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The map label for this gene is cysK [H]

Identifier: 126695478

GI number: 126695478

Start: 130631

End: 131599

Strand: Reverse

Name: cysK [H]

Synonym: P9301_01401

Alternate gene names: 126695478

Gene position: 131599-130631 (Counterclockwise)

Preceding gene: 126695484

Following gene: 126695477

Centisome position: 8.02

GC content: 36.12

Gene sequence:

>969_bases
ATGGAAATAGCAAATGATATAACTTCTCTTGTTGGAAATACCCCATTAGTTAGATTAAATCGAATTAGAAATCATTTTAA
TTGCTATCCAGAAATAATAGCCAAATTAGAAAGTTTCAATCCATCAGCGTCCGTGAAGGATCGCATCGCTTATTCAATGT
TATGCAAAGCAGAAGAAGACGGTTTGATAAAACCAGATAAAACAACATTGATTGAAGCTACAAGTGGTAATACGGGCATC
GCATTAGCAATGGTTGCTGCAGCAAAAGGCTATAAATTGATATTAACTATGCCGGATACGATGAGTATTGAGAGGAGGGC
AATGTTGAGAGCATATGGAGCTGAATTACAGTTAACGCCTGGGAAAGAAGGAATGAAAGGAGCTTTAGATTTAGCTAATG
AGTTGTCTTCAACCATTGCAAATAGCTATCAATTTAATCAATTTGAAAACTTTGCTAATCCGGATATTCATGAAAGAACA
ACGGCACAAGAAATATGGTCTCAATCCAATAACAATTTAGATGGACTCGTTACAGGAGTAGGAACAGGAGGAACAATCAC
GGGTTGCGCACGTTTCCTGAAAAAAGTTAATCCAAATTGCAAAATTTATGCTGTAGAGCCCCAAAAAAGTGCTGTGATTT
CTGGAGAAAAAGCTGGATCTCATTCGATTCAAGGAATAGGAGCAGGTTTCGTGCCGAAAGTACTGGATACTAAATTAATT
GATGAAATTATAAAAATAGATGACGATGAAGCATTTTATTATGGGCGTTTATTAGCTCGATTGGAAGGCCTTTTATCTGG
CATAAGTAGCGGTGCAGCTCTAGCAGCAACTATTAAAATCGGTGAAAGGAAAGAACTAACTAACAAAAGATTGATAGTTA
TTCTTCCAAGTTTTGGTGAAAGATATTTATCAACAGCAATGTTTGAATCTAATACTTCAATTCAAGCCAGAAAAGATGGT
TATCTCTAA

Upstream 100 bases:

>100_bases
ATTTTTAATTAAATTCTTTTGAGAAAATTTTATAAAAGATCTACAAATACATTTATCATGTATTTAGAAGATTGTATTTT
TAAATTTAAAAAATCATTTC

Downstream 100 bases:

>100_bases
TCCATAATTTATAAAAATGGAAAAAAATTTATATGAAGAATTAGGCCTCAAAAAAAATGCAACCAGAAGTCAAATCAAAT
CTTCATATCGCTCTTTAGTA

Product: O-acetylserine (thiol)-lyase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MEIANDITSLVGNTPLVRLNRIRNHFNCYPEIIAKLESFNPSASVKDRIAYSMLCKAEEDGLIKPDKTTLIEATSGNTGI
ALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTPGKEGMKGALDLANELSSTIANSYQFNQFENFANPDIHERT
TAQEIWSQSNNNLDGLVTGVGTGGTITGCARFLKKVNPNCKIYAVEPQKSAVISGEKAGSHSIQGIGAGFVPKVLDTKLI
DEIIKIDDDEAFYYGRLLARLEGLLSGISSGAALAATIKIGERKELTNKRLIVILPSFGERYLSTAMFESNTSIQARKDG
YL

Sequences:

