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The map label for this gene is pyrE [H]

Identifier: 125624315

GI number: 125624315

Start: 1483705

End: 1484334

Strand: Reverse

Name: pyrE [H]

Synonym: llmg_1509

Alternate gene names: 125624315

Gene position: 1484334-1483705 (Counterclockwise)

Preceding gene: 125624316

Following gene: 125624314

Centisome position: 58.68

GC content: 40.32

Gene sequence:

>630_bases
ATGTCAATATCAAAAGCCATTGCTGCAGATTTATTAGAAATTAAGGCGGTCAGTCTTTCACCAAGCCAACCTTTTACTTG
GGCCTCAGGAATTAAATCACCAATTTATACTGATAATCGAGTGACATTAGCCTATCCAGAAGTTCGTAGTCAAATCGAAG
GAGCTTTTGCGGAATTGATTAAAACGGAATTTCCAGAAGTTGAAGTGATTGCTGGAACTGCGACAGCCGGTATTCCCCAT
GGAGCGATTATTGCTGACTATCTCAAATTACCATTTGCTTATATCCGTAGTAAACCAAAAGACCATGGGGCTGGTAATCA
AGTTGAAGGTCGTGTGGCTAAAGGGCAAAAAATGGTTGTAGTTGAAGATTTGATTTCCACTGGAGGTTCTGTCTTAGAAG
CGGTCGCGGCCGCAGAACGTGAAGGCGCTGATGTCCTTGGTGTGGTTGCCATTTTCACTTATGAATTAGAAAAAGCGAAC
AGTAAATTTGCTGACGCCGATGTCAAATTGGCGACACTGACAAATTATTCTGAGTTGATTGAAATTGCTAAAGAAACAGG
ATATGTCACCAAAGAAGAACTAGAGTTACTCAAAAAATTCAAAGAAAATCAAGAAACTTGGCAAGCATAA

Upstream 100 bases:

>100_bases
TCTGTCAGTTCAATACGACCAAAGGAAGTCATTGAATCGGTAGCTAAATGAACAATCAGCTTTGCTGATAGTTCTGTCAG
TAAACTATAAAGGAGAAATC

Downstream 100 bases:

>100_bases
TTTACTGATAGAAGTTAAAAAATCTTTGTCAGCGAAGTTGATTGTTTGCTGATAAATATTACTTAGGTACAAAGCTGTCA
GCTTGATTTAACTCACAGAA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSISKAIAADLLEIKAVSLSPSQPFTWASGIKSPIYTDNRVTLAYPEVRSQIEGAFAELIKTEFPEVEVIAGTATAGIPH
GAIIADYLKLPFAYIRSKPKDHGAGNQVEGRVAKGQKMVVVEDLISTGGSVLEAVAAAEREGADVLGVVAIFTYELEKAN
SKFADADVKLATLTNYSELIEIAKETGYVTKEELELLKKFKENQETWQA

Sequences:

>Translated_209_residues
MSISKAIAADLLEIKAVSLSPSQPFTWASGIKSPIYTDNRVTLAYPEVRSQIEGAFAELIKTEFPEVEVIAGTATAGIPH
GAIIADYLKLPFAYIRSKPKDHGAGNQVEGRVAKGQKMVVVEDLISTGGSVLEAVAAAEREGADVLGVVAIFTYELEKAN
SKFADADVKLATLTNYSELIEIAKETGYVTKEELELLKKFKENQETWQA
>Mature_208_residues
SISKAIAADLLEIKAVSLSPSQPFTWASGIKSPIYTDNRVTLAYPEVRSQIEGAFAELIKTEFPEVEVIAGTATAGIPHG
AIIADYLKLPFAYIRSKPKDHGAGNQVEGRVAKGQKMVVVEDLISTGGSVLEAVAAAEREGADVLGVVAIFTYELEKANS
KFADADVKLATLTNYSELIEIAKETGYVTKEELELLKKFKENQETWQA

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=180, Percent_Identity=26.1111111111111, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17554964, Length=172, Percent_Identity=28.4883720930233, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508631, Length=170, Percent_Identity=24.1176470588235, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17933654, Length=196, Percent_Identity=27.5510204081633, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 22592; Mature: 22461

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISKAIAADLLEIKAVSLSPSQPFTWASGIKSPIYTDNRVTLAYPEVRSQIEGAFAELI
CCCHHHHHHHHHHHHEEECCCCCCCCHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
KTEFPEVEVIAGTATAGIPHGAIIADYLKLPFAYIRSKPKDHGAGNQVEGRVAKGQKMVV
HCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEE
VEDLISTGGSVLEAVAAAEREGADVLGVVAIFTYELEKANSKFADADVKLATLTNYSELI
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHH
EIAKETGYVTKEELELLKKFKENQETWQA
HHHHHCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SISKAIAADLLEIKAVSLSPSQPFTWASGIKSPIYTDNRVTLAYPEVRSQIEGAFAELI
CCHHHHHHHHHHHHEEECCCCCCCCHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
KTEFPEVEVIAGTATAGIPHGAIIADYLKLPFAYIRSKPKDHGAGNQVEGRVAKGQKMVV
HCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEE
VEDLISTGGSVLEAVAAAEREGADVLGVVAIFTYELEKANSKFADADVKLATLTNYSELI
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHH
EIAKETGYVTKEELELLKKFKENQETWQA
HHHHHCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]