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The map label for this gene is glmU

Identifier: 124265750

GI number: 124265750

Start: 588953

End: 590335

Strand: Direct

Name: glmU

Synonym: Mpe_A0557

Alternate gene names: 124265750

Gene position: 588953-590335 (Clockwise)

Preceding gene: 124265748

Following gene: 124265751

Centisome position: 14.56

GC content: 70.93

Gene sequence:

>1383_bases
ATGCTGGACATCGTGATCATGGCCGCCGGCAAGGGCACCCGCATGAAGTCGAGTCGGCCCAAGGTGCTGCACACCCTGGC
CGGGCGAGCCTTATTGCAGCACGTGCTGGCCACGGCCGCCGGTCTGGGGGCGCAAAGACTCATCACGATCACGGGTCATG
GCGCCGAGCAGGTGGAGGCGGCCATGCGCTCGGCCTTTCCCGCGGCGCCGCTCGCCTTCGTGCGGCAGGAGCCGCAGCTC
GGCACCGGGCACGCCGTGCAGCAGGCGGTGCCGCTGCTCGACGATGCCGGCACCACCCTGATCCTCAACGGCGACACGCC
GCTGATCGAGGCGTCGACGGCGCGTGCGCTGGTCGATGCCTGCGACGGCACACGGCTCGCGCTGCTGACCATCGACCTGG
CCGACCCCACCGGCTACGGCCGCATCCTCCGTGACGGCGACGGGCGGGGCGAGAAGCTGCTCGGCATCGTCGAGCACAAG
GACGCCAGCGCGGAACAGCGCGCCGTCCGCGAGGTCTACACCGGCATGATGGCCGCGCCCACCGCGCTGCTGAAGCGCTG
GCTCGCGTGCCTGTCCAACGACAACGCCCAGCGCGAGTACTACCTGACCGACGTGGTCGCGATGGCCGTTGCCGACGGCG
TGGCGGTGGTCGCTGCGCAGCCCGCCAGCGAGACCGAGGTGCTGGGCGTCAACAGCCCGCTGCAGTTGGCGGATCTGGAG
CGCCGTCTGCAGCGCAAGCAGGCCGAGGCACTGCTCGAGGCCGGCGTGCGGCTGGCCGACCCGGCGCGCTTCGACCTGCG
CGGCACCTTGGGCTGCGGCAGCGATGTCGAGATCGACGTCAACTGCGTCTTCGAAGGTCGGGTCGAACTCGGCGACGGCG
TGCGCATCGGGGCCCACTGCGTGATCCGCGACGCGCGCATCGCCGCGGGTGCGGTGATCCATCCGTTCACGCACATCGAC
GGTGCCGAGGTCGGTGCGGGCGCGCTGGTCGGGCCGTTCGCACGCCTGCGGCCGGGCGCCGAGCTGGGCGCCGAGGTGCA
CATCGGCAACTTCGTCGAAGTCAAGAATTCCACGCTCGCGCGCGGCGCCAAGGCCAACCACCTGGCCTACCTGGGGGATG
CGACGGTCGGCGAACGCGTGAACTACGGCGCCGGCAGCATCACCGCCAACTACGACGGCGCGAACAAGCACCGCACCGTG
ATCGGCGACGACGTGCATGTGGGCAGCAACTGCGTGCTCGTTGCACCGGTCACGCTGGGCGCGGGCGCCACGATCGGCGG
CGGCAGCACGATCAGCAAGGACGTGCCGGCTGGGCAACTGGGTGTGGCCCGGGCGCGGCAGACCGTGATCGCAGGCTGGC
AACGGCCGCAGAAAAAACGCTAG

Upstream 100 bases:

>100_bases
GGCCTGCGTGTAAGCCAACCGCAGCGCGCTGCAGCCGCCCAGTGCCAACAGTACACAGGCCGCGATAATTCTCCAACCTC
TCAACCACCTGACCATCAGC

Downstream 100 bases:

>100_bases
CAGTTGTTACGCCGGTAACGGCGGGCCGAGCGGGCGCGTGGCCTTGCGTGGGCACGGTGGGCGCGCCAGCGGCACAGTTG
CAACAGCGGGGCGCAGCCGA

Product: glucosamine-1-phosphate N-acetyltransferase / UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MLDIVIMAAGKGTRMKSSRPKVLHTLAGRALLQHVLATAAGLGAQRLITITGHGAEQVEAAMRSAFPAAPLAFVRQEPQL
GTGHAVQQAVPLLDDAGTTLILNGDTPLIEASTARALVDACDGTRLALLTIDLADPTGYGRILRDGDGRGEKLLGIVEHK
DASAEQRAVREVYTGMMAAPTALLKRWLACLSNDNAQREYYLTDVVAMAVADGVAVVAAQPASETEVLGVNSPLQLADLE
RRLQRKQAEALLEAGVRLADPARFDLRGTLGCGSDVEIDVNCVFEGRVELGDGVRIGAHCVIRDARIAAGAVIHPFTHID
GAEVGAGALVGPFARLRPGAELGAEVHIGNFVEVKNSTLARGAKANHLAYLGDATVGERVNYGAGSITANYDGANKHRTV
IGDDVHVGSNCVLVAPVTLGAGATIGGGSTISKDVPAGQLGVARARQTVIAGWQRPQKKR

Sequences:

