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The map label for this gene is fdhA [H]

Identifier: 126447029

GI number: 126447029

Start: 1908783

End: 1909982

Strand: Reverse

Name: fdhA [H]

Synonym: BMA10247_A1981

Alternate gene names: 126447029

Gene position: 1909982-1908783 (Counterclockwise)

Preceding gene: 126446305

Following gene: 126446147

Centisome position: 81.18

GC content: 67.25

Gene sequence:

>1200_bases
ATGAGCAGCAACCGAGGTGTCGTGTATCAGGGGCCGGGCAAGGTCGAAGTGCGGAAGATCGACTATCCGAAGATGGTCGA
TCCGAGCGGCCGCGCGATCGGCCACGGCGTGATCCTGAAGGTCGTCAGCACGAATATCTGCGGCTCCGATCAGCACATGG
TGCGCGGCCGCACGACGGCGCCCGTCGGTCTCGTGCTCGGCCACGAGATCACGGGCGAGGTGATCGAGGTCGGCCGCGAT
GCCGAGACGCTGAAGATCGGCGATCTCGTATCGGTGCCGTTCAACGTCGCGTGCGGCCGCTGCGCGATGTGCAAGGAGCA
GCACACGGGCGTGTGCCTGAACGTGAATCCGGCGCGCGCGGGCGGCGCGTACGGCTATGTCGACATGGGCGGCTGGATCG
GCGGGCAAGCCGAATACGTGCTCGTGCCGTACGCCGACTTCAACCTGCTGAAATTCCCCGATCGCGATCGGGCCATGGCG
AAGATCCGCGATCTCACGTGCCTGTCGGACATCCTGCCGACCGGCTATCACGGCGCGGTCACGGCCGGCGTGAAGCCCGG
CTCGACGGTTTACGTCGCGGGCGCGGGCCCGGTGGGGATGGCGGCCGCCGCGTCGGCGCGGCTGCTCGGCGCCGCATGCA
CGATCGTCGGCGACATGAACGCCGAGCGCCTCGCGCACGCGAAGGCGATGGGCTTCGAGGTGGTCGATCTGTCGAAGGAC
GCGACGCTCGGCGAGCAGATCGAGCAAATCCTCGGCAAGCCGGAGATCGATTGCGCGGTTGACTGCGTCGGCTTCGAGGC
GCACGGCCACGGCTCGTCCGGCCATGCGCAGGAGGCGCCCGCGACGGTGCTGAACTCGCTGATGGAAATCACCCGGCCCG
CGGGCGCGATCGGCATTCCGGGCCTGTACGTGACCGACGATCCGGGCGCCGTCGATGTCGCCGCCAAGCACGGCAGCCTG
AGCATTCGTTTCGGTCTCGGCTGGGCGAAATCGCATTCGTTCCATACCGGCCAGACGCCCGTGCTCAAGTACAGCCGCAA
CCTGATGCAGGCGATCCTGTTCGACCGGCTGCCGATCGCGGAAATCGTCAACGTGGCGGTGATTTCGCTCGACGACGCGC
CGGAGGGCTACAAGAAGTTCGACGGCGGCGCGCCGCGCAAATTCGTCATCGATCCGCACGGGATGCTGAAGGCGGCCTGA

Upstream 100 bases:

>100_bases
CGGACTACCCTCGAAAGGCTCGCTGCAAGTCCGGCCGGCGCGTGAGCGCGCCGGCCGGGCGACGCGCGGCGCACCGCCAA
CGAGACATGGAGACGAAGCG

Downstream 100 bases:

>100_bases
CGCGCACACGCACGCGGGTGCGGCCTCGCGCCGACACCGCCCGCGCAGCGACGCGGCCCGCCGGTTTTCGCGAACCGGCG
GGCCGTTCGTTTCGGTATGC

Product: glutathione-independent formaldehyde dehydrogenase

Products: NA

Alternate protein names: FALDH; FDH [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSSNRGVVYQGPGKVEVRKIDYPKMVDPSGRAIGHGVILKVVSTNICGSDQHMVRGRTTAPVGLVLGHEITGEVIEVGRD
AETLKIGDLVSVPFNVACGRCAMCKEQHTGVCLNVNPARAGGAYGYVDMGGWIGGQAEYVLVPYADFNLLKFPDRDRAMA
KIRDLTCLSDILPTGYHGAVTAGVKPGSTVYVAGAGPVGMAAAASARLLGAACTIVGDMNAERLAHAKAMGFEVVDLSKD
ATLGEQIEQILGKPEIDCAVDCVGFEAHGHGSSGHAQEAPATVLNSLMEITRPAGAIGIPGLYVTDDPGAVDVAAKHGSL
SIRFGLGWAKSHSFHTGQTPVLKYSRNLMQAILFDRLPIAEIVNVAVISLDDAPEGYKKFDGGAPRKFVIDPHGMLKAA

Sequences:

>Translated_399_residues
MSSNRGVVYQGPGKVEVRKIDYPKMVDPSGRAIGHGVILKVVSTNICGSDQHMVRGRTTAPVGLVLGHEITGEVIEVGRD
AETLKIGDLVSVPFNVACGRCAMCKEQHTGVCLNVNPARAGGAYGYVDMGGWIGGQAEYVLVPYADFNLLKFPDRDRAMA
KIRDLTCLSDILPTGYHGAVTAGVKPGSTVYVAGAGPVGMAAAASARLLGAACTIVGDMNAERLAHAKAMGFEVVDLSKD
ATLGEQIEQILGKPEIDCAVDCVGFEAHGHGSSGHAQEAPATVLNSLMEITRPAGAIGIPGLYVTDDPGAVDVAAKHGSL
SIRFGLGWAKSHSFHTGQTPVLKYSRNLMQAILFDRLPIAEIVNVAVISLDDAPEGYKKFDGGAPRKFVIDPHGMLKAA
>Mature_398_residues
SSNRGVVYQGPGKVEVRKIDYPKMVDPSGRAIGHGVILKVVSTNICGSDQHMVRGRTTAPVGLVLGHEITGEVIEVGRDA
ETLKIGDLVSVPFNVACGRCAMCKEQHTGVCLNVNPARAGGAYGYVDMGGWIGGQAEYVLVPYADFNLLKFPDRDRAMAK
IRDLTCLSDILPTGYHGAVTAGVKPGSTVYVAGAGPVGMAAAASARLLGAACTIVGDMNAERLAHAKAMGFEVVDLSKDA
TLGEQIEQILGKPEIDCAVDCVGFEAHGHGSSGHAQEAPATVLNSLMEITRPAGAIGIPGLYVTDDPGAVDVAAKHGSLS
IRFGLGWAKSHSFHTGQTPVLKYSRNLMQAILFDRLPIAEIVNVAVISLDDAPEGYKKFDGGAPRKFVIDPHGMLKAA

Specific function: Catalyzes the oxidation of long-chain alcohols but is inactive against ethanol [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=204, Percent_Identity=33.8235294117647, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI34577061, Length=204, Percent_Identity=32.843137254902, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI4501929, Length=205, Percent_Identity=33.1707317073171, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI156627571, Length=279, Percent_Identity=30.4659498207885, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI71743840, Length=226, Percent_Identity=29.646017699115, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI262073058, Length=226, Percent_Identity=29.646017699115, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI71565154, Length=248, Percent_Identity=27.0161290322581, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4501939, Length=204, Percent_Identity=28.4313725490196, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1786825, Length=407, Percent_Identity=34.1523341523341, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1790045, Length=285, Percent_Identity=31.5789473684211, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI87082125, Length=240, Percent_Identity=34.5833333333333, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790718, Length=269, Percent_Identity=26.0223048327138, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788073, Length=238, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI226510992, Length=262, Percent_Identity=30.5343511450382, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787863, Length=230, Percent_Identity=30.8695652173913, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87081918, Length=208, Percent_Identity=33.6538461538462, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1788075, Length=288, Percent_Identity=25.6944444444444, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=236, Percent_Identity=29.2372881355932, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=242, Percent_Identity=26.8595041322314, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=274, Percent_Identity=31.7518248175182, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=274, Percent_Identity=31.7518248175182, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=278, Percent_Identity=29.8561151079137, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=259, Percent_Identity=26.6409266409266, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=130, Percent_Identity=34.6153846153846, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737897, Length=279, Percent_Identity=27.9569892473118, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17137530, Length=244, Percent_Identity=29.5081967213115, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17737895, Length=213, Percent_Identity=30.9859154929577, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR014184
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.2.1.46 [H]

Molecular weight: Translated: 41826; Mature: 41694

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNRGVVYQGPGKVEVRKIDYPKMVDPSGRAIGHGVILKVVSTNICGSDQHMVRGRTTA
CCCCCCEEEECCCEEEEEEECCCCCCCCCCCEECCEEEEEEEECCCCCCCCCEECCCCCC
PVGLVLGHEITGEVIEVGRDAETLKIGDLVSVPFNVACGRCAMCKEQHTGVCLNVNPARA
CEEEEECCCCCCHHHHCCCCCCEEEECCEEECCCCCCCCCHHHHHCCCCCEEEECCCCCC
GGAYGYVDMGGWIGGQAEYVLVPYADFNLLKFPDRDRAMAKIRDLTCLSDILPTGYHGAV
CCCEEEEECCCCCCCCCCEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEE
TAGVKPGSTVYVAGAGPVGMAAAASARLLGAACTIVGDMNAERLAHAKAMGFEVVDLSKD
EECCCCCCEEEEECCCCCCHHHHHHHHHHHEEEEEEECCCHHHHHHHHHCCEEEEECCCC
ATLGEQIEQILGKPEIDCAVDCVGFEAHGHGSSGHAQEAPATVLNSLMEITRPAGAIGIP
CHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
GLYVTDDPGAVDVAAKHGSLSIRFGLGWAKSHSFHTGQTPVLKYSRNLMQAILFDRLPIA
EEEEECCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
EIVNVAVISLDDAPEGYKKFDGGAPRKFVIDPHGMLKAA
HHCEEEEEEECCCCCHHHHCCCCCCEEEEECCCCCEECC
>Mature Secondary Structure 
SSNRGVVYQGPGKVEVRKIDYPKMVDPSGRAIGHGVILKVVSTNICGSDQHMVRGRTTA
CCCCCEEEECCCEEEEEEECCCCCCCCCCCEECCEEEEEEEECCCCCCCCCEECCCCCC
PVGLVLGHEITGEVIEVGRDAETLKIGDLVSVPFNVACGRCAMCKEQHTGVCLNVNPARA
CEEEEECCCCCCHHHHCCCCCCEEEECCEEECCCCCCCCCHHHHHCCCCCEEEECCCCCC
GGAYGYVDMGGWIGGQAEYVLVPYADFNLLKFPDRDRAMAKIRDLTCLSDILPTGYHGAV
CCCEEEEECCCCCCCCCCEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEE
TAGVKPGSTVYVAGAGPVGMAAAASARLLGAACTIVGDMNAERLAHAKAMGFEVVDLSKD
EECCCCCCEEEEECCCCCCHHHHHHHHHHHEEEEEEECCCHHHHHHHHHCCEEEEECCCC
ATLGEQIEQILGKPEIDCAVDCVGFEAHGHGSSGHAQEAPATVLNSLMEITRPAGAIGIP
CHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
GLYVTDDPGAVDVAAKHGSLSIRFGLGWAKSHSFHTGQTPVLKYSRNLMQAILFDRLPIA
EEEEECCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
EIVNVAVISLDDAPEGYKKFDGGAPRKFVIDPHGMLKAA
HHCEEEEEEECCCCCHHHHCCCCCCEEEEECCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]