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The map label for this gene is hisI

Identifier: 13471053

GI number: 13471053

Start: 745536

End: 745997

Strand: Direct

Name: hisI

Synonym: mlr0923

Alternate gene names: 13471053

Gene position: 745536-745997 (Clockwise)

Preceding gene: 13471052

Following gene: 13471054

Centisome position: 10.6

GC content: 60.82

Gene sequence:

>462_bases
ATGTCGGCACTGGGATTTCCCAAAACTCCGTCAGACAAGAAGGCCCTGGAGGAAGGCGCGGTGTTCTCACCGCGCTTCGA
CCCCGCCGGCCTTGTCACCGTCGTCGTCACCGATGCCGAAGACGGCATGCTGCTGATGGTCGCGCATATGAATGCGCAGG
CACTCGCGCTGACGCTGGAAACAGGCATCGCCCACTACTGGTCGCGCTCGCGCAACGCGCTTTGGAAGAAGGGCGAAACC
TCGGGCAATTTCCAGCACGTCGTCGAGATGCGCACGGACTGTGATCAGGATGCATTGTGGCTGCGCGTCAAAGTGTTGGG
CCACGACGCAACCTGTCACACCGGCCGGCGTTCATGCTTTTATCGGACGGTGGGGCTTGTCGACGGCAAGGGGACGCTTG
TTGACGACGGCAGCAAGCCGCTGTTCGATGCGGAATTCACGTATCGGAAGCCATCGTCTTGA

Upstream 100 bases:

>100_bases
TATCGCTAGGCCATGATCCCGAAAAACGCGGACCGGTTTTCTCTGGACAAACGAAAACGTTTGTCCAGAGATCATGGTCA
AATAGGAAGATACACCGGCG

Downstream 100 bases:

>100_bases
ACCATCTGCCTCACGCCAACCACACAGATTCATCATTTCGATACGGCCTGTCCGTATATTAGTCTTGGGACAAGGGAGAT
CATGATGCTCGAGTGGGCGT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MSALGFPKTPSDKKALEEGAVFSPRFDPAGLVTVVVTDAEDGMLLMVAHMNAQALALTLETGIAHYWSRSRNALWKKGET
SGNFQHVVEMRTDCDQDALWLRVKVLGHDATCHTGRRSCFYRTVGLVDGKGTLVDDGSKPLFDAEFTYRKPSS

Sequences:

>Translated_153_residues
MSALGFPKTPSDKKALEEGAVFSPRFDPAGLVTVVVTDAEDGMLLMVAHMNAQALALTLETGIAHYWSRSRNALWKKGET
SGNFQHVVEMRTDCDQDALWLRVKVLGHDATCHTGRRSCFYRTVGLVDGKGTLVDDGSKPLFDAEFTYRKPSS
>Mature_152_residues
SALGFPKTPSDKKALEEGAVFSPRFDPAGLVTVVVTDAEDGMLLMVAHMNAQALALTLETGIAHYWSRSRNALWKKGETS
GNFQHVVEMRTDCDQDALWLRVKVLGHDATCHTGRRSCFYRTVGLVDGKGTLVDDGSKPLFDAEFTYRKPSS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=47.2527472527472, Blast_Score=87, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319819, Length=93, Percent_Identity=40.8602150537634, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_RHILO (Q98LQ5)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102622.1
- ProteinModelPortal:   Q98LQ5
- SMR:   Q98LQ5
- GeneID:   1225285
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr0923
- NMPDR:   fig|266835.1.peg.727
- HOGENOM:   HBG294308
- OMA:   CHVGYRS
- ProtClustDB:   PRK00051
- BRENDA:   3.5.4.19
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 16821; Mature: 16690

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALGFPKTPSDKKALEEGAVFSPRFDPAGLVTVVVTDAEDGMLLMVAHMNAQALALTLE
CCCCCCCCCCCHHHHHHCCCEECCCCCCCCEEEEEEEECCCCEEEEEEECCCEEEEEEHH
TGIAHYWSRSRNALWKKGETSGNFQHVVEMRTDCDQDALWLRVKVLGHDATCHTGRRSCF
HHHHHHHHCCCCCEECCCCCCCCHHHEEEHHCCCCCCCEEEEEEEECCCCCCCCCCCEEE
YRTVGLVDGKGTLVDDGSKPLFDAEFTYRKPSS
EEEEEEECCCCCEEECCCCCEECCEECCCCCCC
>Mature Secondary Structure 
SALGFPKTPSDKKALEEGAVFSPRFDPAGLVTVVVTDAEDGMLLMVAHMNAQALALTLE
CCCCCCCCCCHHHHHHCCCEECCCCCCCCEEEEEEEECCCCEEEEEEECCCEEEEEEHH
TGIAHYWSRSRNALWKKGETSGNFQHVVEMRTDCDQDALWLRVKVLGHDATCHTGRRSCF
HHHHHHHHCCCCCEECCCCCCCCHHHEEEHHCCCCCCCEEEEEEEECCCCCCCCCCCEEE
YRTVGLVDGKGTLVDDGSKPLFDAEFTYRKPSS
EEEEEEECCCCCEEECCCCCEECCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968