Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 125624314

GI number: 125624314

Start: 1482282

End: 1483553

Strand: Reverse

Name: pyrC [H]

Synonym: llmg_1508

Alternate gene names: 125624314

Gene position: 1483553-1482282 (Counterclockwise)

Preceding gene: 125624315

Following gene: 125624313

Centisome position: 58.65

GC content: 39.62

Gene sequence:

>1272_bases
ATGACTTTATTAATCAAAAATGGTCGTCTGATTGACCCTAAATCAAATCGTGATGAAATTTTAGATATTTTAATTGAAGA
GAATAAAATAGCTAAAATTGGCACAAACTTATCAGAAGAAAATACTGAAATCATTGACGCAAGCGGTCTAGTGATTGCTC
CTGGATTGATTGACGTTCATGTTCATTTTCGTGAACCAGGACAGACCCATAAAGAAACGATTCATAGTGGCGCAAAATCA
GCGGCGGCGGGCGGTTTTACAACGGTTGTCATGATGGCCAATACGAAACCTATTTTATCTACGCCAAAAGTACTGACAGA
GACTTTAGCAATTGCCAAAAAAGAAGCAATTAAGATTAAAGCAGTTGCATCAATTACGCAAGATTTTGATGGGGAAAACT
TGACAGATTTTGCTGAACTCATCAAAGCAGGGGCAATTGGTTTTTCTGACGATGGTATACCGTTGACAGACGCTGGAGTC
TTGCGGGAAGCCTTACAGAAATCCAAACTAACAGATAGTTTGCTTTCGATTCATGAAGAAGACCCAAATCTAATCGGGAC
ACTTGGAGTTAATGATGGAGAAGTGGCTCATAAATGTGGCTTCACAGGAGCGCCGACCGTTTCAGAATACAGTATGATGG
CGCGTGATACTATGATTGCTTATGAAACAGGCGCACGCTTGCACTTACAGCATCTGTCTGCAGGAGAATCTGTCGAAGTG
GTTCGATTTGCTAAAAATTTGGGCGCGAAAATTACAGCAGAAGTGACACCACAACATTTTTCGATTACAGAACAGATGAT
TTTCGAGCAAGGGACAAATGCGAAACTCAATCCTCCATTGCGTAGAGATGCAGATATCAGTAAAATTATTGCGGGCTTAA
AAGATGGGACAATTGATGTGATTGCGACTGACCATGCCCCTCATACTCATGAAGAAAAAAATGTCAGCATTGATAAAGCC
CCATCAGGAATGATTGGCTTAGAAACTTCATTGCAACTTGGTTTGACGAATTTGGTTGCCAAAGGTCATTTGACTTTGCT
CGAATTACTGACAAAAATGACCCTCAATCCAGCTAAATTATATGATTTTGATGCAGGTTACCTTGCAGAAGCTGGTCCGG
CTGACCTTGTGATATTTGATGCCGAAAATACCTATCAAGTTGGTGAAACTTTTGATTCCAAAGCGACCAACTCACCGTTT
ATCTATCAAAAAGTTCAAGGACAAATTAAATATACAATTTGTGACGGAAATATAGTTTATCAAGCAAAATAA

Upstream 100 bases:

>100_bases
ATAAATATTACTTAGGTACAAAGCTGTCAGCTTGATTTAACTCACAGAAATTATTGAATTGGCAAATGACAGGATTTGTC
AGTAAAATCGAAAGGTGAAA

Downstream 100 bases:

>100_bases
AAGCGCTAAGCGCTTTTTTTGTTATTTTAATGAAAAAAAGATGATTGAAGTTTTTAGAATTGAAATTTGGCTTTTAAGAC
ATTTTGAGGTTGTAAGGCTT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTLLIKNGRLIDPKSNRDEILDILIEENKIAKIGTNLSEENTEIIDASGLVIAPGLIDVHVHFREPGQTHKETIHSGAKS
AAAGGFTTVVMMANTKPILSTPKVLTETLAIAKKEAIKIKAVASITQDFDGENLTDFAELIKAGAIGFSDDGIPLTDAGV
LREALQKSKLTDSLLSIHEEDPNLIGTLGVNDGEVAHKCGFTGAPTVSEYSMMARDTMIAYETGARLHLQHLSAGESVEV
VRFAKNLGAKITAEVTPQHFSITEQMIFEQGTNAKLNPPLRRDADISKIIAGLKDGTIDVIATDHAPHTHEEKNVSIDKA
PSGMIGLETSLQLGLTNLVAKGHLTLLELLTKMTLNPAKLYDFDAGYLAEAGPADLVIFDAENTYQVGETFDSKATNSPF
IYQKVQGQIKYTICDGNIVYQAK

Sequences:

>Translated_423_residues
MTLLIKNGRLIDPKSNRDEILDILIEENKIAKIGTNLSEENTEIIDASGLVIAPGLIDVHVHFREPGQTHKETIHSGAKS
AAAGGFTTVVMMANTKPILSTPKVLTETLAIAKKEAIKIKAVASITQDFDGENLTDFAELIKAGAIGFSDDGIPLTDAGV
LREALQKSKLTDSLLSIHEEDPNLIGTLGVNDGEVAHKCGFTGAPTVSEYSMMARDTMIAYETGARLHLQHLSAGESVEV
VRFAKNLGAKITAEVTPQHFSITEQMIFEQGTNAKLNPPLRRDADISKIIAGLKDGTIDVIATDHAPHTHEEKNVSIDKA
PSGMIGLETSLQLGLTNLVAKGHLTLLELLTKMTLNPAKLYDFDAGYLAEAGPADLVIFDAENTYQVGETFDSKATNSPF
IYQKVQGQIKYTICDGNIVYQAK
>Mature_422_residues
TLLIKNGRLIDPKSNRDEILDILIEENKIAKIGTNLSEENTEIIDASGLVIAPGLIDVHVHFREPGQTHKETIHSGAKSA
AAGGFTTVVMMANTKPILSTPKVLTETLAIAKKEAIKIKAVASITQDFDGENLTDFAELIKAGAIGFSDDGIPLTDAGVL
REALQKSKLTDSLLSIHEEDPNLIGTLGVNDGEVAHKCGFTGAPTVSEYSMMARDTMIAYETGARLHLQHLSAGESVEVV
RFAKNLGAKITAEVTPQHFSITEQMIFEQGTNAKLNPPLRRDADISKIIAGLKDGTIDVIATDHAPHTHEEKNVSIDKAP
SGMIGLETSLQLGLTNLVAKGHLTLLELLTKMTLNPAKLYDFDAGYLAEAGPADLVIFDAENTYQVGETFDSKATNSPFI
YQKVQGQIKYTICDGNIVYQAK

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=392, Percent_Identity=30.8673469387755, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4503051, Length=453, Percent_Identity=23.3995584988962, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI62422571, Length=457, Percent_Identity=23.6323851203501, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786722, Length=437, Percent_Identity=29.2906178489703, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI87082175, Length=439, Percent_Identity=26.879271070615, Blast_Score=129, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI193204318, Length=383, Percent_Identity=28.1984334203655, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI86575075, Length=445, Percent_Identity=25.1685393258427, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=439, Percent_Identity=27.1070615034169, Blast_Score=116, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24642586, Length=393, Percent_Identity=29.2620865139949, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI18859883, Length=419, Percent_Identity=27.2076372315036, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45569; Mature: 45438

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLIKNGRLIDPKSNRDEILDILIEENKIAKIGTNLSEENTEIIDASGLVIAPGLIDVH
CEEEEECCEEECCCCCHHHHHHEEECCCCEEEECCCCCCCCCEEEECCCCEEECCEEEEE
VHFREPGQTHKETIHSGAKSAAAGGFTTVVMMANTKPILSTPKVLTETLAIAKKEAIKIK
EEECCCCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHEEEE
AVASITQDFDGENLTDFAELIKAGAIGFSDDGIPLTDAGVLREALQKSKLTDSLLSIHEE
EHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
DPNLIGTLGVNDGEVAHKCGFTGAPTVSEYSMMARDTMIAYETGARLHLQHLSAGESVEV
CCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHEEEEEECCCEEEEEECCCCCCHHH
VRFAKNLGAKITAEVTPQHFSITEQMIFEQGTNAKLNPPLRRDADISKIIAGLKDGTIDV
HHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEE
IATDHAPHTHEEKNVSIDKAPSGMIGLETSLQLGLTNLVAKGHLTLLELLTKMTLNPAKL
EEECCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHE
YDFDAGYLAEAGPADLVIFDAENTYQVGETFDSKATNSPFIYQKVQGQIKYTICDGNIVY
EECCCCCCCCCCCCCEEEECCCCCEECCCCCCCCCCCCCEEEEEECCEEEEEEECCEEEE
QAK
EEC
>Mature Secondary Structure 
TLLIKNGRLIDPKSNRDEILDILIEENKIAKIGTNLSEENTEIIDASGLVIAPGLIDVH
EEEEECCEEECCCCCHHHHHHEEECCCCEEEECCCCCCCCCEEEECCCCEEECCEEEEE
VHFREPGQTHKETIHSGAKSAAAGGFTTVVMMANTKPILSTPKVLTETLAIAKKEAIKIK
EEECCCCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHEEEE
AVASITQDFDGENLTDFAELIKAGAIGFSDDGIPLTDAGVLREALQKSKLTDSLLSIHEE
EHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
DPNLIGTLGVNDGEVAHKCGFTGAPTVSEYSMMARDTMIAYETGARLHLQHLSAGESVEV
CCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHEEEEEECCCEEEEEECCCCCCHHH
VRFAKNLGAKITAEVTPQHFSITEQMIFEQGTNAKLNPPLRRDADISKIIAGLKDGTIDV
HHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEE
IATDHAPHTHEEKNVSIDKAPSGMIGLETSLQLGLTNLVAKGHLTLLELLTKMTLNPAKL
EEECCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHE
YDFDAGYLAEAGPADLVIFDAENTYQVGETFDSKATNSPFIYQKVQGQIKYTICDGNIVY
EECCCCCCCCCCCCCEEEECCCCCEECCCCCCCCCCCCCEEEEEECCEEEEEEECCEEEE
QAK
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]