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The map label for this gene is glmU

Identifier: 126695975

GI number: 126695975

Start: 565769

End: 567118

Strand: Reverse

Name: glmU

Synonym: P9301_06371

Alternate gene names: 126695975

Gene position: 567118-565769 (Counterclockwise)

Preceding gene: 126695976

Following gene: 126695970

Centisome position: 34.54

GC content: 31.56

Gene sequence:

>1350_bases
ATGTTAAGTGTTGCGATATTAGCGGCAGGCAAGGGCACTAGGATGGAAAGCTCATTGCCAAAAGTTTTACATAAAATTTC
TGGCAAAAGTCTTCTACAAAGAGTAATTGATTCATGTGTGGAATTAAAACCTGATCAAATTTTCGTAATTACTGGACACA
AATCAAAAGAAGTAGAAAAGTCAATTTCAAACGAAAAAAAAATTCATATTGTTATTCAAGAACCTCAATCAGGAACCGGT
CATGCTATCCAAATACTTTGTAGAGAAGTAAAAAAACATGAAGGAAAACTTTTAGTCCTTAACGGCGATGTGCCACTCAT
TAGGCCTAGTACTTTAAAAAGGCTTTTATATTTACACGATTCAAAAAATGCCGATGTTTCTTTAATTACTACAAAGAAAA
GAAATCCTCACGGATATGGCAGAGTTTTTTTAAAGGGAGATTTTATAGAGAGAATTGTTGAAGAAAAAGATTGCAATGAT
CTAGAAAGAGAAAACCGATTAATAAATGCGGGTGTTTACTGTTTTAACTGGGGTAAATTGTCAGAAATAATTAATACCTT
GCGAAGTAATAATAATCAAAAAGAAATTTACTTAACAGATACCATATCTATGCTAAAAAATTCCTTAAGCCTCGAGGTAG
AGGATAATGGAGAGCTTCAAGGGATTAATAACAGAATTCAACTATCAGAATGCGAGGAAAATATGCAGAATTCAATTAAA
GAAAAGCATATGCTTAATGGGGTAACTTTTATTAATAAAGCAAGTTGTTCAATTAGTGAAGAAGCTGAAATTGGTAAGGA
TGTGATTATAGAGGCGAATACACATCTAAGAGGAAATACAAAAATAAAAAGTCATTGCATTATCGGACCAAATACTTTTA
TTGAGAATTCTTATGTGGGATTAAATTGTGAAATTTCAAACTCTACTGTTTATGCTTCTCAGATAATGGATTATATAAAA
ATTGGCCCTTATAGTCATATAAGACCTAATTCCAAAATATCTTCCTTTAGCAAAATAGGTAATTTTGTTGAAATTAAAAA
TAGTCAATTAGAGGAAGAATCTAAAGTAAACCATTTAAGTTATATTGGCGATTCTATTATTGGAAGATCTACAAATATTG
GAGCAGGTACTATTACTGCAAATTTTGATGGCGAGAAAAAACATCAAACAAAAATTGGTAAAAATTCCAGCATTGGTGCA
AATACAGTTTTTGTAGCGCCAATAAATCTTGGGGAATCAGTTACAACAGGAGCTGGTTCAGTGATCACAAAAGACTCAAA
AGATAATTCATTAGCAATCTCAAGAACTCAGCAAGTAAATATAGAAAATTGGGAAAGAAAGAAATCCTGA

Upstream 100 bases:

>100_bases
TTTTTTTCAAATCTATTATCTACAAATAAATGGAGAGAGAAGTGGGGAATGACGAAGTTATCCGTTAAGAGTAAGATTTA
AATAGGGATTTCAAATAAAC

Downstream 100 bases:

>100_bases
TCTAATTGATTAATTCAATAATTTTTTCAAGTTGCCAACTTCTGCTCCCTTTAATAAGAATAGAATCACCTTTTTTTGTG
GATTTGTTTATCTCTTTAGG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MLSVAILAAGKGTRMESSLPKVLHKISGKSLLQRVIDSCVELKPDQIFVITGHKSKEVEKSISNEKKIHIVIQEPQSGTG
HAIQILCREVKKHEGKLLVLNGDVPLIRPSTLKRLLYLHDSKNADVSLITTKKRNPHGYGRVFLKGDFIERIVEEKDCND
LERENRLINAGVYCFNWGKLSEIINTLRSNNNQKEIYLTDTISMLKNSLSLEVEDNGELQGINNRIQLSECEENMQNSIK
EKHMLNGVTFINKASCSISEEAEIGKDVIIEANTHLRGNTKIKSHCIIGPNTFIENSYVGLNCEISNSTVYASQIMDYIK
IGPYSHIRPNSKISSFSKIGNFVEIKNSQLEEESKVNHLSYIGDSIIGRSTNIGAGTITANFDGEKKHQTKIGKNSSIGA
NTVFVAPINLGESVTTGAGSVITKDSKDNSLAISRTQQVNIENWERKKS

Sequences:

