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The map label for this gene is lon [H]

Identifier: 126207860

GI number: 126207860

Start: 425663

End: 428071

Strand: Reverse

Name: lon [H]

Synonym: APL_0376

Alternate gene names: 126207860

Gene position: 428071-425663 (Counterclockwise)

Preceding gene: 126207861

Following gene: 126207856

Centisome position: 18.82

GC content: 42.47

Gene sequence:

>2409_bases
ATGGCACCAAGAAAAAAGAAAGCAATTGAATTGCCACTTCTTCCATTACGTGATGTAGTGGTCTTTCCTTATATGGTTAT
GCCGTTATTCGTAGGTCGTGAAAAATCCATTCAGGCTTTACGTGCGGCGATGGATTCAAATAAACAATTATTTCTTGTTA
CACAACAAGATCCTAATAAAGAAGAACCGACAACAGAAGATGTGTATTCCGTTGGCGTGATCGCTAATATTATTCAAATG
TTGAATCTACCGGACGGTACGGTCAAAGTACTGGTTGAAGGTCAGCAACGCGCTAAAATCGAGCATATCCATGATGATGA
AAACGGCTTCTGGGCGGGCGTACAACCTTTAATTTCTGAATACGAAGATGAAAACGACGAATTAAAAACAATTGCAAGAG
CTGCATTAAATGAATTTGAAGGTTATGTAAAAAATAACAAGAAAATTCCGGCGGAAATTCTACCTAAGTTACAAAAAATT
TCATTGGAAGACCGCCTTGCAGACACAATGGCTTCAAACTTAATTGCATCCGTACAGAAAAAACAAGCATTATTAGAAGA
AACTAACTTAATTGCTCGTTTTGAAGCATTATTAGTTGCGATGGCAACCGAGTTGGATTCGCTAGAAACCGAAACGCGTA
TTCGTAATCGTGTGAAACAGCAAATGGAAAAAAACCAACGCGATTATTATTTAAACGAGCAAATTAAAGCGATTCAAAAA
GAGCTTGGTAACGGTGAAGATGCCGAACAAACCGAACTGGATAAATTAAAAGAACAGATCAAAGAAGCGAAGCTACCGCT
CGAAGTAAAAGAAAAACTGGATAGCGAGTTTAAAAAGTTAAAAGCGATGCCGCAAAGTTCTTCCGAAGCGACCGTCGTAC
GCGGCTATATCGATTGGGTCTTAAAAATGCCGTGGAACAAAAAATCAACTGTGAAAAAAGACTTGGCGAAAGCGCAAGAA
ATTTTAGACAAAGATCACTATGGCTTGGAGCGTGTTAAAGAGCGCATTGTCGAATACCTTGCGGTACAAAGCCGTTTAAA
CAAACTTAAAGGCCCGATTCTTTGCTTAGTCGGTCCTCCGGGTGTGGGTAAAACCTCTCTTGGGCAATCTATCGCTAATG
CAACCGGTCGTAAATATGTTCGTATGGCGTTAGGCGGTGTGCGTGACGAAGCGGAAATCCGCGGTCATCGCCGTACTTAT
ATCGGTTCTATGCCGGGTTCATTAATGATGAAAATGGCAAAAGTCGGCGTGAAAAATCCGTTGTTCTTGCTCGATGAAAT
CGACAAAATGGCGCAAGATATGCGCGGTGACCCGGCTTCGGCATTACTTGAAGTATTAGATCCGGAGCAAAACAAAGCGT
TTAACGACCATTATTTAGAAGTCGATTACGATCTTTCCGACGTAATGTTCGTAGCAACGTCAAACTCAATGAATATTCCG
CCGGCATTACTCGACCGTATGGAAGTGATTCGTCTTTCCGGTTATACCGAAGATGAGAAAATGCACATTGCCCGTGACCA
CTTAATTGCCAAACAGCAAGAAAATAACGGCTTAAAAGCGGGTGAATTAACTATCGAAGATAGTGCTATTTTAAGCATTA
TTCGTTACTACACTCGTGAAGCCGGTGTGCGTAGTCTTGAACGTGAAATTGCTAAGATCTGTCGTAAAGCGGTGAAAACT
TTGGTGTTGGACAAAAAAGTCAAATCAATTACGGTAACCGAAGACAATATCGCCGATTACTTGGGTGTAAAACGTTTTGA
TTACGGTAAAATGGACAGCCAAAACCGTGTCGGTGAAGTAACCGGCTTAGCTTGGACGGAAGTCGGCGGCGATTTACTCA
CCATCGAAACCACTTCGGTCGGCGGTAAAGGTAAATTCTCATTTACCGGTTCATTAGGCGATGTGATGAAAGAATCGATT
CAAGCGGCAATGATGGTGGTACGTGCAAGATCCGCACAATTAGGCATTGCGGATGACTTCTATGAAAAACGTGATATTCA
CGTACACGTGCCGGACGGCGCAACGCCGAAAGACGGCCCGAGTGCAGGTATTGCAATGTGTACCGCATTAATTTCAAGTT
TAACCGGCAATCCTGTTCGCAAAGAAGTGGCGATGACCGGTGAAATTAGCTTACGTGGTAAAGTATTACCGATCGGCGGC
TTAAAAGAGAAATTATTGGCGGCACACCGTGGCGGCATTACTACCGTGATTATTCCGAAAGACAACGAAAAAGATCTGGA
AGAGATTCCTGAAAATGCCAAAGCGGCATTGGCTATTCATTCGGTGGAAACGATTGACGAAGTGTTAGCGATTGCACTAG
AAAATCCGCCGATGGGGATTGAGGTGATCTCTCCTAAATCACAAACGATTAAAGTGAAAAAAACTCGCTCAAAAGCGGCT
ATTCAATAA

Upstream 100 bases:

>100_bases
TATTTCCTCTCTTTTTAATTTTAATCAAATTTTCGCTTGTTTTTCCAAAAATCAGCCCCATAATGGGCTAATCATTGATA
GAAAAATAAGAGAGATATAT

Downstream 100 bases:

>100_bases
TCGTAATAATATAACGTAAAAAGGGCTTCAAATTATTTGAAGCCCTTTGTTTTTCTATAATAAGCGGTCGTATTTTCTGC
AAAATTTACCAGAAATCAGA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 802; Mature: 801

Protein sequence:

>802_residues
MAPRKKKAIELPLLPLRDVVVFPYMVMPLFVGREKSIQALRAAMDSNKQLFLVTQQDPNKEEPTTEDVYSVGVIANIIQM
LNLPDGTVKVLVEGQQRAKIEHIHDDENGFWAGVQPLISEYEDENDELKTIARAALNEFEGYVKNNKKIPAEILPKLQKI
SLEDRLADTMASNLIASVQKKQALLEETNLIARFEALLVAMATELDSLETETRIRNRVKQQMEKNQRDYYLNEQIKAIQK
ELGNGEDAEQTELDKLKEQIKEAKLPLEVKEKLDSEFKKLKAMPQSSSEATVVRGYIDWVLKMPWNKKSTVKKDLAKAQE
ILDKDHYGLERVKERIVEYLAVQSRLNKLKGPILCLVGPPGVGKTSLGQSIANATGRKYVRMALGGVRDEAEIRGHRRTY
IGSMPGSLMMKMAKVGVKNPLFLLDEIDKMAQDMRGDPASALLEVLDPEQNKAFNDHYLEVDYDLSDVMFVATSNSMNIP
PALLDRMEVIRLSGYTEDEKMHIARDHLIAKQQENNGLKAGELTIEDSAILSIIRYYTREAGVRSLEREIAKICRKAVKT
LVLDKKVKSITVTEDNIADYLGVKRFDYGKMDSQNRVGEVTGLAWTEVGGDLLTIETTSVGGKGKFSFTGSLGDVMKESI
QAAMMVVRARSAQLGIADDFYEKRDIHVHVPDGATPKDGPSAGIAMCTALISSLTGNPVRKEVAMTGEISLRGKVLPIGG
LKEKLLAAHRGGITTVIIPKDNEKDLEEIPENAKAALAIHSVETIDEVLAIALENPPMGIEVISPKSQTIKVKKTRSKAA
IQ

Sequences:

>Translated_802_residues
MAPRKKKAIELPLLPLRDVVVFPYMVMPLFVGREKSIQALRAAMDSNKQLFLVTQQDPNKEEPTTEDVYSVGVIANIIQM
LNLPDGTVKVLVEGQQRAKIEHIHDDENGFWAGVQPLISEYEDENDELKTIARAALNEFEGYVKNNKKIPAEILPKLQKI
SLEDRLADTMASNLIASVQKKQALLEETNLIARFEALLVAMATELDSLETETRIRNRVKQQMEKNQRDYYLNEQIKAIQK
ELGNGEDAEQTELDKLKEQIKEAKLPLEVKEKLDSEFKKLKAMPQSSSEATVVRGYIDWVLKMPWNKKSTVKKDLAKAQE
ILDKDHYGLERVKERIVEYLAVQSRLNKLKGPILCLVGPPGVGKTSLGQSIANATGRKYVRMALGGVRDEAEIRGHRRTY
IGSMPGSLMMKMAKVGVKNPLFLLDEIDKMAQDMRGDPASALLEVLDPEQNKAFNDHYLEVDYDLSDVMFVATSNSMNIP
PALLDRMEVIRLSGYTEDEKMHIARDHLIAKQQENNGLKAGELTIEDSAILSIIRYYTREAGVRSLEREIAKICRKAVKT
LVLDKKVKSITVTEDNIADYLGVKRFDYGKMDSQNRVGEVTGLAWTEVGGDLLTIETTSVGGKGKFSFTGSLGDVMKESI
QAAMMVVRARSAQLGIADDFYEKRDIHVHVPDGATPKDGPSAGIAMCTALISSLTGNPVRKEVAMTGEISLRGKVLPIGG
LKEKLLAAHRGGITTVIIPKDNEKDLEEIPENAKAALAIHSVETIDEVLAIALENPPMGIEVISPKSQTIKVKKTRSKAA
IQ
>Mature_801_residues
APRKKKAIELPLLPLRDVVVFPYMVMPLFVGREKSIQALRAAMDSNKQLFLVTQQDPNKEEPTTEDVYSVGVIANIIQML
NLPDGTVKVLVEGQQRAKIEHIHDDENGFWAGVQPLISEYEDENDELKTIARAALNEFEGYVKNNKKIPAEILPKLQKIS
LEDRLADTMASNLIASVQKKQALLEETNLIARFEALLVAMATELDSLETETRIRNRVKQQMEKNQRDYYLNEQIKAIQKE
LGNGEDAEQTELDKLKEQIKEAKLPLEVKEKLDSEFKKLKAMPQSSSEATVVRGYIDWVLKMPWNKKSTVKKDLAKAQEI
LDKDHYGLERVKERIVEYLAVQSRLNKLKGPILCLVGPPGVGKTSLGQSIANATGRKYVRMALGGVRDEAEIRGHRRTYI
GSMPGSLMMKMAKVGVKNPLFLLDEIDKMAQDMRGDPASALLEVLDPEQNKAFNDHYLEVDYDLSDVMFVATSNSMNIPP
ALLDRMEVIRLSGYTEDEKMHIARDHLIAKQQENNGLKAGELTIEDSAILSIIRYYTREAGVRSLEREIAKICRKAVKTL
VLDKKVKSITVTEDNIADYLGVKRFDYGKMDSQNRVGEVTGLAWTEVGGDLLTIETTSVGGKGKFSFTGSLGDVMKESIQ
AAMMVVRARSAQLGIADDFYEKRDIHVHVPDGATPKDGPSAGIAMCTALISSLTGNPVRKEVAMTGEISLRGKVLPIGGL
KEKLLAAHRGGITTVIIPKDNEKDLEEIPENAKAALAIHSVETIDEVLAIALENPPMGIEVISPKSQTIKVKKTRSKAAI
Q

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=831, Percent_Identity=37.7858002406739, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI21396489, Length=620, Percent_Identity=42.4193548387097, Blast_Score=509, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=786, Percent_Identity=68.8295165394402, Blast_Score=1102, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=701, Percent_Identity=38.6590584878745, Blast_Score=477, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17556486, Length=544, Percent_Identity=40.8088235294118, Blast_Score=430, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319449, Length=653, Percent_Identity=41.5007656967841, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI221513036, Length=620, Percent_Identity=44.6774193548387, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=44.6774193548387, Blast_Score=522, Evalue=1e-148,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89160; Mature: 89029

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRKKKAIELPLLPLRDVVVFPYMVMPLFVGREKSIQALRAAMDSNKQLFLVTQQDPNK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCCCC
EEPTTEDVYSVGVIANIIQMLNLPDGTVKVLVEGQQRAKIEHIHDDENGFWAGVQPLISE
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHCCCCCCCCCHHHHHHHHH
YEDENDELKTIARAALNEFEGYVKNNKKIPAEILPKLQKISLEDRLADTMASNLIASVQK
HCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
KQALLEETNLIARFEALLVAMATELDSLETETRIRNRVKQQMEKNQRDYYLNEQIKAIQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ELGNGEDAEQTELDKLKEQIKEAKLPLEVKEKLDSEFKKLKAMPQSSSEATVVRGYIDWV
HHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LKMPWNKKSTVKKDLAKAQEILDKDHYGLERVKERIVEYLAVQSRLNKLKGPILCLVGPP
HCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
GVGKTSLGQSIANATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGSLMMKMAKVGVKNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHEECCCCHHHHHHHHHHCCCCC
LFLLDEIDKMAQDMRGDPASALLEVLDPEQNKAFNDHYLEVDYDLSDVMFVATSNSMNIP
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCC
PALLDRMEVIRLSGYTEDEKMHIARDHLIAKQQENNGLKAGELTIEDSAILSIIRYYTRE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEECEEEECHHHHHHHHHHHHHH
AGVRSLEREIAKICRKAVKTLVLDKKVKSITVTEDNIADYLGVKRFDYGKMDSQNRVGEV
HHHHHHHHHHHHHHHHHHHHHHHHCHHCEEEEECHHHHHHHCCCCCCCCCCCCCCCCCHH
TGLAWTEVGGDLLTIETTSVGGKGKFSFTGSLGDVMKESIQAAMMVVRARSAQLGIADDF
CCEEHHHCCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
YEKRDIHVHVPDGATPKDGPSAGIAMCTALISSLTGNPVRKEVAMTGEISLRGKVLPIGG
HCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEEECEEEECCEEEECCC
LKEKLLAAHRGGITTVIIPKDNEKDLEEIPENAKAALAIHSVETIDEVLAIALENPPMGI
HHHHHHHHHCCCEEEEEEECCCCHHHHHCCCCHHHHEEHHHHHHHHHHHHHHCCCCCCCE
EVISPKSQTIKVKKTRSKAAIQ
EEECCCCCEEEEEECCHHCCCC
>Mature Secondary Structure 
APRKKKAIELPLLPLRDVVVFPYMVMPLFVGREKSIQALRAAMDSNKQLFLVTQQDPNK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCCCC
EEPTTEDVYSVGVIANIIQMLNLPDGTVKVLVEGQQRAKIEHIHDDENGFWAGVQPLISE
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHCCCCCCCCCHHHHHHHHH
YEDENDELKTIARAALNEFEGYVKNNKKIPAEILPKLQKISLEDRLADTMASNLIASVQK
HCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
KQALLEETNLIARFEALLVAMATELDSLETETRIRNRVKQQMEKNQRDYYLNEQIKAIQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ELGNGEDAEQTELDKLKEQIKEAKLPLEVKEKLDSEFKKLKAMPQSSSEATVVRGYIDWV
HHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LKMPWNKKSTVKKDLAKAQEILDKDHYGLERVKERIVEYLAVQSRLNKLKGPILCLVGPP
HCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
GVGKTSLGQSIANATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGSLMMKMAKVGVKNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHEECCCCHHHHHHHHHHCCCCC
LFLLDEIDKMAQDMRGDPASALLEVLDPEQNKAFNDHYLEVDYDLSDVMFVATSNSMNIP
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCC
PALLDRMEVIRLSGYTEDEKMHIARDHLIAKQQENNGLKAGELTIEDSAILSIIRYYTRE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEECEEEECHHHHHHHHHHHHHH
AGVRSLEREIAKICRKAVKTLVLDKKVKSITVTEDNIADYLGVKRFDYGKMDSQNRVGEV
HHHHHHHHHHHHHHHHHHHHHHHHCHHCEEEEECHHHHHHHCCCCCCCCCCCCCCCCCHH
TGLAWTEVGGDLLTIETTSVGGKGKFSFTGSLGDVMKESIQAAMMVVRARSAQLGIADDF
CCEEHHHCCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
YEKRDIHVHVPDGATPKDGPSAGIAMCTALISSLTGNPVRKEVAMTGEISLRGKVLPIGG
HCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEEECEEEECCEEEECCC
LKEKLLAAHRGGITTVIIPKDNEKDLEEIPENAKAALAIHSVETIDEVLAIALENPPMGI
HHHHHHHHHCCCEEEEEEECCCCHHHHHCCCCHHHHEEHHHHHHHHHHHHHHCCCCCCCE
EVISPKSQTIKVKKTRSKAAIQ
EEECCCCCEEEEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]