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The map label for this gene is lpxB [H]

Identifier: 126696858

GI number: 126696858

Start: 1286813

End: 1287991

Strand: Reverse

Name: lpxB [H]

Synonym: P9301_15201

Alternate gene names: 126696858

Gene position: 1287991-1286813 (Counterclockwise)

Preceding gene: 126696859

Following gene: 126696857

Centisome position: 78.45

GC content: 30.96

Gene sequence:

>1179_bases
ATGAATAAAAAGATATTTATAAGTACTGGAGAAGTCTCTGGAGATTTGCACGGAAGTCTTTTATCAAAAGCGTTATTAGA
TGAAGCCAAAAAAAAATCTATAGATTTAGAAATTTGCGGATTAGGTGGGGAGAGAATGCAGAAAGAAGGTGTAAAAATTC
TTCAAGATACTACTTCAATTAGTGCAATAGGAATTTGGGAGGCTTTACCTCTGATTCTCCCAACAATAATAATTCAAAAA
AGATTCTATAAATTACTAAAAAAATATCCCCCAGATTGCTTAATATTGATTGACTATATGGGTCCCAATATAAAAATTGG
TACTAAATTAAAAAGATCGAAGACAAAAATTCCAATTTTTTACTATATTGCTCCCCAAGAGTGGGCTTGGAGGATTGGGA
ATAATACTACAACAAATCTAATAAAATTTTCTGATAAAATTTTTGCGATTTTTAAGAAAGAAGCAGAATTTTACAAAAAG
AGGGGTGGAAATGTTTTATGGGTTGGGCATCCAATGATTGATTTGACAAAAAAACTTCCTCTGAAGAAAGATGCTAGAAC
TATTCTCAACCTTCGCCCAGATCAAAACATCATCCTTTTAATGCCCGCATCAAGACCTCAAGAATTGAAGTATATATTAC
CTACTTTTATGAAAACGGCTAAAAAATTACAACAAAAATATCCAAGTTTGGTTGTCTTTATCCCCTCCTGTCGAAGTACT
TTTGATGAAATATTCAAAAAAGCCTTAAGAAAATATCAAATTAAAGGATTTGTGATTTCTCAAAAAGATAGCACAAAATT
AAAGCCTCACATTTATTCGCTCACTAAAATTGCTCTTTGTAAATCTGGGACAGTTAATATGGAATTAGCTTTGTATGGAA
TTCCACAGATCGTTGGTTACAGAGTTAGCAGGGTAACTGCTTTTATTGCTAAAAAAATTCTCAATTTCAAGGTAAGATTT
ATTTCCCCAGTAAATTTGTTAGTTAATAAATTAATAATCCCTGAGTTTGTGCAGAGAGAATTTGACGAAAAGAAAATTTT
CTCCAAATCTTGTAAGATTCTTGAGAGGAAGTCAGAAAAAATAAAAATTAAAAAAGGTTATGCTTTTTTAAAAAAAGAAT
TGGGAGAAAATGGCGTAGTCCAAAGAGCTGCTAAAGAGATTATTAATTCTATTATTTGA

Upstream 100 bases:

>100_bases
TAATGAAAGGAGAATTAGATCTTTCATCTTCAAAATTATGTAGTTTTTTAAAAGAGTCAATATCTAACGAAAGAAGAGGA
CCAATGCCCATAGTGAATTT

Downstream 100 bases:

>100_bases
ACTTTATAATAAAAAAATGAAATATTTTTTACCTCTCATAATTGCTCTTTCAATATTTATCCACCCTGTAAATGCTTTTG
CAGAGGAATTGATTCTTGCA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MNKKIFISTGEVSGDLHGSLLSKALLDEAKKKSIDLEICGLGGERMQKEGVKILQDTTSISAIGIWEALPLILPTIIIQK
RFYKLLKKYPPDCLILIDYMGPNIKIGTKLKRSKTKIPIFYYIAPQEWAWRIGNNTTTNLIKFSDKIFAIFKKEAEFYKK
RGGNVLWVGHPMIDLTKKLPLKKDARTILNLRPDQNIILLMPASRPQELKYILPTFMKTAKKLQQKYPSLVVFIPSCRST
FDEIFKKALRKYQIKGFVISQKDSTKLKPHIYSLTKIALCKSGTVNMELALYGIPQIVGYRVSRVTAFIAKKILNFKVRF
ISPVNLLVNKLIIPEFVQREFDEKKIFSKSCKILERKSEKIKIKKGYAFLKKELGENGVVQRAAKEIINSII