>Translated_460_residues
MLDIVIMAAGKGTRMKSSRPKVLHTLAGRALLQHVLATAAGLGAQRLITITGHGAEQVEAAMRSAFPAAPLAFVRQEPQL
GTGHAVQQAVPLLDDAGTTLILNGDTPLIEASTARALVDACDGTRLALLTIDLADPTGYGRILRDGDGRGEKLLGIVEHK
DASAEQRAVREVYTGMMAAPTALLKRWLACLSNDNAQREYYLTDVVAMAVADGVAVVAAQPASETEVLGVNSPLQLADLE
RRLQRKQAEALLEAGVRLADPARFDLRGTLGCGSDVEIDVNCVFEGRVELGDGVRIGAHCVIRDARIAAGAVIHPFTHID
GAEVGAGALVGPFARLRPGAELGAEVHIGNFVEVKNSTLARGAKANHLAYLGDATVGERVNYGAGSITANYDGANKHRTV
IGDDVHVGSNCVLVAPVTLGAGATIGGGSTISKDVPAGQLGVARARQTVIAGWQRPQKKR
>Mature_460_residues
MLDIVIMAAGKGTRMKSSRPKVLHTLAGRALLQHVLATAAGLGAQRLITITGHGAEQVEAAMRSAFPAAPLAFVRQEPQL
GTGHAVQQAVPLLDDAGTTLILNGDTPLIEASTARALVDACDGTRLALLTIDLADPTGYGRILRDGDGRGEKLLGIVEHK
DASAEQRAVREVYTGMMAAPTALLKRWLACLSNDNAQREYYLTDVVAMAVADGVAVVAAQPASETEVLGVNSPLQLADLE
RRLQRKQAEALLEAGVRLADPARFDLRGTLGCGSDVEIDVNCVFEGRVELGDGVRIGAHCVIRDARIAAGAVIHPFTHID
GAEVGAGALVGPFARLRPGAELGAEVHIGNFVEVKNSTLARGAKANHLAYLGDATVGERVNYGAGSITANYDGANKHRTV
IGDDVHVGSNCVLVAPVTLGAGATIGGGSTISKDVPAGQLGVARARQTVIAGWQRPQKKR

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=459, Percent_Identity=52.9411764705882, Blast_Score=468, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_METPP (A2SD80)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019754.1
- ProteinModelPortal:   A2SD80
- SMR:   A2SD80
- STRING:   A2SD80
- GeneID:   4785243
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0557
- NMPDR:   fig|279263.3.peg.2798
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   A2SD80
- ProtClustDB:   CLSK951126
- BioCyc:   MPET420662:MPE_A0557-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 47959; Mature: 47959

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 367-367 BINDING 76-76 BINDING 140-140 BINDING 158-158 BINDING 391-391 BINDING 409-409 BINDING 427-427 BINDING 444-444

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIVIMAAGKGTRMKSSRPKVLHTLAGRALLQHVLATAAGLGAQRLITITGHGAEQVEA
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
AMRSAFPAAPLAFVRQEPQLGTGHAVQQAVPLLDDAGTTLILNGDTPLIEASTARALVDA
HHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCEEECHHHHHHHHH
CDGTRLALLTIDLADPTGYGRILRDGDGRGEKLLGIVEHKDASAEQRAVREVYTGMMAAP
CCCCEEEEEEEEECCCCCCCCEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
TALLKRWLACLSNDNAQREYYLTDVVAMAVADGVAVVAAQPASETEVLGVNSPLQLADLE
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCEEEECCCCCHHHHHH
RRLQRKQAEALLEAGVRLADPARFDLRGTLGCGSDVEIDVNCVFEGRVELGDGVRIGAHC
HHHHHHHHHHHHHCCCEECCCCCEEEEEECCCCCCCEEEEEEEEECCEECCCCEEECCEE
VIRDARIAAGAVIHPFTHIDGAEVGAGALVGPFARLRPGAELGAEVHIGNFVEVKNSTLA
EEECCHHHCCEEECCCCCCCCCCCCCCHHHCCHHHCCCCHHCCCEEEECCEEEECCCHHH
RGAKANHLAYLGDATVGERVNYGAGSITANYDGANKHRTVIGDDVHVGSNCVLVAPVTLG
CCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCEEECCCEEEEEEEEEC
AGATIGGGSTISKDVPAGQLGVARARQTVIAGWQRPQKKR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLDIVIMAAGKGTRMKSSRPKVLHTLAGRALLQHVLATAAGLGAQRLITITGHGAEQVEA
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
AMRSAFPAAPLAFVRQEPQLGTGHAVQQAVPLLDDAGTTLILNGDTPLIEASTARALVDA
HHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCEEECHHHHHHHHH
CDGTRLALLTIDLADPTGYGRILRDGDGRGEKLLGIVEHKDASAEQRAVREVYTGMMAAP
CCCCEEEEEEEEECCCCCCCCEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
TALLKRWLACLSNDNAQREYYLTDVVAMAVADGVAVVAAQPASETEVLGVNSPLQLADLE
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCEEEECCCCCHHHHHH
RRLQRKQAEALLEAGVRLADPARFDLRGTLGCGSDVEIDVNCVFEGRVELGDGVRIGAHC
HHHHHHHHHHHHHCCCEECCCCCEEEEEECCCCCCCEEEEEEEEECCEECCCCEEECCEE
VIRDARIAAGAVIHPFTHIDGAEVGAGALVGPFARLRPGAELGAEVHIGNFVEVKNSTLA
EEECCHHHCCEEECCCCCCCCCCCCCCHHHCCHHHCCCCHHCCCEEEECCEEEECCCHHH
RGAKANHLAYLGDATVGERVNYGAGSITANYDGANKHRTVIGDDVHVGSNCVLVAPVTLG
CCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCEEECCCEEEEEEEEEC
AGATIGGGSTISKDVPAGQLGVARARQTVIAGWQRPQKKR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA