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The map label for this gene is purK [H]

Identifier: 138893914

GI number: 138893914

Start: 265614

End: 266762

Strand: Direct

Name: purK [H]

Synonym: GTNG_0238

Alternate gene names: 138893914

Gene position: 265614-266762 (Clockwise)

Preceding gene: 138893913

Following gene: 138893915

Centisome position: 7.48

GC content: 52.74

Gene sequence:

>1149_bases
TTGACTAAGCGACGGATTGTTCCGGGGCAGACGATCGGCATTATTGGCGGTGGACAACTGGGACGGATGATGGCTCTCGC
GGCGCGCGAGATGGGGTTTCGCATTGCGGTTCTCGATCCAACGCCCGGCTCCCCGTGCGGACAGGTGGCTGATGTGGAAA
TCACCGCACCGTACCACGATTTGAATGCTATTGCCGAATTGGCGCGCGTTAGCCATATCATTACGTATGAGTTTGAAAAT
ATCGATGCACGGGCGCTTGAGTGGCTTGAGGAAAACGCCTATGTCCCGCAAGGAAGCCGATTGCTTGCAGTGACGCAAGA
TCGGGCGCTCGAGAAGGCGGCGATTGTGGAAGCTGGCTTGCCGGTGGCACCGTATGCCGAAGTGAATGGATGGGATGAGT
TGGAACAGGCCGTTAGGACGATCGGTTTTCCGTGCGTGTTAAAAACGCGACGCGGTGGTTATGACGGCAAAGGGCAATAT
GTGCTGCGGGGAGAAAGGGATTTAGCCAAAGCAGCAGAGTTATTTGACTTTGGTCCGTGTATTTTAGAAGGTTGGGTGTC
GTTTGTGAAGGAAATGTCAGTCATTGTCGCCCGTAATGGCGATGGGGAGACGGCCGTTTTTCCGGTGGCAGAAAACATTC
ATGTCGAGAACATTTTGCATCAAACGATCGTTCCAGCTCGCATCCCGGAACATGTCGAGGAACGGGCGATCCGTTACGCA
AAGACATTGGCAACATCGTTTTCACTCGTCGGGACGTTGGCGGTGGAAATGTTTTTGACAGAAGATGGGGAAATTTATAT
TAATGAGCTAGCCCCTAGACCGCACAACTCGGGTCATTATACAATCAATGCATGTGCCACGTCTCAATTCGCTCAGCACA
TCCGTGCTGTCTGCAACTGGCCGCTTGGGTCGACCGAATTGTTGAAGCCGGCCGTAATGGTCAATATTTTAGGCGAGCAC
GTCGAGTCGATTATTCGACAAATTGATGCGTTTGCTGGCACGACCTATGTCCATCTTTACGGCAAACACGAAGCGAAGCC
GAAGCGAAAGATGGGCCATGTGACCGTGTTGGCGGACAATGTGGATGAGGCGCTGGCGAGATTGGAGTCGTGGCAAATTT
GGCATGATCGGAGGCTAGAACGAGTATGA

Upstream 100 bases:

>100_bases
GCGGTGTCGATCGTTGGGCTGTTTGAGCCGCGCTATATGGAAGCGCTCAAGGCGCGGAGAGAAGCGATTCGAAAACAAGT
AGTGGAAAGCAGTGATCAAC

Downstream 100 bases:

>100_bases
TTGAACGCTACACAAGACCCGAAATGGGAGCCATTTGGACAGAGGAAAACCGCTTTAAGGCGTGGCTTGAGGTGGAATTG
CTTGCGTGCGAGGCGTGGGC

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MTKRRIVPGQTIGIIGGGQLGRMMALAAREMGFRIAVLDPTPGSPCGQVADVEITAPYHDLNAIAELARVSHIITYEFEN
IDARALEWLEENAYVPQGSRLLAVTQDRALEKAAIVEAGLPVAPYAEVNGWDELEQAVRTIGFPCVLKTRRGGYDGKGQY
VLRGERDLAKAAELFDFGPCILEGWVSFVKEMSVIVARNGDGETAVFPVAENIHVENILHQTIVPARIPEHVEERAIRYA
KTLATSFSLVGTLAVEMFLTEDGEIYINELAPRPHNSGHYTINACATSQFAQHIRAVCNWPLGSTELLKPAVMVNILGEH
VESIIRQIDAFAGTTYVHLYGKHEAKPKRKMGHVTVLADNVDEALARLESWQIWHDRRLERV

Sequences:

>Translated_382_residues
MTKRRIVPGQTIGIIGGGQLGRMMALAAREMGFRIAVLDPTPGSPCGQVADVEITAPYHDLNAIAELARVSHIITYEFEN
IDARALEWLEENAYVPQGSRLLAVTQDRALEKAAIVEAGLPVAPYAEVNGWDELEQAVRTIGFPCVLKTRRGGYDGKGQY
VLRGERDLAKAAELFDFGPCILEGWVSFVKEMSVIVARNGDGETAVFPVAENIHVENILHQTIVPARIPEHVEERAIRYA
KTLATSFSLVGTLAVEMFLTEDGEIYINELAPRPHNSGHYTINACATSQFAQHIRAVCNWPLGSTELLKPAVMVNILGEH
VESIIRQIDAFAGTTYVHLYGKHEAKPKRKMGHVTVLADNVDEALARLESWQIWHDRRLERV
>Mature_381_residues
TKRRIVPGQTIGIIGGGQLGRMMALAAREMGFRIAVLDPTPGSPCGQVADVEITAPYHDLNAIAELARVSHIITYEFENI
DARALEWLEENAYVPQGSRLLAVTQDRALEKAAIVEAGLPVAPYAEVNGWDELEQAVRTIGFPCVLKTRRGGYDGKGQYV
LRGERDLAKAAELFDFGPCILEGWVSFVKEMSVIVARNGDGETAVFPVAENIHVENILHQTIVPARIPEHVEERAIRYAK
TLATSFSLVGTLAVEMFLTEDGEIYINELAPRPHNSGHYTINACATSQFAQHIRAVCNWPLGSTELLKPAVMVNILGEHV
ESIIRQIDAFAGTTYVHLYGKHEAKPKRKMGHVTVLADNVDEALARLESWQIWHDRRLERV

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=364, Percent_Identity=31.3186813186813, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1788155, Length=367, Percent_Identity=26.4305177111717, Blast_Score=111, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6324702, Length=381, Percent_Identity=34.9081364829396, Blast_Score=229, Evalue=7e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006115
- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp; PF03446 NAD_binding_2 [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 42278; Mature: 42147

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRRIVPGQTIGIIGGGQLGRMMALAAREMGFRIAVLDPTPGSPCGQVADVEITAPYHD
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEECCHHH
LNAIAELARVSHIITYEFENIDARALEWLEENAYVPQGSRLLAVTQDRALEKAAIVEAGL
HHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHCCC
PVAPYAEVNGWDELEQAVRTIGFPCVLKTRRGGYDGKGQYVLRGERDLAKAAELFDFGPC
CCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEECCHHHHHHHHHHCCCHH
ILEGWVSFVKEMSVIVARNGDGETAVFPVAENIHVENILHQTIVPARIPEHVEERAIRYA
HHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
KTLATSFSLVGTLAVEMFLTEDGEIYINELAPRPHNSGHYTINACATSQFAQHIRAVCNW
HHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHCC
PLGSTELLKPAVMVNILGEHVESIIRQIDAFAGTTYVHLYGKHEAKPKRKMGHVTVLADN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHCCCEEEEECC
VDEALARLESWQIWHDRRLERV
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKRRIVPGQTIGIIGGGQLGRMMALAAREMGFRIAVLDPTPGSPCGQVADVEITAPYHD
CCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEECCHHH
LNAIAELARVSHIITYEFENIDARALEWLEENAYVPQGSRLLAVTQDRALEKAAIVEAGL
HHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHCCC
PVAPYAEVNGWDELEQAVRTIGFPCVLKTRRGGYDGKGQYVLRGERDLAKAAELFDFGPC
CCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEECCHHHHHHHHHHCCCHH
ILEGWVSFVKEMSVIVARNGDGETAVFPVAENIHVENILHQTIVPARIPEHVEERAIRYA
HHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
KTLATSFSLVGTLAVEMFLTEDGEIYINELAPRPHNSGHYTINACATSQFAQHIRAVCNW
HHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHCC
PLGSTELLKPAVMVNILGEHVESIIRQIDAFAGTTYVHLYGKHEAKPKRKMGHVTVLADN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHCCCEEEEECC
VDEALARLESWQIWHDRRLERV
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]