Click here to switch to the map view.

The map label for this gene is deoA

Identifier: 13357928

GI number: 13357928

Start: 418752

End: 420053

Strand: Direct

Name: deoA

Synonym: UU368

Alternate gene names: 13357928

Gene position: 418752-420053 (Clockwise)

Preceding gene: 13357921

Following gene: 13357929

Centisome position: 55.71

GC content: 27.11

Gene sequence:

>1302_bases
ATGTTAAATGTTGTAGAAATTATTAGCAAGAAAAAAAATAATATTGAATTAAGTGAACAAGAAATTAAATTTGTTTATGA
TGGTTTTGTTAATAAGACAATTCCAGATTATCAAATGGCAGCTTTTTTAATGGCTGTTAATTTTTGTGGATATAGTGAAA
ATGAACAATACTATGCAACTAAAGCAATGGTTGAATCTGGTAAATTATTAGATTTGCGTGTTGAAAATAAAATTGTTGTT
GACAAACATTCATCTGGTGGTGTGGGAGATAAAGTTTCAATTATTTTAACTCCTTTACTATCAGCTTTAGGATTATACGT
TGGAAAAATGTCTGGTCGAGGATTAGGGCATACTGGTGGTACAGTTGATAAATTAGAATCATTGAATTTAAATTTAGATT
TTGATTTAAAAACATACATGAATCAGCTAAAAGATAATGGTTTATTATTAACTGGTCAATCAGATGATATGGTTGTGGCT
GATAAATATATTTATGCATTACGAGATGTAACAGCAACAAGTGATGTGTTTGATCTTATGATAGGATCAATTATGGCTAA
AAAATTAGCTTTAATTACTGATTATATTTTCTTAGATGTTAAAGTTGGTGAAGGAGCATTTTGTAAAAATGTTGCACAAG
CAGAATCTTTAGCAACAAAGATGTTAAAATTATCAAAGAAATTTAATCGTAATACAATTATCCATTTAACAAATATGGAC
CAACCTTTAGGAAAAGCAATTGGTAATGCTATTGAAATTAAAGAAAGTATGGATTATTTATTAGGTAAACCAGTGCCCCA
AGATTTATATGATTTAATTAATCAGTTTGCTTTAGACATCTTAATTGATACAAAATTCGCTAAAAACAAGGAAGATGCTC
AATCTAAGATTGATAACGTCATTAAAAATGGTTTAGCTTATCAAAAATTTGTGAATTGAGTAAAATGATACAAAGGTGAT
TATATTAGTCTTGAAAATGATACATATTTTAACCCTAAATACAAATTAGAGATTTTAGCAAAACAAGATGGATATTTAGA
CTTTAAATCAACAAAAGAATTGGGTATGATTGCTGTTGATTTAAAAGCAGGACGTAAAGTTAAAACTGATCAATTAGATT
TTCAAGCTGGAATTTATTTAAATAAGAAAAATAATGATTTCGTTAAAACAAATGAAGTTATTGCTACACTTTATGCTAGC
GAGCCAATTAATGATGAAGTTGTTAATAAATACCATAACAATGTAGTTTATTTAAAAACACCAAAACAAATTGCACCATC
AATTATTAAAGTAATGCGTTAA

Upstream 100 bases:

>100_bases
TATTAATATAGATTAGTAAAACTCACTTATTTTAAAAACTTTCGTGTTTTTCTTTGCTAAAATTAAAGATAAGTTTTTAA
AAATTAAATTGGTGAAATTT

Downstream 100 bases:

>100_bases
ATAATAAAAAAGTAAGGAAGAATATTTATTATGCTGAAATTAAGTACGAATGAGATTAGAAAAAAGTGAATTGAATTTTT
TGAGTCAAAGGATCATTTAT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLNVVEIISKKKNNIELSEQEIKFVYDGFVNKTIPDYQMAAFLMAVNFCGYSENEQYYATKAMVESGKLLDLRVENKIVV
DKHSSGGVGDKVSIILTPLLSALGLYVGKMSGRGLGHTGGTVDKLESLNLNLDFDLKTYMNQLKDNGLLLTGQSDDMVVA
DKYIYALRDVTATSDVFDLMIGSIMAKKLALITDYIFLDVKVGEGAFCKNVAQAESLATKMLKLSKKFNRNTIIHLTNMD
QPLGKAIGNAIEIKESMDYLLGKPVPQDLYDLINQFALDILIDTKFAKNKEDAQSKIDNVIKNGLAYQKFVNWVKWYKGD
YISLENDTYFNPKYKLEILAKQDGYLDFKSTKELGMIAVDLKAGRKVKTDQLDFQAGIYLNKKNNDFVKTNEVIATLYAS
EPINDEVVNKYHNNVVYLKTPKQIAPSIIKVMR

Sequences:

>Translated_433_residues
MLNVVEIISKKKNNIELSEQEIKFVYDGFVNKTIPDYQMAAFLMAVNFCGYSENEQYYATKAMVESGKLLDLRVENKIVV
DKHSSGGVGDKVSIILTPLLSALGLYVGKMSGRGLGHTGGTVDKLESLNLNLDFDLKTYMNQLKDNGLLLTGQSDDMVVA
DKYIYALRDVTATSDVFDLMIGSIMAKKLALITDYIFLDVKVGEGAFCKNVAQAESLATKMLKLSKKFNRNTIIHLTNMD
QPLGKAIGNAIEIKESMDYLLGKPVPQDLYDLINQFALDILIDTKFAKNKEDAQSKIDNVIKNGLAYQKFVN*VK*YKGD
YISLENDTYFNPKYKLEILAKQDGYLDFKSTKELGMIAVDLKAGRKVKTDQLDFQAGIYLNKKNNDFVKTNEVIATLYAS
EPINDEVVNKYHNNVVYLKTPKQIAPSIIKVMR
>Mature_433_residues
MLNVVEIISKKKNNIELSEQEIKFVYDGFVNKTIPDYQMAAFLMAVNFCGYSENEQYYATKAMVESGKLLDLRVENKIVV
DKHSSGGVGDKVSIILTPLLSALGLYVGKMSGRGLGHTGGTVDKLESLNLNLDFDLKTYMNQLKDNGLLLTGQSDDMVVA
DKYIYALRDVTATSDVFDLMIGSIMAKKLALITDYIFLDVKVGEGAFCKNVAQAESLATKMLKLSKKFNRNTIIHLTNMD
QPLGKAIGNAIEIKESMDYLLGKPVPQDLYDLINQFALDILIDTKFAKNKEDAQSKIDNVIKNGLAYQKFVN*VK*YKGD
YISLENDTYFNPKYKLEILAKQDGYLDFKSTKELGMIAVDLKAGRKVKTDQLDFQAGIYLNKKNNDFVKTNEVIATLYAS
EPINDEVVNKYHNNVVYLKTPKQIAPSIIKVMR

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=390, Percent_Identity=32.8205128205128, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI4503445, Length=390, Percent_Identity=32.8205128205128, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI166158922, Length=390, Percent_Identity=32.8205128205128, Blast_Score=196, Evalue=4e-50,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=36.1386138613861, Blast_Score=246, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 48271; Mature: 48271

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNVVEIISKKKNNIELSEQEIKFVYDGFVNKTIPDYQMAAFLMAVNFCGYSENEQYYAT
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEHH
KAMVESGKLLDLRVENKIVVDKHSSGGVGDKVSIILTPLLSALGLYVGKMSGRGLGHTGG
HHHHCCCCEEEEEECCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
TVDKLESLNLNLDFDLKTYMNQLKDNGLLLTGQSDDMVVADKYIYALRDVTATSDVFDLM
CHHHHHHCCCEEEECHHHHHHHHCCCCEEEECCCCCEEEHHHHHHHHHHCCCHHHHHHHH
IGSIMAKKLALITDYIFLDVKVGEGAFCKNVAQAESLATKMLKLSKKFNRNTIIHLTNMD
HHHHHHHHHHHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
QPLGKAIGNAIEIKESMDYLLGKPVPQDLYDLINQFALDILIDTKFAKNKEDAQSKIDNV
CHHHHHCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHH
IKNGLAYQKFVNVKYKGDYISLENDTYFNPKYKLEILAKQDGYLDFKSTKELGMIAVDLK
HHCCCCEEHEEEEEECCCEEEECCCCEECCCEEEEEEEECCCEEEECCCCCCCEEEEEEC
AGRKVKTDQLDFQAGIYLNKKNNDFVKTNEVIATLYASEPINDEVVNKYHNNVVYLKTPK
CCCEECCCCCCEEEEEEEECCCCCCEEHHHEEEEEECCCCCCHHHHHHHHCCEEEEECCH
QIAPSIIKVMR
HHHHHHHHHCC
>Mature Secondary Structure
MLNVVEIISKKKNNIELSEQEIKFVYDGFVNKTIPDYQMAAFLMAVNFCGYSENEQYYAT
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEHH
KAMVESGKLLDLRVENKIVVDKHSSGGVGDKVSIILTPLLSALGLYVGKMSGRGLGHTGG
HHHHCCCCEEEEEECCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
TVDKLESLNLNLDFDLKTYMNQLKDNGLLLTGQSDDMVVADKYIYALRDVTATSDVFDLM
CHHHHHHCCCEEEECHHHHHHHHCCCCEEEECCCCCEEEHHHHHHHHHHCCCHHHHHHHH
IGSIMAKKLALITDYIFLDVKVGEGAFCKNVAQAESLATKMLKLSKKFNRNTIIHLTNMD
HHHHHHHHHHHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
QPLGKAIGNAIEIKESMDYLLGKPVPQDLYDLINQFALDILIDTKFAKNKEDAQSKIDNV
CHHHHHCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHH
IKNGLAYQKFVNVKYKGDYISLENDTYFNPKYKLEILAKQDGYLDFKSTKELGMIAVDLK
HHCCCCEEHEEEEEECCCEEEECCCCEECCCEEEEEEEECCCEEEECCCCCCCEEEEEEC
AGRKVKTDQLDFQAGIYLNKKNNDFVKTNEVIATLYASEPINDEVVNKYHNNVVYLKTPK
CCCEECCCCCCEEEEEEEECCCCCCEEHHHEEEEEECCCCCCHHHHHHHHCCEEEEECCH
QIAPSIIKVMR
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8349569 [H]