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The map label for this gene is uvrB

Identifier: 13472362

GI number: 13472362

Start: 2129956

End: 2132568

Strand: Direct

Name: uvrB

Synonym: mlr2631

Alternate gene names: 13472362

Gene position: 2129956-2132568 (Clockwise)

Preceding gene: 13472361

Following gene: 13472363

Centisome position: 30.27

GC content: 63.72

Gene sequence:

>2613_bases
ATGGTGTCGGACTTCGAGCCAGCGGGTGACCAGCCGACCGCCATCAAGGACCTTGTCGAAGGCGTCGACAACAATGACCG
CACCCAGGTGCTGCTCGGCGTCACCGGCTCCGGCAAAACTTTCACCATGGCCAAGGTGATCGAGGAAACGCAGCGCCCTG
CCTTGATCCTGGCGCCAAACAAGACGCTGGCGGCGCAGCTTTATTCCGAGTTCAAGAAATTCTTCCCCGACAATGCGGTG
GAGTATTTCGTCTCCTATTACGACTACTACCAGCCGGAAGCCTATGTTCCGCGCACCGACACCTTCATCGAGAAGGAATC
CTCGATCAACGAGCAGATCGACCGCATGCGCCACTCGGCGACGCGCTCGTTGCTCGAGCGCGACGACGTCATTATCGTCG
CCTCGGTGTCCTGCATCTACGGTATCGGTTCGGTCGAGACCTATACGGCGATGACCTTCCAGATGCAGATCGGCGACCGG
CTCGACCAGCGCGCTCTGCTCGCCGACCTCGTCGCCCAGCAATACAAGCGGCAGGACATCAATTTCGTGCGTGGCTCGTT
TCGCGTGCGCGGCGACACGATCGAGATCTTCCCGGCCCACCTTGAAGACCGCGCCTGGCGCATCTCGATGTTCGGCGACG
AGATCGAGCAGATCACCGAGTTCGACCCGCTGACCGGCCAAAAGACCGGCGAGCTGAAAAGCGTCAAGATCTACGCCAAC
TCGCACTATGTGACGCCGCGCCCGACGCTCAACCAGGCGATCAAGTCGATCAAGGAAGAACTCAAGCAGCGTCTGGTCGA
ACTCGAGCGTGCCGGCCGCCTGCTGGAAGCACAGCGCCTGGAACAGCGCACCCGCTTCGACCTCGAAATGCTGGAAGCCA
CCGGCTCCTGCGCCGGCATCGAGAACTATTCGCGTTATCTCACCGGCCGCCAGCCGGGCGATCCGCCGCCGACCTTGTTC
GAATATATTCCCGACAATGCGCTGGTGTTCATCGACGAAAGCCACGTCACCGTGCCGCAGATCGGCGGCATGTATCGCGG
CGACTTCAGGCGCAAGGCGACGCTGGCCGAGTACGGCTTCCGGCTGCCTTCCTGCATGGACAACCGGCCGCTGCGCTTCG
AGGAATGGGACGCTATGCGCCCGCTCTCCGTCGCCGTTTCGGCGACGCCGGGCGGCTGGGAAATGGAACAGTCCGGCGGC
GTCTTCGCCGAGCAGGTCATCCGCCCGACCGGCTTGATCGACCCGCCGGTCGAGGTGCGCCCGGCCAAAAGCCAGGTCGA
CGATGTCGTCGGCGAGATCCGCGAAACAACAAAGGCCGGCTACCGCACGCTGGTCACCGTGCTGACCAAGCGCATGGCCG
AGGACCTGACCGAATATCTGCACGAGCAGGGCGTGCGCGTGCGCTACATGCACTCCGACATCGACACGCTGGAGCGCATC
GAGATCCTGCGCGATTTGCGCCTCGGCGCTTTCGACGTGCTGGTCGGCATCAACCTTTTGCGTGAAGGCCTCGACATTCC
CGAATGCGGCTTCGTCGCCATTCTCGATGCCGACAAGGAAGGGTTCCTGCGCTCGGAAACCTCGCTCATCCAGACCATCG
GCCGCGCCGCCCGTAACGTCGACGGCAAGGTCATCCTCTATGCCGACCAGGTCACCGGCTCGATGGAGCGGGCGATGGCC
GAGACCAACCGCCGCCGCGAAAAGCAGATGGAGTGGAACGCCGCCAACGGCATCACGCCGGAGTCGGTCAAATCGCGCAT
CTCCGACATTCTGGACTCGGTCTACGAGAAGGACCATGTCCGCGCCGACATCTCGCAGTTCACCGACAGCGCCGGCGCCA
TGATGGGCAACAACCTCAAGGCCCATCTCGACGCGATGGAAAAACAGATGCGCGACGCCGCCGCCAATCTCGACTTCGAG
AAGGCCGCCCGCATCCGCGACGAGATCAAGCGGCTGCGTGAGATGGAACTGTCGATCTCCGAAGACCCGCTGGCCAAATA
CGCCGACATGGAAAGCCCGGTCTCGGGCCGCGAAAAGGGCAAGCACAACAAGGGCGTGGCCAAGCACCGTACGGCAGAGG
AACAGGAGCGTTTTCGCAAGCTCGACGAGGCACGCGCCGCCGAAGAGGCCGCCAGGGCTGCCCGACCCAACCTCTTCCGC
AAGCCGGCGCTTGACGAGATGGGCGCCGACGGCGCCGTGCCGGCGAAGAAGCCGCTGTTCGCCAAACCCTCGATCGACGA
CATGGGGCCCGGCACCGACATGCCGACGCCTGCGGGTGCGGTGTCACGCTCGCTGTTCAAGAAACAGTCGGCGTCCGAAG
CGCACGGTTCCGACTTCGGTATTCCAGGCGAGCCGGTCAGGCCGCTGTTCAAGAAGAACTCGCTGGACGAGATGACCGTG
CGGCGCACCGAAAAGCCGGTCGAAGGAAAAGTGCCGGCGAAGCCCCAGCCGATCTCCCATCCTGTGGGGGCCGGCAGGAC
AGACGTGAAGGATCGTGACGATTCCGCCAAGCCAATCGTTCGCCAGCGCGCCGGCATCGGCTCCTACGAGGACCCAGGCG
ACGCCCGCCGCGAAAAGCGCAGGCCGGGGAAAACGGGCAGGCCGGGGAAGTAG

Upstream 100 bases:

>100_bases
GCTGATCGAATCCGGCAATCCGCTGCACAAGGACGGCGTGCTGTGGACGCCGCACCGCCCCGCCCGGCCGGAAAAGTCGG
AAGGCGGCATCGCCATCAAG

Downstream 100 bases:

>100_bases
CGGCTTCTTCCTTCCCCCTTGCGGGAGCAGGGAAACGCTCTTCCTCGTCGCGGCTTAACATCTGCTTGTCAAAGTCGGAA
CAGCCTCTGGACTATGCGCT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 870; Mature: 870

Protein sequence:

>870_residues
MVSDFEPAGDQPTAIKDLVEGVDNNDRTQVLLGVTGSGKTFTMAKVIEETQRPALILAPNKTLAAQLYSEFKKFFPDNAV
EYFVSYYDYYQPEAYVPRTDTFIEKESSINEQIDRMRHSATRSLLERDDVIIVASVSCIYGIGSVETYTAMTFQMQIGDR
LDQRALLADLVAQQYKRQDINFVRGSFRVRGDTIEIFPAHLEDRAWRISMFGDEIEQITEFDPLTGQKTGELKSVKIYAN
SHYVTPRPTLNQAIKSIKEELKQRLVELERAGRLLEAQRLEQRTRFDLEMLEATGSCAGIENYSRYLTGRQPGDPPPTLF
EYIPDNALVFIDESHVTVPQIGGMYRGDFRRKATLAEYGFRLPSCMDNRPLRFEEWDAMRPLSVAVSATPGGWEMEQSGG
VFAEQVIRPTGLIDPPVEVRPAKSQVDDVVGEIRETTKAGYRTLVTVLTKRMAEDLTEYLHEQGVRVRYMHSDIDTLERI
EILRDLRLGAFDVLVGINLLREGLDIPECGFVAILDADKEGFLRSETSLIQTIGRAARNVDGKVILYADQVTGSMERAMA
ETNRRREKQMEWNAANGITPESVKSRISDILDSVYEKDHVRADISQFTDSAGAMMGNNLKAHLDAMEKQMRDAAANLDFE
KAARIRDEIKRLREMELSISEDPLAKYADMESPVSGREKGKHNKGVAKHRTAEEQERFRKLDEARAAEEAARAARPNLFR
KPALDEMGADGAVPAKKPLFAKPSIDDMGPGTDMPTPAGAVSRSLFKKQSASEAHGSDFGIPGEPVRPLFKKNSLDEMTV
RRTEKPVEGKVPAKPQPISHPVGAGRTDVKDRDDSAKPIVRQRAGIGSYEDPGDARREKRRPGKTGRPGK

Sequences:

>Translated_870_residues
MVSDFEPAGDQPTAIKDLVEGVDNNDRTQVLLGVTGSGKTFTMAKVIEETQRPALILAPNKTLAAQLYSEFKKFFPDNAV
EYFVSYYDYYQPEAYVPRTDTFIEKESSINEQIDRMRHSATRSLLERDDVIIVASVSCIYGIGSVETYTAMTFQMQIGDR
LDQRALLADLVAQQYKRQDINFVRGSFRVRGDTIEIFPAHLEDRAWRISMFGDEIEQITEFDPLTGQKTGELKSVKIYAN
SHYVTPRPTLNQAIKSIKEELKQRLVELERAGRLLEAQRLEQRTRFDLEMLEATGSCAGIENYSRYLTGRQPGDPPPTLF
EYIPDNALVFIDESHVTVPQIGGMYRGDFRRKATLAEYGFRLPSCMDNRPLRFEEWDAMRPLSVAVSATPGGWEMEQSGG
VFAEQVIRPTGLIDPPVEVRPAKSQVDDVVGEIRETTKAGYRTLVTVLTKRMAEDLTEYLHEQGVRVRYMHSDIDTLERI
EILRDLRLGAFDVLVGINLLREGLDIPECGFVAILDADKEGFLRSETSLIQTIGRAARNVDGKVILYADQVTGSMERAMA
ETNRRREKQMEWNAANGITPESVKSRISDILDSVYEKDHVRADISQFTDSAGAMMGNNLKAHLDAMEKQMRDAAANLDFE
KAARIRDEIKRLREMELSISEDPLAKYADMESPVSGREKGKHNKGVAKHRTAEEQERFRKLDEARAAEEAARAARPNLFR
KPALDEMGADGAVPAKKPLFAKPSIDDMGPGTDMPTPAGAVSRSLFKKQSASEAHGSDFGIPGEPVRPLFKKNSLDEMTV
RRTEKPVEGKVPAKPQPISHPVGAGRTDVKDRDDSAKPIVRQRAGIGSYEDPGDARREKRRPGKTGRPGK
>Mature_870_residues
MVSDFEPAGDQPTAIKDLVEGVDNNDRTQVLLGVTGSGKTFTMAKVIEETQRPALILAPNKTLAAQLYSEFKKFFPDNAV
EYFVSYYDYYQPEAYVPRTDTFIEKESSINEQIDRMRHSATRSLLERDDVIIVASVSCIYGIGSVETYTAMTFQMQIGDR
LDQRALLADLVAQQYKRQDINFVRGSFRVRGDTIEIFPAHLEDRAWRISMFGDEIEQITEFDPLTGQKTGELKSVKIYAN
SHYVTPRPTLNQAIKSIKEELKQRLVELERAGRLLEAQRLEQRTRFDLEMLEATGSCAGIENYSRYLTGRQPGDPPPTLF
EYIPDNALVFIDESHVTVPQIGGMYRGDFRRKATLAEYGFRLPSCMDNRPLRFEEWDAMRPLSVAVSATPGGWEMEQSGG
VFAEQVIRPTGLIDPPVEVRPAKSQVDDVVGEIRETTKAGYRTLVTVLTKRMAEDLTEYLHEQGVRVRYMHSDIDTLERI
EILRDLRLGAFDVLVGINLLREGLDIPECGFVAILDADKEGFLRSETSLIQTIGRAARNVDGKVILYADQVTGSMERAMA
ETNRRREKQMEWNAANGITPESVKSRISDILDSVYEKDHVRADISQFTDSAGAMMGNNLKAHLDAMEKQMRDAAANLDFE
KAARIRDEIKRLREMELSISEDPLAKYADMESPVSGREKGKHNKGVAKHRTAEEQERFRKLDEARAAEEAARAARPNLFR
KPALDEMGADGAVPAKKPLFAKPSIDDMGPGTDMPTPAGAVSRSLFKKQSASEAHGSDFGIPGEPVRPLFKKNSLDEMTV
RRTEKPVEGKVPAKPQPISHPVGAGRTDVKDRDDSAKPIVRQRAGIGSYEDPGDARREKRRPGKTGRPGK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=675, Percent_Identity=57.9259259259259, Blast_Score=783, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_RHILO (Q98I01)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_103929.1
- ProteinModelPortal:   Q98I01
- GeneID:   1226590
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr2631
- NMPDR:   fig|266835.1.peg.2033
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 97535; Mature: 97535

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSDFEPAGDQPTAIKDLVEGVDNNDRTQVLLGVTGSGKTFTMAKVIEETQRPALILAPN
CCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCC
KTLAAQLYSEFKKFFPDNAVEYFVSYYDYYQPEAYVPRTDTFIEKESSINEQIDRMRHSA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TRSLLERDDVIIVASVSCIYGIGSVETYTAMTFQMQIGDRLDQRALLADLVAQQYKRQDI
HHHHHHCCCEEEEEEHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
NFVRGSFRVRGDTIEIFPAHLEDRAWRISMFGDEIEQITEFDPLTGQKTGELKSVKIYAN
HHHHCCEEEECCEEEEECCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEC
SHYVTPRPTLNQAIKSIKEELKQRLVELERAGRLLEAQRLEQRTRFDLEMLEATGSCAGI
CEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
ENYSRYLTGRQPGDPPPTLFEYIPDNALVFIDESHVTVPQIGGMYRGDFRRKATLAEYGF
HHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHCCCCCCCCCHHHHHHHHHHCC
RLPSCMDNRPLRFEEWDAMRPLSVAVSATPGGWEMEQSGGVFAEQVIRPTGLIDPPVEVR
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCC
PAKSQVDDVVGEIRETTKAGYRTLVTVLTKRMAEDLTEYLHEQGVRVRYMHSDIDTLERI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
EILRDLRLGAFDVLVGINLLREGLDIPECGFVAILDADKEGFLRSETSLIQTIGRAARNV
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCC
DGKVILYADQVTGSMERAMAETNRRREKQMEWNAANGITPESVKSRISDILDSVYEKDHV
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RADISQFTDSAGAMMGNNLKAHLDAMEKQMRDAAANLDFEKAARIRDEIKRLREMELSIS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
EDPLAKYADMESPVSGREKGKHNKGVAKHRTAEEQERFRKLDEARAAEEAARAARPNLFR
CCHHHHHHCCCCCCCCHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KPALDEMGADGAVPAKKPLFAKPSIDDMGPGTDMPTPAGAVSRSLFKKQSASEAHGSDFG
CCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
IPGEPVRPLFKKNSLDEMTVRRTEKPVEGKVPAKPQPISHPVGAGRTDVKDRDDSAKPIV
CCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
RQRAGIGSYEDPGDARREKRRPGKTGRPGK
HHHCCCCCCCCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MVSDFEPAGDQPTAIKDLVEGVDNNDRTQVLLGVTGSGKTFTMAKVIEETQRPALILAPN
CCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCC
KTLAAQLYSEFKKFFPDNAVEYFVSYYDYYQPEAYVPRTDTFIEKESSINEQIDRMRHSA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TRSLLERDDVIIVASVSCIYGIGSVETYTAMTFQMQIGDRLDQRALLADLVAQQYKRQDI
HHHHHHCCCEEEEEEHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
NFVRGSFRVRGDTIEIFPAHLEDRAWRISMFGDEIEQITEFDPLTGQKTGELKSVKIYAN
HHHHCCEEEECCEEEEECCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEC
SHYVTPRPTLNQAIKSIKEELKQRLVELERAGRLLEAQRLEQRTRFDLEMLEATGSCAGI
CEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
ENYSRYLTGRQPGDPPPTLFEYIPDNALVFIDESHVTVPQIGGMYRGDFRRKATLAEYGF
HHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHCCCCCCCCCHHHHHHHHHHCC
RLPSCMDNRPLRFEEWDAMRPLSVAVSATPGGWEMEQSGGVFAEQVIRPTGLIDPPVEVR
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCC
PAKSQVDDVVGEIRETTKAGYRTLVTVLTKRMAEDLTEYLHEQGVRVRYMHSDIDTLERI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
EILRDLRLGAFDVLVGINLLREGLDIPECGFVAILDADKEGFLRSETSLIQTIGRAARNV
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCC
DGKVILYADQVTGSMERAMAETNRRREKQMEWNAANGITPESVKSRISDILDSVYEKDHV
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RADISQFTDSAGAMMGNNLKAHLDAMEKQMRDAAANLDFEKAARIRDEIKRLREMELSIS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
EDPLAKYADMESPVSGREKGKHNKGVAKHRTAEEQERFRKLDEARAAEEAARAARPNLFR
CCHHHHHHCCCCCCCCHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KPALDEMGADGAVPAKKPLFAKPSIDDMGPGTDMPTPAGAVSRSLFKKQSASEAHGSDFG
CCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
IPGEPVRPLFKKNSLDEMTVRRTEKPVEGKVPAKPQPISHPVGAGRTDVKDRDDSAKPIV
CCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
RQRAGIGSYEDPGDARREKRRPGKTGRPGK
HHHCCCCCCCCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968