Click here to switch to the map view.

The map label for this gene is gcp

Identifier: 124485477

GI number: 124485477

Start: 625013

End: 626590

Strand: Reverse

Name: gcp

Synonym: Mlab_0653

Alternate gene names: 124485477

Gene position: 626590-625013 (Counterclockwise)

Preceding gene: 124485478

Following gene: 124485476

Centisome position: 34.71

GC content: 56.91

Gene sequence:

>1578_bases
ATGCCCGAAAAAAGGGTCCTCGGCATTGAAGGAACTGCATGGAACTTCAGTGCCGCTGTTTTTGCAGAAGATTTAGTTTG
TCTTCACTCTGCACCGTATGTTCCGCCAACCGGCGGTATTCACCCGCGTGAAGCTGCCCAGCATCATGCGTCTGTTGCGT
CGGATGTTATCAGAAAAGCTCTGGATGAAGCGGGAGAGAAAATCGACGCCGTTGCTTTTTCCATTGGCCCGGGTCTTGGC
CCCTCGCTTCGAATCGCGGCTACGACAGCCCGCACTCTTGCGCTGAAGCTTGGCGTCCCGCTTATCGGCGTGAATCACTG
TGTGGCCCATGTCGAGATCGGCAGATGGTACACAAAATTCGCCGACCCTATCGTGCTCTACGCATCGGGTGCAAACACCC
AGGTCCTTGGCTTTCTGAACGGAAAGTACCGGATCTTCGGCGAGACGCTGGATATCGGACTCGGCAACGCACTCGACAAA
TTCGCGCGGAGTCATAACCTCCCCCACCCAGGCGGCCCCATCATCGAAAAGATGGCGAAGGACGGATCTTATATTCACCT
TCCCTACACGGTGAAAGGCATGGACCTTGCATTCTCCGGCTTGATGAGTGCCGCAAAGGAAGCGACCCAGCGGGGCGAAT
CCATGGAAGATGTCTGCTTCAGTTTCCAGGAAACGGCCTTTGCCATGTGTGTGGAAGTGACCGAACGGGCCCTTGCCCAC
ACAGGAAAGGATGAGGTCATTTTAGTCGGCGGCGTCGGGGCAAACGCACGCCTCCAGGAGATGCTCGCAAAAATGTGCGA
GGAACGCGGAGCGAAGTTCATGGCTCCCCCAAGAGTCTATATGGGTGACAACGGCGCGATGATCGCCTACACCGGAAAGA
TCATGCTCGAAGCCGGATCCACGATCCCGATTGCTGAATCCGTGGTGAATCCCGGATTCAGATCCGATCAGGTCGAGGTG
ACCTGGCGGCACGATGCCGGCCAGCTCTTCGCTCCCGGCCAATCGGAAACTGCCGAGCGCGGTGCGGAGGCTTCGGTCAA
TCTCACGGACAAGGACGTGGTGAAAACCCGTCTTGCCAAAGGATACCGGGTACCCGAACTCGACCGGCATCTCATTGCCG
AACGAACCCGGGCCGAAGCCCGTGCGATTTCAGCAGCGAGACGCGGCGGCGTGCCGGTTCCGGTGATCCGCGATGTGACC
GATCACGAGATCGTGATGGAAAAACTCGATGGTGATGTTCTCAAGTACGTCATGAACGAAGAGTACGCCAAAGGTGCGGG
GCTCACGGTTGGTAAACTCCACAAGGCGGGGATAACGCACGGAGACCTCACGACCTCGAACATGATCTGGCATAACGACC
GCGTGTATCTGATCGACTTTGGTCTCTCGCAGATGACGGAAGAGATCGAACCGCGCGGCGTCGATCTGCACGTTCTCTTC
CAGACGCTGGAAAGCACGACCGAAAATCCGGAGACGCTCAAATCCGCATTCATCAATGGATACTGCGCGGCGTTTTCCGA
AGCCGAAAACGTGATCCGGCGCGAACACGAGATCGAACTGCGCGGGAGATACTTATGA

Upstream 100 bases:

>100_bases
CCCGCGCTGCGGAGCCGGTGTCTTCATGGGCGAACACAAAGACCGGTTTTCCTGCGGAAAGTGCGGATACACCGAGTTTA
AGCAATAAAATATTTTATCT

Downstream 100 bases:

