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The map label for this gene is glyA-2 [H]

Identifier: 126446147

GI number: 126446147

Start: 1905872

End: 1907146

Strand: Reverse

Name: glyA-2 [H]

Synonym: BMA10247_A1979

Alternate gene names: 126446147

Gene position: 1907146-1905872 (Counterclockwise)

Preceding gene: 126447029

Following gene: 126447351

Centisome position: 81.06

GC content: 67.76

Gene sequence:

>1275_bases
ATGTCGAACGCCAATCCCTTCTTCTCGCAATCGCTCGCCGAGCGCGACGCGTCCGTGCGCGGCGCGATCCTCAAGGAACT
CGAACGCCAGCAGTCGCAAGTCGAGCTGATCGCGTCGGAGAACATCGTGTCGCGCGCGGTGCTCGACGCGCAGGGCTCGG
TGCTGACCAACAAGTATGCGGAAGGCTATCCGGGCAAGCGCTATTACGGCGGTTGCGAATTCGCCGACGAAGTCGAGGCG
CTCGCGATCGAGCGCGTGAAGCGGCTCTTCAACGCCGGCCATGCGAACGTGCAGCCGCACTCGGGCGCCCAGGCGAACGG
CGCGGTGATGCTCGCGCTCGCGAAGCCGGGCGACACGGTGCTCGGAATGTCGCTCGACGCGGGCGGACACCTCACGCACG
GCGCGAAGCCGGCGCTGTCCGGCAAGTGGTTCAACGCGCTCCAGTACGGCGTGAGCCGCGACACGATGCTGCTCGATTAC
GACCAGGTCGAGGCGCTCGCGCAGCAGCACAAGCCGAGCCTCATCATCGCCGGCTTCTCCGCCTATCCGCGCAAGCTCGA
CTTCGCGCGGTTTCGCGCGATCGCCGATTCGGTCGGCGCGAAGCTGATGGTCGACATGGCGCATATCGCCGGCGTGATCG
CCGCGGGCCGCCATGCGAACCCGGTCGAACACGCGCACGTCGTCACGTCGACGACGCACAAGACGCTGCGCGGCCCGCGC
GGCGGCTTCGTGCTGACCAACGACGAGGAGATCGCGAAGAAGATCAACTCGGCCGTGTTCCCCGGCCTGCAGGGCGGCCC
GCTGATGCACGTGATCGCCGGCAAGGCGGTGGCGTTCGGCGAGGCGCTGACAGACGATTTCAAGACCTACATCGATCACG
TGCTCGCGAACGCGCAGGCGCTCGGCGACGTGCTGAAGGCGGGCGGCGTCGATCTCGTGACGGGCGGCACCGACAACCAT
CTGCTGCTCGTCGATCTGCGCCCGAAGGGCCTGAAGGGCGCGCAGGTCGAGCAGGCGCTCGAGCGCGCGGGCATCACGTG
CAACAAGAACGGCATTCCGTTCGATCCGGAGAAGCCGACGATCACGTCGGGCATCCGCCTCGGCACGCCGGCGGGCACGA
CGCGCGGCTTCGGCGCAGCGGAGTTCCGCGAGGTCGGCCGGCTGATTCTCGAGGTGTTCGAGGCCCTGCGCACGAACCCG
GAAGGCGATCACGCGACCGAACAGCGCGTGCGGCGCGAGATCTTCGCGCTTTGCGAACGCTTCCCGATCTACTGA

Upstream 100 bases:

>100_bases
TAGAGCCGTCGGCAGCCGCTGCGGCGAAACGCCGAAACGCCGTGAACAGGGCCTTCGGGCCTGCCCCGGAGCCCCTCAAA
ATTCAGTGACGAGACGCCTC

Downstream 100 bases:

>100_bases
CACGCCGGAGCGGAACGAACGCCGCGCGTTCGCACGCCGACCGACCCACGCGCCGACAAGACTGGAGAATCCATGAGCAC
GCTGCACCAGGACAGCATCA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSNANPFFSQSLAERDASVRGAILKELERQQSQVELIASENIVSRAVLDAQGSVLTNKYAEGYPGKRYYGGCEFADEVEA
LAIERVKRLFNAGHANVQPHSGAQANGAVMLALAKPGDTVLGMSLDAGGHLTHGAKPALSGKWFNALQYGVSRDTMLLDY
DQVEALAQQHKPSLIIAGFSAYPRKLDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHANPVEHAHVVTSTTHKTLRGPR
GGFVLTNDEEIAKKINSAVFPGLQGGPLMHVIAGKAVAFGEALTDDFKTYIDHVLANAQALGDVLKAGGVDLVTGGTDNH
LLLVDLRPKGLKGAQVEQALERAGITCNKNGIPFDPEKPTITSGIRLGTPAGTTRGFGAAEFREVGRLILEVFEALRTNP
EGDHATEQRVRREIFALCERFPIY

Sequences:

>Translated_424_residues
MSNANPFFSQSLAERDASVRGAILKELERQQSQVELIASENIVSRAVLDAQGSVLTNKYAEGYPGKRYYGGCEFADEVEA
LAIERVKRLFNAGHANVQPHSGAQANGAVMLALAKPGDTVLGMSLDAGGHLTHGAKPALSGKWFNALQYGVSRDTMLLDY
DQVEALAQQHKPSLIIAGFSAYPRKLDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHANPVEHAHVVTSTTHKTLRGPR
GGFVLTNDEEIAKKINSAVFPGLQGGPLMHVIAGKAVAFGEALTDDFKTYIDHVLANAQALGDVLKAGGVDLVTGGTDNH
LLLVDLRPKGLKGAQVEQALERAGITCNKNGIPFDPEKPTITSGIRLGTPAGTTRGFGAAEFREVGRLILEVFEALRTNP
EGDHATEQRVRREIFALCERFPIY
>Mature_423_residues
SNANPFFSQSLAERDASVRGAILKELERQQSQVELIASENIVSRAVLDAQGSVLTNKYAEGYPGKRYYGGCEFADEVEAL
AIERVKRLFNAGHANVQPHSGAQANGAVMLALAKPGDTVLGMSLDAGGHLTHGAKPALSGKWFNALQYGVSRDTMLLDYD
QVEALAQQHKPSLIIAGFSAYPRKLDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHANPVEHAHVVTSTTHKTLRGPRG
GFVLTNDEEIAKKINSAVFPGLQGGPLMHVIAGKAVAFGEALTDDFKTYIDHVLANAQALGDVLKAGGVDLVTGGTDNHL
LLVDLRPKGLKGAQVEQALERAGITCNKNGIPFDPEKPTITSGIRLGTPAGTTRGFGAAEFREVGRLILEVFEALRTNPE
GDHATEQRVRREIFALCERFPIY

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=406, Percent_Identity=47.2906403940887, Blast_Score=337, Evalue=8e-93,
Organism=Homo sapiens, GI261862352, Length=406, Percent_Identity=47.2906403940887, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI261862350, Length=406, Percent_Identity=47.2906403940887, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI261862348, Length=406, Percent_Identity=47.2906403940887, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI22547186, Length=412, Percent_Identity=48.3009708737864, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI261862346, Length=406, Percent_Identity=46.0591133004926, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI22547189, Length=398, Percent_Identity=45.4773869346734, Blast_Score=301, Evalue=6e-82,
Organism=Escherichia coli, GI1788902, Length=416, Percent_Identity=56.0096153846154, Blast_Score=439, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=49, Blast_Score=348, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=49, Blast_Score=348, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6319739, Length=423, Percent_Identity=42.3167848699764, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6323087, Length=411, Percent_Identity=43.30900243309, Blast_Score=319, Evalue=7e-88,
Organism=Drosophila melanogaster, GI24640005, Length=400, Percent_Identity=48, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI221329721, Length=400, Percent_Identity=48, Blast_Score=352, Evalue=2e-97,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45422; Mature: 45291

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNANPFFSQSLAERDASVRGAILKELERQQSQVELIASENIVSRAVLDAQGSVLTNKYA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
EGYPGKRYYGGCEFADEVEALAIERVKRLFNAGHANVQPHSGAQANGAVMLALAKPGDTV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEE
LGMSLDAGGHLTHGAKPALSGKWFNALQYGVSRDTMLLDYDQVEALAQQHKPSLIIAGFS
EEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECHHHHHHHHHHCCCCEEEECCC
AYPRKLDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHANPVEHAHVVTSTTHKTLRGPR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEHHHHHHHCCCC
GGFVLTNDEEIAKKINSAVFPGLQGGPLMHVIAGKAVAFGEALTDDFKTYIDHVLANAQA
CCEEEECCHHHHHHHHHHHCCCCCCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGDVLKAGGVDLVTGGTDNHLLLVDLRPKGLKGAQVEQALERAGITCNKNGIPFDPEKPT
HHHHHHHCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCC
ITSGIRLGTPAGTTRGFGAAEFREVGRLILEVFEALRTNPEGDHATEQRVRREIFALCER
CCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FPIY
CCCC
>Mature Secondary Structure 
SNANPFFSQSLAERDASVRGAILKELERQQSQVELIASENIVSRAVLDAQGSVLTNKYA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
EGYPGKRYYGGCEFADEVEALAIERVKRLFNAGHANVQPHSGAQANGAVMLALAKPGDTV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEE
LGMSLDAGGHLTHGAKPALSGKWFNALQYGVSRDTMLLDYDQVEALAQQHKPSLIIAGFS
EEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECHHHHHHHHHHCCCCEEEECCC
AYPRKLDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHANPVEHAHVVTSTTHKTLRGPR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEHHHHHHHCCCC
GGFVLTNDEEIAKKINSAVFPGLQGGPLMHVIAGKAVAFGEALTDDFKTYIDHVLANAQA
CCEEEECCHHHHHHHHHHHCCCCCCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGDVLKAGGVDLVTGGTDNHLLLVDLRPKGLKGAQVEQALERAGITCNKNGIPFDPEKPT
HHHHHHHCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCC
ITSGIRLGTPAGTTRGFGAAEFREVGRLILEVFEALRTNPEGDHATEQRVRREIFALCER
CCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FPIY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA