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The map label for this gene is liaR [H]

Identifier: 138894116

GI number: 138894116

Start: 494722

End: 495354

Strand: Direct

Name: liaR [H]

Synonym: GTNG_0442

Alternate gene names: 138894116

Gene position: 494722-495354 (Clockwise)

Preceding gene: 138894115

Following gene: 138894117

Centisome position: 13.93

GC content: 50.08

Gene sequence:

>633_bases
GTGATAAAGGTGTTGCTTGTCGATGATCATGAAATGGTTCGGCTTGGCGTATCCGCGTATTTATCCGCTCAACCGGACAT
GGAGGTGATCGGCGAGGCGGAGGACGGGCAAAAGGGAGTTGAGCTTGCTCTCACATTGCGCCCTGATGTCATTTTGATGG
ACCTTGTGATGGAACCGATAGACGGCATTGCGGCAACGCAGGAAATCATGAGTGCATGGCCGGAGGCGAAAATTATTGTT
GTGACGAGTTTTTTGGATGATGAAAAGGTGTTCGCAGCGCTCGAAGCAGGGGCGACGAGCTATTTGTTGAAAACATCGAA
AGCAAGTGAAATTGCCGACGCCATTCGGGCCACGTTCCATGGACAATCGGTGCTCGAGCCGGAAGTAGCGGGAAAAGTCA
TGCAAAACCGGAGAAGACAGAGGGCGCGTCTGCCACACGAACAGCTTACGAGCCGAGAGATGGAAGTACTTTTATTAATG
GCGCAAGGAAAAACGAACCAAGAAATGGCCGATGAATTGTTCATTTCACTCAAAACGGTGAAGGTGCATGTGAGCAACAT
TCTCGCCAAACTTGGTGTCCAAGATCGGACGCAAGCGGTCATTTATGCTTTTCGTCATGGGTTGGTGAAATGA

Upstream 100 bases:

>100_bases
GGGCGGCGGAAATCGGTGGAACATTGAAAGTAGTCAGCTTAAAAGGCCAAGGAACAAGGTTGGAAGTGAAGGTGCCGCTT
GTGTATAAGGGGGGATGACC

Downstream 100 bases:

>100_bases
TGCGTGCATCATTTAGTTGACATGTGTAAGAATATCGCCATGTTCATACGAAAACCGCTCCACTTCATCAAGACGAACAA
GAAGATGAAACGGGAGCGGT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MIKVLLVDDHEMVRLGVSAYLSAQPDMEVIGEAEDGQKGVELALTLRPDVILMDLVMEPIDGIAATQEIMSAWPEAKIIV
VTSFLDDEKVFAALEAGATSYLLKTSKASEIADAIRATFHGQSVLEPEVAGKVMQNRRRQRARLPHEQLTSREMEVLLLM
AQGKTNQEMADELFISLKTVKVHVSNILAKLGVQDRTQAVIYAFRHGLVK

Sequences:

>Translated_210_residues
MIKVLLVDDHEMVRLGVSAYLSAQPDMEVIGEAEDGQKGVELALTLRPDVILMDLVMEPIDGIAATQEIMSAWPEAKIIV
VTSFLDDEKVFAALEAGATSYLLKTSKASEIADAIRATFHGQSVLEPEVAGKVMQNRRRQRARLPHEQLTSREMEVLLLM
AQGKTNQEMADELFISLKTVKVHVSNILAKLGVQDRTQAVIYAFRHGLVK
>Mature_210_residues
MIKVLLVDDHEMVRLGVSAYLSAQPDMEVIGEAEDGQKGVELALTLRPDVILMDLVMEPIDGIAATQEIMSAWPEAKIIV
VTSFLDDEKVFAALEAGATSYLLKTSKASEIADAIRATFHGQSVLEPEVAGKVMQNRRRQRARLPHEQLTSREMEVLLLM
AQGKTNQEMADELFISLKTVKVHVSNILAKLGVQDRTQAVIYAFRHGLVK

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=200, Percent_Identity=38.5, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=32.2274881516588, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787473, Length=201, Percent_Identity=36.318407960199, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790102, Length=196, Percent_Identity=33.1632653061224, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786747, Length=208, Percent_Identity=25, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1788712, Length=205, Percent_Identity=23.9024390243902, Blast_Score=71, Evalue=4e-14,
Organism=Escherichia coli, GI87082052, Length=104, Percent_Identity=35.5769230769231, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23223; Mature: 23223

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVLLVDDHEMVRLGVSAYLSAQPDMEVIGEAEDGQKGVELALTLRPDVILMDLVMEPI
CEEEEEECCHHHHHHHHHHHHCCCCCHHEECCCCCCCCCEEEEEEECCCHHHHHHHHHHH
DGIAATQEIMSAWPEAKIIVVTSFLDDEKVFAALEAGATSYLLKTSKASEIADAIRATFH
CHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHC
GQSVLEPEVAGKVMQNRRRQRARLPHEQLTSREMEVLLLMAQGKTNQEMADELFISLKTV
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHH
KVHVSNILAKLGVQDRTQAVIYAFRHGLVK
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKVLLVDDHEMVRLGVSAYLSAQPDMEVIGEAEDGQKGVELALTLRPDVILMDLVMEPI
CEEEEEECCHHHHHHHHHHHHCCCCCHHEECCCCCCCCCEEEEEEECCCHHHHHHHHHHH
DGIAATQEIMSAWPEAKIIVVTSFLDDEKVFAALEAGATSYLLKTSKASEIADAIRATFH
CHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHC
GQSVLEPEVAGKVMQNRRRQRARLPHEQLTSREMEVLLLMAQGKTNQEMADELFISLKTV
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHH
KVHVSNILAKLGVQDRTQAVIYAFRHGLVK
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]