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The map label for this gene is aerA [H]

Identifier: 126173799

GI number: 126173799

Start: 1822811

End: 1824103

Strand: Reverse

Name: aerA [H]

Synonym: Sbal_1565

Alternate gene names: 126173799

Gene position: 1824103-1822811 (Counterclockwise)

Preceding gene: 126173800

Following gene: 126173789

Centisome position: 35.58

GC content: 41.53

Gene sequence:

>1293_bases
ATGAGAAAAAAATCTAGCCTGAGTATATTAACTTTATCCTGTTTAACCGCACTTGGAACTGTTTCTTTGTTGGCCGAAGC
GGCTATTCCGAATACTATTCCAAAACTGTCAATGGTAGAACACGCTGCCCCTGATCTTGATTCGCTTAAAAATGATGCGA
TTAACGATCCCTCGTTTATCAGCTCGTTATTCTCCTTGGGACACCATCTTGGATATGCATGGGCTGGCGGTACGGCATCC
CAGTATGTTGGTGAAGACATCGAAGTCAGAAGAGAATCGAGCAACGAATACAGTCTTAAAGCCCGCTATAACGGCAATGA
TCCTTATGAAAGCGGCTACAGAGCGAATGAACGTTTGAAGGTGAATTTACAAAATATCCATTTTGTGACTAATCCTCAAA
GCCTAAAGTTAGGTTCACCTCAAGTTTATGATCGTGAAGCTATTTATACCGCTCCAGTAGTGATTTACAACTGGGGCGAT
ACCGAAGATACCGGTGTAGCCACCCTAAACTATGATTACACCACTAGCTGGGCCAAAACCGATAATTTCTCCTTCTCCGA
GAAAATTGGCGTAACCAATAAATATGAAGTGGGTATTCCAGGAATAGGTGGAGCGAGTTCTGAAATCAGTGCCGAATTTT
CAGCCAGCCAAGGTTGGAGTGAAACCGACGGTAAAAGTACAACGATTTCAAGTCAGGCACAGTACCGAGCAATTATGCCG
CCTCGCAGCAAACGTTATATCTCAATCACTCTGTTTAAACAAAAGGCGGATGTCCCATACACCTCAAGTTTATATATGAT
GTACGATATAAAATATGAGAACTTCTTAAAATGGGGAGGTAATGCGCATATTAATCATCCGACAAATAGACCTAACTTCC
CTTACACCTTTGGCGGAGCGAATGCGAATAATCTCAATGGTCCAGAAGCCTTAGTCGATCAATATCTTCATCAAGATATA
AACGGTTATGGTGTATGGGATTGGCCTGCTGCGATTAGTTCTGCACAGTCAAAAAGTGGCTTTGAGTGGCAATTGGCGAA
TATAGTTAGACAACATGGCGCACCTATCAGCGGTAAATTTACCGCAATCGATTCGAGTCAATTTAATATCGATGCCAGTG
AATCCTATCCGCTAACGGATGAAGATATTGCTAATCGTCCTAAAAGCGCTCAAAAATTAGGACTGAGTCGTAATATTCAA
GTTGCCGTCGGCGAGATCCAAAATAATGATGAAGATGGTTTAATCAAAAAACTGAATATTTCGCAATCAAGTGAAGTCAT
GTTAAACAATTAA

Upstream 100 bases:

>100_bases
TGCCTAGCAGTAATAATTATTTATATGATTTAGGACTACATATAATTGCCATCGACGCTCTCAATGAAAGGACGTATTTT
ATTAAAATAAAGGAACAATC

Downstream 100 bases:

>100_bases
AAACGGTGTTCTTCGGCTCTCAATAATAGCTATGACACGAGTATCAGAGAGATCTAGATACAACTAGCGAATTGCTAGAA
TGTTACTAGCAAATTAGAAA

Product: Aerolysin/hemolysin/leukocidin toxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MRKKSSLSILTLSCLTALGTVSLLAEAAIPNTIPKLSMVEHAAPDLDSLKNDAINDPSFISSLFSLGHHLGYAWAGGTAS
QYVGEDIEVRRESSNEYSLKARYNGNDPYESGYRANERLKVNLQNIHFVTNPQSLKLGSPQVYDREAIYTAPVVIYNWGD
TEDTGVATLNYDYTTSWAKTDNFSFSEKIGVTNKYEVGIPGIGGASSEISAEFSASQGWSETDGKSTTISSQAQYRAIMP
PRSKRYISITLFKQKADVPYTSSLYMMYDIKYENFLKWGGNAHINHPTNRPNFPYTFGGANANNLNGPEALVDQYLHQDI
NGYGVWDWPAAISSAQSKSGFEWQLANIVRQHGAPISGKFTAIDSSQFNIDASESYPLTDEDIANRPKSAQKLGLSRNIQ
VAVGEIQNNDEDGLIKKLNISQSSEVMLNN

Sequences:

