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The map label for this gene is apt

Identifier: 13358051

GI number: 13358051

Start: 584559

End: 585080

Strand: Reverse

Name: apt

Synonym: UU488

Alternate gene names: 13358051

Gene position: 585080-584559 (Counterclockwise)

Preceding gene: 13358052

Following gene: 13358050

Centisome position: 77.83

GC content: 31.8

Gene sequence:

>522_bases
ATGATCAATATTGATTACATTAAATCAAAAATCAGGGATGTACCAGACTTCCCTAAAAAAGGAATCGTTTTTAAGGATAT
TACTCCTTTATTTTTAGAACCAAAAATTATTGAAAAGATTGTTGATGATTTTGCTGACTTTGCTAAATCATTAAATATAG
ATGCTATAATAGGTGCGGAGTCGCGTGGTTTTTTGTTTGCAGCACCATTATCAATCAAATTAAATAAGCCATTTATTTTG
GTACGTAAACCAAATAAGTTACCAAATGATGTTTATAGTGCTGAGTACACATTAGAATATGGTAGTTCTCGTGTGGAGAT
GCACAAAGATGCACTAAAACCAAACCAACGCGTTTTAATTGTTGATGATTTATTAGCAACAGGAGGGACTGTTGCTGCGA
TTGAAAATCTTGTTCGTCAAGCTAAAGGAATTGTAGCAGGGAGTGTTTATTTAATTCGTTTAGGATTTCTAAAAGGTGAA
GAAAAACTAAGTGGAAAAGTTCATGCTTTAATTAATTATTAA

Upstream 100 bases:

>100_bases
TATTAGCTAAGGATGATAATGCAGATAATGTTTATGATAAATTTGATGAACAAGAAATTATGAATATAAATAAATTTTAA
AAGAAAGATTTATAACGATT

Downstream 100 bases:

>100_bases
TTTTTATAAAAATTAAATTCTTACTTTAAGAACCTCCCAATGTTCTTAAAGTATTTTTTTATATTATAATAATATAGGAA
ATTTACACAATATAATGTTC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MINIDYIKSKIRDVPDFPKKGIVFKDITPLFLEPKIIEKIVDDFADFAKSLNIDAIIGAESRGFLFAAPLSIKLNKPFIL
VRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLIVDDLLATGGTVAAIENLVRQAKGIVAGSVYLIRLGFLKGE
EKLSGKVHALINY

Sequences:

>Translated_173_residues
MINIDYIKSKIRDVPDFPKKGIVFKDITPLFLEPKIIEKIVDDFADFAKSLNIDAIIGAESRGFLFAAPLSIKLNKPFIL
VRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLIVDDLLATGGTVAAIENLVRQAKGIVAGSVYLIRLGFLKGE
EKLSGKVHALINY
>Mature_173_residues
MINIDYIKSKIRDVPDFPKKGIVFKDITPLFLEPKIIEKIVDDFADFAKSLNIDAIIGAESRGFLFAAPLSIKLNKPFIL
VRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLIVDDLLATGGTVAAIENLVRQAKGIVAGSVYLIRLGFLKGE
EKLSGKVHALINY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=165, Percent_Identity=42.4242424242424, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=43.4108527131783, Blast_Score=113, Evalue=7e-26,
Organism=Escherichia coli, GI1786675, Length=161, Percent_Identity=44.0993788819876, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=42.9411764705882, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=170, Percent_Identity=39.4117647058824, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=34.5029239766082, Blast_Score=85, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=42.1965317919075, Blast_Score=136, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_UREP2 (B1AJC8)

Other databases:

- EMBL:   CP000942
- RefSeq:   YP_001752572.1
- ProteinModelPortal:   B1AJC8
- SMR:   B1AJC8
- GeneID:   6155368
- GenomeReviews:   CP000942_GR
- KEGG:   upa:UPA3_0506
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   UPAR505682:UPA3_0506-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19245; Mature: 19245

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINIDYIKSKIRDVPDFPKKGIVFKDITPLFLEPKIIEKIVDDFADFAKSLNIDAIIGAE
CCCHHHHHHHHHCCCCCCCCCEEEECCCCHHCCHHHHHHHHHHHHHHHHHCCCEEEECCC
SRGFLFAAPLSIKLNKPFILVRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLI
CCCEEEECCEEEEECCCEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEE
VDDLLATGGTVAAIENLVRQAKGIVAGSVYLIRLGFLKGEEKLSGKVHALINY
EEHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHCCEEEEEEEC
>Mature Secondary Structure
MINIDYIKSKIRDVPDFPKKGIVFKDITPLFLEPKIIEKIVDDFADFAKSLNIDAIIGAE
CCCHHHHHHHHHCCCCCCCCCEEEECCCCHHCCHHHHHHHHHHHHHHHHHCCCEEEECCC
SRGFLFAAPLSIKLNKPFILVRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLI
CCCEEEECCEEEEECCCEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEE
VDDLLATGGTVAAIENLVRQAKGIVAGSVYLIRLGFLKGEEKLSGKVHALINY
EEHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA