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The map label for this gene is irlS [H]

Identifier: 126445789

GI number: 126445789

Start: 1147794

End: 1149188

Strand: Reverse

Name: irlS [H]

Synonym: BMA10247_A1179

Alternate gene names: 126445789

Gene position: 1149188-1147794 (Counterclockwise)

Preceding gene: 126445741

Following gene: 126447722

Centisome position: 48.85

GC content: 69.03

Gene sequence:

>1395_bases
ATGATCAGACGCCTGCTGCCCCGCACGCTGCGCGCGCGCCTGACGGCGCTCATCATCCTGTCGACCGCGGCGACGCTCGC
GCTGAGCGGCGTCGCGCTCTACAGCGCGCTGCACAACCGGCTCGTCGGCATGTCGTCGTACGAGATGTCGGCGACGCTCG
CGGCGATGCGCACGCATCTCGCGAACGTCGCGAACGTCGACGATATCCCGCGCAAATCGGATCTGTGGATCGATCAACTG
CACGGCCATCAGAATCTGGATCTCGCGATCTACGACACCGACGGCCGCCTGCGCTTCGCCACGCGCGGCTTCGTCGCGCC
GCGGCCCGCGCTCGGCGCGCCGCAAACGCGCGTGCCGGCGAGCGCCGCGCCCGCCGGCGCGACGTTCAGCTATCTCGCGG
ACGACGCGCCGCTGCGCGGCGGGAACCCGCGCACCGCGCGCATCGTCGTGCAGTACGACGGCAAGAACGATCATGCGCTG
CTGCGCGCATACGCGTACACGGTCGTCGTGATCGAGGTGCTCGCGGTCGTGCTGACGGCGGCGCTCGCCTACGGCATCGC
GATGCTCGGCCTGAGCCCGCTGCGGCGGCTCGTCGCGCGCGCCGAGCAGATGTCGTCGAGCCGGCTCGCGCAGCCGCTGC
CGGAGCTCGACACGTCGGGCGAGCTCAAGGAAATGGAGCACGCGTTCAACGCCATGCTCAAGCGCCTCGACGAATCGTTC
GTCCGGCTGAGCCAGTTCTCGTCGAATCTCGCGCACGACATGCGCACGCCGCTCACGAACCTGCTCGCCGAGGCGCAGGT
CGCGCTATCGAAGCCGCGCACGGCCGACGAATATCGCGACGTGATCGAATCGAGCATCGACGAGTATCAGCGTCTGTCGC
GCATGATCGAGGACATGCTGTTCCTCGCGCGCTCCGACAACGCGCAGAGCCATCTGGCGATCCGCACGCTCGACGCGGCG
GCACAAGCCGAGCGCGTCGCCGGCTATTACGAGCCGATGGCCGAGGATGCCGAAGTGAGCATCGTCGTGCGCGGCAAGGC
CGAGGTTCGGGCGGACGCGCTGCTCTATCACCGCGCGCTCAGCAACCTGATCAGCAACGCGCTCAATCACGCGCCGCGCG
GCTCGACGATCACGATCGAATGCGCGCAAGCCGCCGACGCGGCGACGATCAGCGTATCGGACACGGGCCGCGGCATCGAG
GCGCCGCACCGCGAACGGATCTTCGAGCGGTTCTACCGCGTCGATCCGGCGCGGCACAATTCGGCGTCCGGCACGGGGCT
CGGCCTGGCGATCGTGCGCTCGATCATGGAAAACCACGGCGGCACGTGCGGCGTCGACAGCGAGCCGCACGTGCGCACGA
CGTTCTGGCTGAAGTTTCCCGCGCACGCGGCCTGA

Upstream 100 bases:

>100_bases
TGCGCTCGAAGATCGACGACGCGTACGAGCCGAAGCTGATCCACACGGTGCGCGGGATGGGCTACGTGCTCGAAGTCAGA
AGCGCGAGCGCGCCGAGCCG

Downstream 100 bases:

>100_bases
TCCGCCGCGTCAGCGGCGTCAGCGGCGCTAGCGGAATCAGCGGCGGCCCGCGGGCGCGGACGCGCCCGGGCGCGCGGGCT
GCCCGGCTTCGGTCGCCCGC

Product: sensor histidine kinase IrlS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MIRRLLPRTLRARLTALIILSTAATLALSGVALYSALHNRLVGMSSYEMSATLAAMRTHLANVANVDDIPRKSDLWIDQL
HGHQNLDLAIYDTDGRLRFATRGFVAPRPALGAPQTRVPASAAPAGATFSYLADDAPLRGGNPRTARIVVQYDGKNDHAL
LRAYAYTVVVIEVLAVVLTAALAYGIAMLGLSPLRRLVARAEQMSSSRLAQPLPELDTSGELKEMEHAFNAMLKRLDESF
VRLSQFSSNLAHDMRTPLTNLLAEAQVALSKPRTADEYRDVIESSIDEYQRLSRMIEDMLFLARSDNAQSHLAIRTLDAA
AQAERVAGYYEPMAEDAEVSIVVRGKAEVRADALLYHRALSNLISNALNHAPRGSTITIECAQAADAATISVSDTGRGIE
APHRERIFERFYRVDPARHNSASGTGLGLAIVRSIMENHGGTCGVDSEPHVRTTFWLKFPAHAA

Sequences:

>Translated_464_residues
MIRRLLPRTLRARLTALIILSTAATLALSGVALYSALHNRLVGMSSYEMSATLAAMRTHLANVANVDDIPRKSDLWIDQL
HGHQNLDLAIYDTDGRLRFATRGFVAPRPALGAPQTRVPASAAPAGATFSYLADDAPLRGGNPRTARIVVQYDGKNDHAL
LRAYAYTVVVIEVLAVVLTAALAYGIAMLGLSPLRRLVARAEQMSSSRLAQPLPELDTSGELKEMEHAFNAMLKRLDESF
VRLSQFSSNLAHDMRTPLTNLLAEAQVALSKPRTADEYRDVIESSIDEYQRLSRMIEDMLFLARSDNAQSHLAIRTLDAA
AQAERVAGYYEPMAEDAEVSIVVRGKAEVRADALLYHRALSNLISNALNHAPRGSTITIECAQAADAATISVSDTGRGIE
APHRERIFERFYRVDPARHNSASGTGLGLAIVRSIMENHGGTCGVDSEPHVRTTFWLKFPAHAA
>Mature_464_residues
MIRRLLPRTLRARLTALIILSTAATLALSGVALYSALHNRLVGMSSYEMSATLAAMRTHLANVANVDDIPRKSDLWIDQL
HGHQNLDLAIYDTDGRLRFATRGFVAPRPALGAPQTRVPASAAPAGATFSYLADDAPLRGGNPRTARIVVQYDGKNDHAL
LRAYAYTVVVIEVLAVVLTAALAYGIAMLGLSPLRRLVARAEQMSSSRLAQPLPELDTSGELKEMEHAFNAMLKRLDESF
VRLSQFSSNLAHDMRTPLTNLLAEAQVALSKPRTADEYRDVIESSIDEYQRLSRMIEDMLFLARSDNAQSHLAIRTLDAA
AQAERVAGYYEPMAEDAEVSIVVRGKAEVRADALLYHRALSNLISNALNHAPRGSTITIECAQAADAATISVSDTGRGIE
APHRERIFERFYRVDPARHNSASGTGLGLAIVRSIMENHGGTCGVDSEPHVRTTFWLKFPAHAA

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance. Probably activates irlR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=332, Percent_Identity=36.144578313253, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1788279, Length=286, Percent_Identity=33.9160839160839, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1786600, Length=203, Percent_Identity=29.5566502463054, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=30.8823529411765, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787894, Length=307, Percent_Identity=28.6644951140065, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI145693157, Length=255, Percent_Identity=25.4901960784314, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790861, Length=266, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=233, Percent_Identity=27.4678111587983, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789403, Length=450, Percent_Identity=25.3333333333333, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788393, Length=253, Percent_Identity=23.7154150197628, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=28.1938325991189, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789808, Length=295, Percent_Identity=28.4745762711864, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=21.6814159292035, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=233, Percent_Identity=24.8927038626609, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788549, Length=233, Percent_Identity=27.4678111587983, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=225, Percent_Identity=28, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790551, Length=289, Percent_Identity=25.6055363321799, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI48994928, Length=223, Percent_Identity=25.5605381165919, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=235, Percent_Identity=25.1063829787234, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50653; Mature: 50653

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRLLPRTLRARLTALIILSTAATLALSGVALYSALHNRLVGMSSYEMSATLAAMRTHL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ANVANVDDIPRKSDLWIDQLHGHQNLDLAIYDTDGRLRFATRGFVAPRPALGAPQTRVPA
HHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCC
SAAPAGATFSYLADDAPLRGGNPRTARIVVQYDGKNDHALLRAYAYTVVVIEVLAVVLTA
CCCCCCCCHHHHCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALAYGIAMLGLSPLRRLVARAEQMSSSRLAQPLPELDTSGELKEMEHAFNAMLKRLDESF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRLSQFSSNLAHDMRTPLTNLLAEAQVALSKPRTADEYRDVIESSIDEYQRLSRMIEDML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FLARSDNAQSHLAIRTLDAAAQAERVAGYYEPMAEDAEVSIVVRGKAEVRADALLYHRAL
HHHCCCCCCHHEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHH
SNLISNALNHAPRGSTITIECAQAADAATISVSDTGRGIEAPHRERIFERFYRVDPARHN
HHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCC
SASGTGLGLAIVRSIMENHGGTCGVDSEPHVRTTFWLKFPAHAA
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCC
>Mature Secondary Structure
MIRRLLPRTLRARLTALIILSTAATLALSGVALYSALHNRLVGMSSYEMSATLAAMRTHL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ANVANVDDIPRKSDLWIDQLHGHQNLDLAIYDTDGRLRFATRGFVAPRPALGAPQTRVPA
HHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCC
SAAPAGATFSYLADDAPLRGGNPRTARIVVQYDGKNDHALLRAYAYTVVVIEVLAVVLTA
CCCCCCCCHHHHCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALAYGIAMLGLSPLRRLVARAEQMSSSRLAQPLPELDTSGELKEMEHAFNAMLKRLDESF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRLSQFSSNLAHDMRTPLTNLLAEAQVALSKPRTADEYRDVIESSIDEYQRLSRMIEDML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FLARSDNAQSHLAIRTLDAAAQAERVAGYYEPMAEDAEVSIVVRGKAEVRADALLYHRAL
HHHCCCCCCHHEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHH
SNLISNALNHAPRGSTITIECAQAADAATISVSDTGRGIEAPHRERIFERFYRVDPARHN
HHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCC
SASGTGLGLAIVRSIMENHGGTCGVDSEPHVRTTFWLKFPAHAA
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]