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Identifier: 13358000

GI number: 13358000

Start: 498470

End: 499525

Strand: Direct

Name: Not Available

Synonym: UU437

Alternate gene names: 13358000

Gene position: 498470-499525 (Clockwise)

Preceding gene: 13357999

Following gene: 13358002

Centisome position: 66.31

GC content: 21.59

Gene sequence:

>1056_bases
ATGCATCTTGATATCGATGCTTTTTATGCTACTGTTAGTGAACTATTACATCCTGAATATAAAAATTTTCCAATTGCTGT
TGGTTCATTAAATTCACGCACAGGTATTATTTCTTCACCTAACTATTTAGCACGTTCTTATGGCGTTAAAGCTGCAATGC
CTATCTTTTTAGCTAAAGAATTATGTCCAAATTTAATTATTTTACCTTCTGAACACAATATTTATCAATCTTACTCAAAA
CATTTTTTTCAAATCATTAATAAATATACAAATAAGATTGAAATAACTTCAATTGATGAATGCTTTATTGATGCAACAGA
TTTAGTTAAAAAATATCATAATAATATCCGCTTGTTAGCAACAAAAATACAAAAAGAAATCAAAAACAAACTAAACCTTA
GTATTTCAATTGGAATTTCATATAATAAAACAATTGCAAAAATGGCAACGGAATTAAATAAACCTTCTGGTATATCAATT
ATTGATGAAAATAAAATTATTAATTTAATTTATGAATTAAATATCAATAAAATTCCCTATATTGGCGAAATAAAATCACA
AGAATTATATGCGATTAACATTTTTAAAATTAAAGAATTAATTGCAACTGAAAATAAACAAAAAATTTCATTAGTTTTAG
GTTCAATATATCAAAATTTAGTCAATGATTTAAAAGGTTTAAGTAAAATTAAAATAATTGATGAAGATATTTATAAAACA
ATTTCACATTCGAAAACATTTAACGAAGATTTGAATGATTTTTATGAAATTTCTAATGAAATGAACGATTTAATTTTAAC
TGTTACTAATCGATTAAAAAAATGTAATTTAATGACTAATAACATCAGTATTTATATTAAATATCCTAGTTTTAAAACAA
AAATTAAGCAAAAACAATTAACTTATTACACTGATGATTATCAAACCATTTTTCTAGCAATTAAAAACTTATTTAAAATA
ATGTATAAAGATGAAACAATACGTTTAATTGGTATCTCACTAAATAAATTAGTAAAAAAAGAAAATGTTAAAAAACAATT
ATTTTTATTTGATTAA

Upstream 100 bases:

>100_bases
AAACATTTAACTCCTACTGATATTTTTGATGAAAAAAAACAAAATCAAGAATATATGATATTTTTACAAAAGCATGAAAA
ATAATCATCAAAAAATCATC

Downstream 100 bases:

>100_bases
TTGATTGTTTTTTAAAAATCTATTCCTTCAATTGTAATTTTTCGACCTCTTAAATTCTTATTTATAAAATGATGTTGAAT
TAAATAAGGTTCTATTTTTG

Product: hypothetical protein

Products: NA

Alternate protein names: Pol IV

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MHLDIDAFYATVSELLHPEYKNFPIAVGSLNSRTGIISSPNYLARSYGVKAAMPIFLAKELCPNLIILPSEHNIYQSYSK
HFFQIINKYTNKIEITSIDECFIDATDLVKKYHNNIRLLATKIQKEIKNKLNLSISIGISYNKTIAKMATELNKPSGISI
IDENKIINLIYELNINKIPYIGEIKSQELYAINIFKIKELIATENKQKISLVLGSIYQNLVNDLKGLSKIKIIDEDIYKT
ISHSKTFNEDLNDFYEISNEMNDLILTVTNRLKKCNLMTNNISIYIKYPSFKTKIKQKQLTYYTDDYQTIFLAIKNLFKI
MYKDETIRLIGISLNKLVKKENVKKQLFLFD

Sequences:

>Translated_351_residues
MHLDIDAFYATVSELLHPEYKNFPIAVGSLNSRTGIISSPNYLARSYGVKAAMPIFLAKELCPNLIILPSEHNIYQSYSK
HFFQIINKYTNKIEITSIDECFIDATDLVKKYHNNIRLLATKIQKEIKNKLNLSISIGISYNKTIAKMATELNKPSGISI
IDENKIINLIYELNINKIPYIGEIKSQELYAINIFKIKELIATENKQKISLVLGSIYQNLVNDLKGLSKIKIIDEDIYKT
ISHSKTFNEDLNDFYEISNEMNDLILTVTNRLKKCNLMTNNISIYIKYPSFKTKIKQKQLTYYTDDYQTIFLAIKNLFKI
MYKDETIRLIGISLNKLVKKENVKKQLFLFD
>Mature_351_residues
MHLDIDAFYATVSELLHPEYKNFPIAVGSLNSRTGIISSPNYLARSYGVKAAMPIFLAKELCPNLIILPSEHNIYQSYSK
HFFQIINKYTNKIEITSIDECFIDATDLVKKYHNNIRLLATKIQKEIKNKLNLSISIGISYNKTIAKMATELNKPSGISI
IDENKIINLIYELNINKIPYIGEIKSQELYAINIFKIKELIATENKQKISLVLGSIYQNLVNDLKGLSKIKIIDEDIYKT
ISHSKTFNEDLNDFYEISNEMNDLILTVTNRLKKCNLMTNNISIYIKYPSFKTKIKQKQLTYYTDDYQTIFLAIKNLFKI
MYKDETIRLIGISLNKLVKKENVKKQLFLFD

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain

Homologues:

Organism=Homo sapiens, GI7705344, Length=114, Percent_Identity=42.1052631578947, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI154350220, Length=323, Percent_Identity=25.3869969040248, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI84043967, Length=406, Percent_Identity=22.1674876847291, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI7706681, Length=319, Percent_Identity=23.8244514106583, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI1786425, Length=356, Percent_Identity=28.9325842696629, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1787432, Length=375, Percent_Identity=24, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI193205700, Length=405, Percent_Identity=25.1851851851852, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17537959, Length=258, Percent_Identity=25.1937984496124, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324921, Length=200, Percent_Identity=29, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19923006, Length=419, Percent_Identity=24.8210023866348, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21355641, Length=225, Percent_Identity=27.5555555555556, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644984, Length=225, Percent_Identity=27.5555555555556, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24668444, Length=157, Percent_Identity=31.8471337579618, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO4_UREP2 (B1AJ79)

Other databases:

- EMBL:   CP000942
- RefSeq:   YP_001752523.1
- ProteinModelPortal:   B1AJ79
- SMR:   B1AJ79
- GeneID:   6155177
- GenomeReviews:   CP000942_GR
- KEGG:   upa:UPA3_0457
- HOGENOM:   HBG734504
- OMA:   GDEHIIR
- ProtClustDB:   CLSK2298939
- BioCyc:   UPAR505682:UPA3_0457-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01113
- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880
- Gene3D:   G3DSA:3.30.1490.100
- PANTHER:   PTHR11076

Pfam domain/function: PF00817 IMS; SSF100879 DNA_pol_Y-fam_little_finger

EC number: =2.7.7.7

Molecular weight: Translated: 40616; Mature: 40616

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS50173 UMUC

Important sites: ACT_SITE 109-109

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLDIDAFYATVSELLHPEYKNFPIAVGSLNSRTGIISSPNYLARSYGVKAAMPIFLAKE
CCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHH
LCPNLIILPSEHNIYQSYSKHFFQIINKYTNKIEITSIDECFIDATDLVKKYHNNIRLLA
HCCCEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCHHHHHHHHHCCCEEHH
TKIQKEIKNKLNLSISIGISYNKTIAKMATELNKPSGISIIDENKIINLIYELNINKIPY
HHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCCEEEEEEEECCCCCCC
IGEIKSQELYAINIFKIKELIATENKQKISLVLGSIYQNLVNDLKGLSKIKIIDEDIYKT
CCCCCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHH
ISHSKTFNEDLNDFYEISNEMNDLILTVTNRLKKCNLMTNNISIYIKYPSFKTKIKQKQL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCEEEEEECCCHHHHHHHHHE
TYYTDDYQTIFLAIKNLFKIMYKDETIRLIGISLNKLVKKENVKKQLFLFD
EEEECCHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MHLDIDAFYATVSELLHPEYKNFPIAVGSLNSRTGIISSPNYLARSYGVKAAMPIFLAKE
CCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHH
LCPNLIILPSEHNIYQSYSKHFFQIINKYTNKIEITSIDECFIDATDLVKKYHNNIRLLA
HCCCEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCHHHHHHHHHCCCEEHH
TKIQKEIKNKLNLSISIGISYNKTIAKMATELNKPSGISIIDENKIINLIYELNINKIPY
HHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCCEEEEEEEECCCCCCC
IGEIKSQELYAINIFKIKELIATENKQKISLVLGSIYQNLVNDLKGLSKIKIIDEDIYKT
CCCCCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHH
ISHSKTFNEDLNDFYEISNEMNDLILTVTNRLKKCNLMTNNISIYIKYPSFKTKIKQKQL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCEEEEEECCCHHHHHHHHHE
TYYTDDYQTIFLAIKNLFKIMYKDETIRLIGISLNKLVKKENVKKQLFLFD
EEEECCHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA