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The map label for this gene is gmk [H]

Identifier: 124022377

GI number: 124022377

Start: 629196

End: 629774

Strand: Direct

Name: gmk [H]

Synonym: P9303_06681

Alternate gene names: 124022377

Gene position: 629196-629774 (Clockwise)

Preceding gene: 124022369

Following gene: 124022380

Centisome position: 23.45

GC content: 53.02

Gene sequence:

>579_bases
ATGCAATCAATGGCTCCATCCGCCGCTGAAGGAAAGCTCACGGTGATTACTGGGCCCAGTGGCGTTGGTAAGGGTTCGTT
GGTGAAGCAACTCCTAGAGCTCCATCCAGAGATCTGGCTGTCTATTTCGGCGACAACGCGTGAAGCCAGGCAAGGCGAGA
TTGAGGGTGATCATTACTTCTTCTTGAACCGTGATCGCTTTGCAGAACTGGTTCAAGCTGGCGGTTGTCTTGAATGGGCT
GAATTTGCAGGCAATCGCTATGGCACCCCACGCCAACCTGTTGAGCAGCAGCTTTCATTAGGCCGTCCGGTTTTGCTTGA
GATTGAACTGGAAGGGGCCCGACAGGTGCGGCGCAGTTTCCCTGAAGCTTTTCAGATTTTTTTGGCACCGCCCAGTTTTG
AGGAGCTTGAACGACGCATTCGTGGACGCGCCACTGATCCTGAAGAGGCAATTCAGCGACGTTTAGCTAGGGCGAGGGAG
GAACTGATGGCTCAGCAGGAGTTTGATGCAGTGGTGATTAATGACAACCTGCAGGTTGCTGTGATTGAGCTGGAGTCTTT
GATGGGTCTGAGCTGTTGA

Upstream 100 bases:

>100_bases
AGCTTGAGAGGTCCATGACCTGGAGGGCAGCAGGGGCCATCGATTCAGTCGGGACCTGGATTGCACGCAGCCTTCCTACT
CTGCGATCCGATTCAATGCA

Downstream 100 bases:

>100_bases
TGCGAAGACTGTTTCCTTACCTTAAAGCGTTATTTGACAACATAGGCCAATAAAAAAAGCCCTTTTAGAGGGCTTTTTGA
AGGGGTTTAGCCAAGAAGCT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MQSMAPSAAEGKLTVITGPSGVGKGSLVKQLLELHPEIWLSISATTREARQGEIEGDHYFFLNRDRFAELVQAGGCLEWA
EFAGNRYGTPRQPVEQQLSLGRPVLLEIELEGARQVRRSFPEAFQIFLAPPSFEELERRIRGRATDPEEAIQRRLARARE
ELMAQQEFDAVVINDNLQVAVIELESLMGLSC

Sequences:

>Translated_192_residues
MQSMAPSAAEGKLTVITGPSGVGKGSLVKQLLELHPEIWLSISATTREARQGEIEGDHYFFLNRDRFAELVQAGGCLEWA
EFAGNRYGTPRQPVEQQLSLGRPVLLEIELEGARQVRRSFPEAFQIFLAPPSFEELERRIRGRATDPEEAIQRRLARARE
ELMAQQEFDAVVINDNLQVAVIELESLMGLSC
>Mature_192_residues
MQSMAPSAAEGKLTVITGPSGVGKGSLVKQLLELHPEIWLSISATTREARQGEIEGDHYFFLNRDRFAELVQAGGCLEWA
EFAGNRYGTPRQPVEQQLSLGRPVLLEIELEGARQVRRSFPEAFQIFLAPPSFEELERRIRGRATDPEEAIQRRLARARE
ELMAQQEFDAVVINDNLQVAVIELESLMGLSC

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=39.4285714285714, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=39.4285714285714, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI226874831, Length=176, Percent_Identity=39.2045454545455, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI14780902, Length=187, Percent_Identity=30.4812834224599, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=29.7752808988764, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI21361598, Length=185, Percent_Identity=27.5675675675676, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI111154074, Length=162, Percent_Identity=30.2469135802469, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI52630447, Length=186, Percent_Identity=27.4193548387097, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4505237, Length=184, Percent_Identity=27.1739130434783, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118255, Length=184, Percent_Identity=27.1739130434783, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118259, Length=184, Percent_Identity=27.1739130434783, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118263, Length=184, Percent_Identity=27.1739130434783, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=182, Percent_Identity=43.4065934065934, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI193203132, Length=179, Percent_Identity=36.3128491620112, Blast_Score=130, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=179, Percent_Identity=36.3128491620112, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI71988041, Length=181, Percent_Identity=23.7569060773481, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71988048, Length=181, Percent_Identity=23.7569060773481, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17557440, Length=188, Percent_Identity=25.531914893617, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=179, Percent_Identity=39.1061452513966, Blast_Score=141, Evalue=7e-35,
Organism=Drosophila melanogaster, GI21356141, Length=178, Percent_Identity=37.6404494382022, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI116007136, Length=181, Percent_Identity=25.414364640884, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45554489, Length=181, Percent_Identity=25.414364640884, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640542, Length=181, Percent_Identity=25.414364640884, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI85724806, Length=181, Percent_Identity=25.414364640884, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45554481, Length=181, Percent_Identity=25.414364640884, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161077626, Length=181, Percent_Identity=25.414364640884, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221330166, Length=159, Percent_Identity=27.0440251572327, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330162, Length=159, Percent_Identity=27.0440251572327, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330164, Length=159, Percent_Identity=27.0440251572327, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21493; Mature: 21493

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSMAPSAAEGKLTVITGPSGVGKGSLVKQLLELHPEIWLSISATTREARQGEIEGDHYF
CCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHEEEEECCHHHHHCCCCCCCEEE
FLNRDRFAELVQAGGCLEWAEFAGNRYGTPRQPVEQQLSLGRPVLLEIELEGARQVRRSF
EECHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHC
PEAFQIFLAPPSFEELERRIRGRATDPEEAIQRRLARAREELMAQQEFDAVVINDNLQVA
HHHHEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEE
VIELESLMGLSC
EEEEHHHCCCCC
>Mature Secondary Structure
MQSMAPSAAEGKLTVITGPSGVGKGSLVKQLLELHPEIWLSISATTREARQGEIEGDHYF
CCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHEEEEECCHHHHHCCCCCCCEEE
FLNRDRFAELVQAGGCLEWAEFAGNRYGTPRQPVEQQLSLGRPVLLEIELEGARQVRRSF
EECHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHC
PEAFQIFLAPPSFEELERRIRGRATDPEEAIQRRLARAREELMAQQEFDAVVINDNLQVA
HHHHEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEE
VIELESLMGLSC
EEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]