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The map label for this gene is gpt

Identifier: 126207743

GI number: 126207743

Start: 285869

End: 286342

Strand: Direct

Name: gpt

Synonym: APL_0255

Alternate gene names: 126207743

Gene position: 285869-286342 (Clockwise)

Preceding gene: 126207741

Following gene: 126207744

Centisome position: 12.57

GC content: 43.25

Gene sequence:

>474_bases
ATGAGTGAAAAATACACAAACGAAAAATATGTTGTAACTTGGGATATGTTCCATATGCACGCCCGTAAATTAGCGGAACG
TCTTTTACCCGCATCACAATGGAAAGGGATTATTGCGGTAAGTCGCGGAGGTTTGTTCCCGGCGGCGGTATTAGCGCGTG
AATTAAGTATCCGTCATGTTGAAACCGTATGTATTTCCAGCTATGACCATGATGAACAAGGCGAATTAAAAGTATTACAC
GCGGCGCAAACAGACGGCGAAGGTTTCATTGTTGTGGACGATTTGGTTGATACCGGTAATACGGCAAAAGAAATTCGCAA
AATGTATCCTAAAGCGAAATTCGTAACCGTATTCGCTAAACCGGCAGGTACACCGTTAGTGGACGATTATGTAATTGATA
TTCCTCAAGAAACGTGGATTGAACAACCTTGGGACTTAGGCATCACATTTGTTCCGCCTCTCGCACGTAAGTAA

Upstream 100 bases:

>100_bases
GAATAATGGAAATGATAGCACGAATGCGCATTTTAGGTTAGAATAACGCAATTTTTTTATTCGGTGCCTTGACACCGCTT
TTTTTTATCTAGGACTTTGT

Downstream 100 bases:

>100_bases
TTCGTGAATAATGGAGAACTGATTAAAAAAATTGGTTCTCCATTTTCAATGGTAACTTTTTCATTTAAATAATAAATAAT
GTTATGTTAGGTAATCTTTA

Product: xanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: Xanthine-guanine phosphoribosyltransferase; XGPRT

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MSEKYTNEKYVVTWDMFHMHARKLAERLLPASQWKGIIAVSRGGLFPAAVLARELSIRHVETVCISSYDHDEQGELKVLH
AAQTDGEGFIVVDDLVDTGNTAKEIRKMYPKAKFVTVFAKPAGTPLVDDYVIDIPQETWIEQPWDLGITFVPPLARK

Sequences:

>Translated_157_residues
MSEKYTNEKYVVTWDMFHMHARKLAERLLPASQWKGIIAVSRGGLFPAAVLARELSIRHVETVCISSYDHDEQGELKVLH
AAQTDGEGFIVVDDLVDTGNTAKEIRKMYPKAKFVTVFAKPAGTPLVDDYVIDIPQETWIEQPWDLGITFVPPLARK
>Mature_156_residues
SEKYTNEKYVVTWDMFHMHARKLAERLLPASQWKGIIAVSRGGLFPAAVLARELSIRHVETVCISSYDHDEQGELKVLHA
AQTDGEGFIVVDDLVDTGNTAKEIRKMYPKAKFVTVFAKPAGTPLVDDYVIDIPQETWIEQPWDLGITFVPPLARK

Specific function: Acts on guanine, xanthine and to a lesser extent hypoxanthine

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily

Homologues:

Organism=Escherichia coli, GI1786433, Length=151, Percent_Identity=75.4966887417219, Blast_Score=251, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XGPT_ACTP2 (A3MYX7)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052968.1
- ProteinModelPortal:   A3MYX7
- SMR:   A3MYX7
- STRING:   A3MYX7
- GeneID:   4848992
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0255
- eggNOG:   COG0503
- HOGENOM:   HBG503428
- OMA:   LVDTFIT
- PhylomeDB:   A3MYX7
- ProtClustDB:   PRK09177
- BioCyc:   APLE416269:APL_0255-MONOMER
- HAMAP:   MF_01903
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.22

Molecular weight: Translated: 17727; Mature: 17595

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 97-97 BINDING 140-140

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKYTNEKYVVTWDMFHMHARKLAERLLPASQWKGIIAVSRGGLFPAAVLARELSIRHV
CCCCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
ETVCISSYDHDEQGELKVLHAAQTDGEGFIVVDDLVDTGNTAKEIRKMYPKAKFVTVFAK
HEEEECCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEC
PAGTPLVDDYVIDIPQETWIEQPWDLGITFVPPLARK
CCCCCCCCCEEEECCHHHHCCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
SEKYTNEKYVVTWDMFHMHARKLAERLLPASQWKGIIAVSRGGLFPAAVLARELSIRHV
CCCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
ETVCISSYDHDEQGELKVLHAAQTDGEGFIVVDDLVDTGNTAKEIRKMYPKAKFVTVFAK
HEEEECCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEC
PAGTPLVDDYVIDIPQETWIEQPWDLGITFVPPLARK
CCCCCCCCCEEEECCHHHHCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA