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The map label for this gene is ung

Identifier: 13358112

GI number: 13358112

Start: 682041

End: 682679

Strand: Reverse

Name: ung

Synonym: UU548

Alternate gene names: 13358112

Gene position: 682679-682041 (Counterclockwise)

Preceding gene: 13358113

Following gene: 13358111

Centisome position: 90.82

GC content: 25.67

Gene sequence:

>639_bases
ATGAAATGAAAAGAATTCATAATTAATGAAACTAAACAAAGTTATTTAAAAAATATTATTAAAAAAATCAACAACATCGA
GAATCATCAAGTAGTTTTTCCTTTAAAAAAACAACGGTTTAGATGTTTTGATTTTTTTGATATTGAACAAACTAAAGTTG
TTATTTTAGGGCAAGATCCATACCATACACCTAAAATAGCTAATGGTTTGTGTTTTAGTGTGGATTTAGGAAATAATTTA
CCAGGATCACTAATCAATATTTTTAAAGCTTTAGAATATGATTTACAAATAAAAAGAACAAACCCTGATTTGTCTGATTG
GGCAAAACAAGGAGTTTTATTGTTGAATACTGTTTTAACTGTTAACGCTCATCAACCAAATTCGCATAAAAATTTTGGTT
ATGAAGAATTAATTAAAAATGTGTTTAACGAACTTAGAAAACAAAAGCATGTTGTTTATTTATTATGAGGAAAACAAGCT
ATGAGTTACATTAATTTGATTGATCAAAAACAAAATTTAATTTTATGTGCTTCACATCCTTCGCCATTAAGTGCACATCG
TGGTTTTTTAACTTGTAAACATTTTAGTAAATGCAATGATTATTTAATTAAACATTTACGCACTCCAATAAAATGATAA

Upstream 100 bases:

>100_bases
ATATTCATAATTTGACTAGTTTTAAAGCTGCTAAGAATAATTTTAGAAAATATCTTTTTAACCTTAATGAAATTAAAAGT
GTAAATGTTAACTATAGCAA

Downstream 100 bases:

>100_bases
AATTTATTAATTAGTGAGGTGAATCTGTGACAAATATAATGAGTGTATTACATACAACTAATACTTCACAAGGTAATGGA
ATTAATTCATGACAATCAAT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKWKEFIINETKQSYLKNIIKKINNIENHQVVFPLKKQRFRCFDFFDIEQTKVVILGQDPYHTPKIANGLCFSVDLGNNL
PGSLINIFKALEYDLQIKRTNPDLSDWAKQGVLLLNTVLTVNAHQPNSHKNFGYEELIKNVFNELRKQKHVVYLLWGKQA
MSYINLIDQKQNLILCASHPSPLSAHRGFLTCKHFSKCNDYLIKHLRTPIKW

Sequences:

>Translated_212_residues
MK*KEFIINETKQSYLKNIIKKINNIENHQVVFPLKKQRFRCFDFFDIEQTKVVILGQDPYHTPKIANGLCFSVDLGNNL
PGSLINIFKALEYDLQIKRTNPDLSDWAKQGVLLLNTVLTVNAHQPNSHKNFGYEELIKNVFNELRKQKHVVYLL*GKQA
MSYINLIDQKQNLILCASHPSPLSAHRGFLTCKHFSKCNDYLIKHLRTPIK*
>Mature_212_residues
MK*KEFIINETKQSYLKNIIKKINNIENHQVVFPLKKQRFRCFDFFDIEQTKVVILGQDPYHTPKIANGLCFSVDLGNNL
PGSLINIFKALEYDLQIKRTNPDLSDWAKQGVLLLNTVLTVNAHQPNSHKNFGYEELIKNVFNELRKQKHVVYLL*GKQA
MSYINLIDQKQNLILCASHPSPLSAHRGFLTCKHFSKCNDYLIKHLRTPIK*

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=210, Percent_Identity=43.8095238095238, Blast_Score=165, Evalue=3e-41,
Organism=Homo sapiens, GI6224979, Length=210, Percent_Identity=43.8095238095238, Blast_Score=164, Evalue=4e-41,
Organism=Escherichia coli, GI1788934, Length=211, Percent_Identity=42.1800947867299, Blast_Score=158, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17556304, Length=206, Percent_Identity=41.747572815534, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6323620, Length=214, Percent_Identity=36.9158878504673, Blast_Score=118, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24195; Mature: 24195

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEFIINETKQSYLKNIIKKINNIENHQVVFPLKKQRFRCFDFFDIEQTKVVILGQDPY
CCCCCEECHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCEECEEEECCCEEEEEECCCCC
HTPKIANGLCFSVDLGNNLPGSLINIFKALEYDLQIKRTNPDLSDWAKQGVLLLNTVLTV
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHCCEEEEEEEEEE
NAHQPNSHKNFGYEELIKNVFNELRKQKHVVYLLGKQAMSYINLIDQKQNLILCASHPSP
ECCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHCCCCCEEEEECCCCC
LSAHRGFLTCKHFSKCNDYLIKHLRTPIK
CHHHCCEEEHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKEFIINETKQSYLKNIIKKINNIENHQVVFPLKKQRFRCFDFFDIEQTKVVILGQDPY
CCCCCEECHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCEECEEEECCCEEEEEECCCCC
HTPKIANGLCFSVDLGNNLPGSLINIFKALEYDLQIKRTNPDLSDWAKQGVLLLNTVLTV
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHCCEEEEEEEEEE
NAHQPNSHKNFGYEELIKNVFNELRKQKHVVYLLGKQAMSYINLIDQKQNLILCASHPSP
ECCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHCCCCCEEEEECCCCC
LSAHRGFLTCKHFSKCNDYLIKHLRTPIK
CHHHCCEEEHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA