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The map label for this gene is purE [H]

Identifier: 138893913

GI number: 138893913

Start: 265133

End: 265621

Strand: Direct

Name: purE [H]

Synonym: GTNG_0237

Alternate gene names: 138893913

Gene position: 265133-265621 (Clockwise)

Preceding gene: 138893911

Following gene: 138893914

Centisome position: 7.47

GC content: 53.99

Gene sequence:

>489_bases
ATGAACCCACTAGTTGGGGTGGTCATGGGAAGCCGTTCAGATTGGGAGACGATGAAGCACGCTTGTGACATTCTTGAAGA
ATTGGGCGTTCCGTTTGAAAAAAAAGTTGTGTCGGCGCATCGGACACCGGATGAGATGTTTCGTTATGCGGAAACGGCAG
AGGAGCGGGGCATAAAAGTGATTATTGCCGGAGCCGGTGGAGCGGCTCATTTGCCGGGGATGATTGCAGCGAAAACGACG
CTGCCGGTAATCGGAGTGCCGGTGCAGTCAAAAGCATTGAACGGGTTGGATTCGTTACTGTCGATCGTGCAAATGCCTGG
CGGGGTGCCGGTGGCAACAGTGGCGATTGGCAAAGCAGGAGCGACCAACGCAGGTTTGCTCGCGGTGTCGATCGTTGGGC
TGTTTGAGCCGCGCTATATGGAAGCGCTCAAGGCGCGGAGAGAAGCGATTCGAAAACAAGTAGTGGAAAGCAGTGATCAA
CTTGACTAA

Upstream 100 bases:

>100_bases
ACAAATTGTGAAAGCCCAGAACGATGCTTTCCCTCGCTTAAGATTGGGAATGTATGTTCTGGGTTTTATTGTGTTTATTA
AAGTTAAGGAGTGGAACGTA

Downstream 100 bases:

>100_bases
GCGACGGATTGTTCCGGGGCAGACGATCGGCATTATTGGCGGTGGACAACTGGGACGGATGATGGCTCTCGCGGCGCGCG
AGATGGGGTTTCGCATTGCG

Product: phosphoribosylaminoimidazole carboxylase I

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MNPLVGVVMGSRSDWETMKHACDILEELGVPFEKKVVSAHRTPDEMFRYAETAEERGIKVIIAGAGGAAHLPGMIAAKTT
LPVIGVPVQSKALNGLDSLLSIVQMPGGVPVATVAIGKAGATNAGLLAVSIVGLFEPRYMEALKARREAIRKQVVESSDQ
LD

Sequences:

>Translated_162_residues
MNPLVGVVMGSRSDWETMKHACDILEELGVPFEKKVVSAHRTPDEMFRYAETAEERGIKVIIAGAGGAAHLPGMIAAKTT
LPVIGVPVQSKALNGLDSLLSIVQMPGGVPVATVAIGKAGATNAGLLAVSIVGLFEPRYMEALKARREAIRKQVVESSDQ
LD
>Mature_162_residues
MNPLVGVVMGSRSDWETMKHACDILEELGVPFEKKVVSAHRTPDEMFRYAETAEERGIKVIIAGAGGAAHLPGMIAAKTT
LPVIGVPVQSKALNGLDSLLSIVQMPGGVPVATVAIGKAGATNAGLLAVSIVGLFEPRYMEALKARREAIRKQVVESSDQ
LD

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=159, Percent_Identity=61.0062893081761, Blast_Score=161, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324702, Length=149, Percent_Identity=60.4026845637584, Blast_Score=173, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17103; Mature: 17103

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLVGVVMGSRSDWETMKHACDILEELGVPFEKKVVSAHRTPDEMFRYAETAEERGIKV
CCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEE
IIAGAGGAAHLPGMIAAKTTLPVIGVPVQSKALNGLDSLLSIVQMPGGVPVATVAIGKAG
EEECCCCCHHCCCHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
ATNAGLLAVSIVGLFEPRYMEALKARREAIRKQVVESSDQLD
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNPLVGVVMGSRSDWETMKHACDILEELGVPFEKKVVSAHRTPDEMFRYAETAEERGIKV
CCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEE
IIAGAGGAAHLPGMIAAKTTLPVIGVPVQSKALNGLDSLLSIVQMPGGVPVATVAIGKAG
EEECCCCCHHCCCHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
ATNAGLLAVSIVGLFEPRYMEALKARREAIRKQVVESSDQLD
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]