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The map label for this gene is copR [H]

Identifier: 13473757

GI number: 13473757

Start: 3544407

End: 3545090

Strand: Direct

Name: copR [H]

Synonym: mlr4457

Alternate gene names: 13473757

Gene position: 3544407-3545090 (Clockwise)

Preceding gene: 13473756

Following gene: 13473758

Centisome position: 50.37

GC content: 65.94

Gene sequence:

>684_bases
ATGCGACTTCTTCTTGTCGAGGACGACCAAAAGACAGCGGACTATATCGTCAGGGGACTGACCGAGGCCGGCCATGTCTG
CGACCTCCTGCGCAACGGCCATGACGCGCTTTTCGCCGCCACCAGCGGCAGCTATGACGTGATCGTCGCCGACCGCATGA
TCCCGGGTCTCGACGGCCTGTCGATGGTCAAGGCGGCGCGCGCGGCGGGCGTGCGCACGCCGGCGATCTTCCTCACCTCC
ATCGGCGGCATCGACGATCGCGTCGAGGGTCTGGAGGCCGGCGGCGACGACTATCTGGTCAAGCCTTTCGCCTTTTCCGA
GCTGCTTGCCCGCATCAACGCGCTTGGCCGGCGGCCGGCGGCGCAGGAGCAGAAGACGGTGCTGCGGGTCGCCGACCTCG
AAATGGACCTCATCATGCGGCGCGTCACGCGCCAGGGCCAGCCGATCGACCTGCAGCCGCGCGAATTCAGCCTGCTCGAG
GTGCTGATGCGCGGCGAGGGCCGCGTCATCACCCGCACCATGCTTCTGGAGCGCGTCTGGGACTTTCATTTCGATCCCAA
GACCAGTGTCGTCGAGACCCATATCAGCCGGCTGCGGGCCAAGGTCGACAAGCCGTTCGAGGCCCAGCTCATCCATACCA
TCCGCAACACCGGCTACAGCCTGCACGCACCGCTTGCGCCATGA

Upstream 100 bases:

>100_bases
CCGCAGCCGGCCTCGTTAGCGCCCAGGGCTCGACCATCCTAGGAACGGGGCCATGCCGGTGATAGCCTGTGCCCGATATC
GGCAATCAACCGGAACGGCG

Downstream 100 bases:

>100_bases
CCGGAAGCTGGTCTCGCCTGCTGCGCAGCACGCCGTTCCGGCTCGCCCTGACATTCGGCTTCCTGTTCATGCTGGCCTTC
GTGCTGTCGGGCGCCATCGT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MRLLLVEDDQKTADYIVRGLTEAGHVCDLLRNGHDALFAATSGSYDVIVADRMIPGLDGLSMVKAARAAGVRTPAIFLTS
IGGIDDRVEGLEAGGDDYLVKPFAFSELLARINALGRRPAAQEQKTVLRVADLEMDLIMRRVTRQGQPIDLQPREFSLLE
VLMRGEGRVITRTMLLERVWDFHFDPKTSVVETHISRLRAKVDKPFEAQLIHTIRNTGYSLHAPLAP

Sequences:

>Translated_227_residues
MRLLLVEDDQKTADYIVRGLTEAGHVCDLLRNGHDALFAATSGSYDVIVADRMIPGLDGLSMVKAARAAGVRTPAIFLTS
IGGIDDRVEGLEAGGDDYLVKPFAFSELLARINALGRRPAAQEQKTVLRVADLEMDLIMRRVTRQGQPIDLQPREFSLLE
VLMRGEGRVITRTMLLERVWDFHFDPKTSVVETHISRLRAKVDKPFEAQLIHTIRNTGYSLHAPLAP
>Mature_227_residues
MRLLLVEDDQKTADYIVRGLTEAGHVCDLLRNGHDALFAATSGSYDVIVADRMIPGLDGLSMVKAARAAGVRTPAIFLTS
IGGIDDRVEGLEAGGDDYLVKPFAFSELLARINALGRRPAAQEQKTVLRVADLEMDLIMRRVTRQGQPIDLQPREFSLLE
VLMRGEGRVITRTMLLERVWDFHFDPKTSVVETHISRLRAKVDKPFEAQLIHTIRNTGYSLHAPLAP

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=47.3214285714286, Blast_Score=221, Evalue=3e-59,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=43.9461883408072, Blast_Score=191, Evalue=5e-50,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=38.4615384615385, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=34.5291479820628, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=32.2727272727273, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=29.9107142857143, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=33.7837837837838, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=31.5555555555556, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=30.8370044052863, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786911, Length=217, Percent_Identity=30.4147465437788, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=33.6283185840708, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=26.8398268398268, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=29.6610169491525, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790299, Length=136, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790863, Length=242, Percent_Identity=26.8595041322314, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25229; Mature: 25229

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLLVEDDQKTADYIVRGLTEAGHVCDLLRNGHDALFAATSGSYDVIVADRMIPGLDGL
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCHH
SMVKAARAAGVRTPAIFLTSIGGIDDRVEGLEAGGDDYLVKPFAFSELLARINALGRRPA
HHHHHHHHCCCCCCHHEEECCCCCHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHCCCCC
AQEQKTVLRVADLEMDLIMRRVTRQGQPIDLQPREFSLLEVLMRGEGRVITRTMLLERVW
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
DFHFDPKTSVVETHISRLRAKVDKPFEAQLIHTIRNTGYSLHAPLAP
HCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCC
>Mature Secondary Structure
MRLLLVEDDQKTADYIVRGLTEAGHVCDLLRNGHDALFAATSGSYDVIVADRMIPGLDGL
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCHH
SMVKAARAAGVRTPAIFLTSIGGIDDRVEGLEAGGDDYLVKPFAFSELLARINALGRRPA
HHHHHHHHCCCCCCHHEEECCCCCHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHCCCCC
AQEQKTVLRVADLEMDLIMRRVTRQGQPIDLQPREFSLLEVLMRGEGRVITRTMLLERVW
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
DFHFDPKTSVVETHISRLRAKVDKPFEAQLIHTIRNTGYSLHAPLAP
HCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]