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The map label for this gene is yrbE [H]

Identifier: 13471115

GI number: 13471115

Start: 825708

End: 826724

Strand: Reverse

Name: yrbE [H]

Synonym: mll1000

Alternate gene names: 13471115

Gene position: 826724-825708 (Counterclockwise)

Preceding gene: 13471116

Following gene: 13471114

Centisome position: 11.75

GC content: 62.93

Gene sequence:

>1017_bases
ATGCCCAAGAATAAGCCTGTCAGTGTCGGACTCATCGGCGCCGGTCGCATCGGTTCTTTCCACGGTGAGACCGTCGCGTG
CCGCCTCGTCGGTGCCGATCTCGTTGGTATCGCTGATCCTGCGCCGGATGCGGCGTCCAACCTCGCTGAGAAGCTCGGCG
TCGAAAGCGCCTACACGGATACGGCCGATCTCCTCTCTCATCCGGGGCTCGAGGCGGTGATTATAGCCACTCCCGCGCGG
TTCCATACGAACGTCCTCGTGCAGGCGGCCGAAGCAGGCAAGGCGATCTTTTGCGAGAAGCCGATGGCATTGACCCTGGA
GGATGCCGACCGGGCAATCGCCGCGGCGCGTTCGGCCGGGGTCCCACTTCAGGTGGGCTTCAACCGGCGCTGGGATCAGG
CCTTTGCTGAGGGGCGAGCAGCGATTGATGCCGGGAAAGTCGGGACGCCGCAGCTCCTTCGCTCTCTCACGCGCGATCCA
GGCCCGTTCGGCGCCGATCCGGCGCGGATCCCACTCTGGACCATCTTCTACGAGACGCTCATCCACGACTTCGACACGCT
GTTGTGGCTCAATCCGGGCGCGCAGCCGGTAGAGGTGTCTGCTGTAGCCGACGCTTTAGTGCGGCCGGATTTCAGGGAAA
ACGGCTTCCTTGACACAGCGGTAGTCACAGTCCGGTTCGACAACGGCTCCATTGCCGTCGCCGAAGCAAACTTCTCGGCA
CTCTACGGCTATGACATCCGCGGCGAGGTCTTCGGCTCCGGCGGCATGGTGACCATGGGCGACGTTCGTCGCTCCAGCAT
GACGCTCTTCGACAAGAACGGCCTGTCGAACGATACCTGGCGCCGCGACACCGACCATTTCGTCCAAGGCTACACGGCGC
AGCTCGCCTCGTTCGTTCGAGCCTCTCGTACCTGCAAAGTTGAAGGACCGACGGGCGAGGACGCGCGCAACGCTCTAAAA
ATTGCGCTTGCCTGCATCGAGTCCGTCTCGAAGAAGCAAGCCATTCCGCTGCGATAG

Upstream 100 bases:

>100_bases
GAAGCCTGGGCCGCCGGCGATCCCGACGCCGCGCTCGAAGCCTTCCGCGAGGCCTTCACGGTCTGACTTACCTCTCCAAC
CCATTTTTAGGATTGCTCGA

Downstream 100 bases:

>100_bases
AAGCTTCTGGAGCTACAGAGGAGTGTGGTCATGCACGAGGCCGTCAAACGACCAAGCGACGTGAGCGAACTCAAAGGCAT
GATTGCCTCACGGACGATCA

Product: dehydrogenase

Products: 2,4,6/3,5-pentahydroxycyclohexanone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MPKNKPVSVGLIGAGRIGSFHGETVACRLVGADLVGIADPAPDAASNLAEKLGVESAYTDTADLLSHPGLEAVIIATPAR
FHTNVLVQAAEAGKAIFCEKPMALTLEDADRAIAAARSAGVPLQVGFNRRWDQAFAEGRAAIDAGKVGTPQLLRSLTRDP
GPFGADPARIPLWTIFYETLIHDFDTLLWLNPGAQPVEVSAVADALVRPDFRENGFLDTAVVTVRFDNGSIAVAEANFSA
LYGYDIRGEVFGSGGMVTMGDVRRSSMTLFDKNGLSNDTWRRDTDHFVQGYTAQLASFVRASRTCKVEGPTGEDARNALK
IALACIESVSKKQAIPLR

Sequences:

>Translated_338_residues
MPKNKPVSVGLIGAGRIGSFHGETVACRLVGADLVGIADPAPDAASNLAEKLGVESAYTDTADLLSHPGLEAVIIATPAR
FHTNVLVQAAEAGKAIFCEKPMALTLEDADRAIAAARSAGVPLQVGFNRRWDQAFAEGRAAIDAGKVGTPQLLRSLTRDP
GPFGADPARIPLWTIFYETLIHDFDTLLWLNPGAQPVEVSAVADALVRPDFRENGFLDTAVVTVRFDNGSIAVAEANFSA
LYGYDIRGEVFGSGGMVTMGDVRRSSMTLFDKNGLSNDTWRRDTDHFVQGYTAQLASFVRASRTCKVEGPTGEDARNALK
IALACIESVSKKQAIPLR
>Mature_337_residues
PKNKPVSVGLIGAGRIGSFHGETVACRLVGADLVGIADPAPDAASNLAEKLGVESAYTDTADLLSHPGLEAVIIATPARF
HTNVLVQAAEAGKAIFCEKPMALTLEDADRAIAAARSAGVPLQVGFNRRWDQAFAEGRAAIDAGKVGTPQLLRSLTRDPG
PFGADPARIPLWTIFYETLIHDFDTLLWLNPGAQPVEVSAVADALVRPDFRENGFLDTAVVTVRFDNGSIAVAEANFSAL
YGYDIRGEVFGSGGMVTMGDVRRSSMTLFDKNGLSNDTWRRDTDHFVQGYTAQLASFVRASRTCKVEGPTGEDARNALKI
ALACIESVSKKQAIPLR

Specific function: Unknown

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI1787574, Length=259, Percent_Identity=25.4826254826255, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1789848, Length=132, Percent_Identity=30.3030303030303, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: 1.1.1.18

Molecular weight: Translated: 36028; Mature: 35897

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKNKPVSVGLIGAGRIGSFHGETVACRLVGADLVGIADPAPDAASNLAEKLGVESAYTD
CCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHHCCCCCCCC
TADLLSHPGLEAVIIATPARFHTNVLVQAAEAGKAIFCEKPMALTLEDADRAIAAARSAG
HHHHHHCCCCCEEEEECCCHHHHHHEEEECCCCCEEEECCCCEEEECHHHHHHHHHHHCC
VPLQVGFNRRWDQAFAEGRAAIDAGKVGTPQLLRSLTRDPGPFGADPARIPLWTIFYETL
CEEEECCCCCHHHHHHCCCCEECCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
IHDFDTLLWLNPGAQPVEVSAVADALVRPDFRENGFLDTAVVTVRFDNGSIAVAEANFSA
HHHHCEEEEECCCCCCEEHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCEEEEECCCEE
LYGYDIRGEVFGSGGMVTMGDVRRSSMTLFDKNGLSNDTWRRDTDHFVQGYTAQLASFVR
EEECCCCCEEECCCCEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ASRTCKVEGPTGEDARNALKIALACIESVSKKQAIPLR
HCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PKNKPVSVGLIGAGRIGSFHGETVACRLVGADLVGIADPAPDAASNLAEKLGVESAYTD
CCCCCEEEEEEECCCCCCCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHHCCCCCCCC
TADLLSHPGLEAVIIATPARFHTNVLVQAAEAGKAIFCEKPMALTLEDADRAIAAARSAG
HHHHHHCCCCCEEEEECCCHHHHHHEEEECCCCCEEEECCCCEEEECHHHHHHHHHHHCC
VPLQVGFNRRWDQAFAEGRAAIDAGKVGTPQLLRSLTRDPGPFGADPARIPLWTIFYETL
CEEEECCCCCHHHHHHCCCCEECCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
IHDFDTLLWLNPGAQPVEVSAVADALVRPDFRENGFLDTAVVTVRFDNGSIAVAEANFSA
HHHHCEEEEECCCCCCEEHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCEEEEECCCEE
LYGYDIRGEVFGSGGMVTMGDVRRSSMTLFDKNGLSNDTWRRDTDHFVQGYTAQLASFVR
EEECCCCCEEECCCCEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ASRTCKVEGPTGEDARNALKIALACIESVSKKQAIPLR
HCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: myo-inositol; NAD+

Specific reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9025289 [H]