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The map label for this gene is pcaR [H]

Identifier: 126443391

GI number: 126443391

Start: 437368

End: 438153

Strand: Reverse

Name: pcaR [H]

Synonym: BURPS668_A0480

Alternate gene names: 126443391

Gene position: 438153-437368 (Counterclockwise)

Preceding gene: 126442683

Following gene: 126442714

Centisome position: 14.01

GC content: 67.18

Gene sequence:

>786_bases
ATGAGCACAGAATTTCAGGCCAAACCCGGCGACTCCTATGTCCAGTCGTTCGCGCGCGGACTCGCGGTGATTCGCGCGTT
CGACGCGGAGCACCCCGAGCAGACGCTCACCGAGGTCGCCTCCGCGACCGGCCTGACCCGCGCGGGCGCGCGGCGCATCC
TGCTGACGCTGCAGACGCTCGGCTACGTCGAGGCCGACGGCCGCCTGTTCCGGCTCACGCCGAAGATCCTCGATCTCGGC
TTCGCGTATCTGACATCGATGCCGTTCTGGAACCTCGCCGAGCCGGTGATGGAGCAATTGTCCGCGCGCATCCACGAAAG
CTGCTCGGCGGCCGTGCTCGATCGCACCGAAATCGTGTACGTGCTGCGCGTGCCGACGCACAAGATCATGACGATCAATC
TGTCGATCGGCAGCCGGCTGCCCGCGTACTGCACGTCGATGGGCCGCGTGCTGCTGTCGTCGCTCGACGCCGCCGCGCTC
GACGACACGCTCGCGCAAAGCACGCTGCGCGCGTACACGCCGCGAACGCTCACCGATCCCGCCGCGCTGAAGGACGAGAT
CGCGACCGTGCGCAGCCAGGGCTGGGCGATCGTCGATCAGGAACTGGAAGCCGGATTGATTTCATTGTCGGCGCCGATCC
GCAACCGGCGCGGGCAGGTGATCGCCGCGATGAACATCAGCGGCAACGCGCAGCGGCACACCGCGAAGCAGATGGTGAAG
GCATTCCTCGATCCGCTGCTGGAAGCGTCGCAGACCGTGTCGCAGCTCGTCGCGCGGCGCGGCTGA

Upstream 100 bases:

>100_bases
GCGCGGCTGCCCGTCAAGCGCCGGGCCCATGCGGGGCGCGGGTTGGCGCAACCCGACCCCATGCGCTAATCTTCTCCGCT
GCACATCATTTCCACCCGCC

Downstream 100 bases:

>100_bases
GCCACGGCTGAAACGGTTCCGCGGCACCGCCCGAACACCGCTGACGCGCCGCTTGCACAGGCGCGCTTGGGAGCCGCCCC
GCCCCCAAGCGCGCACTCTT

Product: beta-ketoadipate pathway transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSTEFQAKPGDSYVQSFARGLAVIRAFDAEHPEQTLTEVASATGLTRAGARRILLTLQTLGYVEADGRLFRLTPKILDLG
FAYLTSMPFWNLAEPVMEQLSARIHESCSAAVLDRTEIVYVLRVPTHKIMTINLSIGSRLPAYCTSMGRVLLSSLDAAAL
DDTLAQSTLRAYTPRTLTDPAALKDEIATVRSQGWAIVDQELEAGLISLSAPIRNRRGQVIAAMNISGNAQRHTAKQMVK
AFLDPLLEASQTVSQLVARRG

Sequences:

>Translated_261_residues
MSTEFQAKPGDSYVQSFARGLAVIRAFDAEHPEQTLTEVASATGLTRAGARRILLTLQTLGYVEADGRLFRLTPKILDLG
FAYLTSMPFWNLAEPVMEQLSARIHESCSAAVLDRTEIVYVLRVPTHKIMTINLSIGSRLPAYCTSMGRVLLSSLDAAAL
DDTLAQSTLRAYTPRTLTDPAALKDEIATVRSQGWAIVDQELEAGLISLSAPIRNRRGQVIAAMNISGNAQRHTAKQMVK
AFLDPLLEASQTVSQLVARRG
>Mature_260_residues
STEFQAKPGDSYVQSFARGLAVIRAFDAEHPEQTLTEVASATGLTRAGARRILLTLQTLGYVEADGRLFRLTPKILDLGF
AYLTSMPFWNLAEPVMEQLSARIHESCSAAVLDRTEIVYVLRVPTHKIMTINLSIGSRLPAYCTSMGRVLLSSLDAAALD
DTLAQSTLRAYTPRTLTDPAALKDEIATVRSQGWAIVDQELEAGLISLSAPIRNRRGQVIAAMNISGNAQRHTAKQMVKA
FLDPLLEASQTVSQLVARRG

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=218, Percent_Identity=30.7339449541284, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI87082359, Length=250, Percent_Identity=28.8, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788131, Length=222, Percent_Identity=31.0810810810811, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1789999, Length=249, Percent_Identity=29.718875502008, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1786715, Length=237, Percent_Identity=25.3164556962025, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1788581, Length=159, Percent_Identity=27.0440251572327, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790752, Length=193, Percent_Identity=24.3523316062176, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28471; Mature: 28340

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEFQAKPGDSYVQSFARGLAVIRAFDAEHPEQTLTEVASATGLTRAGARRILLTLQTL
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GYVEADGRLFRLTPKILDLGFAYLTSMPFWNLAEPVMEQLSARIHESCSAAVLDRTEIVY
CEEECCCEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VLRVPTHKIMTINLSIGSRLPAYCTSMGRVLLSSLDAAALDDTLAQSTLRAYTPRTLTDP
EEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AALKDEIATVRSQGWAIVDQELEAGLISLSAPIRNRRGQVIAAMNISGNAQRHTAKQMVK
HHHHHHHHHHHHCCCEEEHHHHHCCHHEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHH
AFLDPLLEASQTVSQLVARRG
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STEFQAKPGDSYVQSFARGLAVIRAFDAEHPEQTLTEVASATGLTRAGARRILLTLQTL
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GYVEADGRLFRLTPKILDLGFAYLTSMPFWNLAEPVMEQLSARIHESCSAAVLDRTEIVY
CEEECCCEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VLRVPTHKIMTINLSIGSRLPAYCTSMGRVLLSSLDAAALDDTLAQSTLRAYTPRTLTDP
EEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AALKDEIATVRSQGWAIVDQELEAGLISLSAPIRNRRGQVIAAMNISGNAQRHTAKQMVK
HHHHHHHHHHHHCCCEEEHHHHHCCHHEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHH
AFLDPLLEASQTVSQLVARRG
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]