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The map label for this gene is moeA [H]

Identifier: 13470817

GI number: 13470817

Start: 481779

End: 482984

Strand: Direct

Name: moeA [H]

Synonym: mlr0617

Alternate gene names: 13470817

Gene position: 481779-482984 (Clockwise)

Preceding gene: 13470816

Following gene: 13470819

Centisome position: 6.85

GC content: 66.92

Gene sequence:

>1206_bases
ATGGCGCTGGTTCCGGTGGCGGAGGCGCTTGAGCGCCTGCTGGATGGTGCAGCCCCCCTGGCCGGCGAAAGCGTCCCTCT
GTTCGAGGCCGTCGATCGTGTGCTGGCGGAACCGCTCGCAGCACTGCGCACCCAGCCGCCTTTCAACGCTTCGGCCATGG
ATGGTTACGCGGTGCGCGCCGCCGATGTCGCTTCCGTGCCGTCGAAACTCACGGTAATCGGCATGGCGCCGGCCGGGCGC
GGCTTTGACGGCTCACTCGGCGAGCGCCAGGCGGTGCGCATCTTCACCGGCGCGCCGCTGCCCGAGGGTGCGGACACTAT
CGTCATCCAGGAAAACGTCCGCGACCTCGGCGGCGGCCATATCGAAGTGATCGAACCGACGGCCGAGTGGCGCAACATCC
GCCGCGTCGGCCTCGACTTTTCCAAAGGCGACTTCCTGCTGGAGAAAGGTCGCTTACTCGATCCGGCGGCGCTGTCTCTT
ACGGCGTCGGCCAACCATCCCGTGGTCACCGTGGTCAAACGGCCGCTGGTCGCCATCATCGCCACCGGCGACGAGTTGTT
ACCGCCCGGCAGCGAACTCGGGCCGGACCAGATCATCTCGTCCAACGCCTACGGCGTCGCTGCGGTGGCGCAATCGGTCG
GCGCCCGCGCGCTCGATCTCGGCATTGCCGCCGACCGCAAGGACGCCATCGCAGCGCTGGTCAAAAAGGCGGTCGCGGCC
GGTGCGGATGTCATCGTCACGCTTGGTGGCGCCTCGGTCGGCGACCACGACCTGATCCATGACGTGCTGACCGGCGAAGG
CATGACGCTCGGCTTCTGGAAGATCGCCATGCGCCCTGGCAAGCCGCTGATGTTCGGCCGCCTCGGCGATATCAGGTGCA
TCGGCCTGCCCGGCAACCCGGTGGCAAGCCTGGTCTGCTCGCAATTGTTCCTGAAGCCGCTTCTGGCGAGGCTCGGCGGC
CGCGATCATCGCCAGGACATCCGTCCGGCGCGATTGGGCGCCGCAATGCCGGCCAATGATCTGCGCCAGGACTATGTACG
CGCGGTGGTCAGGGAAGACGGTGGCGAACTGGTGGCGACGCCGTTCAGCATCCAGGATTCGTCCATGCTGAGGATGCTGG
CCGACGCCAATGGGCTGATCGTGCGGGCGCCATTTGCCCCTGCATCCGCTGTTGGAGATTCTTGCAGCGTGCTGATGCTG
CGCTGA

Upstream 100 bases:

>100_bases
ACGACATGGCCAAGGCGGTCGACCGCGCCATGCTCATCTCCGGCATCCGCCTGGTCGAAAAGACCGGCGGCAAATCCGGC
GACTATAAGGTTGGCGCCTG

Downstream 100 bases:

>100_bases
AGAACTATCCCATAACGCACTGATAACAGAACAAAAACTGTCTCATCTATTCCGAGATCAAGGTTCGTGTCAGCGCATGC
GCCGGATCGGCGAGGCCATC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MALVPVAEALERLLDGAAPLAGESVPLFEAVDRVLAEPLAALRTQPPFNASAMDGYAVRAADVASVPSKLTVIGMAPAGR
GFDGSLGERQAVRIFTGAPLPEGADTIVIQENVRDLGGGHIEVIEPTAEWRNIRRVGLDFSKGDFLLEKGRLLDPAALSL
TASANHPVVTVVKRPLVAIIATGDELLPPGSELGPDQIISSNAYGVAAVAQSVGARALDLGIAADRKDAIAALVKKAVAA
GADVIVTLGGASVGDHDLIHDVLTGEGMTLGFWKIAMRPGKPLMFGRLGDIRCIGLPGNPVASLVCSQLFLKPLLARLGG
RDHRQDIRPARLGAAMPANDLRQDYVRAVVREDGGELVATPFSIQDSSMLRMLADANGLIVRAPFAPASAVGDSCSVLML
R

Sequences:

>Translated_401_residues
MALVPVAEALERLLDGAAPLAGESVPLFEAVDRVLAEPLAALRTQPPFNASAMDGYAVRAADVASVPSKLTVIGMAPAGR
GFDGSLGERQAVRIFTGAPLPEGADTIVIQENVRDLGGGHIEVIEPTAEWRNIRRVGLDFSKGDFLLEKGRLLDPAALSL
TASANHPVVTVVKRPLVAIIATGDELLPPGSELGPDQIISSNAYGVAAVAQSVGARALDLGIAADRKDAIAALVKKAVAA
GADVIVTLGGASVGDHDLIHDVLTGEGMTLGFWKIAMRPGKPLMFGRLGDIRCIGLPGNPVASLVCSQLFLKPLLARLGG
RDHRQDIRPARLGAAMPANDLRQDYVRAVVREDGGELVATPFSIQDSSMLRMLADANGLIVRAPFAPASAVGDSCSVLML
R
>Mature_400_residues
ALVPVAEALERLLDGAAPLAGESVPLFEAVDRVLAEPLAALRTQPPFNASAMDGYAVRAADVASVPSKLTVIGMAPAGRG
FDGSLGERQAVRIFTGAPLPEGADTIVIQENVRDLGGGHIEVIEPTAEWRNIRRVGLDFSKGDFLLEKGRLLDPAALSLT
ASANHPVVTVVKRPLVAIIATGDELLPPGSELGPDQIISSNAYGVAAVAQSVGARALDLGIAADRKDAIAALVKKAVAAG
ADVIVTLGGASVGDHDLIHDVLTGEGMTLGFWKIAMRPGKPLMFGRLGDIRCIGLPGNPVASLVCSQLFLKPLLARLGGR
DHRQDIRPARLGAAMPANDLRQDYVRAVVREDGGELVATPFSIQDSSMLRMLADANGLIVRAPFAPASAVGDSCSVLMLR

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=397, Percent_Identity=34.0050377833753, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI66932975, Length=397, Percent_Identity=34.0050377833753, Blast_Score=165, Evalue=8e-41,
Organism=Escherichia coli, GI1787049, Length=389, Percent_Identity=36.7609254498715, Blast_Score=203, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI25147659, Length=397, Percent_Identity=29.2191435768262, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562606, Length=340, Percent_Identity=27.0588235294118, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17136978, Length=396, Percent_Identity=29.7979797979798, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24638841, Length=396, Percent_Identity=29.7979797979798, Blast_Score=131, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41774; Mature: 41643

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVPVAEALERLLDGAAPLAGESVPLFEAVDRVLAEPLAALRTQPPFNASAMDGYAVRA
CCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEH
ADVASVPSKLTVIGMAPAGRGFDGSLGERQAVRIFTGAPLPEGADTIVIQENVRDLGGGH
HHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCHHHCCCCE
IEVIEPTAEWRNIRRVGLDFSKGDFLLEKGRLLDPAALSLTASANHPVVTVVKRPLVAII
EEEECCCHHHHHHHHHCCCCCCCCEEEECCCCCCCHHEEEEECCCCCEEEEECCCEEEEE
ATGDELLPPGSELGPDQIISSNAYGVAAVAQSVGARALDLGIAADRKDAIAALVKKAVAA
ECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHC
GADVIVTLGGASVGDHDLIHDVLTGEGMTLGFWKIAMRPGKPLMFGRLGDIRCIGLPGNP
CCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCEEEECCCCEEEEECCCCH
VASLVCSQLFLKPLLARLGGRDHRQDIRPARLGAAMPANDLRQDYVRAVVREDGGELVAT
HHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEC
PFSIQDSSMLRMLADANGLIVRAPFAPASAVGDSCSVLMLR
CCCCCCHHHHHHHHCCCCEEEECCCCCHHHCCCCCEEEEEC
>Mature Secondary Structure 
ALVPVAEALERLLDGAAPLAGESVPLFEAVDRVLAEPLAALRTQPPFNASAMDGYAVRA
CCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEH
ADVASVPSKLTVIGMAPAGRGFDGSLGERQAVRIFTGAPLPEGADTIVIQENVRDLGGGH
HHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCHHHCCCCE
IEVIEPTAEWRNIRRVGLDFSKGDFLLEKGRLLDPAALSLTASANHPVVTVVKRPLVAII
EEEECCCHHHHHHHHHCCCCCCCCEEEECCCCCCCHHEEEEECCCCCEEEEECCCEEEEE
ATGDELLPPGSELGPDQIISSNAYGVAAVAQSVGARALDLGIAADRKDAIAALVKKAVAA
ECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHC
GADVIVTLGGASVGDHDLIHDVLTGEGMTLGFWKIAMRPGKPLMFGRLGDIRCIGLPGNP
CCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCEEEECCCCEEEEECCCCH
VASLVCSQLFLKPLLARLGGRDHRQDIRPARLGAAMPANDLRQDYVRAVVREDGGELVAT
HHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEC
PFSIQDSSMLRMLADANGLIVRAPFAPASAVGDSCSVLMLR
CCCCCCHHHHHHHHCCCCEEEECCCCCHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]