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The map label for this gene is csrD [H]

Identifier: 126174474

GI number: 126174474

Start: 2614772

End: 2616676

Strand: Direct

Name: csrD [H]

Synonym: Sbal_2258

Alternate gene names: 126174474

Gene position: 2614772-2616676 (Clockwise)

Preceding gene: 126174472

Following gene: 126174475

Centisome position: 51.0

GC content: 43.99

Gene sequence:

>1905_bases
ATGACCATGTCAAAATCATATCCAGTTTTTTTACTGATTATTTTCTTAGGTCTCTTTGCTTGGGTGTATCAAAGCGAAAA
CAGCCAATTGCAAGTCCAACAGCAGCAAGAACTCGATAGCTTTAAATCTAGCTTAAGCCGCTACCAACAATGGCAGGGTA
ACGGTGTAGAACTCTTTAAAAAACTTTCTGAAAACTACTCATTCCAGTTCTTCCAATATATTGATGATACCGACGGCCAA
CTGAGCCATACCGAAGGAAGCTTAGACAGTCAACATCCCCACCCTTTAGCGAGTCTATTTTCCATCGAGCTCAGCCACAC
ACAAAAATTGGCAGCGGGTCGTTTACAGGTCAAGCTCAGTGCAAACCAAGCGATTGATACTGCAATTAGTAACACTCAAA
AACTCGGTGCCATGTTGCTAGTGACTTACCTTATTTTGCTATTAGTGTTTATTCTATTAATGTCAAAACATAGGGCTGCG
GTACGTTATGCTGCTGATTATATTTCAAAAATACCAGAATTAGGCTTTTCTGCCGTCGCATCATCGAAACTCACAGGCGA
ACTCACCCCTATTGGTATCTCCCTAGAAGAATGTCGCCTGCAACTTAAAGCCCAAATTGATAAGCTCAATCAAGAAAATG
AAAAACTGCATAAAGCTGCCTATCAAGATGCCGTCACAGGTTTTGGTAGTCGCCAACGTTTCACCCAAAAATTAGAAACC
ATTAGTCATCCCGATGTTCCTCAACTTGGGCTGATGGCAATGGTTAAAGCGACCGAGCTGACCCTCATTAATCAAAAACA
AGGCCGTTCTGCGGGTGATGATTATCTTTCCAGTGTGGCCAATTGCATCCGCAAAGCCTGTAGCCAATATGCAGATGCTG
AATGTTTTAGGGTATCGAGTGCCGATTTTGCGGTGTTTATTCCCGATGTCATGCTAAAAGATGCACCGAAATTTTTAGAC
CAGTTAAAAATTTACCTCGATGAATATCAGCAGATGACGAGTGCAGAATCCGTCGCCCATATAGGCTTAGTACCCTATCG
CCAAGGTACCGAAGCGGTAAATTTACTGACAATTGCCGATACCGCGGTCAGCATAGCTCAGACCCTTGGCCCCAATAGCT
ATCACATCCAAGAGAAACTCAATGGGGATGAGCAGTTTGGTGACGATCGTTGGAAGATGGCAATCCATGATTTAGTGACA
CGCCAAGCATTGAAATTCTACCAGCAGCCTATTCAGCCGTGTCGTACCGATGTAGAAGTTTACCGTGAGTTGTTGGCGCG
CTTTTACAATAGCGAAGGTAAGTTCTTGCCCACCACCACAGTGATTGCTATGGCTGAACGTCACGGTATGAGTTCGGAAT
TGGATAAACTGGTCGTGATCAGTGCATTAAAGATACTTAAAGAAAACCCGACTATTACCGGTAACTTTGGTATCAATATC
AGCGCATTTTCAGCCCATCAAGACATGTTTGTCGCTTGGCTGAAAGATATATTAGGTAAGCAAAAATACATAGCCTCGCG
TTTAGTCTTTGAGATCAATGAGTCCGGCATGCAGTCTAACTTAGGGGCGAGTTATAAATTTGTCCGCGAAGTGCACAGTG
TCGGTTCACGAGTGTCGATTGAGCGTTTTGGCATGAGCTTTACCTCCTTCAAATTCTTCAGCGAAGTGCGCCCCGACTTC
ATAAAGCTCGATGGCAGCTACACGTCTAACATCGATGAAGACAGCAACAATAAGTTCTTCGTACGTATGATGGTGGATGT
CGCCAGACGAATTGGCATTCGGGTCATCGCAACCAGTGTCGAACGCCAAGAAGAAAAATTAACCCTCGAAAAACTCTTAG
TCGATGGATTGCAGGGCTATTACATCGCACAACCCCAAGCCATGGCCATTACAGATCAGATTTAA

Upstream 100 bases:

>100_bases
AGAAAAATTTATGAGTCTCATCACACAGATAGCGGTTTTTAAGTATTTTTGACTTAAACTTATCTTGTTCGAACTCACCT
AAATCTAGAGCGGATTTTTT

Downstream 100 bases:

>100_bases
TACTTTAACGGGTTAATTCATCGCCAAAATTTACAGTAAAGATGGTTAACCCTGCATTCTATATGTTGTTTATGCATACG
GAAAAGTCGATAATACGGCC

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MTMSKSYPVFLLIIFLGLFAWVYQSENSQLQVQQQQELDSFKSSLSRYQQWQGNGVELFKKLSENYSFQFFQYIDDTDGQ
LSHTEGSLDSQHPHPLASLFSIELSHTQKLAAGRLQVKLSANQAIDTAISNTQKLGAMLLVTYLILLLVFILLMSKHRAA
VRYAADYISKIPELGFSAVASSKLTGELTPIGISLEECRLQLKAQIDKLNQENEKLHKAAYQDAVTGFGSRQRFTQKLET
ISHPDVPQLGLMAMVKATELTLINQKQGRSAGDDYLSSVANCIRKACSQYADAECFRVSSADFAVFIPDVMLKDAPKFLD
QLKIYLDEYQQMTSAESVAHIGLVPYRQGTEAVNLLTIADTAVSIAQTLGPNSYHIQEKLNGDEQFGDDRWKMAIHDLVT
RQALKFYQQPIQPCRTDVEVYRELLARFYNSEGKFLPTTTVIAMAERHGMSSELDKLVVISALKILKENPTITGNFGINI
SAFSAHQDMFVAWLKDILGKQKYIASRLVFEINESGMQSNLGASYKFVREVHSVGSRVSIERFGMSFTSFKFFSEVRPDF
IKLDGSYTSNIDEDSNNKFFVRMMVDVARRIGIRVIATSVERQEEKLTLEKLLVDGLQGYYIAQPQAMAITDQI

Sequences:

>Translated_634_residues
MTMSKSYPVFLLIIFLGLFAWVYQSENSQLQVQQQQELDSFKSSLSRYQQWQGNGVELFKKLSENYSFQFFQYIDDTDGQ
LSHTEGSLDSQHPHPLASLFSIELSHTQKLAAGRLQVKLSANQAIDTAISNTQKLGAMLLVTYLILLLVFILLMSKHRAA
VRYAADYISKIPELGFSAVASSKLTGELTPIGISLEECRLQLKAQIDKLNQENEKLHKAAYQDAVTGFGSRQRFTQKLET
ISHPDVPQLGLMAMVKATELTLINQKQGRSAGDDYLSSVANCIRKACSQYADAECFRVSSADFAVFIPDVMLKDAPKFLD
QLKIYLDEYQQMTSAESVAHIGLVPYRQGTEAVNLLTIADTAVSIAQTLGPNSYHIQEKLNGDEQFGDDRWKMAIHDLVT
RQALKFYQQPIQPCRTDVEVYRELLARFYNSEGKFLPTTTVIAMAERHGMSSELDKLVVISALKILKENPTITGNFGINI
SAFSAHQDMFVAWLKDILGKQKYIASRLVFEINESGMQSNLGASYKFVREVHSVGSRVSIERFGMSFTSFKFFSEVRPDF
IKLDGSYTSNIDEDSNNKFFVRMMVDVARRIGIRVIATSVERQEEKLTLEKLLVDGLQGYYIAQPQAMAITDQI
>Mature_633_residues
TMSKSYPVFLLIIFLGLFAWVYQSENSQLQVQQQQELDSFKSSLSRYQQWQGNGVELFKKLSENYSFQFFQYIDDTDGQL
SHTEGSLDSQHPHPLASLFSIELSHTQKLAAGRLQVKLSANQAIDTAISNTQKLGAMLLVTYLILLLVFILLMSKHRAAV
RYAADYISKIPELGFSAVASSKLTGELTPIGISLEECRLQLKAQIDKLNQENEKLHKAAYQDAVTGFGSRQRFTQKLETI
SHPDVPQLGLMAMVKATELTLINQKQGRSAGDDYLSSVANCIRKACSQYADAECFRVSSADFAVFIPDVMLKDAPKFLDQ
LKIYLDEYQQMTSAESVAHIGLVPYRQGTEAVNLLTIADTAVSIAQTLGPNSYHIQEKLNGDEQFGDDRWKMAIHDLVTR
QALKFYQQPIQPCRTDVEVYRELLARFYNSEGKFLPTTTVIAMAERHGMSSELDKLVVISALKILKENPTITGNFGINIS
AFSAHQDMFVAWLKDILGKQKYIASRLVFEINESGMQSNLGASYKFVREVHSVGSRVSIERFGMSFTSFKFFSEVRPDFI
KLDGSYTSNIDEDSNNKFFVRMMVDVARRIGIRVIATSVERQEEKLTLEKLLVDGLQGYYIAQPQAMAITDQI

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=419, Percent_Identity=24.8210023866348, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1788849, Length=222, Percent_Identity=29.2792792792793, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI87082096, Length=233, Percent_Identity=28.3261802575107, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87081980, Length=228, Percent_Identity=26.7543859649123, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1787541, Length=421, Percent_Identity=23.5154394299287, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1787055, Length=230, Percent_Identity=26.9565217391304, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788502, Length=207, Percent_Identity=25.6038647342995, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790496, Length=226, Percent_Identity=21.2389380530973, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786507, Length=249, Percent_Identity=24.4979919678715, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87081845, Length=252, Percent_Identity=23.4126984126984, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI87081921, Length=237, Percent_Identity=22.7848101265823, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 71401; Mature: 71269

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMSKSYPVFLLIIFLGLFAWVYQSENSQLQVQQQQELDSFKSSLSRYQQWQGNGVELFK
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
KLSENYSFQFFQYIDDTDGQLSHTEGSLDSQHPHPLASLFSIELSHTQKLAAGRLQVKLS
HHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEC
ANQAIDTAISNTQKLGAMLLVTYLILLLVFILLMSKHRAAVRYAADYISKIPELGFSAVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHH
SSKLTGELTPIGISLEECRLQLKAQIDKLNQENEKLHKAAYQDAVTGFGSRQRFTQKLET
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ISHPDVPQLGLMAMVKATELTLINQKQGRSAGDDYLSSVANCIRKACSQYADAECFRVSS
CCCCCCCHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHEEECC
ADFAVFIPDVMLKDAPKFLDQLKIYLDEYQQMTSAESVAHIGLVPYRQGTEAVNLLTIAD
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHH
TAVSIAQTLGPNSYHIQEKLNGDEQFGDDRWKMAIHDLVTRQALKFYQQPIQPCRTDVEV
HHHHHHHHCCCCCEEHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRELLARFYNSEGKFLPTTTVIAMAERHGMSSELDKLVVISALKILKENPTITGNFGINI
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCCEEE
SAFSAHQDMFVAWLKDILGKQKYIASRLVFEINESGMQSNLGASYKFVREVHSVGSRVSI
EEECCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEH
ERFGMSFTSFKFFSEVRPDFIKLDGSYTSNIDEDSNNKFFVRMMVDVARRIGIRVIATSV
HHHCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHCCCEEEEHHH
ERQEEKLTLEKLLVDGLQGYYIAQPQAMAITDQI
HHHHHHHHHHHHHHHCCCCEEECCCCCEECCCCC
>Mature Secondary Structure 
TMSKSYPVFLLIIFLGLFAWVYQSENSQLQVQQQQELDSFKSSLSRYQQWQGNGVELFK
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
KLSENYSFQFFQYIDDTDGQLSHTEGSLDSQHPHPLASLFSIELSHTQKLAAGRLQVKLS
HHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEC
ANQAIDTAISNTQKLGAMLLVTYLILLLVFILLMSKHRAAVRYAADYISKIPELGFSAVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHH
SSKLTGELTPIGISLEECRLQLKAQIDKLNQENEKLHKAAYQDAVTGFGSRQRFTQKLET
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ISHPDVPQLGLMAMVKATELTLINQKQGRSAGDDYLSSVANCIRKACSQYADAECFRVSS
CCCCCCCHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHEEECC
ADFAVFIPDVMLKDAPKFLDQLKIYLDEYQQMTSAESVAHIGLVPYRQGTEAVNLLTIAD
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHH
TAVSIAQTLGPNSYHIQEKLNGDEQFGDDRWKMAIHDLVTRQALKFYQQPIQPCRTDVEV
HHHHHHHHCCCCCEEHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRELLARFYNSEGKFLPTTTVIAMAERHGMSSELDKLVVISALKILKENPTITGNFGINI
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCCEEE
SAFSAHQDMFVAWLKDILGKQKYIASRLVFEINESGMQSNLGASYKFVREVHSVGSRVSI
EEECCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEH
ERFGMSFTSFKFFSEVRPDFIKLDGSYTSNIDEDSNNKFFVRMMVDVARRIGIRVIATSV
HHHCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHCCCEEEEHHH
ERQEEKLTLEKLLVDGLQGYYIAQPQAMAITDQI
HHHHHHHHHHHHHHHCCCCEEECCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]