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The map label for this gene is gmk [H]

Identifier: 126207744

GI number: 126207744

Start: 286426

End: 287046

Strand: Direct

Name: gmk [H]

Synonym: APL_0256

Alternate gene names: 126207744

Gene position: 286426-287046 (Clockwise)

Preceding gene: 126207743

Following gene: 126207745

Centisome position: 12.59

GC content: 38.33

Gene sequence:

>621_bases
ATGTTAGGTAATCTTTACATTCTTTCCGCACCAAGCGGTGCCGGTAAATCCTCATTGATTAATGCGTTATTAGCGGATTT
ACCTCGTTCGGAAGTTCAACTTTCTGTTTCGCATACTACGCGTAATCCTCGTCCAGGAGAGGAACATGCGGTACATTATT
ATTTTACTCATCATGCGGAATTCGAATCGTTAATCGAGCAAGGGCATTTTTTAGAATGGGCTGAAGTATTCGGTAATTAT
TACGGTACATCTTTGCCGATGATAGAAAAGAGTTTAGAGAACGGCATTGATGTCTTTTTAGATATCGACTGGCAAGGTGC
ACGTCAAATTCGTAATAAAGTTCCGAATGTAAAGACTATTTTTATTTTACCGCCTTCTCGTGAGGAATTGGAAAAACGTT
TAATCGGAAGAGGTCAAGATTCGGCAGAAACAATCGGTAAAAGAATGGCCGAGGCCGTATCGGAAATGTCTCATTATAAT
GAGTTTGACTATGTGATCGTAAATGATGATTTCCAAACCGCATTAAGTGAGTTAAAAAGTATTTTAACTTCCGAGCGTTT
AAAACAAGCTTCTCAAGCGGTTCGATATGAAAAATTAATTCGCCAATTACTTTCGAAATAA

Upstream 100 bases:

>100_bases
CTCTCGCACGTAAGTAATTCGTGAATAATGGAGAACTGATTAAAAAAATTGGTTCTCCATTTTCAATGGTAACTTTTTCA
TTTAAATAATAAATAATGTT

Downstream 100 bases:

>100_bases
GCGGTCTGAATTGAGAAAAAATTTACCCGAATAAACTATATTTTATTCTAAATCGGCTGAGTTATTCTTTCCCCGATTGA
TAGCAGTTTGTAGGAAACAA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MLGNLYILSAPSGAGKSSLINALLADLPRSEVQLSVSHTTRNPRPGEEHAVHYYFTHHAEFESLIEQGHFLEWAEVFGNY
YGTSLPMIEKSLENGIDVFLDIDWQGARQIRNKVPNVKTIFILPPSREELEKRLIGRGQDSAETIGKRMAEAVSEMSHYN
EFDYVIVNDDFQTALSELKSILTSERLKQASQAVRYEKLIRQLLSK

Sequences:

>Translated_206_residues
MLGNLYILSAPSGAGKSSLINALLADLPRSEVQLSVSHTTRNPRPGEEHAVHYYFTHHAEFESLIEQGHFLEWAEVFGNY
YGTSLPMIEKSLENGIDVFLDIDWQGARQIRNKVPNVKTIFILPPSREELEKRLIGRGQDSAETIGKRMAEAVSEMSHYN
EFDYVIVNDDFQTALSELKSILTSERLKQASQAVRYEKLIRQLLSK
>Mature_206_residues
MLGNLYILSAPSGAGKSSLINALLADLPRSEVQLSVSHTTRNPRPGEEHAVHYYFTHHAEFESLIEQGHFLEWAEVFGNY
YGTSLPMIEKSLENGIDVFLDIDWQGARQIRNKVPNVKTIFILPPSREELEKRLIGRGQDSAETIGKRMAEAVSEMSHYN
EFDYVIVNDDFQTALSELKSILTSERLKQASQAVRYEKLIRQLLSK

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=192, Percent_Identity=42.7083333333333, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI226874833, Length=192, Percent_Identity=42.7083333333333, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI4504221, Length=192, Percent_Identity=42.7083333333333, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI38570142, Length=174, Percent_Identity=31.6091954022989, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI21361598, Length=196, Percent_Identity=28.0612244897959, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI111154074, Length=162, Percent_Identity=30.2469135802469, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI14780902, Length=193, Percent_Identity=29.0155440414508, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI21536464, Length=187, Percent_Identity=28.8770053475936, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=203, Percent_Identity=63.5467980295566, Blast_Score=277, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=40.5555555555556, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=40.5555555555556, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17557440, Length=183, Percent_Identity=28.4153005464481, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=41.8478260869565, Blast_Score=149, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21356141, Length=191, Percent_Identity=40.3141361256544, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI116007136, Length=180, Percent_Identity=28.3333333333333, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI45554481, Length=180, Percent_Identity=28.3333333333333, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI85724806, Length=180, Percent_Identity=28.3333333333333, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24640542, Length=174, Percent_Identity=28.735632183908, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45554489, Length=174, Percent_Identity=28.735632183908, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161077626, Length=174, Percent_Identity=28.735632183908, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23395; Mature: 23395

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGNLYILSAPSGAGKSSLINALLADLPRSEVQLSVSHTTRNPRPGEEHAVHYYFTHHAE
CCCCEEEEECCCCCCHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCEEEEEEECHHH
FESLIEQGHFLEWAEVFGNYYGTSLPMIEKSLENGIDVFLDIDWQGARQIRNKVPNVKTI
HHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCEEE
FILPPSREELEKRLIGRGQDSAETIGKRMAEAVSEMSHYNEFDYVIVNDDFQTALSELKS
EEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
ILTSERLKQASQAVRYEKLIRQLLSK
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLGNLYILSAPSGAGKSSLINALLADLPRSEVQLSVSHTTRNPRPGEEHAVHYYFTHHAE
CCCCEEEEECCCCCCHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCEEEEEEECHHH
FESLIEQGHFLEWAEVFGNYYGTSLPMIEKSLENGIDVFLDIDWQGARQIRNKVPNVKTI
HHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCEEE
FILPPSREELEKRLIGRGQDSAETIGKRMAEAVSEMSHYNEFDYVIVNDDFQTALSELKS
EEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
ILTSERLKQASQAVRYEKLIRQLLSK
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA