Click here to switch to the map view.

The map label for this gene is cusC [C]

Identifier: 126207745

GI number: 126207745

Start: 287148

End: 288542

Strand: Direct

Name: cusC [C]

Synonym: APL_0257

Alternate gene names: 126207745

Gene position: 287148-288542 (Clockwise)

Preceding gene: 126207744

Following gene: 126207755

Centisome position: 12.62

GC content: 40.0

Gene sequence:

>1395_bases
ATGAAACTTTCAAAATTAGCTTTAACACTCTCCGTTGTACTTGCCTTATCGGCTTGTTCAACCACAAAATTAAGTGCGGA
CGGTTCGCTTGAACAAGCGCAGGCGACATATCAACAATATGAAGAAATTACCAAACAGTTCCAAATTAATGAGCAATGGT
GGCAAGGTTATAATGACAGCCAGTTAAATTCGTTAGTTGAGCAAGCGATTGCCAATAACTTGGATTTAGCTAAAAGCGCC
ATTGCAGTAAACCGAGCGCTTTATAATGCGAATTTAGTCGGCGCGAATCTAGTACCGACGTTTAGCGGATCAGGTTCTTC
ATCTGCAGCGAAAGGTGTCGGTTCCACATCGAATCAAATTTCAACCGGCATATCGACTATTTCACATACGGCAAGTTTTA
AGTTAAGTTATACGCTTGATTTATGGCAACGTTTGGCTGATGCGGCAAGTGCGGCGGAATGGGAGCATAAAGCTACGGTT
GAAGATTTAAAAGCGACACGTCTTTCATTATTAAATTCGGTCGTTTCTACTTACTACCAAATTGCTTATTATAAAGATGC
CATCGCAGTGATTGAGCGTACCATTAATAATTATCAGCAAATCTCAACGATTTTAAATAATAAATATGCCGCAGGTGCAA
TCGATCGTTTAGCGGTGGAACAAGCTCAGCAGGCAACATTAAACGCGCGTAATAGTTTAATTTCGGAGCGTACCAATCTT
AAAACGGCAGAGCAGACATTGCGTAATTTGTTAAATTTAAAACCGAATCAAGCGTTACCTACTCGTTATCCGAGTATTTT
AGGTGTTAAATTGCAAGGAATCGATTTAAACGTACCGGTATCGGCAATCGCAAATCGCCCGGATGTTGTAGCCCGTTTAA
ACCGTTTACAAAGCGCATTTAAATCGCTTACCGCAACAGAAAAAAGTTGGTTCCCGACAGTTACGCTTGGCGGTTCGATT
TCGGCAAGCGCCTCAAAAGTCGCAAATATTAGCGATAATCCGGTCGGTAACGGTGTGATTTCATTTGATTTACCGTTTTT
AGATTGGAATCGTGTGAAAAATAACGTGAAAATTTCCGAGTCGGATTATATGACGGCGAAATTAAATTATGAACAGACGG
TGACCAGCGCATTAAATGAAATTGATCAGCACTACTACGCTTATCAACAATCACTCAGCAGTTATGCGACCCTACAACAA
GCATACGAGCATGATAAACGTATCAGTAACTATTATAAAAATCGTTATGAACAAGGCGTATCCGAGTTCCGTGAATGGAT
TAGCGCACTAAATACGGAATTAAATTCCCAGCTTTCTATTTTGAATCAGAAATATATGATTCTATCGAATGAAAATACGG
TGTATCAGTCTATGGCGGGTAAATATAGAAGATAG

Upstream 100 bases:

>100_bases
CGGTCTGAATTGAGAAAAAATTTACCCGAATAAACTATATTTTATTCTAAATCGGCTGAGTTATTCTTTCCCCGATTGAT
AGCAGTTTGTAGGAAACAAT

Downstream 100 bases:

>100_bases
TATTGCGCTAACAAAAAAGCACGAAATGAAAGTTTCGTGCTTTTTTACTATTTTTTATTTTGTTCGGCGGCTCGTTTACG
GCGAATTTCTTTCGGATCGG

Product: outer membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MKLSKLALTLSVVLALSACSTTKLSADGSLEQAQATYQQYEEITKQFQINEQWWQGYNDSQLNSLVEQAIANNLDLAKSA
IAVNRALYNANLVGANLVPTFSGSGSSSAAKGVGSTSNQISTGISTISHTASFKLSYTLDLWQRLADAASAAEWEHKATV
EDLKATRLSLLNSVVSTYYQIAYYKDAIAVIERTINNYQQISTILNNKYAAGAIDRLAVEQAQQATLNARNSLISERTNL
KTAEQTLRNLLNLKPNQALPTRYPSILGVKLQGIDLNVPVSAIANRPDVVARLNRLQSAFKSLTATEKSWFPTVTLGGSI
SASASKVANISDNPVGNGVISFDLPFLDWNRVKNNVKISESDYMTAKLNYEQTVTSALNEIDQHYYAYQQSLSSYATLQQ
AYEHDKRISNYYKNRYEQGVSEFREWISALNTELNSQLSILNQKYMILSNENTVYQSMAGKYRR

Sequences:

>Translated_464_residues
MKLSKLALTLSVVLALSACSTTKLSADGSLEQAQATYQQYEEITKQFQINEQWWQGYNDSQLNSLVEQAIANNLDLAKSA
IAVNRALYNANLVGANLVPTFSGSGSSSAAKGVGSTSNQISTGISTISHTASFKLSYTLDLWQRLADAASAAEWEHKATV
EDLKATRLSLLNSVVSTYYQIAYYKDAIAVIERTINNYQQISTILNNKYAAGAIDRLAVEQAQQATLNARNSLISERTNL
KTAEQTLRNLLNLKPNQALPTRYPSILGVKLQGIDLNVPVSAIANRPDVVARLNRLQSAFKSLTATEKSWFPTVTLGGSI
SASASKVANISDNPVGNGVISFDLPFLDWNRVKNNVKISESDYMTAKLNYEQTVTSALNEIDQHYYAYQQSLSSYATLQQ
AYEHDKRISNYYKNRYEQGVSEFREWISALNTELNSQLSILNQKYMILSNENTVYQSMAGKYRR
>Mature_464_residues
MKLSKLALTLSVVLALSACSTTKLSADGSLEQAQATYQQYEEITKQFQINEQWWQGYNDSQLNSLVEQAIANNLDLAKSA
IAVNRALYNANLVGANLVPTFSGSGSSSAAKGVGSTSNQISTGISTISHTASFKLSYTLDLWQRLADAASAAEWEHKATV
EDLKATRLSLLNSVVSTYYQIAYYKDAIAVIERTINNYQQISTILNNKYAAGAIDRLAVEQAQQATLNARNSLISERTNL
KTAEQTLRNLLNLKPNQALPTRYPSILGVKLQGIDLNVPVSAIANRPDVVARLNRLQSAFKSLTATEKSWFPTVTLGGSI
SASASKVANISDNPVGNGVISFDLPFLDWNRVKNNVKISESDYMTAKLNYEQTVTSALNEIDQHYYAYQQSLSSYATLQQ
AYEHDKRISNYYKNRYEQGVSEFREWISALNTELNSQLSILNQKYMILSNENTVYQSMAGKYRR

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Attached To The Outer Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=484, Percent_Identity=26.2396694214876, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51410; Mature: 51410

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSKLALTLSVVLALSACSTTKLSADGSLEQAQATYQQYEEITKQFQINEQWWQGYNDS
CCHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHH
QLNSLVEQAIANNLDLAKSAIAVNRALYNANLVGANLVPTFSGSGSSSAAKGVGSTSNQI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHH
STGISTISHTASFKLSYTLDLWQRLADAASAAEWEHKATVEDLKATRLSLLNSVVSTYYQ
HHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYYKDAIAVIERTINNYQQISTILNNKYAAGAIDRLAVEQAQQATLNARNSLISERTNL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KTAEQTLRNLLNLKPNQALPTRYPSILGVKLQGIDLNVPVSAIANRPDVVARLNRLQSAF
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHH
KSLTATEKSWFPTVTLGGSISASASKVANISDNPVGNGVISFDLPFLDWNRVKNNVKISE
HHHHHCCCCCCCEEEECCCCCCCHHHHCCCCCCCCCCCEEEEECCCCCHHHHCCCEEECC
SDYMTAKLNYEQTVTSALNEIDQHYYAYQQSLSSYATLQQAYEHDKRISNYYKNRYEQGV
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEFREWISALNTELNSQLSILNQKYMILSNENTVYQSMAGKYRR
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCC
>Mature Secondary Structure
MKLSKLALTLSVVLALSACSTTKLSADGSLEQAQATYQQYEEITKQFQINEQWWQGYNDS
CCHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHH
QLNSLVEQAIANNLDLAKSAIAVNRALYNANLVGANLVPTFSGSGSSSAAKGVGSTSNQI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHH
STGISTISHTASFKLSYTLDLWQRLADAASAAEWEHKATVEDLKATRLSLLNSVVSTYYQ
HHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYYKDAIAVIERTINNYQQISTILNNKYAAGAIDRLAVEQAQQATLNARNSLISERTNL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KTAEQTLRNLLNLKPNQALPTRYPSILGVKLQGIDLNVPVSAIANRPDVVARLNRLQSAF
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHH
KSLTATEKSWFPTVTLGGSISASASKVANISDNPVGNGVISFDLPFLDWNRVKNNVKISE
HHHHHCCCCCCCEEEECCCCCCCHHHHCCCCCCCCCCCEEEEECCCCCHHHHCCCEEECC
SDYMTAKLNYEQTVTSALNEIDQHYYAYQQSLSSYATLQQAYEHDKRISNYYKNRYEQGV
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEFREWISALNTELNSQLSILNQKYMILSNENTVYQSMAGKYRR
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]