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The map label for this gene is lpxA [H]

Identifier: 126696859

GI number: 126696859

Start: 1287988

End: 1288830

Strand: Reverse

Name: lpxA [H]

Synonym: P9301_15211

Alternate gene names: 126696859

Gene position: 1288830-1287988 (Counterclockwise)

Preceding gene: 126696860

Following gene: 126696858

Centisome position: 78.5

GC content: 34.16

Gene sequence:

>843_bases
ATGGACCTTAAAAATACTGAATCATACTCAGACTTTAGTGGTGCAAAAGTTCACCCAAATGCGTTTGTTGATCCAAGTGC
CGAATTACATGACGGGGTTATTATCTCTCAAGGAGCTGTTGTTGGTCCTGATGTGACTATCGGGAAGGGATCCGAAATAG
GACCGAATGCAGTTATTTCTGGAAGAACACAAATTGGTATGAACAATAAAGTTTTTCCTAGTGTTTTTATAGGTCTTGAT
CCCCAGGACCTTAAATATAAAGGGGCCCCTACCGAAGTAATTATTGGAGATAATAATACTTTCAGAGAATGTGTAACTAT
TAATAAAGCAACTGATGAAGGCGAAAAAACTATTATTGGCAATAATAATTTGTTGATGGCTTACACTCACATCGGCCATA
ATTGTGAACTTGGTAATAAGATAGTTTTATCAAATGGTGTTCAAGTTGCAGGCCATGTAAAAATTGAAGATAAAGCTATT
ATTGGAGGTTGTTTAGGTATTCATCAATTTGTACAAATTGGATATTTAGCAATGATTGGAGGAATGACTAGAGTTGATAG
AGATGTACCTCCTTTTTGTTTAGCCGAAGGGCATCCAGGAAGATTGAGAGGTTTGAATAGAATTGGAATTAAGAGAAGTG
GTTTATTAGACAATAAAGATTTTGACTTAAAAATTCTTCAAAGTACTTGGAATCTTCTTTTCAAATCTAATGAGTCGATT
TCAAGTTCATTAGAAAAAGTAATGAAAGGAGAATTAGATCTTTCATCTTCAAAATTATGTAGTTTTTTAAAAGAGTCAAT
ATCTAACGAAAGAAGAGGACCAATGCCCATAGTGAATTTATGA

Upstream 100 bases:

>100_bases
ATTAAAAGACAAAGATTTGGGAAGGTTAAAGGTGAAGCTTACGTTGATGGGAATTTGGTTTGTGCTGGAGAATTAATGTT
TTCATTAGTTGATTAGAGAT

Downstream 100 bases:

>100_bases
ATAAAAAGATATTTATAAGTACTGGAGAAGTCTCTGGAGATTTGCACGGAAGTCTTTTATCAAAAGCGTTATTAGATGAA
GCCAAAAAAAAATCTATAGA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MDLKNTESYSDFSGAKVHPNAFVDPSAELHDGVIISQGAVVGPDVTIGKGSEIGPNAVISGRTQIGMNNKVFPSVFIGLD
PQDLKYKGAPTEVIIGDNNTFRECVTINKATDEGEKTIIGNNNLLMAYTHIGHNCELGNKIVLSNGVQVAGHVKIEDKAI
IGGCLGIHQFVQIGYLAMIGGMTRVDRDVPPFCLAEGHPGRLRGLNRIGIKRSGLLDNKDFDLKILQSTWNLLFKSNESI
SSSLEKVMKGELDLSSSKLCSFLKESISNERRGPMPIVNL

Sequences:

>Translated_280_residues
MDLKNTESYSDFSGAKVHPNAFVDPSAELHDGVIISQGAVVGPDVTIGKGSEIGPNAVISGRTQIGMNNKVFPSVFIGLD
PQDLKYKGAPTEVIIGDNNTFRECVTINKATDEGEKTIIGNNNLLMAYTHIGHNCELGNKIVLSNGVQVAGHVKIEDKAI
IGGCLGIHQFVQIGYLAMIGGMTRVDRDVPPFCLAEGHPGRLRGLNRIGIKRSGLLDNKDFDLKILQSTWNLLFKSNESI
SSSLEKVMKGELDLSSSKLCSFLKESISNERRGPMPIVNL
>Mature_280_residues
MDLKNTESYSDFSGAKVHPNAFVDPSAELHDGVIISQGAVVGPDVTIGKGSEIGPNAVISGRTQIGMNNKVFPSVFIGLD
PQDLKYKGAPTEVIIGDNNTFRECVTINKATDEGEKTIIGNNNLLMAYTHIGHNCELGNKIVLSNGVQVAGHVKIEDKAI
IGGCLGIHQFVQIGYLAMIGGMTRVDRDVPPFCLAEGHPGRLRGLNRIGIKRSGLLDNKDFDLKILQSTWNLLFKSNESI
SSSLEKVMKGELDLSSSKLCSFLKESISNERRGPMPIVNL

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=227, Percent_Identity=39.647577092511, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1786376, Length=218, Percent_Identity=31.651376146789, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 30246; Mature: 30246

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKNTESYSDFSGAKVHPNAFVDPSAELHDGVIISQGAVVGPDVTIGKGSEIGPNAVIS
CCCCCCCCCCCCCCCEECCCCCCCCCCHHHCCEEEECCEEECCCEEECCCCCCCCCCEEC
GRTQIGMNNKVFPSVFIGLDPQDLKYKGAPTEVIIGDNNTFRECVTINKATDEGEKTIIG
CCEEECCCCCCCCEEEECCCHHHCEECCCCCEEEECCCCCEEEEEEEECCCCCCCEEEEC
NNNLLMAYTHIGHNCELGNKIVLSNGVQVAGHVKIEDKAIIGGCLGIHQFVQIGYLAMIG
CCCEEEEEEECCCCCCCCCEEEEECCCEEEEEEEECCCEEEHHHHHHHHHHHHHHHHHHC
GMTRVDRDVPPFCLAEGHPGRLRGLNRIGIKRSGLLDNKDFDLKILQSTWNLLFKSNESI
CCHHHCCCCCCEEEECCCCHHHCCCHHCCCCCCCCCCCCCCCEEEHHHHHHHEECCCCHH
SSSLEKVMKGELDLSSSKLCSFLKESISNERRGPMPIVNL
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MDLKNTESYSDFSGAKVHPNAFVDPSAELHDGVIISQGAVVGPDVTIGKGSEIGPNAVIS
CCCCCCCCCCCCCCCEECCCCCCCCCCHHHCCEEEECCEEECCCEEECCCCCCCCCCEEC
GRTQIGMNNKVFPSVFIGLDPQDLKYKGAPTEVIIGDNNTFRECVTINKATDEGEKTIIG
CCEEECCCCCCCCEEEECCCHHHCEECCCCCEEEECCCCCEEEEEEEECCCCCCCEEEEC
NNNLLMAYTHIGHNCELGNKIVLSNGVQVAGHVKIEDKAIIGGCLGIHQFVQIGYLAMIG
CCCEEEEEEECCCCCCCCCEEEEECCCEEEEEEEECCCEEEHHHHHHHHHHHHHHHHHHC
GMTRVDRDVPPFCLAEGHPGRLRGLNRIGIKRSGLLDNKDFDLKILQSTWNLLFKSNESI
CCHHHCCCCCCEEEECCCCHHHCCCHHCCCCCCCCCCCCCCCEEEHHHHHHHEECCCCHH
SSSLEKVMKGELDLSSSKLCSFLKESISNERRGPMPIVNL
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA