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The map label for this gene is corC [H]

Identifier: 126207856

GI number: 126207856

Start: 421313

End: 422206

Strand: Reverse

Name: corC [H]

Synonym: APL_0372

Alternate gene names: 126207856

Gene position: 422206-421313 (Counterclockwise)

Preceding gene: 126207860

Following gene: 126207855

Centisome position: 18.56

GC content: 43.62

Gene sequence:

>894_bases
ATGAGTGATGAACAACAGAGCGTCAATACGCAACAGGATAAAAAATCGTTTTTACAATCGATTTTCGGCGGCTTATTTCA
ATCCGAACCGAAAAATAGAGAAGACTTGGTTGAAGTAATTCGAGATTCTCTGGATAACGAACTGATCGATAGTGATACCA
AAGATATGATCGAAGGCGTAATGGAGATTTCCGAACTGCGTGTGCGGGATATTATGATACCTCGTCCGCAAATCGTTTAT
ATTGACGCCAATCTTGATCTTACCGCTTGTGTTGATTTAATCATTGAATCCGCTCACTCTCGCTTTCCGGTCATTTTAGA
CGACGGCAAAGATACCGTATTAGGTATTTTACATGCCAAAGATCTCTTAAAATTCCTCAGAACCGATTCCGAAGAGTTTG
AAATGCCAACCATTCTACGCCCTGCAGTGATTGTGCCGGAAAGTAAACGGGTCGATAGAATGTTGAAAGAATTCCGCTCC
GAACGCTTTCATATGGCGCTGGTAGTGGACGAATTCGGTGCGGTATCCGGCTTAGTCACGATTGAAGATATTCTCGAGCA
AATCGTCGGCGATATTGAAGACGAATTCGACGAAGAAGAAATCGAGCCGATTCGCCAGCTTTCTCGCCATACTTATGCGG
TATCGGCACTGACGGATATTGAGAAATTTAACGAAACTTTTGCCACCGATTTTACCGATGAAGAAGTGGATACGGTCGGT
GGTTTAGTGATGCAAGCGTTCGGACATTTACCGAAACGAGGCGAACAAATTCAATTGGAAGGTATCGATTTTAAAGTAAC
TTCCGCCGACAGTCGCCGTCTAATTCAATTACGTGTCACCGTATCGGACGAGCAGCTGGAAAAAATGGAACAGCTGGTCA
GCAACGAAGAATAA

Upstream 100 bases:

>100_bases
AAATAAATTTATTATCAAAGCGATGAATTTGTGATAATTTTCTCTTATATCCAATCAACAGATAAAAATCGGGTAAATAT
TATTTTTAAGAGTAGATACA

Downstream 100 bases:

>100_bases
TGAATAATATATAGGTGAGGTTTTATCCTCACCTTTTGTTTGTGTTATTTCGCTTAATATTAGTTAATCTATCTCTTTAA
AATGAACTTTGTAAAAAATC

Product: magnesium and cobalt efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSDEQQSVNTQQDKKSFLQSIFGGLFQSEPKNREDLVEVIRDSLDNELIDSDTKDMIEGVMEISELRVRDIMIPRPQIVY
IDANLDLTACVDLIIESAHSRFPVILDDGKDTVLGILHAKDLLKFLRTDSEEFEMPTILRPAVIVPESKRVDRMLKEFRS
ERFHMALVVDEFGAVSGLVTIEDILEQIVGDIEDEFDEEEIEPIRQLSRHTYAVSALTDIEKFNETFATDFTDEEVDTVG
GLVMQAFGHLPKRGEQIQLEGIDFKVTSADSRRLIQLRVTVSDEQLEKMEQLVSNEE

Sequences:

>Translated_297_residues
MSDEQQSVNTQQDKKSFLQSIFGGLFQSEPKNREDLVEVIRDSLDNELIDSDTKDMIEGVMEISELRVRDIMIPRPQIVY
IDANLDLTACVDLIIESAHSRFPVILDDGKDTVLGILHAKDLLKFLRTDSEEFEMPTILRPAVIVPESKRVDRMLKEFRS
ERFHMALVVDEFGAVSGLVTIEDILEQIVGDIEDEFDEEEIEPIRQLSRHTYAVSALTDIEKFNETFATDFTDEEVDTVG
GLVMQAFGHLPKRGEQIQLEGIDFKVTSADSRRLIQLRVTVSDEQLEKMEQLVSNEE
>Mature_296_residues
SDEQQSVNTQQDKKSFLQSIFGGLFQSEPKNREDLVEVIRDSLDNELIDSDTKDMIEGVMEISELRVRDIMIPRPQIVYI
DANLDLTACVDLIIESAHSRFPVILDDGKDTVLGILHAKDLLKFLRTDSEEFEMPTILRPAVIVPESKRVDRMLKEFRSE
RFHMALVVDEFGAVSGLVTIEDILEQIVGDIEDEFDEEEIEPIRQLSRHTYAVSALTDIEKFNETFATDFTDEEVDTVGG
LVMQAFGHLPKRGEQIQLEGIDFKVTSADSRRLIQLRVTVSDEQLEKMEQLVSNEE

Specific function: Plays a role in the transport of magnesium and cobalt ions [H]

COG id: COG4535

COG function: function code P; Putative Mg2+ and Co2+ transporter CorC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=224, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI94681046, Length=182, Percent_Identity=34.0659340659341, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1786879, Length=282, Percent_Identity=63.1205673758865, Blast_Score=342, Evalue=1e-95,
Organism=Escherichia coli, GI145693175, Length=251, Percent_Identity=26.2948207171315, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082033, Length=241, Percent_Identity=27.8008298755187, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788119, Length=229, Percent_Identity=31.4410480349345, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790664, Length=245, Percent_Identity=25.3061224489796, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC [H]

EC number: NA

Molecular weight: Translated: 33894; Mature: 33763

Theoretical pI: Translated: 4.11; Mature: 4.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEQQSVNTQQDKKSFLQSIFGGLFQSEPKNREDLVEVIRDSLDNELIDSDTKDMIEGV
CCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
MEISELRVRDIMIPRPQIVYIDANLDLTACVDLIIESAHSRFPVILDDGKDTVLGILHAK
HHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
DLLKFLRTDSEEFEMPTILRPAVIVPESKRVDRMLKEFRSERFHMALVVDEFGAVSGLVT
HHHHHHHCCCCCCCCCHHHCCCEECCCHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHH
IEDILEQIVGDIEDEFDEEEIEPIRQLSRHTYAVSALTDIEKFNETFATDFTDEEVDTVG
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
GLVMQAFGHLPKRGEQIQLEGIDFKVTSADSRRLIQLRVTVSDEQLEKMEQLVSNEE
HHHHHHHCCCCCCCCEEEEECCEEEEECCCCCEEEEEEEEECHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDEQQSVNTQQDKKSFLQSIFGGLFQSEPKNREDLVEVIRDSLDNELIDSDTKDMIEGV
CCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
MEISELRVRDIMIPRPQIVYIDANLDLTACVDLIIESAHSRFPVILDDGKDTVLGILHAK
HHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
DLLKFLRTDSEEFEMPTILRPAVIVPESKRVDRMLKEFRSERFHMALVVDEFGAVSGLVT
HHHHHHHCCCCCCCCCHHHCCCEECCCHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHH
IEDILEQIVGDIEDEFDEEEIEPIRQLSRHTYAVSALTDIEKFNETFATDFTDEEVDTVG
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
GLVMQAFGHLPKRGEQIQLEGIDFKVTSADSRRLIQLRVTVSDEQLEKMEQLVSNEE
HHHHHHHCCCCCCCCEEEEECCEEEEECCCCCEEEEEEEEECHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]