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The map label for this gene is irlR

Identifier: 126445741

GI number: 126445741

Start: 1149185

End: 1149874

Strand: Reverse

Name: irlR

Synonym: BMA10247_A1180

Alternate gene names: 126445741

Gene position: 1149874-1149185 (Counterclockwise)

Preceding gene: 126445970

Following gene: 126445789

Centisome position: 48.87

GC content: 67.97

Gene sequence:

>690_bases
ATGCGAATACTGATCGTGGAAGACGAGCCGAAGACCGGCATGTATCTGCGCAAGGGGCTGACCGAAGCGGGCTTCATCGC
GGACTGGGTCGAGGACGGCGTGACGGGCCTGCATCAGGCCGAGACCGAGGAGTACGACCTGATCATCCTCGACGTGATGC
TGCCCGGCCACGACGGCTGGACGGTGCTCGAGCGGCTGCGCCGCGCGCACTCGACGCCCGTGCTGTTCCTGACCGCGCGC
GACGACGTCGGCGACCGCGTGAAGGGGCTCGAGCTCGGCGCGGACGATTACGTCGTCAAGCCGTTCGATTTCGTCGAGCT
GGTCGCGCGCGTGCGCTCGATCCTGCGCCGCGGGCAGGCGCGCGAATCGACGGTCCTGCGGATCGCCGATCTGGAGCTCG
ACCTGACGCGGCGCAAGGCCACGCGCCAGGGCGACGTCGTGCTGCTGACCGCGAAGGAATTCGCGCTGCTGTGGCTGCTG
ATGCGCCGCGAGGGCGAGATCCTGCCGCGCGCGACGATCGCCTCGCAGGTGTGGGACATGAATTTCAACAGCGACACGAA
CGTCGTCGACGCGGCGATCCGCCGGCTGCGCTCGAAGATCGACGACGCGTACGAGCCGAAGCTGATCCACACGGTGCGCG
GGATGGGCTACGTGCTCGAAGTCAGAAGCGCGAGCGCGCCGAGCCGATGA

Upstream 100 bases:

>100_bases
GCCGCGCGCCACGCTCGGCGCACGCGCGGCCGGATGGCTCGCGAGGCTCGCGCCCGCGGCCGTGCTGCGCCGGCGGCGCG
AATCATCGAGGTGAATCCAG

Downstream 100 bases:

>100_bases
TCAGACGCCTGCTGCCCCGCACGCTGCGCGCGCGCCTGACGGCGCTCATCATCCTGTCGACCGCGGCGACGCTCGCGCTG
AGCGGCGTCGCGCTCTACAG

Product: transcriptional activator IrlR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MRILIVEDEPKTGMYLRKGLTEAGFIADWVEDGVTGLHQAETEEYDLIILDVMLPGHDGWTVLERLRRAHSTPVLFLTAR
DDVGDRVKGLELGADDYVVKPFDFVELVARVRSILRRGQARESTVLRIADLELDLTRRKATRQGDVVLLTAKEFALLWLL
MRREGEILPRATIASQVWDMNFNSDTNVVDAAIRRLRSKIDDAYEPKLIHTVRGMGYVLEVRSASAPSR

Sequences:

>Translated_229_residues
MRILIVEDEPKTGMYLRKGLTEAGFIADWVEDGVTGLHQAETEEYDLIILDVMLPGHDGWTVLERLRRAHSTPVLFLTAR
DDVGDRVKGLELGADDYVVKPFDFVELVARVRSILRRGQARESTVLRIADLELDLTRRKATRQGDVVLLTAKEFALLWLL
MRREGEILPRATIASQVWDMNFNSDTNVVDAAIRRLRSKIDDAYEPKLIHTVRGMGYVLEVRSASAPSR
>Mature_229_residues
MRILIVEDEPKTGMYLRKGLTEAGFIADWVEDGVTGLHQAETEEYDLIILDVMLPGHDGWTVLERLRRAHSTPVLFLTAR
DDVGDRVKGLELGADDYVVKPFDFVELVARVRSILRRGQARESTVLRIADLELDLTRRKATRQGDVVLLTAKEFALLWLL
MRREGEILPRATIASQVWDMNFNSDTNVVDAAIRRLRSKIDDAYEPKLIHTVRGMGYVLEVRSASAPSR

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=60.2678571428571, Blast_Score=267, Evalue=3e-73,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=55.2995391705069, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=40.4545454545455, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=38.8392857142857, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=34.0807174887892, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=34.3612334801762, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=36, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=37.7272727272727, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=38.7387387387387, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=36.2385321100917, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.4449339207048, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=34.2222222222222, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=31.858407079646, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI145693140, Length=190, Percent_Identity=32.6315789473684, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=37.3831775700935, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788713, Length=103, Percent_Identity=35.9223300970874, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790299, Length=122, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IRLR_BURPS (O31395)

Other databases:

- EMBL:   AF005358
- EMBL:   BX571966
- RefSeq:   YP_111046.1
- ProteinModelPortal:   O31395
- SMR:   O31395
- GeneID:   3094904
- GenomeReviews:   BX571966_GR
- KEGG:   bps:BPSS1040
- HOGENOM:   HBG753323
- OMA:   DSDTNIV
- PhylomeDB:   O31395
- ProtClustDB:   CLSK929981
- BioCyc:   BPSE272560:BPSS1040-MONOMER
- GO:   GO:0006350
- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00448
- SMART:   SM00862
- TIGRFAMs:   TIGR01387

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 25985; Mature: 25985

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILIVEDEPKTGMYLRKGLTEAGFIADWVEDGVTGLHQAETEEYDLIILDVMLPGHDGW
CEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCH
TVLERLRRAHSTPVLFLTARDDVGDRVKGLELGADDYVVKPFDFVELVARVRSILRRGQA
HHHHHHHHHCCCCEEEEEECCCCCCHHCCEEECCCCCEECCHHHHHHHHHHHHHHHCCCC
RESTVLRIADLELDLTRRKATRQGDVVLLTAKEFALLWLLMRREGEILPRATIASQVWDM
CCCEEEEEECCEEEHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
NFNSDTNVVDAAIRRLRSKIDDAYEPKLIHTVRGMGYVLEVRSASAPSR
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MRILIVEDEPKTGMYLRKGLTEAGFIADWVEDGVTGLHQAETEEYDLIILDVMLPGHDGW
CEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCH
TVLERLRRAHSTPVLFLTARDDVGDRVKGLELGADDYVVKPFDFVELVARVRSILRRGQA
HHHHHHHHHCCCCEEEEEECCCCCCHHCCEEECCCCCEECCHHHHHHHHHHHHHHHCCCC
RESTVLRIADLELDLTRRKATRQGDVVLLTAKEFALLWLLMRREGEILPRATIASQVWDM
CCCEEEEEECCEEEHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
NFNSDTNVVDAAIRRLRSKIDDAYEPKLIHTVRGMGYVLEVRSASAPSR
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784