>Translated_430_residues
MRKKSSLSILTLSCLTALGTVSLLAEAAIPNTIPKLSMVEHAAPDLDSLKNDAINDPSFISSLFSLGHHLGYAWAGGTAS
QYVGEDIEVRRESSNEYSLKARYNGNDPYESGYRANERLKVNLQNIHFVTNPQSLKLGSPQVYDREAIYTAPVVIYNWGD
TEDTGVATLNYDYTTSWAKTDNFSFSEKIGVTNKYEVGIPGIGGASSEISAEFSASQGWSETDGKSTTISSQAQYRAIMP
PRSKRYISITLFKQKADVPYTSSLYMMYDIKYENFLKWGGNAHINHPTNRPNFPYTFGGANANNLNGPEALVDQYLHQDI
NGYGVWDWPAAISSAQSKSGFEWQLANIVRQHGAPISGKFTAIDSSQFNIDASESYPLTDEDIANRPKSAQKLGLSRNIQ
VAVGEIQNNDEDGLIKKLNISQSSEVMLNN
>Mature_430_residues
MRKKSSLSILTLSCLTALGTVSLLAEAAIPNTIPKLSMVEHAAPDLDSLKNDAINDPSFISSLFSLGHHLGYAWAGGTAS
QYVGEDIEVRRESSNEYSLKARYNGNDPYESGYRANERLKVNLQNIHFVTNPQSLKLGSPQVYDREAIYTAPVVIYNWGD
TEDTGVATLNYDYTTSWAKTDNFSFSEKIGVTNKYEVGIPGIGGASSEISAEFSASQGWSETDGKSTTISSQAQYRAIMP
PRSKRYISITLFKQKADVPYTSSLYMMYDIKYENFLKWGGNAHINHPTNRPNFPYTFGGANANNLNGPEALVDQYLHQDI
NGYGVWDWPAAISSAQSKSGFEWQLANIVRQHGAPISGKFTAIDSSQFNIDASESYPLTDEDIANRPKSAQKLGLSRNIQ
VAVGEIQNNDEDGLIKKLNISQSSEVMLNN

Specific function: Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximatively 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmo

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cell membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerolysin family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005832
- InterPro:   IPR005831
- InterPro:   IPR005830
- InterPro:   IPR005138
- InterPro:   IPR016187 [H]

Pfam domain/function: PF01117 Aerolysin; PF03440 APT [H]

EC number: NA

Molecular weight: Translated: 47368; Mature: 47368

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKSSLSILTLSCLTALGTVSLLAEAAIPNTIPKLSMVEHAAPDLDSLKNDAINDPSFI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHCCCCCHHHH
SSLFSLGHHLGYAWAGGTASQYVGEDIEVRRESSNEYSLKARYNGNDPYESGYRANERLK
HHHHHHHHHHCEEECCCCHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCEEE
VNLQNIHFVTNPQSLKLGSPQVYDREAIYTAPVVIYNWGDTEDTGVATLNYDYTTSWAKT
EEEEEEEEEECCCCEECCCCCCCCCCEEEECCEEEEECCCCCCCCEEEEECCCCCCCCCC
DNFSFSEKIGVTNKYEVGIPGIGGASSEISAEFSASQGWSETDGKSTTISSQAQYRAIMP
CCCCCHHHCCCCCEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCEEECCCCCEEEECC
PRSKRYISITLFKQKADVPYTSSLYMMYDIKYENFLKWGGNAHINHPTNRPNFPYTFGGA
CCCCCEEEEEEEEECCCCCCCCCEEEEEEECHHHHHCCCCCCCCCCCCCCCCCCEEECCC
NANNLNGPEALVDQYLHQDINGYGVWDWPAAISSAQSKSGFEWQLANIVRQHGAPISGKF
CCCCCCCHHHHHHHHHHCCCCCCEEECHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEE
TAIDSSQFNIDASESYPLTDEDIANRPKSAQKLGLSRNIQVAVGEIQNNDEDGLIKKLNI
EEECCCEEEECCCCCCCCCCHHHHCCCCHHHHCCCCCCEEEEEEECCCCCCCCCEEEECC
SQSSEVMLNN
CCCCCEEECC
>Mature Secondary Structure
MRKKSSLSILTLSCLTALGTVSLLAEAAIPNTIPKLSMVEHAAPDLDSLKNDAINDPSFI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHCCCCCHHHH
SSLFSLGHHLGYAWAGGTASQYVGEDIEVRRESSNEYSLKARYNGNDPYESGYRANERLK
HHHHHHHHHHCEEECCCCHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCEEE
VNLQNIHFVTNPQSLKLGSPQVYDREAIYTAPVVIYNWGDTEDTGVATLNYDYTTSWAKT
EEEEEEEEEECCCCEECCCCCCCCCCEEEECCEEEEECCCCCCCCEEEEECCCCCCCCCC
DNFSFSEKIGVTNKYEVGIPGIGGASSEISAEFSASQGWSETDGKSTTISSQAQYRAIMP
CCCCCHHHCCCCCEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCEEECCCCCEEEECC
PRSKRYISITLFKQKADVPYTSSLYMMYDIKYENFLKWGGNAHINHPTNRPNFPYTFGGA
CCCCCEEEEEEEEECCCCCCCCCEEEEEEECHHHHHCCCCCCCCCCCCCCCCCCEEECCC
NANNLNGPEALVDQYLHQDINGYGVWDWPAAISSAQSKSGFEWQLANIVRQHGAPISGKF
CCCCCCCHHHHHHHHHHCCCCCCEEECHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEE
TAIDSSQFNIDASESYPLTDEDIANRPKSAQKLGLSRNIQVAVGEIQNNDEDGLIKKLNI
EEECCCEEEECCCCCCCCCCHHHHCCCCHHHHCCCCCCEEEEEEECCCCCCCCCEEEECC
SQSSEVMLNN
CCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3584074; 3020368; 1382579; 8845373; 12219082; 7510043 [H]