>Translated_322_residues
MEIANDITSLVGNTPLVRLNRIRNHFNCYPEIIAKLESFNPSASVKDRIAYSMLCKAEEDGLIKPDKTTLIEATSGNTGI
ALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTPGKEGMKGALDLANELSSTIANSYQFNQFENFANPDIHERT
TAQEIWSQSNNNLDGLVTGVGTGGTITGCARFLKKVNPNCKIYAVEPQKSAVISGEKAGSHSIQGIGAGFVPKVLDTKLI
DEIIKIDDDEAFYYGRLLARLEGLLSGISSGAALAATIKIGERKELTNKRLIVILPSFGERYLSTAMFESNTSIQARKDG
YL
>Mature_322_residues
MEIANDITSLVGNTPLVRLNRIRNHFNCYPEIIAKLESFNPSASVKDRIAYSMLCKAEEDGLIKPDKTTLIEATSGNTGI
ALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTPGKEGMKGALDLANELSSTIANSYQFNQFENFANPDIHERT
TAQEIWSQSNNNLDGLVTGVGTGGTITGCARFLKKVNPNCKIYAVEPQKSAVISGEKAGSHSIQGIGAGFVPKVLDTKLI
DEIIKIDDDEAFYYGRLLARLEGLLSGISSGAALAATIKIGERKELTNKRLIVILPSFGERYLSTAMFESNTSIQARKDG
YL

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=311, Percent_Identity=42.1221864951768, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI295821200, Length=311, Percent_Identity=42.1221864951768, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI4557415, Length=311, Percent_Identity=42.1221864951768, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=53.1645569620253, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=42.6174496644295, Blast_Score=221, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=51.1400651465798, Blast_Score=296, Evalue=7e-81,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=48.8294314381271, Blast_Score=291, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=47.3856209150327, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=48.1727574750831, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17561720, Length=308, Percent_Identity=44.8051948051948, Blast_Score=240, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=46.2264150943396, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17534315, Length=327, Percent_Identity=34.8623853211009, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI25147552, Length=316, Percent_Identity=35.126582278481, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17561716, Length=120, Percent_Identity=37.5, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71996324, Length=311, Percent_Identity=26.0450160771704, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=40.9523809523809, Blast_Score=219, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6321449, Length=334, Percent_Identity=33.2335329341317, Blast_Score=126, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24643623, Length=324, Percent_Identity=39.8148148148148, Blast_Score=194, Evalue=5e-50,
Organism=Drosophila melanogaster, GI20129101, Length=324, Percent_Identity=39.8148148148148, Blast_Score=194, Evalue=5e-50,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34962; Mature: 34962

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIANDITSLVGNTPLVRLNRIRNHFNCYPEIIAKLESFNPSASVKDRIAYSMLCKAEED
CCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
GLIKPDKTTLIEATSGNTGIALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTP
CCCCCCCCEEEEECCCCCCHHHHEEHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEECC
GKEGMKGALDLANELSSTIANSYQFNQFENFANPDIHERTTAQEIWSQSNNNLDGLVTGV
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEC
GTGGTITGCARFLKKVNPNCKIYAVEPQKSAVISGEKAGSHSIQGIGAGFVPKVLDTKLI
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
DEIIKIDDDEAFYYGRLLARLEGLLSGISSGAALAATIKIGERKELTNKRLIVILPSFGE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHCCCEEEEEECCCCH
RYLSTAMFESNTSIQARKDGYL
HHHHHHHHCCCCCEEECCCCCC
>Mature Secondary Structure
MEIANDITSLVGNTPLVRLNRIRNHFNCYPEIIAKLESFNPSASVKDRIAYSMLCKAEED
CCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
GLIKPDKTTLIEATSGNTGIALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTP
CCCCCCCCEEEEECCCCCCHHHHEEHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEECC
GKEGMKGALDLANELSSTIANSYQFNQFENFANPDIHERTTAQEIWSQSNNNLDGLVTGV
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEC
GTGGTITGCARFLKKVNPNCKIYAVEPQKSAVISGEKAGSHSIQGIGAGFVPKVLDTKLI
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
DEIIKIDDDEAFYYGRLLARLEGLLSGISSGAALAATIKIGERKELTNKRLIVILPSFGE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHCCCEEEEEECCCCH
RYLSTAMFESNTSIQARKDGYL
HHHHHHHHCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]