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The map label for this gene is mccB [H]

Identifier: 13470999

GI number: 13470999

Start: 682158

End: 683345

Strand: Reverse

Name: mccB [H]

Synonym: mll0856

Alternate gene names: 13470999

Gene position: 683345-682158 (Counterclockwise)

Preceding gene: 13471000

Following gene: 13470998

Centisome position: 9.71

GC content: 63.89

Gene sequence:

>1188_bases
ATGAACGAGCATCCGAGCGGTTTCGATCACGATTATCTTGCCGAGGCGGCGACGCTTTTGGCGCATGACGAGCCGTTCCC
GGGTGGCGCGGTGGTGCCGCCGATCTACCAGACCTCGCTGTTCACCTTCGCCAACTATGCCGAAATGGCCGACACATTTG
CCGGCAAACGAAAGCAGCCGATCTATTCGCGCGGCGACAATCCGACGGTGATGGAGTTCGAGGCGCGCGTGGCCGCGCTC
GAGGGCGCCGAGGCCGCGCGCGGCTTTTCCAGCGGCATGGCGGCGATCAGCGCCACCGTGCTTGCCTTCGTTGGCGCGGG
CGAGCGCATTGTCGCCGTGCGCAATTGCTATGGCGATGCCTACCGCTTGTTCGAACGGCTTCTGCCGCGGCTCAACATCA
AGGTCGACTATGTCGACGGCTCCGATCCGGACGCGGTGGCAGCGGCACTTCCCGGCGCCAAGCTGCTCTACCTGGAAAGC
CCGACCTCGATGATGTTCGAGCTCCAGGACATTGCGCATTTGACCCGGCTGGCGAAAGAGCAGGGCATCGTCACCACGAT
CGACAATTCCTGGGCGACGCCGGTGTTCCAGAAGCCGATCTCGCACGGGGTCGACCTGGTGCTGCATTCGGCATCGAAAT
ATCTCGGCGGCCACAGCGACACGGTCGCCGGCGTGGTGGCGGGCTCCGCCGCCCACATCAAGCACATCAACGAGCAGACC
TATTCCTATCTCGGCGGCAAGCTGTCGCCATTCGAGGCCTGGCTGCTGCTGCGCGGCCTGCGCACGCTGCCGCTGCGGCT
GCCGCACCACATGAAGAGCGGGCTAACCCTCGCCGAGCGGCTCAAGGCGCATGCCCATGTCGAGCGCGTCAACCATCCAG
CCTATTCGAACCATCCCGGCAAGGCGACGCTGGCCGGCTATGCCGGTCTGTTCTCCTTCGAGGTGACGGACGATATCGAC
ATCCCGGTCTTCGTCGACGCGCTGAAGTATTTCCGCATCGGCGTCAGCTGGGGCGGGCATGAAAGCCTGGTCGTGCCGGC
CAAGGCGTCGCTGGAGCAGACGCCGGGACTGAATTCGATGGCGCGCTTCGGCGTCAGCCCCCGAACCATCCGCTTCAATG
TCGGATTGGAAAGTGTCGAAGACCTCTGGGCCGACGTCGCCCAGGCCTTCGAAAAAGCCAGAAAATAA

Upstream 100 bases:

>100_bases
GCGACCCGCAAGGCGCCCGCGCCGAGGCGCTCAAGCTGATCGCCACCGTCGAGGACGATCTCAAGCGCGGTGCGGCCAAA
CTCAAACTTTCGAGCCAGAC

Downstream 100 bases:

>100_bases
CAAGCGGGTTCAAAATGGGAGTCTTGAACATGAAAAAACTGACCGTCATGCTTGCCACCGTTGCGGGGCTGGCGATTTCC
GCCGGGAGCGCGCTGGCCGA

Product: hypothetical protein

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MNEHPSGFDHDYLAEAATLLAHDEPFPGGAVVPPIYQTSLFTFANYAEMADTFAGKRKQPIYSRGDNPTVMEFEARVAAL
EGAEAARGFSSGMAAISATVLAFVGAGERIVAVRNCYGDAYRLFERLLPRLNIKVDYVDGSDPDAVAAALPGAKLLYLES
PTSMMFELQDIAHLTRLAKEQGIVTTIDNSWATPVFQKPISHGVDLVLHSASKYLGGHSDTVAGVVAGSAAHIKHINEQT
YSYLGGKLSPFEAWLLLRGLRTLPLRLPHHMKSGLTLAERLKAHAHVERVNHPAYSNHPGKATLAGYAGLFSFEVTDDID
IPVFVDALKYFRIGVSWGGHESLVVPAKASLEQTPGLNSMARFGVSPRTIRFNVGLESVEDLWADVAQAFEKARK

Sequences:

