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The map label for this gene is mazG [H]

Identifier: 126175330

GI number: 126175330

Start: 3664577

End: 3665473

Strand: Reverse

Name: mazG [H]

Synonym: Sbal_3129

Alternate gene names: 126175330

Gene position: 3665473-3664577 (Counterclockwise)

Preceding gene: 126175333

Following gene: 126175329

Centisome position: 71.49

GC content: 48.94

Gene sequence:

>897_bases
ATGACTTCCCACACTGCGCCATTAACTTCATTTTCGACCTCGGGACTTTCTGTAACTGGCCTTTCTGCTACAGATGTTGA
GCCGCTGCTTAACATTATGGAAAAACTGCGCGACCCACAAACAGGTTGCCCGTGGGACAAAGCGCAAACGTTTCAAACCA
TAGTGCCTTTTACCTTAGAGGAAGCCTATGAGGTTGCCGATACCATAGAGCGCTTAGCCTGGGATGAGTTACCCGATGAA
CTTGGGGATTTATTATTTCAAATCGTATTCTATTGTCAGCTCGGTAAAGAGCAGGGGCTGTTTGATTTTGCCACAGTGAT
AGAGAAAATCAGCGACAAGTTAACCCGCCGTCATCCCCATGTGTTTGGCGAGAAAAATCCGCAAATAGGCGATAGCGCCC
AAGCAATGAAAGCCAATTGGGAGGCGATTAAAGCGACTGAGCGTGAACAAAAGGCGCAGCAAGTGGCGGGTGAAACCCAA
GCTGATACTGTGGTTTCTGCGTTAGACAATATTCCGCGTACCCAACCTGCGCTGTCGCGCTCAATCAAAATTCAGCAAAG
GGTGGCGCGAGTCGGTTTCGATTGGGCCGAACTTGAGCCCGTGGTCGCTAAAATCCACGAAGAAATCGATGAAGTCTTGC
ATGAAGTGAATCAACCCGAGCAAGACCAAGCGAAAGTGCAGTCCGAAATGGGCGACTTGCTATTTGCCGTAGTGAATCTA
GCCCGTCATCTTAAGGTCGATCCAGAGCAAGCGCTGCGCCAAGCCAATCTTAAATTTGAACGCCGTTTTCGCGGTGTAGA
ACAGTTGGCGAGTGAGAGCGGTAAAAGCATGCAAGAGCACACATTAATGGAGCTTGATGCCTATTGGGACCAAGTAAAAG
CGACAGAGACGAGATAA

Upstream 100 bases:

>100_bases
GTTATTATAGCCTTTTACTAACAAGCACTGCTGAGGCGTATTCTTTTTGTTCATCCTCAGCATTAGTCCGTTTAAGTATT
TATCTTTTAAGGATATCAGC

Downstream 100 bases:

>100_bases
ACGGCAAATTATCCCGATTGGTGTTTGTCGAATCGCGCCGCCTTTGGTATACTACTGCCCCGTCCTAGTGCTTTCTTACA
AGCACGTATTTTCAAACTCA

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTSHTAPLTSFSTSGLSVTGLSATDVEPLLNIMEKLRDPQTGCPWDKAQTFQTIVPFTLEEAYEVADTIERLAWDELPDE
LGDLLFQIVFYCQLGKEQGLFDFATVIEKISDKLTRRHPHVFGEKNPQIGDSAQAMKANWEAIKATEREQKAQQVAGETQ
ADTVVSALDNIPRTQPALSRSIKIQQRVARVGFDWAELEPVVAKIHEEIDEVLHEVNQPEQDQAKVQSEMGDLLFAVVNL
ARHLKVDPEQALRQANLKFERRFRGVEQLASESGKSMQEHTLMELDAYWDQVKATETR

Sequences:

>Translated_298_residues
MTSHTAPLTSFSTSGLSVTGLSATDVEPLLNIMEKLRDPQTGCPWDKAQTFQTIVPFTLEEAYEVADTIERLAWDELPDE
LGDLLFQIVFYCQLGKEQGLFDFATVIEKISDKLTRRHPHVFGEKNPQIGDSAQAMKANWEAIKATEREQKAQQVAGETQ
ADTVVSALDNIPRTQPALSRSIKIQQRVARVGFDWAELEPVVAKIHEEIDEVLHEVNQPEQDQAKVQSEMGDLLFAVVNL
ARHLKVDPEQALRQANLKFERRFRGVEQLASESGKSMQEHTLMELDAYWDQVKATETR
>Mature_297_residues
TSHTAPLTSFSTSGLSVTGLSATDVEPLLNIMEKLRDPQTGCPWDKAQTFQTIVPFTLEEAYEVADTIERLAWDELPDEL
GDLLFQIVFYCQLGKEQGLFDFATVIEKISDKLTRRHPHVFGEKNPQIGDSAQAMKANWEAIKATEREQKAQQVAGETQA
DTVVSALDNIPRTQPALSRSIKIQQRVARVGFDWAELEPVVAKIHEEIDEVLHEVNQPEQDQAKVQSEMGDLLFAVVNLA
RHLKVDPEQALRQANLKFERRFRGVEQLASESGKSMQEHTLMELDAYWDQVKATETR

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=271, Percent_Identity=54.2435424354244, Blast_Score=288, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 33629; Mature: 33498

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSHTAPLTSFSTSGLSVTGLSATDVEPLLNIMEKLRDPQTGCPWDKAQTFQTIVPFTLE
CCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
EAYEVADTIERLAWDELPDELGDLLFQIVFYCQLGKEQGLFDFATVIEKISDKLTRRHPH
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
VFGEKNPQIGDSAQAMKANWEAIKATEREQKAQQVAGETQADTVVSALDNIPRTQPALSR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHH
SIKIQQRVARVGFDWAELEPVVAKIHEEIDEVLHEVNQPEQDQAKVQSEMGDLLFAVVNL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ARHLKVDPEQALRQANLKFERRFRGVEQLASESGKSMQEHTLMELDAYWDQVKATETR
HHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSHTAPLTSFSTSGLSVTGLSATDVEPLLNIMEKLRDPQTGCPWDKAQTFQTIVPFTLE
CCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
EAYEVADTIERLAWDELPDELGDLLFQIVFYCQLGKEQGLFDFATVIEKISDKLTRRHPH
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
VFGEKNPQIGDSAQAMKANWEAIKATEREQKAQQVAGETQADTVVSALDNIPRTQPALSR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHH
SIKIQQRVARVGFDWAELEPVVAKIHEEIDEVLHEVNQPEQDQAKVQSEMGDLLFAVVNL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ARHLKVDPEQALRQANLKFERRFRGVEQLASESGKSMQEHTLMELDAYWDQVKATETR
HHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]