACAGAGGGATTGTTCCAAAAGTTTG
GACCGGAGCGGGTTATTGATACCCCAATTTCTGAGACCGCGTTCATCGGTGCTGCCATCGGTGCTGCCGCCGAAGGGATA
CGCCCGATTGTAGAATTAATGTTTGTCGACTTTTTTGGAGTTTGTATGGATCAAATTTACAACCATATGGCGAAAATTCC
GTACATGTCCGGCGGTAGAGTGAAGCTGCCGATGGTGTTGATGACGGCAGTGGGAGGCGGTTATAGCGATGCCGCCCAGC
ACTCGCAAACGTTGTACGCCACCTTTGCCCATCTTCCCGGAATGAAAGTCGTCGCTCCGGCGACGCCATATGATTTAAAA
GGAATGATGATTTCGGCTATTCGCGACGATAACCCGGTTGTCTTTATGTTCCATAAAACGCTGCAAGGGCTTGGGTGGAT
GGATCAGCTTGATGCTTCGATTGGTCATGTACCGGAAGAAGCGTATACTGTGCCACTCGGAAAAGCAAACGTCGTGCGCG
AGGGAACAGACATTACCATCGTTGGAATTCAAATGACGGTGCATCATGCGCTTGAAGCAGCCAAAAGACTTGAACAACAA
GGCGTCCAAGCTGAAGTGATCGACTTGCGTTCTCTTGTTCCTCTGGATAAAGAGACAATCATCCAATCTGTCAAAAAGAC
ACACCGTTTGCTTGTTGTTGATGAAGACTATCTGTCGTACGGGATGACGGCGGAAATTGCGGCGATTGCTGCTGAACATT
GCTTGTATGATTTGGAGGCTCCAGTGAAACGGCTTGCTGTTCCGGATGTACCGATTCCTTACAGCCGTCCGCTTGAACAA
TTTGTTTTGCCGAATGCCGATAAAATTTTCCATGAGGCAATTAAGCTTATCAATGAATAA

Upstream 100 bases:

>100_bases
CAGGCGTATGCGTTTGCGAGAGAAAGCGATTATCCTAAGCCGGAAGCGGCATTGGAAGATGTGTTTGTCTAAATCCAATA
GGAGAAAGGAGTTTTGCCAT

Downstream 100 bases:

>100_bases
GGAAAAGTTTGTTCCAAGGGAGGCAGCTTATGTTTGTCGAAGTGACATTGCCCAAACTATCCGATTCCCATGATGAAAGT
TTAATTACGTTTTGGCACGT

Product: thiamine pyrophosphate-dependent dehydrogenases, E1component subunit beta

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MQQTKQRLLTGNKALAEAIRLEMERDPNVFVMGEDVGVYGGIFGATEGLFQKFGPERVIDTPISETAFIGAAIGAAAEGI
RPIVELMFVDFFGVCMDQIYNHMAKIPYMSGGRVKLPMVLMTAVGGGYSDAAQHSQTLYATFAHLPGMKVVAPATPYDLK
GMMISAIRDDNPVVFMFHKTLQGLGWMDQLDASIGHVPEEAYTVPLGKANVVREGTDITIVGIQMTVHHALEAAKRLEQQ
GVQAEVIDLRSLVPLDKETIIQSVKKTHRLLVVDEDYLSYGMTAEIAAIAAEHCLYDLEAPVKRLAVPDVPIPYSRPLEQ
FVLPNADKIFHEAIKLINE

Sequences:

>Translated_339_residues
MQQTKQRLLTGNKALAEAIRLEMERDPNVFVMGEDVGVYGGIFGATEGLFQKFGPERVIDTPISETAFIGAAIGAAAEGI
RPIVELMFVDFFGVCMDQIYNHMAKIPYMSGGRVKLPMVLMTAVGGGYSDAAQHSQTLYATFAHLPGMKVVAPATPYDLK
GMMISAIRDDNPVVFMFHKTLQGLGWMDQLDASIGHVPEEAYTVPLGKANVVREGTDITIVGIQMTVHHALEAAKRLEQQ
GVQAEVIDLRSLVPLDKETIIQSVKKTHRLLVVDEDYLSYGMTAEIAAIAAEHCLYDLEAPVKRLAVPDVPIPYSRPLEQ
FVLPNADKIFHEAIKLINE
>Mature_339_residues
MQQTKQRLLTGNKALAEAIRLEMERDPNVFVMGEDVGVYGGIFGATEGLFQKFGPERVIDTPISETAFIGAAIGAAAEGI
RPIVELMFVDFFGVCMDQIYNHMAKIPYMSGGRVKLPMVLMTAVGGGYSDAAQHSQTLYATFAHLPGMKVVAPATPYDLK
GMMISAIRDDNPVVFMFHKTLQGLGWMDQLDASIGHVPEEAYTVPLGKANVVREGTDITIVGIQMTVHHALEAAKRLEQQ
GVQAEVIDLRSLVPLDKETIIQSVKKTHRLLVVDEDYLSYGMTAEIAAIAAEHCLYDLEAPVKRLAVPDVPIPYSRPLEQ
FVLPNADKIFHEAIKLINE

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=335, Percent_Identity=40.5970149253731, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI291084858, Length=335, Percent_Identity=39.4029850746269, Blast_Score=231, Evalue=5e-61,
Organism=Homo sapiens, GI4557353, Length=328, Percent_Identity=37.5, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI34101272, Length=328, Percent_Identity=37.5, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI133778974, Length=266, Percent_Identity=27.8195488721804, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI225637461, Length=275, Percent_Identity=26.1818181818182, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI225637463, Length=275, Percent_Identity=26.1818181818182, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI225637459, Length=275, Percent_Identity=26.1818181818182, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=332, Percent_Identity=44.8795180722892, Blast_Score=265, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17506935, Length=340, Percent_Identity=37.9411764705882, Blast_Score=203, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6319698, Length=335, Percent_Identity=41.1940298507463, Blast_Score=251, Evalue=1e-67,
Organism=Drosophila melanogaster, GI21358145, Length=332, Percent_Identity=41.2650602409639, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24650940, Length=332, Percent_Identity=41.2650602409639, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI160714832, Length=340, Percent_Identity=37.6470588235294, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI160714828, Length=340, Percent_Identity=37.6470588235294, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24650943, Length=89, Percent_Identity=43.8202247191011, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24650945, Length=89, Percent_Identity=43.8202247191011, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 37195; Mature: 37195

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQTKQRLLTGNKALAEAIRLEMERDPNVFVMGEDVGVYGGIFGATEGLFQKFGPERVID
CCHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCHHCCHHHHHHHHHHHCCCCCCCC
TPISETAFIGAAIGAAAEGIRPIVELMFVDFFGVCMDQIYNHMAKIPYMSGGRVKLPMVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHH
MTAVGGGYSDAAQHSQTLYATFAHLPGMKVVAPATPYDLKGMMISAIRDDNPVVFMFHKT
HHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCEEEEEEHH
LQGLGWMDQLDASIGHVPEEAYTVPLGKANVVREGTDITIVGIQMTVHHALEAAKRLEQQ
HHHCCCHHHHHHHHCCCCCHHEEECCCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHHC
GVQAEVIDLRSLVPLDKETIIQSVKKTHRLLVVDEDYLSYGMTAEIAAIAAEHCLYDLEA
CCCEEEHHHHHHCCCCHHHHHHHHHHHCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHH
PVKRLAVPDVPIPYSRPLEQFVLPNADKIFHEAIKLINE
HHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQQTKQRLLTGNKALAEAIRLEMERDPNVFVMGEDVGVYGGIFGATEGLFQKFGPERVID
CCHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCHHCCHHHHHHHHHHHCCCCCCCC
TPISETAFIGAAIGAAAEGIRPIVELMFVDFFGVCMDQIYNHMAKIPYMSGGRVKLPMVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHH
MTAVGGGYSDAAQHSQTLYATFAHLPGMKVVAPATPYDLKGMMISAIRDDNPVVFMFHKT
HHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCEEEEEEHH
LQGLGWMDQLDASIGHVPEEAYTVPLGKANVVREGTDITIVGIQMTVHHALEAAKRLEQQ
HHHCCCHHHHHHHHCCCCCHHEEECCCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHHC
GVQAEVIDLRSLVPLDKETIIQSVKKTHRLLVVDEDYLSYGMTAEIAAIAAEHCLYDLEA
CCCEEEHHHHHHCCCCHHHHHHHHHHHCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHH
PVKRLAVPDVPIPYSRPLEQFVLPNADKIFHEAIKLINE
HHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]