>Translated_395_residues
MNEHPSGFDHDYLAEAATLLAHDEPFPGGAVVPPIYQTSLFTFANYAEMADTFAGKRKQPIYSRGDNPTVMEFEARVAAL
EGAEAARGFSSGMAAISATVLAFVGAGERIVAVRNCYGDAYRLFERLLPRLNIKVDYVDGSDPDAVAAALPGAKLLYLES
PTSMMFELQDIAHLTRLAKEQGIVTTIDNSWATPVFQKPISHGVDLVLHSASKYLGGHSDTVAGVVAGSAAHIKHINEQT
YSYLGGKLSPFEAWLLLRGLRTLPLRLPHHMKSGLTLAERLKAHAHVERVNHPAYSNHPGKATLAGYAGLFSFEVTDDID
IPVFVDALKYFRIGVSWGGHESLVVPAKASLEQTPGLNSMARFGVSPRTIRFNVGLESVEDLWADVAQAFEKARK
>Mature_395_residues
MNEHPSGFDHDYLAEAATLLAHDEPFPGGAVVPPIYQTSLFTFANYAEMADTFAGKRKQPIYSRGDNPTVMEFEARVAAL
EGAEAARGFSSGMAAISATVLAFVGAGERIVAVRNCYGDAYRLFERLLPRLNIKVDYVDGSDPDAVAAALPGAKLLYLES
PTSMMFELQDIAHLTRLAKEQGIVTTIDNSWATPVFQKPISHGVDLVLHSASKYLGGHSDTVAGVVAGSAAHIKHINEQT
YSYLGGKLSPFEAWLLLRGLRTLPLRLPHHMKSGLTLAERLKAHAHVERVNHPAYSNHPGKATLAGYAGLFSFEVTDDID
IPVFVDALKYFRIGVSWGGHESLVVPAKASLEQTPGLNSMARFGVSPRTIRFNVGLESVEDLWADVAQAFEKARK

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=377, Percent_Identity=32.8912466843501, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI299473759, Length=391, Percent_Identity=29.6675191815857, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI25453487, Length=375, Percent_Identity=29.6, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI1790375, Length=384, Percent_Identity=34.6354166666667, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1789383, Length=375, Percent_Identity=29.8666666666667, Blast_Score=168, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17560056, Length=373, Percent_Identity=34.0482573726542, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71980708, Length=383, Percent_Identity=32.1148825065274, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17538055, Length=381, Percent_Identity=34.1207349081365, Blast_Score=184, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6319307, Length=380, Percent_Identity=31.3157894736842, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321170, Length=319, Percent_Identity=32.6018808777429, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323333, Length=410, Percent_Identity=29.5121951219512, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321904, Length=374, Percent_Identity=26.4705882352941, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321254, Length=402, Percent_Identity=27.8606965174129, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI19922554, Length=401, Percent_Identity=32.1695760598504, Blast_Score=195, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 42887; Mature: 42887

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEHPSGFDHDYLAEAATLLAHDEPFPGGAVVPPIYQTSLFTFANYAEMADTFAGKRKQP
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
IYSRGDNPTVMEFEARVAALEGAEAARGFSSGMAAISATVLAFVGAGERIVAVRNCYGDA
CCCCCCCCEEEEHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHH
YRLFERLLPRLNIKVDYVDGSDPDAVAAALPGAKLLYLESPTSMMFELQDIAHLTRLAKE
HHHHHHHHHHCCEEEEEECCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
QGIVTTIDNSWATPVFQKPISHGVDLVLHSASKYLGGHSDTVAGVVAGSAAHIKHINEQT
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHH
YSYLGGKLSPFEAWLLLRGLRTLPLRLPHHMKSGLTLAERLKAHAHVERVNHPAYSNHPG
HHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCC
KATLAGYAGLFSFEVTDDIDIPVFVDALKYFRIGVSWGGHESLVVPAKASLEQTPGLNSM
CEEHHHHHEEEEEECCCCCCCHHHHHHHHHHHEECCCCCCCCEEECCHHCCCCCCCCCHH
ARFGVSPRTIRFNVGLESVEDLWADVAQAFEKARK
HHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNEHPSGFDHDYLAEAATLLAHDEPFPGGAVVPPIYQTSLFTFANYAEMADTFAGKRKQP
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
IYSRGDNPTVMEFEARVAALEGAEAARGFSSGMAAISATVLAFVGAGERIVAVRNCYGDA
CCCCCCCCEEEEHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHH
YRLFERLLPRLNIKVDYVDGSDPDAVAAALPGAKLLYLESPTSMMFELQDIAHLTRLAKE
HHHHHHHHHHCCEEEEEECCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
QGIVTTIDNSWATPVFQKPISHGVDLVLHSASKYLGGHSDTVAGVVAGSAAHIKHINEQT
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHH
YSYLGGKLSPFEAWLLLRGLRTLPLRLPHHMKSGLTLAERLKAHAHVERVNHPAYSNHPG
HHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCC
KATLAGYAGLFSFEVTDDIDIPVFVDALKYFRIGVSWGGHESLVVPAKASLEQTPGLNSM
CEEHHHHHEEEEEECCCCCCCHHHHHHHHHHHEECCCCCCCCEEECCHHCCCCCCCCCHH
ARFGVSPRTIRFNVGLESVEDLWADVAQAFEKARK
HHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]