>100_bases
TCACCGTTGTTACCGGAAATAAAAACAAAGCCGCGGAGGTCGCCGCATTCTTTGACGGGATCGCGGAAGTGTCCCACATC
GCCTTCGACTGCATCGAGCC

Product: O-sialoglycoprotein endopeptidase/protein kinase

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MPEKRVLGIEGTAWNFSAAVFAEDLVCLHSAPYVPPTGGIHPREAAQHHASVASDVIRKALDEAGEKIDAVAFSIGPGLG
PSLRIAATTARTLALKLGVPLIGVNHCVAHVEIGRWYTKFADPIVLYASGANTQVLGFLNGKYRIFGETLDIGLGNALDK
FARSHNLPHPGGPIIEKMAKDGSYIHLPYTVKGMDLAFSGLMSAAKEATQRGESMEDVCFSFQETAFAMCVEVTERALAH
TGKDEVILVGGVGANARLQEMLAKMCEERGAKFMAPPRVYMGDNGAMIAYTGKIMLEAGSTIPIAESVVNPGFRSDQVEV
TWRHDAGQLFAPGQSETAERGAEASVNLTDKDVVKTRLAKGYRVPELDRHLIAERTRAEARAISAARRGGVPVPVIRDVT
DHEIVMEKLDGDVLKYVMNEEYAKGAGLTVGKLHKAGITHGDLTTSNMIWHNDRVYLIDFGLSQMTEEIEPRGVDLHVLF
QTLESTTENPETLKSAFINGYCAAFSEAENVIRREHEIELRGRYL

Sequences:

>Translated_525_residues
MPEKRVLGIEGTAWNFSAAVFAEDLVCLHSAPYVPPTGGIHPREAAQHHASVASDVIRKALDEAGEKIDAVAFSIGPGLG
PSLRIAATTARTLALKLGVPLIGVNHCVAHVEIGRWYTKFADPIVLYASGANTQVLGFLNGKYRIFGETLDIGLGNALDK
FARSHNLPHPGGPIIEKMAKDGSYIHLPYTVKGMDLAFSGLMSAAKEATQRGESMEDVCFSFQETAFAMCVEVTERALAH
TGKDEVILVGGVGANARLQEMLAKMCEERGAKFMAPPRVYMGDNGAMIAYTGKIMLEAGSTIPIAESVVNPGFRSDQVEV
TWRHDAGQLFAPGQSETAERGAEASVNLTDKDVVKTRLAKGYRVPELDRHLIAERTRAEARAISAARRGGVPVPVIRDVT
DHEIVMEKLDGDVLKYVMNEEYAKGAGLTVGKLHKAGITHGDLTTSNMIWHNDRVYLIDFGLSQMTEEIEPRGVDLHVLF
QTLESTTENPETLKSAFINGYCAAFSEAENVIRREHEIELRGRYL
>Mature_524_residues
PEKRVLGIEGTAWNFSAAVFAEDLVCLHSAPYVPPTGGIHPREAAQHHASVASDVIRKALDEAGEKIDAVAFSIGPGLGP
SLRIAATTARTLALKLGVPLIGVNHCVAHVEIGRWYTKFADPIVLYASGANTQVLGFLNGKYRIFGETLDIGLGNALDKF
ARSHNLPHPGGPIIEKMAKDGSYIHLPYTVKGMDLAFSGLMSAAKEATQRGESMEDVCFSFQETAFAMCVEVTERALAHT
GKDEVILVGGVGANARLQEMLAKMCEERGAKFMAPPRVYMGDNGAMIAYTGKIMLEAGSTIPIAESVVNPGFRSDQVEVT
WRHDAGQLFAPGQSETAERGAEASVNLTDKDVVKTRLAKGYRVPELDRHLIAERTRAEARAISAARRGGVPVPVIRDVTD
HEIVMEKLDGDVLKYVMNEEYAKGAGLTVGKLHKAGITHGDLTTSNMIWHNDRVYLIDFGLSQMTEEIEPRGVDLHVLFQ
TLESTTENPETLKSAFINGYCAAFSEAENVIRREHEIELRGRYL

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain

Homologues:

Organism=Homo sapiens, GI8923380, Length=332, Percent_Identity=48.7951807228916, Blast_Score=298, Evalue=6e-81,
Organism=Homo sapiens, GI41327715, Length=190, Percent_Identity=36.8421052631579, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI116812636, Length=340, Percent_Identity=30.2941176470588, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1789445, Length=325, Percent_Identity=33.8461538461538, Blast_Score=145, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71995670, Length=333, Percent_Identity=44.7447447447448, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17557464, Length=327, Percent_Identity=25.0764525993884, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322891, Length=334, Percent_Identity=41.9161676646707, Blast_Score=263, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6320099, Length=335, Percent_Identity=26.2686567164179, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21357207, Length=344, Percent_Identity=45.0581395348837, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24658177, Length=215, Percent_Identity=32.093023255814, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI20129063, Length=297, Percent_Identity=26.5993265993266, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_METLZ (A2SR70)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030093.1
- ProteinModelPortal:   A2SR70
- SMR:   A2SR70
- STRING:   A2SR70
- MEROPS:   M22.003
- GeneID:   4795757
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_0653
- eggNOG:   arNOG04080
- HOGENOM:   HBG304663
- OMA:   GNCLDQF
- PhylomeDB:   A2SR70
- ProtClustDB:   PRK09605
- BioCyc:   MLAB410358:MLAB_0653-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01447
- InterPro:   IPR022449
- InterPro:   IPR022495
- InterPro:   IPR011009
- InterPro:   IPR009220
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- InterPro:   IPR018934
- PANTHER:   PTHR11735
- PIRSF:   PIRSF036401
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03724
- TIGRFAMs:   TIGR03722
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22; PF01163 RIO1; SSF56112 Kinase_like

EC number: =3.4.24.57

Molecular weight: Translated: 57080; Mature: 56949

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS01016 GLYCOPROTEASE; PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEKRVLGIEGTAWNFSAAVFAEDLVCLHSAPYVPPTGGIHPREAAQHHASVASDVIRKA
CCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LDEAGEKIDAVAFSIGPGLGPSLRIAATTARTLALKLGVPLIGVNHCVAHVEIGRWYTKF
HHHHCCCEEEEEEECCCCCCCCEEEEEHHHHHEEEECCCCEEEHHHHEEEEEHHHHHHHH
ADPIVLYASGANTQVLGFLNGKYRIFGETLDIGLGNALDKFARSHNLPHPGGPIIEKMAK
CCCEEEEECCCCEEEEEEECCEEEEEECEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHC
DGSYIHLPYTVKGMDLAFSGLMSAAKEATQRGESMEDVCFSFQETAFAMCVEVTERALAH
CCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TGKDEVILVGGVGANARLQEMLAKMCEERGAKFMAPPRVYMGDNGAMIAYTGKIMLEAGS
CCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEECCCCEEEECCCCEEEEEEEEEEEECCC
TIPIAESVVNPGFRSDQVEVTWRHDAGQLFAPGQSETAERGAEASVNLTDKDVVKTRLAK
CCCCHHHHCCCCCCCCEEEEEEECCCCCEECCCCCHHHHCCCCCEECCCHHHHHHHHHHC
GYRVPELDRHLIAERTRAEARAISAARRGGVPVPVIRDVTDHEIVMEKLDGDVLKYVMNE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHH
EYAKGAGLTVGKLHKAGITHGDLTTSNMIWHNDRVYLIDFGLSQMTEEIEPRGVDLHVLF
HHCCCCCCCHHHHHHCCCCCCCCCCCCEEEECCEEEEEECCHHHHHHHHCCCCCCHHHHH
QTLESTTENPETLKSAFINGYCAAFSEAENVIRREHEIELRGRYL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PEKRVLGIEGTAWNFSAAVFAEDLVCLHSAPYVPPTGGIHPREAAQHHASVASDVIRKA
CCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LDEAGEKIDAVAFSIGPGLGPSLRIAATTARTLALKLGVPLIGVNHCVAHVEIGRWYTKF
HHHHCCCEEEEEEECCCCCCCCEEEEEHHHHHEEEECCCCEEEHHHHEEEEEHHHHHHHH
ADPIVLYASGANTQVLGFLNGKYRIFGETLDIGLGNALDKFARSHNLPHPGGPIIEKMAK
CCCEEEEECCCCEEEEEEECCEEEEEECEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHC
DGSYIHLPYTVKGMDLAFSGLMSAAKEATQRGESMEDVCFSFQETAFAMCVEVTERALAH
CCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TGKDEVILVGGVGANARLQEMLAKMCEERGAKFMAPPRVYMGDNGAMIAYTGKIMLEAGS
CCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEECCCCEEEECCCCEEEEEEEEEEEECCC
TIPIAESVVNPGFRSDQVEVTWRHDAGQLFAPGQSETAERGAEASVNLTDKDVVKTRLAK
CCCCHHHHCCCCCCCCEEEEEEECCCCCEECCCCCHHHHCCCCCEECCCHHHHHHHHHHC
GYRVPELDRHLIAERTRAEARAISAARRGGVPVPVIRDVTDHEIVMEKLDGDVLKYVMNE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHH
EYAKGAGLTVGKLHKAGITHGDLTTSNMIWHNDRVYLIDFGLSQMTEEIEPRGVDLHVLF
HHCCCCCCCHHHHHHCCCCCCCCCCCCEEEECCEEEEEECCHHHHHHHHCCCCCCHHHHH
QTLESTTENPETLKSAFINGYCAAFSEAENVIRREHEIELRGRYL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA