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The map label for this gene is metC [H]

Identifier: 126207804

GI number: 126207804

Start: 356847

End: 358037

Strand: Reverse

Name: metC [H]

Synonym: APL_0320

Alternate gene names: 126207804

Gene position: 358037-356847 (Counterclockwise)

Preceding gene: 126207805

Following gene: 126207800

Centisome position: 15.74

GC content: 44.75

Gene sequence:

>1191_bases
ATGTCAAACTTATCTCAATTAGAAACTAAATTAGTTCATGCCGGACGTAAATCGCGTTATACCCAAGGTTCTGTTAATCC
TGTCGTGCAACGCGCTTCATCTTTAGTATTTGAATCGGTATCACAAAAAAAGCATGCCACTCGCAACCGCTATAAAGGCG
AATTATTTTACGGCAGACGAGGCACGCTCACCCACTTCGCTCTACAAGACGCGATGTGTGAACTAGAAAGCGGAGCCGGT
TGTTATCTTTATCCGTGCGGCGCGGCGGCCGTGACTAATTCCATTTTAGCTTTCGTATCACAAGGCGATCACGTATTAAT
GACCGGTGCGGCTTATGAGCCGACCCAAGATTTTTGTAACGTTATCTTAAAAAATATTGGTGTAAGCACTACTTATTACG
ATCCGCTCATCGGTGAAGGCATTCGTGCACTTATTCGGCCGAATACTAAAGTGCTATTTTTAGAATCGCCAAGTTCACTG
ACAATGGAAGTGCCGGATATTCCGACCTTGGTGCGCATTGCTCGTGAAGTCAATCCGAATATGGTGATTATGATTGATAA
TACTTGGGCGGGCGGTGTGTTATTCCCTGCGCTTGAATTCGGGATTGATATTTCGATTCAAGCCGGCACAAAATATTTAG
TCGGCCATTCCGATGTGATGATTGGTACTGCAGTATCTAATGCCCGTTGTTGGGATCAACTGCGTGAACATTCGTATTTA
ATGGGACAAATGGTCGATGCGGATTCAGCTTATACCACGGCGCGAGGCTTACGTACGCTCGGTATTCGATTGAAAGAACA
CCAAGAACGCTCTATTCAAGTGGCGCAATGGCTGGCACAACGTCCGGAAGTGAAAGCGGTCTTCCACCCTGCACTTCCAA
GCTGTCCGGGACACGAATTTTTCAAACGTGATTTTAAAGGGGCAAGCGGTCTGTTTTCATTCGAACTTAACCAAAAGTTA
AACGACGAACAATTAGCTAACTTTTTAGATCATTTCGAATTATTTACCATGGCATATTCTTGGGGCGGTTTTGAATCGCT
CATTCTCGCTAACCAACCGGAAGAAATCGCTCGTATCCGTCCTGCAATCGAAAGAAAACTCAGCGGCACACTGATCCGTA
TTCACGTCGGCTTAGAAGCGGTCGAGGATTTGATTGCCGATTTAGAAAAAAGCTTTTCACGTTTAAAATAA

Upstream 100 bases:

>100_bases
CAGTACCGTAGCGTATTCAGATAATCTTACAAGCGGTCGAATTTTTGCAAAATTTTGCTGAAATCCGACCGCTTTTTTAT
AACTATAATAAGGAAATACA

Downstream 100 bases:

>100_bases
CTTCGCTTAAGTAACAAAAAAATGAATTAGGGTTGCACCTAATTCACTTTTATCTCGTTATTCAGACTAAATGAAATTAA
TCTTCGCCCCACACTTCTTT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSNLSQLETKLVHAGRKSRYTQGSVNPVVQRASSLVFESVSQKKHATRNRYKGELFYGRRGTLTHFALQDAMCELESGAG
CYLYPCGAAAVTNSILAFVSQGDHVLMTGAAYEPTQDFCNVILKNIGVSTTYYDPLIGEGIRALIRPNTKVLFLESPSSL
TMEVPDIPTLVRIAREVNPNMVIMIDNTWAGGVLFPALEFGIDISIQAGTKYLVGHSDVMIGTAVSNARCWDQLREHSYL
MGQMVDADSAYTTARGLRTLGIRLKEHQERSIQVAQWLAQRPEVKAVFHPALPSCPGHEFFKRDFKGASGLFSFELNQKL
NDEQLANFLDHFELFTMAYSWGGFESLILANQPEEIARIRPAIERKLSGTLIRIHVGLEAVEDLIADLEKSFSRLK

Sequences:

>Translated_396_residues
MSNLSQLETKLVHAGRKSRYTQGSVNPVVQRASSLVFESVSQKKHATRNRYKGELFYGRRGTLTHFALQDAMCELESGAG
CYLYPCGAAAVTNSILAFVSQGDHVLMTGAAYEPTQDFCNVILKNIGVSTTYYDPLIGEGIRALIRPNTKVLFLESPSSL
TMEVPDIPTLVRIAREVNPNMVIMIDNTWAGGVLFPALEFGIDISIQAGTKYLVGHSDVMIGTAVSNARCWDQLREHSYL
MGQMVDADSAYTTARGLRTLGIRLKEHQERSIQVAQWLAQRPEVKAVFHPALPSCPGHEFFKRDFKGASGLFSFELNQKL
NDEQLANFLDHFELFTMAYSWGGFESLILANQPEEIARIRPAIERKLSGTLIRIHVGLEAVEDLIADLEKSFSRLK
>Mature_395_residues
SNLSQLETKLVHAGRKSRYTQGSVNPVVQRASSLVFESVSQKKHATRNRYKGELFYGRRGTLTHFALQDAMCELESGAGC
YLYPCGAAAVTNSILAFVSQGDHVLMTGAAYEPTQDFCNVILKNIGVSTTYYDPLIGEGIRALIRPNTKVLFLESPSSLT
MEVPDIPTLVRIAREVNPNMVIMIDNTWAGGVLFPALEFGIDISIQAGTKYLVGHSDVMIGTAVSNARCWDQLREHSYLM
GQMVDADSAYTTARGLRTLGIRLKEHQERSIQVAQWLAQRPEVKAVFHPALPSCPGHEFFKRDFKGASGLFSFELNQKLN
DEQLANFLDHFELFTMAYSWGGFESLILANQPEEIARIRPAIERKLSGTLIRIHVGLEAVEDLIADLEKSFSRLK

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=383, Percent_Identity=28.4595300261097, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI299473759, Length=276, Percent_Identity=31.8840579710145, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI25453487, Length=383, Percent_Identity=25.8485639686684, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1789383, Length=390, Percent_Identity=69.7435897435897, Blast_Score=596, Evalue=1e-172,
Organism=Escherichia coli, GI1790375, Length=390, Percent_Identity=33.0769230769231, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17538055, Length=389, Percent_Identity=31.6195372750643, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17560056, Length=388, Percent_Identity=31.1855670103093, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71980708, Length=385, Percent_Identity=31.4285714285714, Blast_Score=178, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6321170, Length=337, Percent_Identity=41.839762611276, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6319307, Length=403, Percent_Identity=27.7915632754342, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=404, Percent_Identity=26.2376237623762, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323333, Length=360, Percent_Identity=24.1666666666667, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321254, Length=299, Percent_Identity=26.0869565217391, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922554, Length=394, Percent_Identity=30.4568527918782, Blast_Score=189, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44051; Mature: 43920

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLSQLETKLVHAGRKSRYTQGSVNPVVQRASSLVFESVSQKKHATRNRYKGELFYGRR
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GTLTHFALQDAMCELESGAGCYLYPCGAAAVTNSILAFVSQGDHVLMTGAAYEPTQDFCN
CCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
VILKNIGVSTTYYDPLIGEGIRALIRPNTKVLFLESPSSLTMEVPDIPTLVRIAREVNPN
HHHHHCCCCCEECCCHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHCCCC
MVIMIDNTWAGGVLFPALEFGIDISIQAGTKYLVGHSDVMIGTAVSNARCWDQLREHSYL
EEEEEECCCCCCHHHHHHHHCEEEEEECCCEEEECCCCEEEEECCCCHHHHHHHHHHHHH
MGQMVDADSAYTTARGLRTLGIRLKEHQERSIQVAQWLAQRPEVKAVFHPALPSCPGHEF
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHH
FKRDFKGASGLFSFELNQKLNDEQLANFLDHFELFTMAYSWGGFESLILANQPEEIARIR
HHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCHHHHHHH
PAIERKLSGTLIRIHVGLEAVEDLIADLEKSFSRLK
HHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNLSQLETKLVHAGRKSRYTQGSVNPVVQRASSLVFESVSQKKHATRNRYKGELFYGRR
CCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GTLTHFALQDAMCELESGAGCYLYPCGAAAVTNSILAFVSQGDHVLMTGAAYEPTQDFCN
CCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
VILKNIGVSTTYYDPLIGEGIRALIRPNTKVLFLESPSSLTMEVPDIPTLVRIAREVNPN
HHHHHCCCCCEECCCHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHCCCC
MVIMIDNTWAGGVLFPALEFGIDISIQAGTKYLVGHSDVMIGTAVSNARCWDQLREHSYL
EEEEEECCCCCCHHHHHHHHCEEEEEECCCEEEECCCCEEEEECCCCHHHHHHHHHHHHH
MGQMVDADSAYTTARGLRTLGIRLKEHQERSIQVAQWLAQRPEVKAVFHPALPSCPGHEF
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHH
FKRDFKGASGLFSFELNQKLNDEQLANFLDHFELFTMAYSWGGFESLILANQPEEIARIR
HHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCHHHHHHH
PAIERKLSGTLIRIHVGLEAVEDLIADLEKSFSRLK
HHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]