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The map label for this gene is rutR [H]

Identifier: 126442714

GI number: 126442714

Start: 436288

End: 437007

Strand: Reverse

Name: rutR [H]

Synonym: BURPS668_A0479

Alternate gene names: 126442714

Gene position: 437007-436288 (Counterclockwise)

Preceding gene: 126443391

Following gene: 126443064

Centisome position: 13.97

GC content: 71.11

Gene sequence:

>720_bases
ATGCCACACGACGATCCGACGACGACGCCCCCCGACGCGCCCGCGCCGCGCGCCCGGACGAAAGCGGCGCACGCGCCGAG
CCGCGCGCGCAAGGCGCACATCCGCGAGCTGAACGAGGCGCACCTGCTCGCATGCGCGGAAGCGGTGTTCGCCGAGCGCG
GCTTCGAGGGCGCGAGCACCGCGCTGATCGCCGAGCGCGCGGGGCTGCCGAAGGCGAACCTGCACTATTACTTTCCGACG
AAGCTCGCGCTGTACCGGCGCGTGCTCGACGACCTGCTCGAGGATTGGCACGCCGCCGCCGACAGCTTCGACGTCGGCGA
CGATCCCGTCGCCGCGCTCGGCGGCTACGTGCGCGCGAAGATGGCGCTGTCGCGCGAGCGGCCGCTCGGCTCGAAGGTGT
GGGCGAACGAGATCATCAGCGGCGCGACGCACATGCAGGACCTGCTGCTCGAACGCGTGAAGCCGTGGATGGATACGCGG
ATCGCGCTGATCGAGCGCTGGATCGCGCGCGGGCTGGTCGAACCGGTCGAGCCGAAGACGCTGCTCTACATGATCTGGGC
GACGACCCAGCATTACGCGGACTTCGACGCGCAGATCGTCGCGCTGTCCGGCAAGCGCGCGCTATCGGCGAAGGCGTTCG
ATGCGACGACCGATGAAGTCGTGCGGCTGATCCTGCGCGCGTGCGGCGCGCGCTCGCCGCACGCGCGGGAGCCGGCGTAG

Upstream 100 bases:

>100_bases
TCCGCCGCCGGCAGGCCGCCGGCGGGCGGCGAAGCGTCGGCGAGCGGCCGCGGCGTCTACAATGACGGCCTCCGATTGCC
GCCCTCCACGAGCGCACGCG

Downstream 100 bases:

>100_bases
CGCGGCACGGCGGGCCGGGAGGGTTCGGGGTTCGGGGTTCGGGGTTCGGACTTTGGAATTCCCGCTTCGAGCCTCGACCG
CCGCTTTGGCTTTGGAGCTC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Rut operon repressor [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MPHDDPTTTPPDAPAPRARTKAAHAPSRARKAHIRELNEAHLLACAEAVFAERGFEGASTALIAERAGLPKANLHYYFPT
KLALYRRVLDDLLEDWHAAADSFDVGDDPVAALGGYVRAKMALSRERPLGSKVWANEIISGATHMQDLLLERVKPWMDTR
IALIERWIARGLVEPVEPKTLLYMIWATTQHYADFDAQIVALSGKRALSAKAFDATTDEVVRLILRACGARSPHAREPA

Sequences:

>Translated_239_residues
MPHDDPTTTPPDAPAPRARTKAAHAPSRARKAHIRELNEAHLLACAEAVFAERGFEGASTALIAERAGLPKANLHYYFPT
KLALYRRVLDDLLEDWHAAADSFDVGDDPVAALGGYVRAKMALSRERPLGSKVWANEIISGATHMQDLLLERVKPWMDTR
IALIERWIARGLVEPVEPKTLLYMIWATTQHYADFDAQIVALSGKRALSAKAFDATTDEVVRLILRACGARSPHAREPA
>Mature_238_residues
PHDDPTTTPPDAPAPRARTKAAHAPSRARKAHIRELNEAHLLACAEAVFAERGFEGASTALIAERAGLPKANLHYYFPTK
LALYRRVLDDLLEDWHAAADSFDVGDDPVAALGGYVRAKMALSRERPLGSKVWANEIISGATHMQDLLLERVKPWMDTRI
ALIERWIARGLVEPVEPKTLLYMIWATTQHYADFDAQIVALSGKRALSAKAFDATTDEVVRLILRACGARSPHAREPA

Specific function: Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginin

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787249, Length=190, Percent_Identity=38.4210526315789, Blast_Score=140, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR019915
- InterPro:   IPR001647
- InterPro:   IPR013573 [H]

Pfam domain/function: PF08362 TetR_C_3; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 26389; Mature: 26258

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHDDPTTTPPDAPAPRARTKAAHAPSRARKAHIRELNEAHLLACAEAVFAERGFEGAST
CCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALIAERAGLPKANLHYYFPTKLALYRRVLDDLLEDWHAAADSFDVGDDPVAALGGYVRAK
HHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
MALSRERPLGSKVWANEIISGATHMQDLLLERVKPWMDTRIALIERWIARGLVEPVEPKT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LLYMIWATTQHYADFDAQIVALSGKRALSAKAFDATTDEVVRLILRACGARSPHAREPA
EEEEEEHHHHHHCCCCCEEEEECCCHHHCCHHCCCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PHDDPTTTPPDAPAPRARTKAAHAPSRARKAHIRELNEAHLLACAEAVFAERGFEGAST
CCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALIAERAGLPKANLHYYFPTKLALYRRVLDDLLEDWHAAADSFDVGDDPVAALGGYVRAK
HHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
MALSRERPLGSKVWANEIISGATHMQDLLLERVKPWMDTRIALIERWIARGLVEPVEPKT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LLYMIWATTQHYADFDAQIVALSGKRALSAKAFDATTDEVVRLILRACGARSPHAREPA
EEEEEEHHHHHHCCCCCEEEEECCCHHHCCHHCCCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]