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The map label for this gene is purQ [H]

Identifier: 138893919

GI number: 138893919

Start: 269768

End: 271996

Strand: Direct

Name: purQ [H]

Synonym: GTNG_0243

Alternate gene names: 138893919

Gene position: 269768-271996 (Clockwise)

Preceding gene: 138893918

Following gene: 138893920

Centisome position: 7.6

GC content: 53.39

Gene sequence:

>2229_bases
ATGTCGTTACTGCTTGAGCCGAATGCGGCAATGATTAAAGAACAAAAATTGTATCGTGAAATGGGATTAACGGATGAGGA
GTTTGCGCGCATTGAAGCGATTTTGGGAAGACTGCCGAACTATACGGAAACGGGTATTTTTTCCGTTATGTGGTCAGAGC
ATTGCAGCTATAAAAACTCCAAACCAGTGTTAAAAAAATTCCCGACCGATGGTCCGCATGTGCTGCAAGGACCAGGTGAA
GGTGCGGGGATTGTAGATATCGGCGATGGGTTGGCGGTGGCGTTTAAAATCGAAAGCCACAACCATCCGTCAGCGATCGA
GCCGTATCAGGGGGCGGCGACTGGGGTCGGTGGCATCATCCGCGACGTCTTTTCGATGGGGGCTCGGCCGATTGCGCTCC
TTAACTCGCTTCGATTTGGCGAGTTGACGTCGCCGCGCGTCAAATATTTGTTTGAGCATGTCGTTGCTGGTATTGCCGGA
TACGGCAACTGCATCGGTATTCCGACCGTCGGCGGTGAAGTGCAGTTTGATCCGGCGTATGAAGGCAACCCGTTGGTTAA
CGCCATGTGTGTCGGCATCATCCGCCATGAAGACATTCAACGTGGTGTCGCGACAGGTGTTGGCAATACAGTTATGTACG
TCGGGGCGAAAACGGGTCGCGATGGCATCCACGGGGCGACGTTTGCATCCGAAGAATTAAGTGAGCAATCGGAAGCAAAA
CGCCCGGCCGTGCAAGTTGGCGATCCGTTTATGGAGAAACTGCTGCTTGAAGCGTGTCTAGAAGCGGTTAAGTCCGACGC
GCTAGTCGGCATTCAAGATATGGGCGCCGCTGGATTGACGAGCTCGTCCGCTGAGATGGCAAGCAAAGGCGGCTTCGGCA
TTGAAATGAATTTAGATCTCGTTCCGCAGCGCGAGACGGGCATGACGCCATACGAAATGATGTTGTCCGAATCACAGGAA
CGGATGCTGCTTGTTGTCGAGCAAGGACGGGAAGAGGAGATCGCAGCGATTTTTGCGAAATACGGTTTGGAAGCAAAAGC
GATCGGTAAAGTGACTGATGATAAAATGCTCCGCCTGTTTTTCCACGGTGAAGTGGTGGCAGAAATTCCGGTTGATGCGT
TGGCAAAAGACGCACCGGTATATCATAAGCCGTCGGCAGAGCCGGATTATTATCGCGAATTTCAAGCGATGCCGACATAT
ATTCCGCAAATTGAGGATTACAACCGGACGTTGCTTGGGCTGTTGGCGCAACCGACCATCGCTAGCAAGGAATGGGTGTA
TGACCAGTATGACTACATGGTGCGGACGAACACAGTCGTTGCACCAGGGTCGGACGCGGCAGTCGTGCGCATTCGCGGCA
CGAACAAGGCGCTTGCGCTCACCACGGACTGCAACTCGCGCTATTTGTACTTGGATCCGGAAATGGGCGGGAAAATTGCC
GTCGCCGAGGCGGCGCGCAACGTCGTTTGCTCCGGGGCGAAACCGCTCGCCATTACAGATTGCCTCAACTTCGGCAATCC
GGAAAAGCCGGACATCTTTTGGCAGCTCGAAAAGGCGGTTGACGGAATGAGCGAAGCGTGCCGAACGCTCGGAACACCGG
TTGTGAGCGGCAACGTCTCGCTTTACAACGAAACGAACGGCGAAGCCGTATATCCGACACCGGTCGTCGGTATGGTTGGG
CTCGTTGATGACCTTTCTCATGTAACGACCCAGCCGTTTAAGCAAGCGGGCGATTTGATTTATGTGATCGGTGAGGCGAA
GCCGGAGTTTGGCGGCAGTGAGTTGCAAAAATGGCTGGAAGGTCGCATTTTTGGAAAAGCGCCAGAACTCGATTTGGCGG
TCGAAGCAAGCCGCCAGCGTCAGTTGCTAACCGCGATTCGCGCTGGGGTCGTGGCGTCAGCACATGATGTCGCTGAAGGC
GGATTGGCGGTTGCGCTCGCTGAATGTGTCATCGGCGCTTCTGGGTTAGGTGCGAACGTGACGGTCAGCGGCGATCTTGT
GAGTGAACTATTCAGCGAAACGCAGTCTCGCTTTGTGGTTTCGGTGAAAAAAGAACATCAGGAAGCATTTGAGCAGCTCG
TAGAAGCGAAATTAATCGGTGAAGTGACCAATGACAGCATACTGACAGTAAACGGGGAACATGGGGGAACGGTTATTCGC
CTTTCGGTCGACGAAATGCGAAACGTCTGGAAAGGGGCTATTCCATGCTTGCTGAAATCAAAGGATTGA

Upstream 100 bases:

>100_bases
GGTATGATGCCGCATCCGGAGCGGGCCGTCGACGCCTTGCTCGGCAGCGCGGACGGACTGAAACTATTCCGATCGATCGT
CAACTATTGGAGGGAGACGC

Downstream 100 bases:

>100_bases
ACGAGGAGTGCGGCATTTTCGGCATTTGGGGGCATGAGGACGCCGCTAGGCTTACCTATTACGGGCTCCACAGCTTGCAG
CACCGCGGCCAAGAAGGAGC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 742; Mature: 741

Protein sequence:

>742_residues
MSLLLEPNAAMIKEQKLYREMGLTDEEFARIEAILGRLPNYTETGIFSVMWSEHCSYKNSKPVLKKFPTDGPHVLQGPGE
GAGIVDIGDGLAVAFKIESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPIALLNSLRFGELTSPRVKYLFEHVVAGIAG
YGNCIGIPTVGGEVQFDPAYEGNPLVNAMCVGIIRHEDIQRGVATGVGNTVMYVGAKTGRDGIHGATFASEELSEQSEAK
RPAVQVGDPFMEKLLLEACLEAVKSDALVGIQDMGAAGLTSSSAEMASKGGFGIEMNLDLVPQRETGMTPYEMMLSESQE
RMLLVVEQGREEEIAAIFAKYGLEAKAIGKVTDDKMLRLFFHGEVVAEIPVDALAKDAPVYHKPSAEPDYYREFQAMPTY
IPQIEDYNRTLLGLLAQPTIASKEWVYDQYDYMVRTNTVVAPGSDAAVVRIRGTNKALALTTDCNSRYLYLDPEMGGKIA
VAEAARNVVCSGAKPLAITDCLNFGNPEKPDIFWQLEKAVDGMSEACRTLGTPVVSGNVSLYNETNGEAVYPTPVVGMVG
LVDDLSHVTTQPFKQAGDLIYVIGEAKPEFGGSELQKWLEGRIFGKAPELDLAVEASRQRQLLTAIRAGVVASAHDVAEG
GLAVALAECVIGASGLGANVTVSGDLVSELFSETQSRFVVSVKKEHQEAFEQLVEAKLIGEVTNDSILTVNGEHGGTVIR
LSVDEMRNVWKGAIPCLLKSKD

Sequences:

>Translated_742_residues
MSLLLEPNAAMIKEQKLYREMGLTDEEFARIEAILGRLPNYTETGIFSVMWSEHCSYKNSKPVLKKFPTDGPHVLQGPGE
GAGIVDIGDGLAVAFKIESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPIALLNSLRFGELTSPRVKYLFEHVVAGIAG
YGNCIGIPTVGGEVQFDPAYEGNPLVNAMCVGIIRHEDIQRGVATGVGNTVMYVGAKTGRDGIHGATFASEELSEQSEAK
RPAVQVGDPFMEKLLLEACLEAVKSDALVGIQDMGAAGLTSSSAEMASKGGFGIEMNLDLVPQRETGMTPYEMMLSESQE
RMLLVVEQGREEEIAAIFAKYGLEAKAIGKVTDDKMLRLFFHGEVVAEIPVDALAKDAPVYHKPSAEPDYYREFQAMPTY
IPQIEDYNRTLLGLLAQPTIASKEWVYDQYDYMVRTNTVVAPGSDAAVVRIRGTNKALALTTDCNSRYLYLDPEMGGKIA
VAEAARNVVCSGAKPLAITDCLNFGNPEKPDIFWQLEKAVDGMSEACRTLGTPVVSGNVSLYNETNGEAVYPTPVVGMVG
LVDDLSHVTTQPFKQAGDLIYVIGEAKPEFGGSELQKWLEGRIFGKAPELDLAVEASRQRQLLTAIRAGVVASAHDVAEG
GLAVALAECVIGASGLGANVTVSGDLVSELFSETQSRFVVSVKKEHQEAFEQLVEAKLIGEVTNDSILTVNGEHGGTVIR
LSVDEMRNVWKGAIPCLLKSKD
>Mature_741_residues
SLLLEPNAAMIKEQKLYREMGLTDEEFARIEAILGRLPNYTETGIFSVMWSEHCSYKNSKPVLKKFPTDGPHVLQGPGEG
AGIVDIGDGLAVAFKIESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPIALLNSLRFGELTSPRVKYLFEHVVAGIAGY
GNCIGIPTVGGEVQFDPAYEGNPLVNAMCVGIIRHEDIQRGVATGVGNTVMYVGAKTGRDGIHGATFASEELSEQSEAKR
PAVQVGDPFMEKLLLEACLEAVKSDALVGIQDMGAAGLTSSSAEMASKGGFGIEMNLDLVPQRETGMTPYEMMLSESQER
MLLVVEQGREEEIAAIFAKYGLEAKAIGKVTDDKMLRLFFHGEVVAEIPVDALAKDAPVYHKPSAEPDYYREFQAMPTYI
PQIEDYNRTLLGLLAQPTIASKEWVYDQYDYMVRTNTVVAPGSDAAVVRIRGTNKALALTTDCNSRYLYLDPEMGGKIAV
AEAARNVVCSGAKPLAITDCLNFGNPEKPDIFWQLEKAVDGMSEACRTLGTPVVSGNVSLYNETNGEAVYPTPVVGMVGL
VDDLSHVTTQPFKQAGDLIYVIGEAKPEFGGSELQKWLEGRIFGKAPELDLAVEASRQRQLLTAIRAGVVASAHDVAEGG
LAVALAECVIGASGLGANVTVSGDLVSELFSETQSRFVVSVKKEHQEAFEQLVEAKLIGEVTNDSILTVNGEHGGTVIRL
SVDEMRNVWKGAIPCLLKSKD

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=715, Percent_Identity=24.0559440559441, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI48994899, Length=811, Percent_Identity=25.8939580764488, Blast_Score=133, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17553022, Length=655, Percent_Identity=21.8320610687023, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321498, Length=717, Percent_Identity=23.1520223152022, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 79876; Mature: 79745

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLLEPNAAMIKEQKLYREMGLTDEEFARIEAILGRLPNYTETGIFSVMWSEHCSYKNS
CCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCC
KPVLKKFPTDGPHVLQGPGEGAGIVDIGDGLAVAFKIESHNHPSAIEPYQGAATGVGGII
CCHHHHCCCCCCEEEECCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDVFSMGARPIALLNSLRFGELTSPRVKYLFEHVVAGIAGYGNCIGIPTVGGEVQFDPAY
HHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCC
EGNPLVNAMCVGIIRHEDIQRGVATGVGNTVMYVGAKTGRDGIHGATFASEELSEQSEAK
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHC
RPAVQVGDPFMEKLLLEACLEAVKSDALVGIQDMGAAGLTSSSAEMASKGGFGIEMNLDL
CCCEECCCHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCCCHHHHHCCCCEEEEEEEE
VPQRETGMTPYEMMLSESQERMLLVVEQGREEEIAAIFAKYGLEAKAIGKVTDDKMLRLF
CCCCCCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCHHHHCCCCCCCEEEEE
FHGEVVAEIPVDALAKDAPVYHKPSAEPDYYREFQAMPTYIPQIEDYNRTLLGLLAQPTI
ECCCEEEECCHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCC
ASKEWVYDQYDYMVRTNTVVAPGSDAAVVRIRGTNKALALTTDCNSRYLYLDPEMGGKIA
CCCCCCCCCCCEEEEECEEEECCCCEEEEEEECCCCEEEEEECCCCCEEEECCCCCCEEE
VAEAARNVVCSGAKPLAITDCLNFGNPEKPDIFWQLEKAVDGMSEACRTLGTPVVSGNVS
HHHHHHHHEECCCCCEEEEHHHCCCCCCCCCHHEEHHHHHHHHHHHHHHHCCCEEECCEE
LYNETNGEAVYPTPVVGMVGLVDDLSHVTTQPFKQAGDLIYVIGEAKPEFGGSELQKWLE
EEECCCCCEECCCCHHHHHHHHHHHHHHHCCHHHHCCCEEEEEECCCCCCCHHHHHHHHC
GRIFGKAPELDLAVEASRQRQLLTAIRAGVVASAHDVAEGGLAVALAECVIGASGLGANV
CCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHCCCCCCCEE
TVSGDLVSELFSETQSRFVVSVKKEHQEAFEQLVEAKLIGEVTNDSILTVNGEHGGTVIR
EECHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEE
LSVDEMRNVWKGAIPCLLKSKD
EEHHHHHHHHHCCCCCEEECCC
>Mature Secondary Structure 
SLLLEPNAAMIKEQKLYREMGLTDEEFARIEAILGRLPNYTETGIFSVMWSEHCSYKNS
CEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCC
KPVLKKFPTDGPHVLQGPGEGAGIVDIGDGLAVAFKIESHNHPSAIEPYQGAATGVGGII
CCHHHHCCCCCCEEEECCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDVFSMGARPIALLNSLRFGELTSPRVKYLFEHVVAGIAGYGNCIGIPTVGGEVQFDPAY
HHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCC
EGNPLVNAMCVGIIRHEDIQRGVATGVGNTVMYVGAKTGRDGIHGATFASEELSEQSEAK
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHC
RPAVQVGDPFMEKLLLEACLEAVKSDALVGIQDMGAAGLTSSSAEMASKGGFGIEMNLDL
CCCEECCCHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCCCHHHHHCCCCEEEEEEEE
VPQRETGMTPYEMMLSESQERMLLVVEQGREEEIAAIFAKYGLEAKAIGKVTDDKMLRLF
CCCCCCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCHHHHCCCCCCCEEEEE
FHGEVVAEIPVDALAKDAPVYHKPSAEPDYYREFQAMPTYIPQIEDYNRTLLGLLAQPTI
ECCCEEEECCHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCC
ASKEWVYDQYDYMVRTNTVVAPGSDAAVVRIRGTNKALALTTDCNSRYLYLDPEMGGKIA
CCCCCCCCCCCEEEEECEEEECCCCEEEEEEECCCCEEEEEECCCCCEEEECCCCCCEEE
VAEAARNVVCSGAKPLAITDCLNFGNPEKPDIFWQLEKAVDGMSEACRTLGTPVVSGNVS
HHHHHHHHEECCCCCEEEEHHHCCCCCCCCCHHEEHHHHHHHHHHHHHHHCCCEEECCEE
LYNETNGEAVYPTPVVGMVGLVDDLSHVTTQPFKQAGDLIYVIGEAKPEFGGSELQKWLE
EEECCCCCEECCCCHHHHHHHHHHHHHHHCCHHHHCCCEEEEEECCCCCCCHHHHHHHHC
GRIFGKAPELDLAVEASRQRQLLTAIRAGVVASAHDVAEGGLAVALAECVIGASGLGANV
CCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHCCCCCCCEE
TVSGDLVSELFSETQSRFVVSVKKEHQEAFEQLVEAKLIGEVTNDSILTVNGEHGGTVIR
EECHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEE
LSVDEMRNVWKGAIPCLLKSKD
EEHHHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA