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The map label for this gene is tktA [H]

Identifier: 124265452

GI number: 124265452

Start: 279373

End: 281415

Strand: Direct

Name: tktA [H]

Synonym: Mpe_A0259

Alternate gene names: 124265452

Gene position: 279373-281415 (Clockwise)

Preceding gene: 124265448

Following gene: 124265453

Centisome position: 6.91

GC content: 69.26

Gene sequence:

>2043_bases
ATGGCTGCCCTCGAATCCCGCACGCCCGCCACCCCCGACACCTCGCTGATGGCCAACGCGATCCGCGCGCTGGCGATGGA
CGCAGTGCAACAGGCCAATTCGGGCCACCCTGGCGCGCCGATGGGCATGGCCGACATCGCGGTCGCGCTGTGGGGCCGAC
ACCTGCGCCACAACCCGGCCAACCCGGCCTGGGCCGACCGTGATCGCTTCGTGCTGAGCAACGGCCACGGATCGATGCTG
ATCTATGCGCTGCTGCACCTGACCGGGTATGCGCTGCCGCTCGAGGAACTGCGCAACTTCCGCCAGCTTCACAGCAAGAC
GCCGGGCCACCCCGAGGTCGGCATCACGCCCGGCGTCGAGACGACCACCGGCCCGCTGGGGCAGGGCCTCAGCAACGCGG
TCGGCATGGCGCTGGCCGAGAAGCTGCTGGCGGCGGAGTTCAACCGCGACGGCTATGCCATCGTCGATCATCACACCTAT
GTCTTCCTCGGCGACGGCTGCCTGATGGAGGGCATCAGCCACGAGGCCAGCGCGCTGGCGGGCGCCTGGAAGCTCGACAA
GCTGATCGCGCTGTACGACGACAACGGGATCAGCATCGATGGCCAGGTGGCGCCGTGGTTCGTGGACGACACCGCGAAGC
GCTTCGCGGCCTACGGCTGGAATGTGATCGGGCCGATCGACGGTCACGATGTCGATGCAGTCGACGCGGCGATCACGCAA
GCCAAGCGCCATGTGGGCCAACCCAGTCTGATCGTGTGCAAGACCGCGATCGGCAAGGGCTCACCGAACCGCGCCAATAC
CGCCAAGGCGCACGGCGAGCCGCTCGGCGCCGAGGAGATTGCGCTCACGCGGGCCACGATCGGCTGGCCGCATGCGCCAT
TCGAGATCCCGGCCGAGGCCTACAACGACTGGGACGCCAAGGACGCCGGTGCCAACCTGCAGGCCGACTGGGAAGGCCGC
TTCGAGGCCTACCGCGCCGACCATCCCGCCGCCGCGGCCGAGTTCGAACGCCGGATGGCGGGCGCGCTGCCGGAGAACTT
TGCGCAGATCGCAGTGGACGCTGCCATCGCGGCACACGCCAAGGCCGAGACGGTCGCCAGCCGCAAGGCCAGCCAGCTCG
CGCTGGAGGCCTTCACCGCTGCGTTGCCCGAACTGCTGGGCGGCAGTGCCGACCTCACCGGCTCGAATCTCACCAACACC
AAGAGCACACCGGCGCTGCGCTTCGATGCGGCAGGTGCTTCGAACGGTGGCCGCCACATCAACTACGGCGTGCGCGAGTT
CGGCATGGCGGCGTTGATGAACGGCATCGCGCTGCACGGCGGCTTCATCCCCTACGGCGGCACCTTCCTGACCTTCAGCG
ACTACTCGCGCAACGCCATCCGCATGGCCGCGCTGATGAAGCAGCGCGTGGTGCATGTCTTCACCCACGACAGCATCGGC
CTCGGCGAGGACGGCCCGACGCACCAGAGCGTGGAGCACGCCGCGAGCCTGCGGCTGATCCCGAACCTCGATGTCTGGCG
TCCCGCCGACACGGCCGAGACCACGATCGCGTGGACCAAGGCGCTGCTGAACGTGGACCGCCCGACCGCGCTGCTGCTGT
CGCGTCAGAACCTGCCCTACCTGCCGAAGGCCGGGCTCGACGAGGTGGCGCGCGGCGCCTATGTGCTGGCCGAGCCGGCC
GAGGTGGGGCTGAAGAGGAAGGCCCAGGCAGTGCTCATCGCGACCGGGTCCGAGGTGCAGCTCGCGCTGCATGCGCAGCA
GCAGCTCGCCGCCGCCGGCATCGCGGTGCGCGTGGTGTCGATGCCCAGCACCACCACCTTCGATCGCCAGGACGTGGCCT
ACAAGCGCCGCGTGTTGCCCGACGGGCTGCCGCGGGTGGCGGTGGAGGCCGGCGTCACCGATGGCTGGTGGAAGTACGGT
TGCGCAGCCGTCATCGGCCTCGACACCTACGGCGAGTCGGCCCCGGCCGGTGCGTTGTTCAAGCACTTCGGCTTCACGGC
CGAGAACGTGGCCGCGACCGTGCGCCGGGTGCTGAAGAAGTGA

Upstream 100 bases:

>100_bases
CAAATCGGCGGTGAGGTGCAGACCCTGCATGGGTGGCGCGACGGGGCTCGTAAAATCGTCGATTCTGCCGCTTCCGTGGC
GCCCTTTTCCCCTGCAAACC

Downstream 100 bases:

>100_bases
GGGCCCGCCCGCCGCTGCGAGGCTCCGTGACATCTGCCGCGGGGAGCACGGCCGGATGTCGGGGCCGGCGCGGCGGCGCG
GGGCGTTTTGTCGTCGAATG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MAALESRTPATPDTSLMANAIRALAMDAVQQANSGHPGAPMGMADIAVALWGRHLRHNPANPAWADRDRFVLSNGHGSML
IYALLHLTGYALPLEELRNFRQLHSKTPGHPEVGITPGVETTTGPLGQGLSNAVGMALAEKLLAAEFNRDGYAIVDHHTY
VFLGDGCLMEGISHEASALAGAWKLDKLIALYDDNGISIDGQVAPWFVDDTAKRFAAYGWNVIGPIDGHDVDAVDAAITQ
AKRHVGQPSLIVCKTAIGKGSPNRANTAKAHGEPLGAEEIALTRATIGWPHAPFEIPAEAYNDWDAKDAGANLQADWEGR
FEAYRADHPAAAAEFERRMAGALPENFAQIAVDAAIAAHAKAETVASRKASQLALEAFTAALPELLGGSADLTGSNLTNT
KSTPALRFDAAGASNGGRHINYGVREFGMAALMNGIALHGGFIPYGGTFLTFSDYSRNAIRMAALMKQRVVHVFTHDSIG
LGEDGPTHQSVEHAASLRLIPNLDVWRPADTAETTIAWTKALLNVDRPTALLLSRQNLPYLPKAGLDEVARGAYVLAEPA
EVGLKRKAQAVLIATGSEVQLALHAQQQLAAAGIAVRVVSMPSTTTFDRQDVAYKRRVLPDGLPRVAVEAGVTDGWWKYG
CAAVIGLDTYGESAPAGALFKHFGFTAENVAATVRRVLKK

Sequences:

>Translated_680_residues
MAALESRTPATPDTSLMANAIRALAMDAVQQANSGHPGAPMGMADIAVALWGRHLRHNPANPAWADRDRFVLSNGHGSML
IYALLHLTGYALPLEELRNFRQLHSKTPGHPEVGITPGVETTTGPLGQGLSNAVGMALAEKLLAAEFNRDGYAIVDHHTY
VFLGDGCLMEGISHEASALAGAWKLDKLIALYDDNGISIDGQVAPWFVDDTAKRFAAYGWNVIGPIDGHDVDAVDAAITQ
AKRHVGQPSLIVCKTAIGKGSPNRANTAKAHGEPLGAEEIALTRATIGWPHAPFEIPAEAYNDWDAKDAGANLQADWEGR
FEAYRADHPAAAAEFERRMAGALPENFAQIAVDAAIAAHAKAETVASRKASQLALEAFTAALPELLGGSADLTGSNLTNT
KSTPALRFDAAGASNGGRHINYGVREFGMAALMNGIALHGGFIPYGGTFLTFSDYSRNAIRMAALMKQRVVHVFTHDSIG
LGEDGPTHQSVEHAASLRLIPNLDVWRPADTAETTIAWTKALLNVDRPTALLLSRQNLPYLPKAGLDEVARGAYVLAEPA
EVGLKRKAQAVLIATGSEVQLALHAQQQLAAAGIAVRVVSMPSTTTFDRQDVAYKRRVLPDGLPRVAVEAGVTDGWWKYG
CAAVIGLDTYGESAPAGALFKHFGFTAENVAATVRRVLKK
>Mature_679_residues
AALESRTPATPDTSLMANAIRALAMDAVQQANSGHPGAPMGMADIAVALWGRHLRHNPANPAWADRDRFVLSNGHGSMLI
YALLHLTGYALPLEELRNFRQLHSKTPGHPEVGITPGVETTTGPLGQGLSNAVGMALAEKLLAAEFNRDGYAIVDHHTYV
FLGDGCLMEGISHEASALAGAWKLDKLIALYDDNGISIDGQVAPWFVDDTAKRFAAYGWNVIGPIDGHDVDAVDAAITQA
KRHVGQPSLIVCKTAIGKGSPNRANTAKAHGEPLGAEEIALTRATIGWPHAPFEIPAEAYNDWDAKDAGANLQADWEGRF
EAYRADHPAAAAEFERRMAGALPENFAQIAVDAAIAAHAKAETVASRKASQLALEAFTAALPELLGGSADLTGSNLTNTK
STPALRFDAAGASNGGRHINYGVREFGMAALMNGIALHGGFIPYGGTFLTFSDYSRNAIRMAALMKQRVVHVFTHDSIGL
GEDGPTHQSVEHAASLRLIPNLDVWRPADTAETTIAWTKALLNVDRPTALLLSRQNLPYLPKAGLDEVARGAYVLAEPAE
VGLKRKAQAVLIATGSEVQLALHAQQQLAAAGIAVRVVSMPSTTTFDRQDVAYKRRVLPDGLPRVAVEAGVTDGWWKYGC
AAVIGLDTYGESAPAGALFKHFGFTAENVAATVRRVLKK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=709, Percent_Identity=26.2341325811001, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI4507521, Length=709, Percent_Identity=26.2341325811001, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI133778974, Length=597, Percent_Identity=26.8006700167504, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI225637459, Length=603, Percent_Identity=23.5489220563847, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI225637461, Length=507, Percent_Identity=24.0631163708087, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI225637463, Length=507, Percent_Identity=24.0631163708087, Blast_Score=103, Evalue=5e-22,
Organism=Escherichia coli, GI48994911, Length=667, Percent_Identity=60.8695652173913, Blast_Score=819, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=667, Percent_Identity=59.0704647676162, Blast_Score=791, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=607, Percent_Identity=28.171334431631, Blast_Score=174, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325331, Length=670, Percent_Identity=47.0149253731343, Blast_Score=584, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6319593, Length=670, Percent_Identity=43.2835820895522, Blast_Score=536, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24666278, Length=687, Percent_Identity=24.3085880640466, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI45551847, Length=268, Percent_Identity=33.2089552238806, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45550715, Length=268, Percent_Identity=33.2089552238806, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24645119, Length=232, Percent_Identity=33.6206896551724, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72305; Mature: 72173

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALESRTPATPDTSLMANAIRALAMDAVQQANSGHPGAPMGMADIAVALWGRHLRHNPA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
NPAWADRDRFVLSNGHGSMLIYALLHLTGYALPLEELRNFRQLHSKTPGHPEVGITPGVE
CCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
TTTGPLGQGLSNAVGMALAEKLLAAEFNRDGYAIVDHHTYVFLGDGCLMEGISHEASALA
CCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEECCCHHHHCCCHHHHHHH
GAWKLDKLIALYDDNGISIDGQVAPWFVDDTAKRFAAYGWNVIGPIDGHDVDAVDAAITQ
HHHHHCEEEEEECCCCEEECCCCCCEEECHHHHHHHHCCCCEECCCCCCCCHHHHHHHHH
AKRHVGQPSLIVCKTAIGKGSPNRANTAKAHGEPLGAEEIALTRATIGWPHAPFEIPAEA
HHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHEEEEEECCCCCCCCCCCHHH
YNDWDAKDAGANLQADWEGRFEAYRADHPAAAAEFERRMAGALPENFAQIAVDAAIAAHA
CCCCCCCCCCCCCEECCCCCHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KAETVASRKASQLALEAFTAALPELLGGSADLTGSNLTNTKSTPALRFDAAGASNGGRHI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEE
NYGVREFGMAALMNGIALHGGFIPYGGTFLTFSDYSRNAIRMAALMKQRVVHVFTHDSIG
ECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHEEEEECCCCC
LGEDGPTHQSVEHAASLRLIPNLDVWRPADTAETTIAWTKALLNVDRPTALLLSRQNLPY
CCCCCCCHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCC
LPKAGLDEVARGAYVLAEPAEVGLKRKAQAVLIATGSEVQLALHAQQQLAAAGIAVRVVS
CCCCCHHHHHCCCEEEECHHHHCHHCCCCEEEEEECCCEEEEHHHHHHHHHCCEEEEEEE
MPSTTTFDRQDVAYKRRVLPDGLPRVAVEAGVTDGWWKYGCAAVIGLDTYGESAPAGALF
CCCCCCCCHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHCCEEEEEECCCCCCCCHHHHH
KHFGFTAENVAATVRRVLKK
HHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AALESRTPATPDTSLMANAIRALAMDAVQQANSGHPGAPMGMADIAVALWGRHLRHNPA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
NPAWADRDRFVLSNGHGSMLIYALLHLTGYALPLEELRNFRQLHSKTPGHPEVGITPGVE
CCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
TTTGPLGQGLSNAVGMALAEKLLAAEFNRDGYAIVDHHTYVFLGDGCLMEGISHEASALA
CCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEECCCHHHHCCCHHHHHHH
GAWKLDKLIALYDDNGISIDGQVAPWFVDDTAKRFAAYGWNVIGPIDGHDVDAVDAAITQ
HHHHHCEEEEEECCCCEEECCCCCCEEECHHHHHHHHCCCCEECCCCCCCCHHHHHHHHH
AKRHVGQPSLIVCKTAIGKGSPNRANTAKAHGEPLGAEEIALTRATIGWPHAPFEIPAEA
HHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHEEEEEECCCCCCCCCCCHHH
YNDWDAKDAGANLQADWEGRFEAYRADHPAAAAEFERRMAGALPENFAQIAVDAAIAAHA
CCCCCCCCCCCCCEECCCCCHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KAETVASRKASQLALEAFTAALPELLGGSADLTGSNLTNTKSTPALRFDAAGASNGGRHI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEE
NYGVREFGMAALMNGIALHGGFIPYGGTFLTFSDYSRNAIRMAALMKQRVVHVFTHDSIG
ECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHEEEEECCCCC
LGEDGPTHQSVEHAASLRLIPNLDVWRPADTAETTIAWTKALLNVDRPTALLLSRQNLPY
CCCCCCCHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCC
LPKAGLDEVARGAYVLAEPAEVGLKRKAQAVLIATGSEVQLALHAQQQLAAAGIAVRVVS
CCCCCHHHHHCCCEEEECHHHHCHHCCCCEEEEEECCCEEEEHHHHHHHHHCCEEEEEEE
MPSTTTFDRQDVAYKRRVLPDGLPRVAVEAGVTDGWWKYGCAAVIGLDTYGESAPAGALF
CCCCCCCCHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHCCEEEEEECCCCCCCCHHHHH
KHFGFTAENVAATVRRVLKK
HHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]