Click here to switch to the map view.

The map label for this gene is rnr [H]

Identifier: 13470989

GI number: 13470989

Start: 671507

End: 673813

Strand: Direct

Name: rnr [H]

Synonym: mlr0841

Alternate gene names: 13470989

Gene position: 671507-673813 (Clockwise)

Preceding gene: 13470988

Following gene: 13470990

Centisome position: 9.54

GC content: 65.37

Gene sequence:

>2307_bases
GTGGCGCGCAGGATCACCGGACGGAGCCACGGCGATCCACGCACCGCCGACACGAGGGCCAAGGTCAAGGACGACTATCG
GCCTTCGCGCGACGAAATCCTGCGCTATATCGCCGAAAATCCCGATCGTGCCGGAAAGCGCGACATCGCCAAGGCCTTCG
CTTTGCGCGGCGATGACCGCATCTGGCTGAAAGACATTCTGCGCGACCTGCAGGATGAAGGCGTGCTGACCAAGGAGCGC
AAGCGGCTGGCCCGCGTCGGCGCCCTGCCCCATGTCGCCGTGCTCGACATTTTTGGCCGTGACGGCGACGGCATCCTGCT
GGCGCATCCGGCGGAGTCAATCGGCAGCGGCGAGCCGCCCGTGGTCTCGATCCGCGTTTCGCGCAGCGGCAACGGCCCGG
CGCCCGGCATTGGCGACCGCGTCCTGGCCAAGACCTTCCCGACCGATGATCCGTCCGGCCCCGCCTATACCGGCCGGGTG
ATGAAGATCTTCGAGAAGCGCACCGATGCCGTCCTCGGCGTCTTTCGCGTGCTAAAGGACGGCACCTTCCGCATCGAACC
GGTGGAACGGCGCCAGCCCGAACTGATCGTCGACAAGGAATTCCAGAACGGCGCTGAGAATGGCGACCTGGTCGAGGTCG
AGCCCGCGCGGGCTTCCCGCTACGGGCTGCCGAAAGCCAAGGTGCTCAATGTGCTCGGCTCGTTGACCAGTGAAAAGGCG
GTCTCGATGATCGCCATCCACGCCCACGACATCCCGCACATCTTTCCGGCTGATGTCATCGCCGAATCCGAAGCCGTCAA
GCCGGCAACGCTTGACCGCCGCGAGGACTGGCGCGACCTGCCTCTCGTCACCATCGATCCGGCCGACGCCAAGGACCACG
ATGACGCGGTCTTCGCGACGCCTGATCTCGACGAAAAGAACCCGGGCGGCGTGATCGCCACCGTGGCGATCGCCGACGTT
GCCGCCTATGTCCGCTATGGCACGGCGCTGGACCGCGAAGCCTTGAAGCGCGGCAATTCGGTCTATTTCCCGGATCGCGT
CGTGCCGATGCTGCCGGAGCGCATCTCGAACGATCTCTGTTCGCTGCGAGAGGGCCAGGATCGCCCGGCGCTGGCCGTGC
GCATGACCTTCTCCGCCGAAGGTCACAAGATCAGGCACTCCTTCCACCGCGTGATGATGAAATCGGCGGCGAAGCTTGCC
TATCCGCAGGCGCAGGCGGCCATCGACGGCGCGCCCGACGAGAAGACCGGCCCGATCCTCGACACCGTGCTGAAGCCGCT
CTGGGATGCCTATGCGATCCTCAAGCGCGGTCGCGCCGGCCGACAGCCGCTCGAACTCGACCTACCGGAGCGCAAGATCA
TGCTCAAGCCGGACGGCACGGTCGACCGTGTCATCGTGCCGGAACGGCTCGATGCCCATAAGCTGATCGAAGAATTCATG
ATCCAGGCCAATGTCGCCGCCGCCGAGACGCTGGAGGCGAAGAAGCAGGCGCTGGTCTACCGCGTCCACGACGCGCCGTC
GCTCGCCAAGCAGGAATCGCTACGCGAATTCCTGCAGACGCTCGGCCTGTCACTGGCGCGCGGCGCGCAGATGCGGCCCA
GCCAGTTCAACGGCATTCTCGAGCGCGTGCGCGGCGCCGACAACGAGGCACTGGTCAACGAGGTGGTGCTGCGCTCGCAG
AGCCAGGCTGAATACTCGCCCGGGAATATCGGCCATTTCGGCCTCAACCTCAGGCGCTACGCGCATTTCACCTCGCCGAT
CCGCCGCTATGCCGATTTGATCGTGCATCGCGGGCTTATTGCCGCACTCGGCCTCGGACCGGGAGGACTGACGCAGGACG
AAGCAGCTCGGCTCGAAGACGTTGCGATACTGATCTCCGGCACGGAACGGCGTGCCATGGCGGCCGAGCGCGACACGGTC
GACCGGCTGATTGCAGCCTATCTCGCCGAGCGCATCGACGACCGCTTCGACGCCCGCATCTCCGGCGTCACCAAATCAGG
ACTATTTGTCCAATTGCCGCAATATGGCGCCGATGGCTTCATCCCCGTGTCAACGCTGGGCGGCGATTACTATATATACG
ACGAAGCCGCTCGCTCGCTCTTCGGAGAACGCACGGGCAAAGGCTACCAGCTCGCGGACCATGTCGAGGTCCGGCTCGTC
GAGGTGGCACCCATGGCCGGCGCCATGCGCTTCGAGATGCTGACAGACCCGAAGCCCCTGCCAGGCTCCACCAGGTCGTT
TCACAAGGCCAAGGGCCGCGCCCGTGCGTCGCAATCGCGACCGGGTTCGCGCGGCAGGAGACGATAA

Upstream 100 bases:

>100_bases
CGGCAAGAAGCCGTTCCGCAAGGCAGCCGCGGCCAAGGCGCCCGCGGCCAAGAAAACAGCCGCCAGGAAGCCGGCGGCGA
AGAAAAAAGGGTAGGACGGC

Downstream 100 bases:

>100_bases
TGCCAAAGGAATTAGGGATACAAGAACAGGTTTTCGGCGGTGAACATCACACTGGCCGGGTTGCCCGCCCCTTGTGGACG
GCGATGAAGCGCGGCCTTTT

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 768; Mature: 767

Protein sequence:

>768_residues
MARRITGRSHGDPRTADTRAKVKDDYRPSRDEILRYIAENPDRAGKRDIAKAFALRGDDRIWLKDILRDLQDEGVLTKER
KRLARVGALPHVAVLDIFGRDGDGILLAHPAESIGSGEPPVVSIRVSRSGNGPAPGIGDRVLAKTFPTDDPSGPAYTGRV
MKIFEKRTDAVLGVFRVLKDGTFRIEPVERRQPELIVDKEFQNGAENGDLVEVEPARASRYGLPKAKVLNVLGSLTSEKA
VSMIAIHAHDIPHIFPADVIAESEAVKPATLDRREDWRDLPLVTIDPADAKDHDDAVFATPDLDEKNPGGVIATVAIADV
AAYVRYGTALDREALKRGNSVYFPDRVVPMLPERISNDLCSLREGQDRPALAVRMTFSAEGHKIRHSFHRVMMKSAAKLA
YPQAQAAIDGAPDEKTGPILDTVLKPLWDAYAILKRGRAGRQPLELDLPERKIMLKPDGTVDRVIVPERLDAHKLIEEFM
IQANVAAAETLEAKKQALVYRVHDAPSLAKQESLREFLQTLGLSLARGAQMRPSQFNGILERVRGADNEALVNEVVLRSQ
SQAEYSPGNIGHFGLNLRRYAHFTSPIRRYADLIVHRGLIAALGLGPGGLTQDEAARLEDVAILISGTERRAMAAERDTV
DRLIAAYLAERIDDRFDARISGVTKSGLFVQLPQYGADGFIPVSTLGGDYYIYDEAARSLFGERTGKGYQLADHVEVRLV
EVAPMAGAMRFEMLTDPKPLPGSTRSFHKAKGRARASQSRPGSRGRRR

Sequences:

>Translated_768_residues
MARRITGRSHGDPRTADTRAKVKDDYRPSRDEILRYIAENPDRAGKRDIAKAFALRGDDRIWLKDILRDLQDEGVLTKER
KRLARVGALPHVAVLDIFGRDGDGILLAHPAESIGSGEPPVVSIRVSRSGNGPAPGIGDRVLAKTFPTDDPSGPAYTGRV
MKIFEKRTDAVLGVFRVLKDGTFRIEPVERRQPELIVDKEFQNGAENGDLVEVEPARASRYGLPKAKVLNVLGSLTSEKA
VSMIAIHAHDIPHIFPADVIAESEAVKPATLDRREDWRDLPLVTIDPADAKDHDDAVFATPDLDEKNPGGVIATVAIADV
AAYVRYGTALDREALKRGNSVYFPDRVVPMLPERISNDLCSLREGQDRPALAVRMTFSAEGHKIRHSFHRVMMKSAAKLA
YPQAQAAIDGAPDEKTGPILDTVLKPLWDAYAILKRGRAGRQPLELDLPERKIMLKPDGTVDRVIVPERLDAHKLIEEFM
IQANVAAAETLEAKKQALVYRVHDAPSLAKQESLREFLQTLGLSLARGAQMRPSQFNGILERVRGADNEALVNEVVLRSQ
SQAEYSPGNIGHFGLNLRRYAHFTSPIRRYADLIVHRGLIAALGLGPGGLTQDEAARLEDVAILISGTERRAMAAERDTV
DRLIAAYLAERIDDRFDARISGVTKSGLFVQLPQYGADGFIPVSTLGGDYYIYDEAARSLFGERTGKGYQLADHVEVRLV
EVAPMAGAMRFEMLTDPKPLPGSTRSFHKAKGRARASQSRPGSRGRRR
>Mature_767_residues
ARRITGRSHGDPRTADTRAKVKDDYRPSRDEILRYIAENPDRAGKRDIAKAFALRGDDRIWLKDILRDLQDEGVLTKERK
RLARVGALPHVAVLDIFGRDGDGILLAHPAESIGSGEPPVVSIRVSRSGNGPAPGIGDRVLAKTFPTDDPSGPAYTGRVM
KIFEKRTDAVLGVFRVLKDGTFRIEPVERRQPELIVDKEFQNGAENGDLVEVEPARASRYGLPKAKVLNVLGSLTSEKAV
SMIAIHAHDIPHIFPADVIAESEAVKPATLDRREDWRDLPLVTIDPADAKDHDDAVFATPDLDEKNPGGVIATVAIADVA
AYVRYGTALDREALKRGNSVYFPDRVVPMLPERISNDLCSLREGQDRPALAVRMTFSAEGHKIRHSFHRVMMKSAAKLAY
PQAQAAIDGAPDEKTGPILDTVLKPLWDAYAILKRGRAGRQPLELDLPERKIMLKPDGTVDRVIVPERLDAHKLIEEFMI
QANVAAAETLEAKKQALVYRVHDAPSLAKQESLREFLQTLGLSLARGAQMRPSQFNGILERVRGADNEALVNEVVLRSQS
QAEYSPGNIGHFGLNLRRYAHFTSPIRRYADLIVHRGLIAALGLGPGGLTQDEAARLEDVAILISGTERRAMAAERDTVD
RLIAAYLAERIDDRFDARISGVTKSGLFVQLPQYGADGFIPVSTLGGDYYIYDEAARSLFGERTGKGYQLADHVEVRLVE
VAPMAGAMRFEMLTDPKPLPGSTRSFHKAKGRARASQSRPGSRGRRR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=548, Percent_Identity=27.9197080291971, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI190014625, Length=548, Percent_Identity=27.9197080291971, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI134288890, Length=484, Percent_Identity=30.3719008264463, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI219521928, Length=587, Percent_Identity=26.0647359454855, Blast_Score=144, Evalue=4e-34,
Organism=Homo sapiens, GI19115966, Length=587, Percent_Identity=26.0647359454855, Blast_Score=144, Evalue=4e-34,
Organism=Escherichia coli, GI87082383, Length=731, Percent_Identity=34.06292749658, Blast_Score=347, Evalue=2e-96,
Organism=Escherichia coli, GI1787542, Length=461, Percent_Identity=34.4902386117137, Blast_Score=180, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI212645896, Length=492, Percent_Identity=31.7073170731707, Blast_Score=185, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17553506, Length=543, Percent_Identity=28.1767955801105, Blast_Score=160, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324552, Length=543, Percent_Identity=28.9134438305709, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320499, Length=378, Percent_Identity=25.6613756613757, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24649634, Length=547, Percent_Identity=27.2394881170018, Blast_Score=162, Evalue=8e-40,
Organism=Drosophila melanogaster, GI19922976, Length=378, Percent_Identity=29.6296296296296, Blast_Score=137, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24654597, Length=378, Percent_Identity=29.6296296296296, Blast_Score=137, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24654592, Length=378, Percent_Identity=29.6296296296296, Blast_Score=136, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 84602; Mature: 84470

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRITGRSHGDPRTADTRAKVKDDYRPSRDEILRYIAENPDRAGKRDIAKAFALRGDDR
CCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
IWLKDILRDLQDEGVLTKERKRLARVGALPHVAVLDIFGRDGDGILLAHPAESIGSGEPP
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEECCHHHCCCCCCC
VVSIRVSRSGNGPAPGIGDRVLAKTFPTDDPSGPAYTGRVMKIFEKRTDAVLGVFRVLKD
EEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GTFRIEPVERRQPELIVDKEFQNGAENGDLVEVEPARASRYGLPKAKVLNVLGSLTSEKA
CCEEECCHHCCCCCEEEECHHCCCCCCCCEEEECCCCHHHCCCCHHHHHHHHHHHHHHHH
VSMIAIHAHDIPHIFPADVIAESEAVKPATLDRREDWRDLPLVTIDPADAKDHDDAVFAT
HEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEC
PDLDEKNPGGVIATVAIADVAAYVRYGTALDREALKRGNSVYFPDRVVPMLPERISNDLC
CCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHCCCCEECCCCHHHHHHHHHHHHHH
SLREGQDRPALAVRMTFSAEGHKIRHSFHRVMMKSAAKLAYPQAQAAIDGAPDEKTGPIL
HHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHH
DTVLKPLWDAYAILKRGRAGRQPLELDLPERKIMLKPDGTVDRVIVPERLDAHKLIEEFM
HHHHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEECCCCCCCEEECCCCCCHHHHHHHHH
IQANVAAAETLEAKKQALVYRVHDAPSLAKQESLREFLQTLGLSLARGAQMRPSQFNGIL
HHCCHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHH
ERVRGADNEALVNEVVLRSQSQAEYSPGNIGHFGLNLRRYAHFTSPIRRYADLIVHRGLI
HHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHH
AALGLGPGGLTQDEAARLEDVAILISGTERRAMAAERDTVDRLIAAYLAERIDDRFDARI
HHHCCCCCCCCHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGVTKSGLFVQLPQYGADGFIPVSTLGGDYYIYDEAARSLFGERTGKGYQLADHVEVRLV
CCCCCCCEEEECCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHCCCCCCEEECCCEEEEE
EVAPMAGAMRFEMLTDPKPLPGSTRSFHKAKGRARASQSRPGSRGRRR
EECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ARRITGRSHGDPRTADTRAKVKDDYRPSRDEILRYIAENPDRAGKRDIAKAFALRGDDR
CCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
IWLKDILRDLQDEGVLTKERKRLARVGALPHVAVLDIFGRDGDGILLAHPAESIGSGEPP
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEECCHHHCCCCCCC
VVSIRVSRSGNGPAPGIGDRVLAKTFPTDDPSGPAYTGRVMKIFEKRTDAVLGVFRVLKD
EEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GTFRIEPVERRQPELIVDKEFQNGAENGDLVEVEPARASRYGLPKAKVLNVLGSLTSEKA
CCEEECCHHCCCCCEEEECHHCCCCCCCCEEEECCCCHHHCCCCHHHHHHHHHHHHHHHH
VSMIAIHAHDIPHIFPADVIAESEAVKPATLDRREDWRDLPLVTIDPADAKDHDDAVFAT
HEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEC
PDLDEKNPGGVIATVAIADVAAYVRYGTALDREALKRGNSVYFPDRVVPMLPERISNDLC
CCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHCCCCEECCCCHHHHHHHHHHHHHH
SLREGQDRPALAVRMTFSAEGHKIRHSFHRVMMKSAAKLAYPQAQAAIDGAPDEKTGPIL
HHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHH
DTVLKPLWDAYAILKRGRAGRQPLELDLPERKIMLKPDGTVDRVIVPERLDAHKLIEEFM
HHHHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEECCCCCCCEEECCCCCCHHHHHHHHH
IQANVAAAETLEAKKQALVYRVHDAPSLAKQESLREFLQTLGLSLARGAQMRPSQFNGIL
HHCCHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHH
ERVRGADNEALVNEVVLRSQSQAEYSPGNIGHFGLNLRRYAHFTSPIRRYADLIVHRGLI
HHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHH
AALGLGPGGLTQDEAARLEDVAILISGTERRAMAAERDTVDRLIAAYLAERIDDRFDARI
HHHCCCCCCCCHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGVTKSGLFVQLPQYGADGFIPVSTLGGDYYIYDEAARSLFGERTGKGYQLADHVEVRLV
CCCCCCCEEEECCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHCCCCCCEEECCCEEEEE
EVAPMAGAMRFEMLTDPKPLPGSTRSFHKAKGRARASQSRPGSRGRRR
EECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]