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The map label for this gene is pyrG [H]

Identifier: 126175329

GI number: 126175329

Start: 3662823

End: 3664460

Strand: Reverse

Name: pyrG [H]

Synonym: Sbal_3128

Alternate gene names: 126175329

Gene position: 3664460-3662823 (Counterclockwise)

Preceding gene: 126175330

Following gene: 126175328

Centisome position: 71.47

GC content: 45.18

Gene sequence:

>1638_bases
ATGACTACAAGGTATATCTTCGTTACTGGTGGCGTTGTTTCATCACTAGGTAAAGGCATTGCAGCAGCATCATTAGCTGC
AATTTTAGAGGCCCGCGGTCTCAATGTAACCATCATGAAACTGGACCCTTACATTAACGTTGATCCGGGTACCATGAGCC
CAACCCAACATGGCGAAGTATTTGTTACTGAAGACGGTGCAGAAACAGATCTCGACTTGGGTCACTACGAGCGTTTCATC
CGTACTAAGATGAATCGTCGTAACAACTTCACTACCGGTCGAATTTACGAAGAAGTATTACGTAAAGAACGTCGTGGCGA
TTATTTGGGCGCAACCATTCAGGTTATCCCACACATCACTAATGCGATTAAAGAAAAAGTATTAGCAGGTGGCGAAGGCC
ATGATGTGGCTATCGTCGAAATCGGCGGTACTGTGGGTGATATCGAATCTTTGCCGTTCCTAGAGTCTATCCGTCAGCTC
GGTGTTGAGCTAGGTCGTGATCGTACTCTGTTCATGCATTTAACCTTAGTGCCTTTCTTGGGTGCTGCTGGCGAAGTGAA
AACTAAGCCAACTCAACACTCAGTGAAAGAGCTGCGTTCTATCGGTATTGCACCAGATGTGTTGGTTTGCCGTGGTGACC
GTGCGATTCCTGCTAATGAAAAAGCCAAAATTTCGCTGTTCTGCAACGTCGAAGAGCGTGCGGTTATTTCATTAAAAGAT
GTTGATAGTATTTATAAAATCCCAGCTTTGTTACGTTCACAAGGTTTGGATGACTTAGTGGTTAAGCGTTTCGGTTTAGA
ATGCCGTGAAGCGGATCTGTCTGAGTGGGAAAATGTGATTTACCAAGAAGCTAATCCAAACGGCGAAGTCGTTATTGGTA
TGGTGGGTAAATACATTGAACTGCCAGATGCCTATAAGTCAGTTAACGAAGCATTAAAACATGCTGGCCTTAAAAACCGC
GTATCTGTGACTATCAAGTATATTGATTCACAAACCGTAGAAGCCAAAGGCGAAGAAGTCTTACAGGGCTTAGACGGTAT
CTTAGTACCAGGCGGTTTTGGCGAGCGTGGTGTTGAAGGTAAGATACTGGCGGCGAAATTTGCCCGTGAAAACAATCTAC
CGTATTTCGGTATTTGTTTAGGTATGCAAGTTGCCCTGATTGAATTTGCGCGTAATGTTGCAGGCATGGCCGATGCACAT
TCAACTGAATTCAATAAAGAAACACCATTCCCAGTCGTGGGTTTGATCACTGAATGGATTGACGAAGAAGGTAACGTCGA
GCAGCGCCATGAAGCGTCTGACTTAGGTGGCACTATGCGTTTAGGCGCTCAATTGTGTCATTTACTCGATGGTTCGAAAG
CGGCTCAAGCCTACAAAGGCAATAGCTGTGTAGAACGTCACCGTCACCGTTATGAAGTGAACAACAAATACAGAGAGCGT
TTAGAACAAGCTGGCATGATCTTCAGCGGTTTGTCTTCTGATCGTAAGCTGGTGGAAATGATCGAATTAAAAGATCACCC
ATGGTTTGTTGCAGGTCAATTCCATCCTGAGTTCACCTCAACTCCGCGCGATGGTCACCCATTGTTCGAAGGGTTTATTG
CTGCGGCAAGTGCGCATCAAAAACGTGATCTGAAGTAA

Upstream 100 bases:

>100_bases
ATTGGTGTTTGTCGAATCGCGCCGCCTTTGGTATACTACTGCCCCGTCCTAGTGCTTTCTTACAAGCACGTATTTTCAAA
CTCATTTTCTCAGGTTCAGC

Downstream 100 bases:

>100_bases
GAATATTTGAGGCCGGACCCGCGACAGTGGGGCCGGCCTTTTGTTACACTCATCAGACTTGAAACATAAGAACTTAATAC
CTCTGGGTATAAACAGTATG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MTTRYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEVFVTEDGAETDLDLGHYERFI
RTKMNRRNNFTTGRIYEEVLRKERRGDYLGATIQVIPHITNAIKEKVLAGGEGHDVAIVEIGGTVGDIESLPFLESIRQL
GVELGRDRTLFMHLTLVPFLGAAGEVKTKPTQHSVKELRSIGIAPDVLVCRGDRAIPANEKAKISLFCNVEERAVISLKD
VDSIYKIPALLRSQGLDDLVVKRFGLECREADLSEWENVIYQEANPNGEVVIGMVGKYIELPDAYKSVNEALKHAGLKNR
VSVTIKYIDSQTVEAKGEEVLQGLDGILVPGGFGERGVEGKILAAKFARENNLPYFGICLGMQVALIEFARNVAGMADAH
STEFNKETPFPVVGLITEWIDEEGNVEQRHEASDLGGTMRLGAQLCHLLDGSKAAQAYKGNSCVERHRHRYEVNNKYRER
LEQAGMIFSGLSSDRKLVEMIELKDHPWFVAGQFHPEFTSTPRDGHPLFEGFIAAASAHQKRDLK

Sequences:

>Translated_545_residues
MTTRYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEVFVTEDGAETDLDLGHYERFI
RTKMNRRNNFTTGRIYEEVLRKERRGDYLGATIQVIPHITNAIKEKVLAGGEGHDVAIVEIGGTVGDIESLPFLESIRQL
GVELGRDRTLFMHLTLVPFLGAAGEVKTKPTQHSVKELRSIGIAPDVLVCRGDRAIPANEKAKISLFCNVEERAVISLKD
VDSIYKIPALLRSQGLDDLVVKRFGLECREADLSEWENVIYQEANPNGEVVIGMVGKYIELPDAYKSVNEALKHAGLKNR
VSVTIKYIDSQTVEAKGEEVLQGLDGILVPGGFGERGVEGKILAAKFARENNLPYFGICLGMQVALIEFARNVAGMADAH
STEFNKETPFPVVGLITEWIDEEGNVEQRHEASDLGGTMRLGAQLCHLLDGSKAAQAYKGNSCVERHRHRYEVNNKYRER
LEQAGMIFSGLSSDRKLVEMIELKDHPWFVAGQFHPEFTSTPRDGHPLFEGFIAAASAHQKRDLK
>Mature_544_residues
TTRYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEVFVTEDGAETDLDLGHYERFIR
TKMNRRNNFTTGRIYEEVLRKERRGDYLGATIQVIPHITNAIKEKVLAGGEGHDVAIVEIGGTVGDIESLPFLESIRQLG
VELGRDRTLFMHLTLVPFLGAAGEVKTKPTQHSVKELRSIGIAPDVLVCRGDRAIPANEKAKISLFCNVEERAVISLKDV
DSIYKIPALLRSQGLDDLVVKRFGLECREADLSEWENVIYQEANPNGEVVIGMVGKYIELPDAYKSVNEALKHAGLKNRV
SVTIKYIDSQTVEAKGEEVLQGLDGILVPGGFGERGVEGKILAAKFARENNLPYFGICLGMQVALIEFARNVAGMADAHS
TEFNKETPFPVVGLITEWIDEEGNVEQRHEASDLGGTMRLGAQLCHLLDGSKAAQAYKGNSCVERHRHRYEVNNKYRERL
EQAGMIFSGLSSDRKLVEMIELKDHPWFVAGQFHPEFTSTPRDGHPLFEGFIAAASAHQKRDLK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=557, Percent_Identity=44.524236983842, Blast_Score=474, Evalue=1e-134,
Organism=Homo sapiens, GI28559085, Length=560, Percent_Identity=43.9285714285714, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI28559083, Length=560, Percent_Identity=43.9285714285714, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI221316689, Length=560, Percent_Identity=43.9285714285714, Blast_Score=462, Evalue=1e-130,
Organism=Escherichia coli, GI1789142, Length=545, Percent_Identity=77.6146788990826, Blast_Score=857, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=611, Percent_Identity=38.1342062193126, Blast_Score=418, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322563, Length=569, Percent_Identity=43.4094903339192, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319432, Length=570, Percent_Identity=41.4035087719298, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24664469, Length=557, Percent_Identity=45.7809694793537, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI21357815, Length=503, Percent_Identity=44.5328031809145, Blast_Score=409, Evalue=1e-114,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 60109; Mature: 59978

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEV
CCEEEEEEECHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEE
FVTEDGAETDLDLGHYERFIRTKMNRRNNFTTGRIYEEVLRKERRGDYLGATIQVIPHIT
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NAIKEKVLAGGEGHDVAIVEIGGTVGDIESLPFLESIRQLGVELGRDRTLFMHLTLVPFL
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHC
GAAGEVKTKPTQHSVKELRSIGIAPDVLVCRGDRAIPANEKAKISLFCNVEERAVISLKD
CCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEEEECCCCEEEEHHH
VDSIYKIPALLRSQGLDDLVVKRFGLECREADLSEWENVIYQEANPNGEVVIGMVGKYIE
HHHHHHHHHHHHHCCCHHHHHHHHCCCHHCCHHHHHHHHHEECCCCCCCEEEEECCCHHC
LPDAYKSVNEALKHAGLKNRVSVTIKYIDSQTVEAKGEEVLQGLDGILVPGGFGERGVEG
CCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHCCHHHHHHCCCCEEECCCCCCCCCCC
KILAAKFARENNLPYFGICLGMQVALIEFARNVAGMADAHSTEFNKETPFPVVGLITEWI
CEEEEEHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
DEEGNVEQRHEASDLGGTMRLGAQLCHLLDGSKAAQAYKGNSCVERHRHRYEVNNKYRER
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCHHHHHH
LEQAGMIFSGLSSDRKLVEMIELKDHPWFVAGQFHPEFTSTPRDGHPLFEGFIAAASAHQ
HHHCCHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
KRDLK
HCCCC
>Mature Secondary Structure 
TTRYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEV
CEEEEEEECHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEE
FVTEDGAETDLDLGHYERFIRTKMNRRNNFTTGRIYEEVLRKERRGDYLGATIQVIPHIT
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NAIKEKVLAGGEGHDVAIVEIGGTVGDIESLPFLESIRQLGVELGRDRTLFMHLTLVPFL
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHC
GAAGEVKTKPTQHSVKELRSIGIAPDVLVCRGDRAIPANEKAKISLFCNVEERAVISLKD
CCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEEEECCCCEEEEHHH
VDSIYKIPALLRSQGLDDLVVKRFGLECREADLSEWENVIYQEANPNGEVVIGMVGKYIE
HHHHHHHHHHHHHCCCHHHHHHHHCCCHHCCHHHHHHHHHEECCCCCCCEEEEECCCHHC
LPDAYKSVNEALKHAGLKNRVSVTIKYIDSQTVEAKGEEVLQGLDGILVPGGFGERGVEG
CCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHCCHHHHHHCCCCEEECCCCCCCCCCC
KILAAKFARENNLPYFGICLGMQVALIEFARNVAGMADAHSTEFNKETPFPVVGLITEWI
CEEEEEHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
DEEGNVEQRHEASDLGGTMRLGAQLCHLLDGSKAAQAYKGNSCVERHRHRYEVNNKYRER
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCHHHHHH
LEQAGMIFSGLSSDRKLVEMIELKDHPWFVAGQFHPEFTSTPRDGHPLFEGFIAAASAHQ
HHHCCHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
KRDLK
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA