Click here to switch to the map view.

The map label for this gene is garR [H]

Identifier: 126445751

GI number: 126445751

Start: 1787256

End: 1788146

Strand: Direct

Name: garR [H]

Synonym: BMA10247_A1857

Alternate gene names: 126445751

Gene position: 1787256-1788146 (Clockwise)

Preceding gene: 126447897

Following gene: 126446249

Centisome position: 75.97

GC content: 72.39

Gene sequence:

>891_bases
ATGTCACGCAATGTTGGAGTCATCGGGCTGGGTGCGATGGGCCTGGAGGTCGCGCGCTCGCTGCTGCGCGCGGGCTTTCG
TGTGCACGCATGCGACGTGCGCGAGGACGTGCTCGCCGCCTTCGCCGCCGAAGGCGGCGTGCGCTGCGCGACGCCCGCCG
AGCTGGGCGCGCTGTGCGGCGTCGTGGTCACGCTCGTCGTCAACGCGCAGCAGACGGACGCGGTGCTGTTCGGCGAGCAA
GGCGCCGCGGCCGCGATGCCGCGCGGCGGCGTCGTGATCTCGAGCGCGACGGTCGCGCCGGACTTCGCCGCGCAACTCGG
CGCGCGGCTCGCGGCGGCCGGCCTGCTGATGCTCGACGCGCCCGTGTCCGGCGGCGCCGCGCGCGCCGCCTCCGGCGAGA
TGACGATGATGACTTCCGGCCCCGCCGCCGCGTACGAAGCCTGCGGCGACGTGCTCGCCGCGATCGCGGGCAAGGTCTAC
CGGCTCGGCGATGCGCACGGCGCGGGCTCGAAGGTGAAGATCATCAATCAGTTGCTGGCCGGCGTGCACATCGCGGCGGC
GGCCGAGGCGATGGCGCTCGGCTTGCGCGAAGGCGTCGACCCCGACGCGCTGTACGACGTGATCACGCACAGCGCCGGCA
ATTCGTGGATGTTCGAGAACCGCGTGCCGCACATCCTGAACGGCGACTACACGCCGCTGTCGGCGGTCGACATCTTCGTG
AAGGATCTCGGCCTCGTGCTCGACACCGCGCGCCGCAGCCAATTCCCGCTGCCGCTGTCGGCGACCGCGCACCAGATGTT
CATGAGCGCGTCGAGCGCGGGCCACGGCGGCGAGGACGACTCGGCCGTCATCAAGACGTTCCCCGGCATCGCGCTGCCGG
CGCGCCGCTGA

Upstream 100 bases:

>100_bases
GGAGCAAGCCGGCATTTGCTGAGCCGCGATCCGCGAACGGCCGCGCGCCGCCCGCGAATCGCCCGACGAACGAATCGAGA
AACCGCGAACAAGGTTGACC

Downstream 100 bases:

>100_bases
TTCACCGGAGTTGCCTGCCTCCATGAGCACCGATCAAGCCCTTCGCCCCCTGCTCGGCTGCATCGCCGACGATTTCACCG
GCGCGACCGATCTCGCGAAC

Product: 2-hydroxy-3-oxopropionate reductase

Products: 2-hydroxy-3-oxopropanoate; NADH; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSRNVGVIGLGAMGLEVARSLLRAGFRVHACDVREDVLAAFAAEGGVRCATPAELGALCGVVVTLVVNAQQTDAVLFGEQ
GAAAAMPRGGVVISSATVAPDFAAQLGARLAAAGLLMLDAPVSGGAARAASGEMTMMTSGPAAAYEACGDVLAAIAGKVY
RLGDAHGAGSKVKIINQLLAGVHIAAAAEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFV
KDLGLVLDTARRSQFPLPLSATAHQMFMSASSAGHGGEDDSAVIKTFPGIALPARR

Sequences:

>Translated_296_residues
MSRNVGVIGLGAMGLEVARSLLRAGFRVHACDVREDVLAAFAAEGGVRCATPAELGALCGVVVTLVVNAQQTDAVLFGEQ
GAAAAMPRGGVVISSATVAPDFAAQLGARLAAAGLLMLDAPVSGGAARAASGEMTMMTSGPAAAYEACGDVLAAIAGKVY
RLGDAHGAGSKVKIINQLLAGVHIAAAAEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFV
KDLGLVLDTARRSQFPLPLSATAHQMFMSASSAGHGGEDDSAVIKTFPGIALPARR
>Mature_295_residues
SRNVGVIGLGAMGLEVARSLLRAGFRVHACDVREDVLAAFAAEGGVRCATPAELGALCGVVVTLVVNAQQTDAVLFGEQG
AAAAMPRGGVVISSATVAPDFAAQLGARLAAAGLLMLDAPVSGGAARAASGEMTMMTSGPAAAYEACGDVLAAIAGKVYR
LGDAHGAGSKVKIINQLLAGVHIAAAAEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFVK
DLGLVLDTARRSQFPLPLSATAHQMFMSASSAGHGGEDDSAVIKTFPGIALPARR

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=288, Percent_Identity=30.2083333333333, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI40556376, Length=285, Percent_Identity=24.5614035087719, Blast_Score=104, Evalue=8e-23,
Organism=Escherichia coli, GI1789092, Length=306, Percent_Identity=53.921568627451, Blast_Score=278, Evalue=3e-76,
Organism=Escherichia coli, GI145693186, Length=280, Percent_Identity=32.5, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1790315, Length=282, Percent_Identity=29.7872340425532, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786719, Length=282, Percent_Identity=27.3049645390071, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17557316, Length=271, Percent_Identity=30.2583025830258, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24655230, Length=288, Percent_Identity=31.5972222222222, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI19922568, Length=288, Percent_Identity=31.5972222222222, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI28574115, Length=284, Percent_Identity=24.2957746478873, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: 1.1.1.60

Molecular weight: Translated: 30032; Mature: 29901

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRNVGVIGLGAMGLEVARSLLRAGFRVHACDVREDVLAAFAAEGGVRCATPAELGALCG
CCCCCCEEEECHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHCCCCEECCHHHHHHHHH
VVVTLVVNAQQTDAVLFGEQGAAAAMPRGGVVISSATVAPDFAAQLGARLAAAGLLMLDA
HHHHHHHCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCEEEEEC
PVSGGAARAASGEMTMMTSGPAAAYEACGDVLAAIAGKVYRLGDAHGAGSKVKIINQLLA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHH
GVHIAAAAEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCHHCCCCCCCHHHHHHHH
KDLGLVLDTARRSQFPLPLSATAHQMFMSASSAGHGGEDDSAVIKTFPGIALPARR
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SRNVGVIGLGAMGLEVARSLLRAGFRVHACDVREDVLAAFAAEGGVRCATPAELGALCG
CCCCCEEEECHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHCCCCEECCHHHHHHHHH
VVVTLVVNAQQTDAVLFGEQGAAAAMPRGGVVISSATVAPDFAAQLGARLAAAGLLMLDA
HHHHHHHCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCEEEEEC
PVSGGAARAASGEMTMMTSGPAAAYEACGDVLAAIAGKVYRLGDAHGAGSKVKIINQLLA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHH
GVHIAAAAEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCHHCCCCCCCHHHHHHHH
KDLGLVLDTARRSQFPLPLSATAHQMFMSASSAGHGGEDDSAVIKTFPGIALPARR
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-glycerate; NAD+; NADP+

Specific reaction: (R)-glycerate + NAD(P)+ = 2-hydroxy-3-oxopropanoate + NAD(P)H + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]