Sequences:

>Translated_392_residues
MNKKIFISTGEVSGDLHGSLLSKALLDEAKKKSIDLEICGLGGERMQKEGVKILQDTTSISAIGIWEALPLILPTIIIQK
RFYKLLKKYPPDCLILIDYMGPNIKIGTKLKRSKTKIPIFYYIAPQEWAWRIGNNTTTNLIKFSDKIFAIFKKEAEFYKK
RGGNVLWVGHPMIDLTKKLPLKKDARTILNLRPDQNIILLMPASRPQELKYILPTFMKTAKKLQQKYPSLVVFIPSCRST
FDEIFKKALRKYQIKGFVISQKDSTKLKPHIYSLTKIALCKSGTVNMELALYGIPQIVGYRVSRVTAFIAKKILNFKVRF
ISPVNLLVNKLIIPEFVQREFDEKKIFSKSCKILERKSEKIKIKKGYAFLKKELGENGVVQRAAKEIINSII
>Mature_392_residues
MNKKIFISTGEVSGDLHGSLLSKALLDEAKKKSIDLEICGLGGERMQKEGVKILQDTTSISAIGIWEALPLILPTIIIQK
RFYKLLKKYPPDCLILIDYMGPNIKIGTKLKRSKTKIPIFYYIAPQEWAWRIGNNTTTNLIKFSDKIFAIFKKEAEFYKK
RGGNVLWVGHPMIDLTKKLPLKKDARTILNLRPDQNIILLMPASRPQELKYILPTFMKTAKKLQQKYPSLVVFIPSCRST
FDEIFKKALRKYQIKGFVISQKDSTKLKPHIYSLTKIALCKSGTVNMELALYGIPQIVGYRVSRVTAFIAKKILNFKVRF
ISPVNLLVNKLIIPEFVQREFDEKKIFSKSCKILERKSEKIKIKKGYAFLKKELGENGVVQRAAKEIINSII

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=341, Percent_Identity=29.0322580645161, Blast_Score=142, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 44872; Mature: 44872

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKIFISTGEVSGDLHGSLLSKALLDEAKKKSIDLEICGLGGERMQKEGVKILQDTTSI
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCHHHHHHCCCC
SAIGIWEALPLILPTIIIQKRFYKLLKKYPPDCLILIDYMGPNIKIGTKLKRSKTKIPIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCCCCCCEEE
YYIAPQEWAWRIGNNTTTNLIKFSDKIFAIFKKEAEFYKKRGGNVLWVGHPMIDLTKKLP
EEECCCCCEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHCCC
LKKDARTILNLRPDQNIILLMPASRPQELKYILPTFMKTAKKLQQKYPSLVVFIPSCRST
CCCCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHH
FDEIFKKALRKYQIKGFVISQKDSTKLKPHIYSLTKIALCKSGTVNMELALYGIPQIVGY
HHHHHHHHHHHHHHCEEEEECCCCCCCCCHHHHHHHHHEECCCCCEEEEEEECCHHHHHH
RVSRVTAFIAKKILNFKVRFISPVNLLVNKLIIPEFVQREFDEKKIFSKSCKILERKSEK
HHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
IKIKKGYAFLKKELGENGVVQRAAKEIINSII
EEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKKIFISTGEVSGDLHGSLLSKALLDEAKKKSIDLEICGLGGERMQKEGVKILQDTTSI
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCHHHHHHCCCC
SAIGIWEALPLILPTIIIQKRFYKLLKKYPPDCLILIDYMGPNIKIGTKLKRSKTKIPIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCCCCCCEEE
YYIAPQEWAWRIGNNTTTNLIKFSDKIFAIFKKEAEFYKKRGGNVLWVGHPMIDLTKKLP
EEECCCCCEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHCCC
LKKDARTILNLRPDQNIILLMPASRPQELKYILPTFMKTAKKLQQKYPSLVVFIPSCRST
CCCCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHH
FDEIFKKALRKYQIKGFVISQKDSTKLKPHIYSLTKIALCKSGTVNMELALYGIPQIVGY
HHHHHHHHHHHHHHCEEEEECCCCCCCCCHHHHHHHHHEECCCCCEEEEEEECCHHHHHH
RVSRVTAFIAKKILNFKVRFISPVNLLVNKLIIPEFVQREFDEKKIFSKSCKILERKSEK
HHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
IKIKKGYAFLKKELGENGVVQRAAKEIINSII
EEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA