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The map label for this gene is acoA [H]

Identifier: 138894291

GI number: 138894291

Start: 686492

End: 687478

Strand: Direct

Name: acoA [H]

Synonym: GTNG_0617

Alternate gene names: 138894291

Gene position: 686492-687478 (Clockwise)

Preceding gene: 138894290

Following gene: 138894292

Centisome position: 19.34

GC content: 48.43

Gene sequence:

>987_bases
TTGACTATTTTCAAGGATCATCTTCTTTGGATGTATGAAATGATGTACAAAATTCGCTACTACGAAGACAAAATGGCCGA
AGCGTATGCAGAAGGGAAATCTCCGGTGTTTAATATCGGCGCAGGGCCAGTGCCTGGGGAAATGCATTTGGCCACCGGAC
AGGAACCAGCTGCAGTTGGGATATGTGTTCACTTGAAAAAGGAAGATACGGTGACTGCTCCGCACCGCCCGCATCACCAT
GCGATTGCCAAAGGGGTTGATTTGAACCGGATGACTGCGGAGATTTTCGGAAAAGTCACTGGACTGGGAAAAGGAAAAGG
GGGGCATATGCACTTGTTTGACCCCGACGTCAAGTTTTCTTGTGGCGGGATCGTAGGGGCTGGCATTCCTCATGCCCTCG
GAGCAGCGCTAGCGGCTAAGAAAAAAGGGAAGGATTGGGTGGCGGTTGCGTTTATTGGTGAAGGAGCTGCCAATCAAGGA
TCATTTCATGAATCGCTGAATATGGCGGCGCTATGGAAGTTGCCATTAATTGTTGTCGTAGAAAATAATGAATATGGGAT
TTCCGTTCCGAAAACGGCGTCTACGGCTGTTTCCTCGAATGATGTACGGGCAGCTGCTTACGGCATCCAAGGGTATTATG
TGAAAGACAACGATCCGATTGAGATGTACAACGTATCGAAAGAAGCTGTGAAACGGGCGCGGAATGGAGAGGGGCCGTCA
ATCATTGAGATTGAAACATACCGTTATTTGGGGCATTTCCAAGGAGATCCGGAACTGTACCGAGACAAAAACGAAGTAAC
GTTGCTTCGAGAAAAAGATCCGATTATTCGACTGCGTAACCGTTTGCTCAATGAATACGGGGTAACAGAGGAGACCATTG
CGCAATTGGAAGGCAAAGCAAGATCCGAGGTCGACCAGGCGTATGCGTTTGCGAGAGAAAGCGATTATCCTAAGCCGGAA
GCGGCATTGGAAGATGTGTTTGTCTAA

Upstream 100 bases:

>100_bases
GGACAATTCAGCGGACAAAGATAAGGAAACAAGCATTGGAACGATTTTTGCATTATGGGAAATTGAAAGCGGTATCAATC
GAGTGAAGGAGGAGAGAAAG

Downstream 100 bases:

>100_bases
ATCCAATAGGAGAAAGGAGTTTTGCCATATGCAACAAACAAAACAGCGGTTGTTAACAGGAAATAAAGCGTTGGCTGAAG
CGATTCGGCTTGAAATGGAA

Product: thiamine pyrophosphate-dependent dehydrogenases, E1component subunit alpha

Products: NA

Alternate protein names: Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit alpha [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MTIFKDHLLWMYEMMYKIRYYEDKMAEAYAEGKSPVFNIGAGPVPGEMHLATGQEPAAVGICVHLKKEDTVTAPHRPHHH
AIAKGVDLNRMTAEIFGKVTGLGKGKGGHMHLFDPDVKFSCGGIVGAGIPHALGAALAAKKKGKDWVAVAFIGEGAANQG
SFHESLNMAALWKLPLIVVVENNEYGISVPKTASTAVSSNDVRAAAYGIQGYYVKDNDPIEMYNVSKEAVKRARNGEGPS
IIEIETYRYLGHFQGDPELYRDKNEVTLLREKDPIIRLRNRLLNEYGVTEETIAQLEGKARSEVDQAYAFARESDYPKPE
AALEDVFV

Sequences:

>Translated_328_residues
MTIFKDHLLWMYEMMYKIRYYEDKMAEAYAEGKSPVFNIGAGPVPGEMHLATGQEPAAVGICVHLKKEDTVTAPHRPHHH
AIAKGVDLNRMTAEIFGKVTGLGKGKGGHMHLFDPDVKFSCGGIVGAGIPHALGAALAAKKKGKDWVAVAFIGEGAANQG
SFHESLNMAALWKLPLIVVVENNEYGISVPKTASTAVSSNDVRAAAYGIQGYYVKDNDPIEMYNVSKEAVKRARNGEGPS
IIEIETYRYLGHFQGDPELYRDKNEVTLLREKDPIIRLRNRLLNEYGVTEETIAQLEGKARSEVDQAYAFARESDYPKPE
AALEDVFV
>Mature_327_residues
TIFKDHLLWMYEMMYKIRYYEDKMAEAYAEGKSPVFNIGAGPVPGEMHLATGQEPAAVGICVHLKKEDTVTAPHRPHHHA
IAKGVDLNRMTAEIFGKVTGLGKGKGGHMHLFDPDVKFSCGGIVGAGIPHALGAALAAKKKGKDWVAVAFIGEGAANQGS
FHESLNMAALWKLPLIVVVENNEYGISVPKTASTAVSSNDVRAAAYGIQGYYVKDNDPIEMYNVSKEAVKRARNGEGPSI
IEIETYRYLGHFQGDPELYRDKNEVTLLREKDPIIRLRNRLLNEYGVTEETIAQLEGKARSEVDQAYAFARESDYPKPEA
ALEDVFV

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde. The alpha subunit is probably the catalytic subunit of the enzyme [H]

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=320, Percent_Identity=35.625, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI4505685, Length=320, Percent_Identity=34.6875, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI291084742, Length=320, Percent_Identity=34.6875, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI291084744, Length=320, Percent_Identity=34.375, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI291084757, Length=320, Percent_Identity=30, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI11386135, Length=279, Percent_Identity=32.258064516129, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI258645172, Length=279, Percent_Identity=32.6164874551971, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17536047, Length=329, Percent_Identity=33.1306990881459, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI32564172, Length=329, Percent_Identity=33.1306990881459, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI86563357, Length=280, Percent_Identity=29.2857142857143, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI86563355, Length=280, Percent_Identity=29.2857142857143, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=330, Percent_Identity=36.0606060606061, Blast_Score=179, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24639748, Length=305, Percent_Identity=36.3934426229508, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24639740, Length=314, Percent_Identity=35.031847133758, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24639744, Length=313, Percent_Identity=35.1437699680511, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI28571106, Length=313, Percent_Identity=35.1437699680511, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24639746, Length=273, Percent_Identity=36.6300366300366, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21355903, Length=247, Percent_Identity=26.7206477732794, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: NA

Molecular weight: Translated: 36124; Mature: 35992

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIFKDHLLWMYEMMYKIRYYEDKMAEAYAEGKSPVFNIGAGPVPGEMHLATGQEPAAVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEECCCCCCEEE
ICVHLKKEDTVTAPHRPHHHAIAKGVDLNRMTAEIFGKVTGLGKGKGGHMHLFDPDVKFS
EEEEEECCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEE
CGGIVGAGIPHALGAALAAKKKGKDWVAVAFIGEGAANQGSFHESLNMAALWKLPLIVVV
CCCEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHCCCEEEECCCEEEEE
ENNEYGISVPKTASTAVSSNDVRAAAYGIQGYYVKDNDPIEMYNVSKEAVKRARNGEGPS
ECCCCCEECCCCCCHHCCCCCCEEEEEEEEEEEECCCCCEEEEECCHHHHHHHHCCCCCC
IIEIETYRYLGHFQGDPELYRDKNEVTLLREKDPIIRLRNRLLNEYGVTEETIAQLEGKA
EEEEEEEEEEECCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHCCHH
RSEVDQAYAFARESDYPKPEAALEDVFV
HHHHHHHHHHHHCCCCCCCHHHHHHCCC
>Mature Secondary Structure 
TIFKDHLLWMYEMMYKIRYYEDKMAEAYAEGKSPVFNIGAGPVPGEMHLATGQEPAAVG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEECCCCCCEEE
ICVHLKKEDTVTAPHRPHHHAIAKGVDLNRMTAEIFGKVTGLGKGKGGHMHLFDPDVKFS
EEEEEECCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEE
CGGIVGAGIPHALGAALAAKKKGKDWVAVAFIGEGAANQGSFHESLNMAALWKLPLIVVV
CCCEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHCCCEEEECCCEEEEE
ENNEYGISVPKTASTAVSSNDVRAAAYGIQGYYVKDNDPIEMYNVSKEAVKRARNGEGPS
ECCCCCEECCCCCCHHCCCCCCEEEEEEEEEEEECCCCCEEEEECCHHHHHHHHCCCCCC
IIEIETYRYLGHFQGDPELYRDKNEVTLLREKDPIIRLRNRLLNEYGVTEETIAQLEGKA
EEEEEEEEEEECCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHCCHH
RSEVDQAYAFARESDYPKPEAALEDVFV
HHHHHHHHHHHHCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969503; 10368162; 9384377 [H]