>Translated_449_residues
MLSVAILAAGKGTRMESSLPKVLHKISGKSLLQRVIDSCVELKPDQIFVITGHKSKEVEKSISNEKKIHIVIQEPQSGTG
HAIQILCREVKKHEGKLLVLNGDVPLIRPSTLKRLLYLHDSKNADVSLITTKKRNPHGYGRVFLKGDFIERIVEEKDCND
LERENRLINAGVYCFNWGKLSEIINTLRSNNNQKEIYLTDTISMLKNSLSLEVEDNGELQGINNRIQLSECEENMQNSIK
EKHMLNGVTFINKASCSISEEAEIGKDVIIEANTHLRGNTKIKSHCIIGPNTFIENSYVGLNCEISNSTVYASQIMDYIK
IGPYSHIRPNSKISSFSKIGNFVEIKNSQLEEESKVNHLSYIGDSIIGRSTNIGAGTITANFDGEKKHQTKIGKNSSIGA
NTVFVAPINLGESVTTGAGSVITKDSKDNSLAISRTQQVNIENWERKKS
>Mature_449_residues
MLSVAILAAGKGTRMESSLPKVLHKISGKSLLQRVIDSCVELKPDQIFVITGHKSKEVEKSISNEKKIHIVIQEPQSGTG
HAIQILCREVKKHEGKLLVLNGDVPLIRPSTLKRLLYLHDSKNADVSLITTKKRNPHGYGRVFLKGDFIERIVEEKDCND
LERENRLINAGVYCFNWGKLSEIINTLRSNNNQKEIYLTDTISMLKNSLSLEVEDNGELQGINNRIQLSECEENMQNSIK
EKHMLNGVTFINKASCSISEEAEIGKDVIIEANTHLRGNTKIKSHCIIGPNTFIENSYVGLNCEISNSTVYASQIMDYIK
IGPYSHIRPNSKISSFSKIGNFVEIKNSQLEEESKVNHLSYIGDSIIGRSTNIGAGTITANFDGEKKHQTKIGKNSSIGA
NTVFVAPINLGESVTTGAGSVITKDSKDNSLAISRTQQVNIENWERKKS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=451, Percent_Identity=38.1374722838137, Blast_Score=309, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_PROM0 (A3PBY5)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090861.1
- ProteinModelPortal:   A3PBY5
- SMR:   A3PBY5
- STRING:   A3PBY5
- GeneID:   4911124
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_06371
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   MERTCLA
- ProtClustDB:   PRK14360
- BioCyc:   PMAR167546:P9301ORF_0652-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 49830; Mature: 49830

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 358-358 BINDING 73-73 BINDING 140-140 BINDING 154-154 BINDING 169-169 BINDING 418-418 BINDING 435-435

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVAILAAGKGTRMESSLPKVLHKISGKSLLQRVIDSCVELKPDQIFVITGHKSKEVEK
CEEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
SISNEKKIHIVIQEPQSGTGHAIQILCREVKKHEGKLLVLNGDVPLIRPSTLKRLLYLHD
HHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEECHHHHHHHHEEEC
SKNADVSLITTKKRNPHGYGRVFLKGDFIERIVEEKDCNDLERENRLINAGVYCFNWGKL
CCCCCEEEEEECCCCCCCCEEEEEECHHHHHHHHHCCCCHHHHHCEEEECCEEEEECHHH
SEIINTLRSNNNQKEIYLTDTISMLKNSLSLEVEDNGELQGINNRIQLSECEENMQNSIK
HHHHHHHHCCCCCEEEEEEHHHHHHHCCEEEEECCCCCEECCCCEEEHHHHHHHHHHHHH
EKHMLNGVTFINKASCSISEEAEIGKDVIIEANTHLRGNTKIKSHCIIGPNTFIENSYVG
HHHHHCCEEEEECCCCCCCCHHHCCCEEEEEECCCCCCCCEEEEEEEECCCCEECCCEEE
LNCEISNSTVYASQIMDYIKIGPYSHIRPNSKISSFSKIGNFVEIKNSQLEEESKVNHLS
EEEEECCCEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHH
YIGDSIIGRSTNIGAGTITANFDGEKKHQTKIGKNSSIGANTVFVAPINLGESVTTGAGS
HHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCC
VITKDSKDNSLAISRTQQVNIENWERKKS
EEECCCCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MLSVAILAAGKGTRMESSLPKVLHKISGKSLLQRVIDSCVELKPDQIFVITGHKSKEVEK
CEEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
SISNEKKIHIVIQEPQSGTGHAIQILCREVKKHEGKLLVLNGDVPLIRPSTLKRLLYLHD
HHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEECHHHHHHHHEEEC
SKNADVSLITTKKRNPHGYGRVFLKGDFIERIVEEKDCNDLERENRLINAGVYCFNWGKL
CCCCCEEEEEECCCCCCCCEEEEEECHHHHHHHHHCCCCHHHHHCEEEECCEEEEECHHH
SEIINTLRSNNNQKEIYLTDTISMLKNSLSLEVEDNGELQGINNRIQLSECEENMQNSIK
HHHHHHHHCCCCCEEEEEEHHHHHHHCCEEEEECCCCCEECCCCEEEHHHHHHHHHHHHH
EKHMLNGVTFINKASCSISEEAEIGKDVIIEANTHLRGNTKIKSHCIIGPNTFIENSYVG
HHHHHCCEEEEECCCCCCCCHHHCCCEEEEEECCCCCCCCEEEEEEEECCCCEECCCEEE
LNCEISNSTVYASQIMDYIKIGPYSHIRPNSKISSFSKIGNFVEIKNSQLEEESKVNHLS
EEEEECCCEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHH
YIGDSIIGRSTNIGAGTITANFDGEKKHQTKIGKNSSIGANTVFVAPINLGESVTTGAGS
HHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCC
VITKDSKDNSLAISRTQQVNIENWERKKS
EEECCCCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA