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The map label for this gene is Hgd [H]

Identifier: 13472343

GI number: 13472343

Start: 2108383

End: 2109300

Strand: Direct

Name: Hgd [H]

Synonym: mlr2606

Alternate gene names: 13472343

Gene position: 2108383-2109300 (Clockwise)

Preceding gene: 13472342

Following gene: 13472345

Centisome position: 29.97

GC content: 65.69

Gene sequence:

>918_bases
GTGAGCGAGAGCTACGCCTTCATCGGCCTCGGCCATCTCGGCGGCAACCTTGCCCCCAGCCTGATCCGCAACGGTTTTGC
GATCACCGTCTTCGACCGCGACCCGGCTGCCGTCGAGCGCCTCGTGACGCTCGGCGCCACGGCGGCGAACAGCCCGGCCG
AGGCGGCGGCGCGAGCCGGCAATGCCATCACTTGCCTGCCCTCGCCGAAAATCAGCGAAGCAGTGCTTGCCGGTCCCGGC
GGCTTGCTCGAAGGTTTGCCGAAGGGCGGCACCTGGATCGAGATGTCGACCAATGGCCGCGACGAAATCATGCGCCTTGC
CGCCCTCGCCTCGGCCGAAGGCGTCGAGACACTGGAATGCCCGGTCACCGGCGGCGTGCATCTGGCGGCGGTAGGAAAGA
TCACCGCGCTGGTCGGCGGCGATGCCGCGCTTTACGAACGCCATCGCGCGGCCATCGAGGCGATGTGCGCGCGCTCCTTC
CTGATGGGGCCGATCGGCTCGGCCGCGGTGATCAAGGTGATCACCAACATGCTCGCCTTCATCCATCTCGTCGCCGCCGG
CGAGGCACTGATGCTGGCCAAGCAGGGCGGCCTTGACCTCGCCCAATCCTACCACGCCATCGTTGCCTCCTCCGGCAACA
GCTTCGTCCACGAGACCGAAAGCCAGTTGGTGCTCAACGGCTCCTACGACATCGGCTTCACCATGGACCTGGCGCTGAAG
GACCTCGGTTTTGCGTTGGGCATGGGCAAGGATTTCGGCGTGCCGCTGGAGCTGGCATCCCGCGTCAATGCAATTTTTGA
AAAGGGCAAGGCGGCCTATGGCGGCGGCGCCTGGTCGACCCAGATCGTCAAATTGCTCGAGGATGCCGTCGGCACCGACC
TGCGCGCACCCGGTTTTCCAGCCAGACTGGAAATCTGA

Upstream 100 bases:

>100_bases
AACCGGGGCTGGGCGTCGAGCTCAACGAAGCGGTCTGCGATGCCCATCCCTACACCGGCAAGGATTTGCACCTGCAGATG
ATGCAGACCCCGTTGATGCC

Downstream 100 bases:

>100_bases
CCGGAGACCGGAAAACCAAGCAATTTCATTTGCTTGAATCGATAGCCGGATTCAGTTTCAAAAAGACTTGAATCAATCTG
GCAACGCCTTGATTCAATAT

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSESYAFIGLGHLGGNLAPSLIRNGFAITVFDRDPAAVERLVTLGATAANSPAEAAARAGNAITCLPSPKISEAVLAGPG
GLLEGLPKGGTWIEMSTNGRDEIMRLAALASAEGVETLECPVTGGVHLAAVGKITALVGGDAALYERHRAAIEAMCARSF
LMGPIGSAAVIKVITNMLAFIHLVAAGEALMLAKQGGLDLAQSYHAIVASSGNSFVHETESQLVLNGSYDIGFTMDLALK
DLGFALGMGKDFGVPLELASRVNAIFEKGKAAYGGGAWSTQIVKLLEDAVGTDLRAPGFPARLEI

Sequences:

>Translated_305_residues
MSESYAFIGLGHLGGNLAPSLIRNGFAITVFDRDPAAVERLVTLGATAANSPAEAAARAGNAITCLPSPKISEAVLAGPG
GLLEGLPKGGTWIEMSTNGRDEIMRLAALASAEGVETLECPVTGGVHLAAVGKITALVGGDAALYERHRAAIEAMCARSF
LMGPIGSAAVIKVITNMLAFIHLVAAGEALMLAKQGGLDLAQSYHAIVASSGNSFVHETESQLVLNGSYDIGFTMDLALK
DLGFALGMGKDFGVPLELASRVNAIFEKGKAAYGGGAWSTQIVKLLEDAVGTDLRAPGFPARLEI
>Mature_304_residues
SESYAFIGLGHLGGNLAPSLIRNGFAITVFDRDPAAVERLVTLGATAANSPAEAAARAGNAITCLPSPKISEAVLAGPGG
LLEGLPKGGTWIEMSTNGRDEIMRLAALASAEGVETLECPVTGGVHLAAVGKITALVGGDAALYERHRAAIEAMCARSFL
MGPIGSAAVIKVITNMLAFIHLVAAGEALMLAKQGGLDLAQSYHAIVASSGNSFVHETESQLVLNGSYDIGFTMDLALKD
LGFALGMGKDFGVPLELASRVNAIFEKGKAAYGGGAWSTQIVKLLEDAVGTDLRAPGFPARLEI

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=269, Percent_Identity=28.996282527881, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI23308751, Length=268, Percent_Identity=28.7313432835821, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI145693186, Length=262, Percent_Identity=30.5343511450382, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790315, Length=279, Percent_Identity=32.6164874551971, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786719, Length=281, Percent_Identity=28.1138790035587, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789092, Length=283, Percent_Identity=27.5618374558304, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17557316, Length=270, Percent_Identity=30.7407407407407, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24655230, Length=273, Percent_Identity=30.03663003663, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19922568, Length=273, Percent_Identity=30.03663003663, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574115, Length=274, Percent_Identity=23.3576642335766, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 31346; Mature: 31215

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESYAFIGLGHLGGNLAPSLIRNGFAITVFDRDPAAVERLVTLGATAANSPAEAAARAG
CCCCEEEEEECCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHCC
NAITCLPSPKISEAVLAGPGGLLEGLPKGGTWIEMSTNGRDEIMRLAALASAEGVETLEC
CEEEECCCCCCCHHHCCCCCHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEC
PVTGGVHLAAVGKITALVGGDAALYERHRAAIEAMCARSFLMGPIGSAAVIKVITNMLAF
CCCCCEEEEEHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IHLVAAGEALMLAKQGGLDLAQSYHAIVASSGNSFVHETESQLVLNGSYDIGFTMDLALK
HHHHHCCCEEEEEECCCHHHHHHHHEEEECCCCCCEEECCCEEEEECCCCCCEEHHHHHH
DLGFALGMGKDFGVPLELASRVNAIFEKGKAAYGGGAWSTQIVKLLEDAVGTDLRAPGFP
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
ARLEI
CEECC
>Mature Secondary Structure 
SESYAFIGLGHLGGNLAPSLIRNGFAITVFDRDPAAVERLVTLGATAANSPAEAAARAG
CCCEEEEEECCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHCC
NAITCLPSPKISEAVLAGPGGLLEGLPKGGTWIEMSTNGRDEIMRLAALASAEGVETLEC
CEEEECCCCCCCHHHCCCCCHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEC
PVTGGVHLAAVGKITALVGGDAALYERHRAAIEAMCARSFLMGPIGSAAVIKVITNMLAF
CCCCCEEEEEHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IHLVAAGEALMLAKQGGLDLAQSYHAIVASSGNSFVHETESQLVLNGSYDIGFTMDLALK
HHHHHCCCEEEEEECCCHHHHHHHHEEEECCCCCCEEECCCEEEEECCCCCCEEHHHHHH
DLGFALGMGKDFGVPLELASRVNAIFEKGKAAYGGGAWSTQIVKLLEDAVGTDLRAPGFP
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
ARLEI
CEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA