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The map label for this gene is rnr1 [H]

Identifier: 126207636

GI number: 126207636

Start: 165232

End: 166896

Strand: Direct

Name: rnr1 [H]

Synonym: APL_0148

Alternate gene names: 126207636

Gene position: 165232-166896 (Clockwise)

Preceding gene: 126207635

Following gene: 126207638

Centisome position: 7.26

GC content: 41.02

Gene sequence:

>1665_bases
ATGACTTATTCTAATTCTCGTCCTGATTTTGAATGGCTGAACGAAGACAGCCGCTTATTTTTACAACGTGGTTATTTACT
TGAAGGAACCACCGCATTAGATCGTATCCGTTTTATCGCAGAACACGCCGAACGTAAACTCGGTATTGAAGGCTATGCGG
ATAAATTTTATCACTATATGGGACGCGGTTATTTCTCGCTTTCCTCACCGATTTGGTCAAACTTCGGTTTAGATCGCGGC
TTGCCGATTTCTTGTTTTGGTAGCTATATCGGCGACTCAATCCATGAAATTATGGTGACAACCGCCGAAGTCGGTATGAT
GAGTAAAATCGGCGGCGGTACGTCGGCTTATTTCGGTGATATTCGCCCGCGCGGTTCGGTAATCAGAAATAACGGTAAAT
CGGACGGTTCGTTTAACTTTAGTAAACTATTCGATACCGTTATTGATGTTATTTCTCAAGGTACGTCACGTAAAGGACAA
TTTGCCGGCTATATCGATATCGAACACGGCGATATTGACGAATGGCTAGATATTCATACCGAAGGTAATCCGATCCAATT
AATGTACTACGGCGTATGTGTCGGTCATGATTGGTTGGAGTCAATGAAAGCGGGCGATCCGTATAAACGCCAGCTTTGGG
CGAAATTGTTACAACGTAAAACCGAAACGGGTATTCCGTATTTATTCTTTAAAGATAATGCGAATGCCGGTCGTCCGGAC
GTATATAAAGATAAAAATATGACGGTACACGCTTCGAACTTATGTACCGAAATTATGTTGCCGTCAAGCTCGGACGAAAG
TTTCGTTTGTTGTTTATCTTCAATGAACCTGCTTTATTTTGATGAGTGGAAAGATACCGATGCACCGGAAGTATTAACTT
ACTTCTTAGACGTGGTAATGAGCGAGTTTATCGAGAAAAGTAAAGATATGCCGTTCTTAGAGCGTGCGAATCGCTTTGCG
ACTCGTCACCGCGCGTTAGGTTTGGGCGTATTGGGCTGGCACAGTTATTTACAATCGCATAATATTGCGTTTGACAGCTT
CCAAGCGATGCAGAAAAACAATTTAATCTTTAAAACGCTGCAAGAGAAAACCTTAAAGGCTTCGCAAGAATTAGCGAAAC
GTTTCGGTGAACCGGAACTTTTAAAAGGTTATGGTCGTCGTAATACCACTCTAATGAGTATCGCACCGACTAAATCAAGC
AGTTTTATTTTAGGTAGCGTATCGCCGTCGGTCGAGCCGTTTAAATCTAACTACTATGTAAAAGATTTAGCGAAAATCAA
AACCGTGTATAAAAACCCGTTCTTAGAGAAATTACTTCAGGAAAAAGGTTTGGATACGGAAGAAATTTGGGAATCGATTT
TACATAATGACGGCTCCGTACAGCATTTGGAACAATTAACCGACGAAGAAAAAGAAGTATTTAAAACTTTCTCTGAAATC
AGTCAGTTAAGCGTGATTCAGCAAGCGGCACAACGTCAGAAATATATCGACCAAGGTCAAAGTATTAATATTATGGTTCA
TCCGGCAACACCGGCACGTGATTTAAACCAATTATACTTAACCGCAGAAGAACTCGGTTTAAAATCAATTTATTACCAAT
ACTCAATGAGTGCGGCGCAAGTCTTTAACCGTAACTTATTAAGCTGTTCTAGCTGTGAAGGTTAA

Upstream 100 bases:

>100_bases
ACCGAGTGGTTTGATATTGAAATTCTATCGACGAAAGAAACGGATTTCTTTAACAAACGTAGTACCGATTACAGCAAAAA
AATGAAGCAGATTACCGCAG

Downstream 100 bases:

>100_bases
TTAGAAGCATTAAAAACACCACCGAAAGGTGGTGTTTTTATATCTGTCTTTAGCATTTGGTAACCTGTCGGTTTGCCCGA
TTACAAAAAAGCACGAGTAA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MTYSNSRPDFEWLNEDSRLFLQRGYLLEGTTALDRIRFIAEHAERKLGIEGYADKFYHYMGRGYFSLSSPIWSNFGLDRG
LPISCFGSYIGDSIHEIMVTTAEVGMMSKIGGGTSAYFGDIRPRGSVIRNNGKSDGSFNFSKLFDTVIDVISQGTSRKGQ
FAGYIDIEHGDIDEWLDIHTEGNPIQLMYYGVCVGHDWLESMKAGDPYKRQLWAKLLQRKTETGIPYLFFKDNANAGRPD
VYKDKNMTVHASNLCTEIMLPSSSDESFVCCLSSMNLLYFDEWKDTDAPEVLTYFLDVVMSEFIEKSKDMPFLERANRFA
TRHRALGLGVLGWHSYLQSHNIAFDSFQAMQKNNLIFKTLQEKTLKASQELAKRFGEPELLKGYGRRNTTLMSIAPTKSS
SFILGSVSPSVEPFKSNYYVKDLAKIKTVYKNPFLEKLLQEKGLDTEEIWESILHNDGSVQHLEQLTDEEKEVFKTFSEI
SQLSVIQQAAQRQKYIDQGQSINIMVHPATPARDLNQLYLTAEELGLKSIYYQYSMSAAQVFNRNLLSCSSCEG

Sequences:

>Translated_554_residues
MTYSNSRPDFEWLNEDSRLFLQRGYLLEGTTALDRIRFIAEHAERKLGIEGYADKFYHYMGRGYFSLSSPIWSNFGLDRG
LPISCFGSYIGDSIHEIMVTTAEVGMMSKIGGGTSAYFGDIRPRGSVIRNNGKSDGSFNFSKLFDTVIDVISQGTSRKGQ
FAGYIDIEHGDIDEWLDIHTEGNPIQLMYYGVCVGHDWLESMKAGDPYKRQLWAKLLQRKTETGIPYLFFKDNANAGRPD
VYKDKNMTVHASNLCTEIMLPSSSDESFVCCLSSMNLLYFDEWKDTDAPEVLTYFLDVVMSEFIEKSKDMPFLERANRFA
TRHRALGLGVLGWHSYLQSHNIAFDSFQAMQKNNLIFKTLQEKTLKASQELAKRFGEPELLKGYGRRNTTLMSIAPTKSS
SFILGSVSPSVEPFKSNYYVKDLAKIKTVYKNPFLEKLLQEKGLDTEEIWESILHNDGSVQHLEQLTDEEKEVFKTFSEI
SQLSVIQQAAQRQKYIDQGQSINIMVHPATPARDLNQLYLTAEELGLKSIYYQYSMSAAQVFNRNLLSCSSCEG
>Mature_553_residues
TYSNSRPDFEWLNEDSRLFLQRGYLLEGTTALDRIRFIAEHAERKLGIEGYADKFYHYMGRGYFSLSSPIWSNFGLDRGL
PISCFGSYIGDSIHEIMVTTAEVGMMSKIGGGTSAYFGDIRPRGSVIRNNGKSDGSFNFSKLFDTVIDVISQGTSRKGQF
AGYIDIEHGDIDEWLDIHTEGNPIQLMYYGVCVGHDWLESMKAGDPYKRQLWAKLLQRKTETGIPYLFFKDNANAGRPDV
YKDKNMTVHASNLCTEIMLPSSSDESFVCCLSSMNLLYFDEWKDTDAPEVLTYFLDVVMSEFIEKSKDMPFLERANRFAT
RHRALGLGVLGWHSYLQSHNIAFDSFQAMQKNNLIFKTLQEKTLKASQELAKRFGEPELLKGYGRRNTTLMSIAPTKSSS
FILGSVSPSVEPFKSNYYVKDLAKIKTVYKNPFLEKLLQEKGLDTEEIWESILHNDGSVQHLEQLTDEEKEVFKTFSEIS
QLSVIQQAAQRQKYIDQGQSINIMVHPATPARDLNQLYLTAEELGLKSIYYQYSMSAAQVFNRNLLSCSSCEG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=568, Percent_Identity=30.8098591549296, Blast_Score=191, Evalue=2e-48,
Organism=Escherichia coli, GI1789030, Length=629, Percent_Identity=22.0985691573927, Blast_Score=106, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17555242, Length=609, Percent_Identity=29.8850574712644, Blast_Score=189, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6320914, Length=608, Percent_Identity=28.4539473684211, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322123, Length=620, Percent_Identity=28.3870967741935, Blast_Score=180, Evalue=5e-46,
Organism=Drosophila melanogaster, GI17352481, Length=612, Percent_Identity=27.9411764705882, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 63023; Mature: 62892

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSNSRPDFEWLNEDSRLFLQRGYLLEGTTALDRIRFIAEHAERKLGIEGYADKFYHYM
CCCCCCCCCHHHCCCCHHHHHHCCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GRGYFSLSSPIWSNFGLDRGLPISCFGSYIGDSIHEIMVTTAEVGMMSKIGGGTSAYFGD
CCCCEEECCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC
IRPRGSVIRNNGKSDGSFNFSKLFDTVIDVISQGTSRKGQFAGYIDIEHGDIDEWLDIHT
CCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHEECC
EGNPIQLMYYGVCVGHDWLESMKAGDPYKRQLWAKLLQRKTETGIPYLFFKDNANAGRPD
CCCCEEEEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
VYKDKNMTVHASNLCTEIMLPSSSDESFVCCLSSMNLLYFDEWKDTDAPEVLTYFLDVVM
CCCCCCCEEEHHHHHHHHCCCCCCCCCEEEHHHCCCEEEEECCCCCCHHHHHHHHHHHHH
SEFIEKSKDMPFLERANRFATRHRALGLGVLGWHSYLQSHNIAFDSFQAMQKNNLIFKTL
HHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHH
QEKTLKASQELAKRFGEPELLKGYGRRNTTLMSIAPTKSSSFILGSVSPSVEPFKSNYYV
HHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCHH
KDLAKIKTVYKNPFLEKLLQEKGLDTEEIWESILHNDGSVQHLEQLTDEEKEVFKTFSEI
HHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SQLSVIQQAAQRQKYIDQGQSINIMVHPATPARDLNQLYLTAEELGLKSIYYQYSMSAAQ
HHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
VFNRNLLSCSSCEG
HHHCCCCCCCCCCC
>Mature Secondary Structure 
TYSNSRPDFEWLNEDSRLFLQRGYLLEGTTALDRIRFIAEHAERKLGIEGYADKFYHYM
CCCCCCCCHHHCCCCHHHHHHCCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GRGYFSLSSPIWSNFGLDRGLPISCFGSYIGDSIHEIMVTTAEVGMMSKIGGGTSAYFGD
CCCCEEECCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC
IRPRGSVIRNNGKSDGSFNFSKLFDTVIDVISQGTSRKGQFAGYIDIEHGDIDEWLDIHT
CCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHEECC
EGNPIQLMYYGVCVGHDWLESMKAGDPYKRQLWAKLLQRKTETGIPYLFFKDNANAGRPD
CCCCEEEEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
VYKDKNMTVHASNLCTEIMLPSSSDESFVCCLSSMNLLYFDEWKDTDAPEVLTYFLDVVM
CCCCCCCEEEHHHHHHHHCCCCCCCCCEEEHHHCCCEEEEECCCCCCHHHHHHHHHHHHH
SEFIEKSKDMPFLERANRFATRHRALGLGVLGWHSYLQSHNIAFDSFQAMQKNNLIFKTL
HHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHH
QEKTLKASQELAKRFGEPELLKGYGRRNTTLMSIAPTKSSSFILGSVSPSVEPFKSNYYV
HHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCHH
KDLAKIKTVYKNPFLEKLLQEKGLDTEEIWESILHNDGSVQHLEQLTDEEKEVFKTFSEI
HHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SQLSVIQQAAQRQKYIDQGQSINIMVHPATPARDLNQLYLTAEELGLKSIYYQYSMSAAQ
HHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
VFNRNLLSCSSCEG
HHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]